scholarly journals Arboviruses emerging in Brazil: challenges for clinic and implications for public health

2017 ◽  
Vol 51 (0) ◽  
Author(s):  
Maria Rita Donalisio ◽  
André Ricardo Ribas Freitas ◽  
Andrea Paula Bruno Von Zuben

ABSTRACT Arboviruses have been emerging in different parts of the world due to genetic changes in the virus, alteration of the host and vector population dynamics, or because of anthropogenic environmental factors. These viruses’ capacity for adaptation is notable, as well as the likelihood of their emergence and establishment in new geographic areas. In Brazilian epidemiologic scenario, the most common arboviruses are DENV, CHIKV, and ZIKV, although others may spread in the country. Little is yet known of the impact of viral co-circulation, which would theoretically result in more intense viremia or other immunological alterations that could trigger autoimmune diseases, such as Guillain-Barré syndrome. The impact on morbidity and mortality intensifies as extensive epidemics lead to a high number of affected individuals, severe cases, and implications for health services, mainly due to the absence of treatment, vaccines, and effective prevention and control measures.

2021 ◽  
Author(s):  
Chunmei Su ◽  
Zhiqin Zhang ◽  
Xu Zhao ◽  
Hanlin Peng ◽  
Yi Hong ◽  
...  

Abstract Background: Nosocomial infections (NIs) are an important cause of mortality, and increasing evidence reveals that the prevalence of NIs can be reduced through effective prevention and control measures. The aim of this study was to investigate the impact of the prevention and control measures for the COVID-19 pandemic on NIs.Methods: A retrospective study was conducted to analyze the prevalence of NIs before and after COVID-19 pandemic for six months in the Children’s Hospital of Soochow University.Results: A total of 39,914 patients in 2019 and 34,645 patients in 2020 were admitted to the hospital during the study. There were 1.39% (481/34645) of patients with NIs in 2020, which was significantly lower than the 2.56% (1021/39914) of patients in 2019. The rate of critical and fatal cases was also decreased. Except for the ICU, the prevalence of nosocomial infection in most departments decreased from 2019 to 2020. Regarding the source of infections, a significant reduction was mainly observed in respiratory (0.99% vs 0.42%, p=0.000) and digestive tract (0.63% vs 0.14%, p=0.000). The microorganism analysis of respiratory infections indicated an obvious decline in acinetobacters and fungi. The most significant decline of pathogens in gastrointestinal infections was observed for rotavirus. The comparison of catheter-related nosocomial infections between 2019 and 2020 did not show significant differences. Conclusions: The prevention and control measures for the COVID-19 pandemic have reduced the nosocomial infection in almost all departments, except the ICU, mainly regarding respiratory, gastrointestinal, and oral infections, while catheter-related infections did not show any differences.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chunmei Su ◽  
Zhiqin Zhang ◽  
Xu Zhao ◽  
Hanlin Peng ◽  
Yi Hong ◽  
...  

Abstract Background Nosocomial infections (NIs) are an important cause of mortality, and increasing evidence reveals that the prevalence of NIs can be reduced through effective prevention and control measures. The aim of this study was to investigate the impact of the prevention and control measures for the COVID-19 pandemic on NIs. Methods A retrospective study was conducted to analyze the prevalence of NIs before and after COVID-19 pandemic for 6 months in the Children’s Hospital of Soochow University. Results A total of 39,914 patients in 2019 and 34,645 patients in 2020 were admitted to the hospital during the study. There were 1.39% (481/34645) of patients with NIs in 2020, which was significantly lower than the 2.56% (1021/39914) of patients in 2019. The rate of critical and fatal cases was also decreased. In addition, the rate of appropriate handwashing, the number of protective gloves and aprons used per person and the number of healthcare staff per patients were significantly increased. Except for the ICU, the prevalence of nosocomial infection in most departments decreased from 2019 to 2020. Regarding the source of infections, a significant reduction was mainly observed in respiratory (0.99% vs 0.42%, p = 0.000) and digestive tract (0.63% vs 0.14%, p = 0.000). The microorganism analysis of respiratory infections indicated an obvious decline in acinetobacters and fungi. The most significant decline of pathogens in gastrointestinal infections was observed for rotavirus. The comparison of catheter-related nosocomial infections between 2019 and 2020 did not show significant differences. Conclusions The prevention and control measures for the COVID-19 pandemic have reduced the nosocomial infection in almost all departments, except the ICU, mainly regarding respiratory, gastrointestinal, and oral infections, while catheter-related infections did not show any differences.


Author(s):  
Y. Arockia Suganthi ◽  
Chitra K. ◽  
J. Magelin Mary

Dengue fever is a painful mosquito-borne infection caused by different types of virus in various localities of the world. There is no particular medicine or vaccine to treat person suffering from dengue fever. Dengue viruses are transmitted by the bite of female Aedes (Ae) mosquitoes. Dengue fever viruses are mainly transmitted by Aedes which can be active in tropical or subtropical climates. Aedes Aegypti is the key step to avoid infection transmission to save millions of people in all over the world. This paper provides a standard guideline in the planning of dengue prevention and control measures. At the same time gives the priorities including clinical management and hospitalized dengue patients have to address essentially.


2020 ◽  
Vol 8 ◽  
Author(s):  
Zhong Sun ◽  
Guozhong He ◽  
Ninghao Huang ◽  
Hongyu Chen ◽  
Shuwei Zhang ◽  
...  

Background: COVID-19 developed into a global pandemic in 2020 and poses challenges regarding the prevention and control capabilities of countries. A large number of inbound travelers from other regions could lead to a renewed outbreak of COVID-19 in the local regions. Globally, as a result of the imbalance in the control of the epidemic, all countries are facing the risk of a renewed COVID-19 outbreak brought about by travelers from epidemic areas. Therefore, studies on a proper management of the inbound travelers are urgent.Methods: We collected a total of 4,733,414 inbound travelers and 174 COVID-19 diagnosed patients in Yunnan province from 21 January 2020 to 20 February 2020. Data on place of origin, travel history, age, and gender, as well as whether they had suspected clinical manifestations for inbound travelers in Yunnan were collected. The impact of inbound travelers on the local epidemic was analyzed with a collinear statistical analysis and the effect of the control measures on the epidemic was evaluated with a sophisticated modeling approach.Results: Of the 174 COVID-19 patients, 60.9% were not from Yunnan, and 76.4% had a history of travel in Hubei. The amount of new daily cases in Yunnan was significant correlated with the number of inbound travelers from Hubei and suspected cases among them. Using Susceptible–Exposed–Infectious–Recovered (SEIR) model analysis, we found that the prevention and control measures dropped the local R0 down to 1.07 in Yunnan province.Conclusions: Our preliminary analysis showed that the proper management of inbound travelers from outbreak areas has a significantly positive effect on the prevention and control of the virus. In the process of resettlement, some effective measures taken by Yunnan province may provide an important reference for preventing the renewed COVID-19 outbreak in other regions.


2020 ◽  
Vol 9 (4) ◽  
Author(s):  
Nashi Masnad Alreshidi ◽  
Hassan Haridi ◽  
Rana Alaseeri ◽  
Michelle Garcia ◽  
Fe Gaspar ◽  
...  

Background: Coronavirus disease 2019 (COVID-19) pandemic extended to reach most countries in the globe during few months. Preparedness of healthcare institutions and healthcare workers (HCWs) are crucial for applying effective prevention and control measures. This study aimed to assess HCWs knowledge, emotions and perception of preparedness of their institutions towards COVID-19 pandemic.Design: A cross-sectional, web-based survey was conducted among hospital HCWs in Saudi Arabia during April 27, 2020 to May 03, 2020.Results: Overall, 1004 completed responses were received. The majority were females (78.8), nurses (84.9%) at middle age 25-39 years (71.8%). Among participants, 95.5% reported receiving training on safely use of personal protective equipment (PPE) and 94.9% did fit the test for N95 respirator. The participants possessed a fair knowledge about COVID-19 disease with a mean knowledge score 6. 61±1.35 points on a scale of 10 points. Most participants (88.7%) were committed to continue work as a professional and ethical duty, however, 27.1% of them scored high on a negative emotional impact scale. Participants appreciated most aspects of institutional preparedness for COVID-19 pandemic; however, they were concerned with the continuous PPE supply. Factors that independently associated with good knowledge and negative emotional response were determined using multivariate logistic regression analysis.Conclusions: Findings revealed fair knowledge about COVID-19 pandemic among HCWs in Saudi hospitals. Concerns and worries were expressed regard working with the highly infectious COVID-19 patients. Participants, appreciated most aspects of institutional preparedness, however they were concerned about the continuous availability and supply of PPE.


2021 ◽  
Vol 14 (2) ◽  
pp. 139-154
Author(s):  
M. Focker ◽  
H.J. van der Fels-Klerx ◽  
N. Magan ◽  
S.G. Edwards ◽  
M. Grahovac ◽  
...  

The presence of mycotoxins in cereals has led to large economic losses in Europe. In the course of the European project MyToolBox, prevention and control measures to reduce mycotoxin contamination in cereals were developed. This study aimed to estimate the impact of these prevention and control measures on both the reduction in crop losses and the increased volume of crops suitable for food and/or feed. It focused on the following measures: the use of fungicides during wheat cultivation, the use of resistant maize cultivars and/or biocontrol during maize cultivation, the use of real time sensors in storage silos, the use of innovative milling strategies during the pasta making process, and the employment of degrading enzymes during the process of bioethanol and Dried Distillers Grains with Solubles (DDGS) production. The impact assessment was based on the annual volume of cereals produced, the annual levels of mycotoxin contamination, and experimental data on the prevention and control measures collected in the course of the MyToolBox project. Results are expressed in terms of reduced volumes of cereals lost, or as additional volumes of cereals available for food meeting the current European legal limits. Results showed that a reduction in crop losses as well as an increase in the volume of crops suitable as food and/or feed is feasible with each proposed prevention or control measure along the supply chain. The impact was the largest in areas and in years with the highest mycotoxin contamination levels but would have less impact in years with low mycotoxin levels. In further research, the impact assessment may be validated using future data from more years and European sites. Decision makers in the food and feed supply chain can use this impact assessment to decide on the relevant prevention and control strategies to apply.


Bionatura ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 1410-1417
Author(s):  
Daniel Tinôco ◽  
Suzana Borschiver

The World Scientific Community has carried out several studies on the novel coronavirus, responsible for the current COVID-19 pandemic. This study aimed to verify the development level and research evolution on COVID-19, summarizing experts' main trends in the first half of 2020. The most cited articles focused on understanding the disease, addressing aspects of its transmission, viral activity period, symptoms, health complications, risk factors, and the estimate of new cases. These papers also focused on the treatment/prevention and management of COVID-19. Several drugs and alternative treatments have been investigated, such as the convalescent plasma transfusion and stem cell transplantation, while an efficient vaccine is developed. Prevention and control measures, such as social isolation and immediate case identification, were also investigated. Therefore, the main COVID-19 trends were identified and classified in disease, treatment/prevention, and pandemic management, contributing to scientific understanding and future studies.


2020 ◽  
Author(s):  
Qing Zheng ◽  
Lei Wang ◽  
Hongbin Wang ◽  
Wenjing Gui

Abstract COVID-19 has been spreading around the world since the end of 2019, and there is no sign of a slowdown. Previous studies on seasonality of similar infectious diseases have hinted that meteorological factors may influence COVID-19 outbreaks as well1. Here we show, based on data collected in 132 cities of China, that relative humidity, as an essential meteorological indicator, is positively correlated with the growth rate of incidence of COVID-19, which contradicts previous research findings. Our result suggests an increasing risk of COVID-19 cases as summer and rain seasons arrive in many places of the world. They also help countries and regions to formulate pandemic prevention and control measures and policies according to local meteorological characteristics.


2018 ◽  
Vol 23 (45) ◽  
pp. 173-178
Author(s):  
Marco Orsini ◽  
Denise Flávio De Carvalho ◽  
José Teixeira De Seixas Filho ◽  
Rossano Fiorelli ◽  
Eduardo Lima Trajano

Background: In Brazilian territory, the most common arboviruses are DENV (Dengue), CHIKV (Chikungunya), and ZIKV (Zica), although others may spread in the country. These arboviruses has also resulted in a number of neurologic diseases such as Guillain-Barré syndrome, meningoencephalitis, myositis and cranial nerve palsies. This article reports the case of a woman, 33 years that suddenly developed shooting fever, muscle pain and ascedent weakness, receiving subsequently the diagnosis of guillain-barré syndrome for probable unspecified viral infection. After a few days of hospitalization, the diagnosis of Guillain-Barre by possible CHIKV fever were confirmed across clinical evaluation, cerebrospinal fluid, electrophysiological findings and the specific titles of IgM for CHIKV. Months after treatment with intravenous immunoglobulin remains with muscle weakness in lower limbs and difficulties in performing daily activities. The article becomes important because chikungunya infection causes a high number of affected individuals, with severe cases (as presented), and implications for health services, mainly due to the absence of specific treatment, vaccines, and effective prevention and control measures.


Author(s):  
Vilma Andia-Choquepuma ◽  
Daniza Juana Leon-Escobedo ◽  
Himer Avila-George ◽  
orge Sánchez-Garcés ◽  
Ruth Elizabeth Villafuerte-Alcántara ◽  
...  

After the World Health Organization declared the outbreak of Coronavirus (COVID-19) a pandemic, the Peruvian government took preventive measures to counteract the spread of the virus by issuing Supreme Decree No. 008-2020-SA. This decree contains prevention and control measures aimed at ports, airports, land entry points, educational centers, transportation and workplaces.


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