scholarly journals Cavernous body reduction in four patients with erectile dysfunction due to insufficient venous occlusion and a deficit of elastic fibers in the tunica albugínea

2007 ◽  
Vol 33 (6) ◽  
pp. 785-794 ◽  
Author(s):  
Fabrizio Iacono ◽  
Domenico Prezioso ◽  
Stefania Chierchia ◽  
Raffaele Galasso ◽  
Gennaro Iapicca ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Tunica Albuginea ◽  
Venous Occlusion ◽  
Elastic Fibers ◽  
Cavernous Body

scholarly journals COMPARİSON OF PREOPERATİVE PENİLE ELASTOGRAPHİC ULTRASOUND FİNDİNGS AND PATHOLOGİCAL TİSSUE RESULTS OF PATİENTS İMPLEMENTED WİTH PENİLE PROSTHESİS

2021 ◽  
Author(s):  
Yunus Erol BOZKURT ◽  
Bilal Gumus ◽  
Fatih DÜZGÜN ◽  
Nalan NEŞE
Keyword(s):  
Erectile Dysfunction ◽  
Shear Wave ◽  
Elastic Fiber ◽  
Muscle Fibers ◽  
Penile Prosthesis ◽  
Shear Wave Elastography ◽  
Elastic Fibers ◽  
Tissue Samples ◽  
Spearman’S Correlation ◽  
Cavernous Body

Objective Histopathologically to determine the relationship between penile elastography ultrasonography and erectile dysfunction. Material and Method 12 patients who applied to our clinic for erectile dysfunction in the last 1 year and accepted this study were included . Preoperative two-dimensional shear wave elastography imaging was performed in 12 patients and recorded in the Pascal (kPa) unit. Approximately 0.5x0.5x0.5 cm tissue samples were taken from the right and left spongy tissue during penile prosthesis implantation operation. Tissue samples were sent to the pathology department. The percentage of the area covered by muscle fibers and elastic fibers in the corpus cavernosum was noted semi-quantitatively (ratio of muscle fibers and cavernous body elastic fiber score). All data obtained were compared with each other. Results Cavernous body elastic fiber score data(Grouped Score 1, 2 and 3) and percentage of cavernous body muscle fibers data (Grouped %10,%20,%30… %100) were compared with Shear wave elastography data (kPa). The results were not statistically significant according to the Kruskal Wallis Test and Spearman’s correlation test. Cavernous body elastic fiber score and the percentage of cavernous body muscle fibers were also compared, it was not statistically significant according to the Kruskal Wallis test and Spearman’s correlation test. The data we obtained as a result of our study showed that penile elastographic imaging is not a reliable method in the diagnosis of erectile dysfunction. Conclusions Penile shear wave elastography can be used clinically to quantitatively assess the amount of smooth muscle cells and elastic fibers in the penis, but it deserves to be studied with a larger number of patients and a more specific interpretation of the pathology preparation. Keywords: Penile elastography, erectile dysfunction, penile prosthesis, shear wave

Tunica Albuginea Reefing: A Novel Technique for the Treatment of Erectile Dysfunction

2011 ◽  
Vol 24 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Olfat el-Sibai ◽  
Ali A. Shafik ◽  
Ismail A. Shafik
Keyword(s):  
Erectile Dysfunction ◽  
Tunica Albuginea ◽  
Novel Technique

scholarly journals MODERN METHODS OF CORRECTION OF VEIN-OCCLUSIVE ERECTILE DYSFUNCTION

2020 ◽  
pp. 106-115
Author(s):  
Александр Книгавко
Keyword(s):  
Stem Cells ◽  
Erectile Dysfunction ◽  
Venous Occlusion ◽  
Long Term Results ◽  
Surgical Removal ◽  
Subjective Data ◽  
Vascular Growth ◽  
Dorsal Vein ◽  
Vascular Growth Factor

Aim: to study the long-term effectiveness of stimulation of the vein-occlusive mechanism by the addition of autologous stem cells and PRP therapy in the surgical removal of venous leak.Materials and Methods: comprehensive examination and treatment of 156 patients with vein-occlusive erectile dysfunction was carried out. Most of them – 112 (82.9%), – had left-sided or bilateral varicocele. In 86 patients of the first group with a proximal form of vein-occlusive erectile dysfunction, ligation of deep dorsal veins and veins of the penis and Marmara operation from a foam-pubic incision were performed. In 49 patients of the second group with a distal form of vein-occlusive erectile dysfunction, embolization of deep dorsal veins and veins of the Santorini plexus was performed through a conductor in the deep dorsal vein of the penis. To improve the venous occlusion mechanism, 1 million autologous endothelial stem cells and 2 millions autologous fibroblast stem cells were injected into each cavernous body, which were activated by vascular growth factor into the ligated veins (deep dorsal and large veins of the penis) in a retrograde direction during occlusive operations for 48 patients (groups 1b and 2b, respectively) and compared long-term results.Results: The effectiveness of surgical treatment according to subjective data (IIEF questionnaire) – after 2 months was almost equal, but after 18 months it was significantly higher in subgroups 1b and 2b (68,9% и 75,5) and according to objective data (no venous leakage with dopplerography of the penis), after 18 months in 73.4% and 91.4%, respectively.Conclusions: The use of autologous (endothelial and fibroblast) stem cells with the course of PRP therapy improves the veno-occlusive mechanism, increases the efficiency and long-term results of vein-occlusive surgeries for the treatment of VOED, creating an effective alternative to phalloprosthetics for men with this problem.

scholarly journals Use of inflatable penile prostheses AMS CX with momentary squeeze in a patient with Peyronie’s disease after removal of two previously implanted penile prostheses

2014 ◽  
Vol 86 (1) ◽  
pp. 46
Author(s):  
Patrizio Vicini ◽  
Ferdinando De Marco ◽  
Gabriele Antonini ◽  
Ettore De Berardinis ◽  
Riccardo Giovannone ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Tunica Albuginea ◽  
Penile Prosthesis ◽  
Longitudinal Axis ◽  
Peyronie’S Disease ◽  
Neurovascular Bundle ◽  
Complex Case ◽  
Sexual Life ◽  
Penile Prostheses ◽  
Peyronie's Disease

Objective: Peyronie's disease (PD) is a fibrotic wound-healing condition of the tunica albuginea that results in penile deformity, curvature, hinging, narrowing and shortening, penile pain, and in some cases, erectile dysfunction (ED). Surgery remains the gold standard treatment option, ensuring the faster and trustworthy treatment. For those patients who have erectile dysfunction and PD, penile prosthesis placement with straightening procedure is the best method to solve both diseases. The aim of this article is to present the use of hydraulic penile prostheses AMS CX with Momentary Squeeze associated with a complete isolation of the neurovascular bundle in a complex case after removal of two previously implanted prostheses in a man suffering from Peyronie’s disease and erectile dysfunction. Material and method: A 50 year-old patient underwent two previous prosthetic implants in another hospital. The first implantation was performed using an infrapubic approach followed by placement of a three-component hydraulic penile prosthesis. After six months the prosthesis was removed using an infra-pubic approach and two soft prosthesis Virilis II were implanted during the same surgery. One year after the second operation we implanted a hydraulic penile prosthesis AMS CX with Mo - mentary Squeeze after complete isolation of the neurovascular bundle, fixing the two crural tips at the same level of albuginea of the two corpora cavernosa. Result: Twelve months after surgery the penis was completely straight without penile shortening and the patient was fully satisfied with his sexual life. Conclusion: The procedure enabled a perfect alignment of the cylinders along the longitudinal axis and penile prosthetic symmetry to obtain a good penile rigidity and a perfect penile straightening.

Tunica albuginea overlapping: a novel technique for the treatment of erectile dysfunction

Andrologia ◽  
2005 ◽  
Vol 37 (5) ◽  
pp. 180-184 ◽  
Author(s):  
A. Shafik ◽  
I. Shafik ◽  
O. El Sibai ◽  
A. A. Shafik
Keyword(s):  
Erectile Dysfunction ◽  
Tunica Albuginea ◽  
Novel Technique

scholarly journals The histopathological effects of intracavernosal mitomycin-C injection in a rat Peyronie's disease model

2017 ◽  
Vol 11 (11) ◽  
pp. E441-5 ◽  
Author(s):  
Engin Kaya ◽  
Yusuf Kibar ◽  
Sercan Yilmaz ◽  
Ayhan Ozcan ◽  
Burak Kopru ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Tunica Albuginea ◽  
Peyronie’S Disease ◽  
Elastic Fibers ◽  
Antifibrotic Effect ◽  
Peyronie's Disease ◽  
Group 3 ◽  
Group 2 ◽  
Tgf Β1 ◽  
Group 1

Introduction: We aimed to evaluate whether or not mitomycin-C (MMC) has an antifibrotic effect on transforming growth factor-beta (TGF-β)-induced Peyronie’s disease (PD) in a rat model.Methods: Eighteen 12-week-old male Sprague-Dawley rats were divided into three groups: Group 1=TGF-β1 (n=7); Group 2=TGF-β1+MMC (n=7); and Group 3=Sham group (0.25 ml bovine serum albumin injected) (n=4). All groups were sacrificed on the sixth week of the procedure and their penises were excised. All penis specimens were evaluated semi-quantitatively and quantitatively with histochemical, immunohistochemistry, and image analysis.Results: Both Group 1 and Group 2 had significantly higher fibrosis scores and lower elastic fibers in both outer surface of tunica albuginea (TA) and subsinusoidal area compared with Group 3. When compared with Group 1, the amount of collagen was significantly decreased in Group 2. Intracavernosal MMC injection (Group 2) ended up with lower elastic fibers when compared with Group 1. According to the quantitative analyses, when compared with Groups 1 and 3, lower dorsal, ventral, and trabecular thickening values were seen in Group 2. These parameters were only statistically significant when compared with Group 1, suggesting the antifibrotic effect of TGF-β1-induced fibrosis. Both Groups 1 and 2 showed lower decorin staining levels in subsinusoidal areas of tunica albuginea (SATA) and subsinusoidal areas of trabecular wall (SATW) when compared with Group 3. The statistically significant difference was only detected between Group 1 and Group 3.Conclusions: Our study demonstrates the antifibrotic effects of MMC on PD. Further clinical studies are necessary to make inferences regarding its clinical use.

scholarly journals Morphological analysis of the elastic and collagen fibers in the ram penis

2018 ◽  
Vol 38 (11) ◽  
pp. 2159-2165 ◽  
Author(s):  
Bruno Cesar Schimming ◽  
Gustavo N. Moraes
Keyword(s):  
Extracellular Matrix ◽  
Morphological Analysis ◽  
Sigmoid Flexure ◽  
Tunica Albuginea ◽  
Corpus Cavernosum ◽  
Reproductive Organs ◽  
Collagen Fibers ◽  
Elastic Fibers ◽  
Corpus Spongiosum ◽  
Domestic Ruminants

ABSTRACT: The penis represents the organ of the male’s copulation. It is essential to know the reproductive biology and the morphology of the reproductive organs to increase animal production. In order to contribute to this knowledge and provides information on the ram reproductive morphology, the purpose of this work was to describe the distribution, based on light microscopy, of the collagen and elastic fibers in the ram penis. For that, were collected transverse fragments of the penis (root, sigmoid flexure, body and glans) of seven rams. The specimens were fixed in paraformaldehyde for 24h and destined for the histological routine. The extracellular matrix of the ram penis was composed of collagen and elastic fibers. The penis was enveloped by the tunica albuginea, consisting essentially of collagen fibers, which were arranged in two layers: an outer longitudinal and an inner circular. This tunic emitted septa that penetrated the corpus cavernosum. The elastic fibers appeared transversely and longitudinally in the corpus cavernosum, corpus spongiosum, and next to the neurovascular bundle of the penis. This structure was not different to that reported for other domestic ruminants such as cattle and buffaloes.

Effects of castration on penile extracellular matrix morphology in domestic cats

2017 ◽  
Vol 19 (12) ◽  
pp. 1261-1266 ◽  
Author(s):  
Nathalia CS Borges ◽  
Marco A Pereira-Sampaio ◽  
Vivian Alves Pereira ◽  
Marcelo Abidu-Figueiredo ◽  
Maurício Alves Chagas
Keyword(s):  
Extracellular Matrix ◽  
Tunica Albuginea ◽  
Corpus Cavernosum ◽  
Collagen Fibers ◽  
Elastic Fibers ◽  
Corpus Spongiosum ◽  
Predisposing Factor ◽  
Luminal Area ◽  
Matrix Morphology ◽  
Student’S T

Objectives This study was undertaken to verify the possible modifications caused by hormonal deprivation in the extracellular matrix in the penises of neutered cats. Methods Twenty-seven penises from domestic shorthair cats were collected: 14 samples from intact cats and 13 from neutered cats. Sections were stained with Weigert’s resorcin-fuchsin, hematoxylin and eosin, and picrosirius red. Histomorphometric analysis was performed using light microscopy and image analysis software. The following parameters were analyzed: density of the elastic fibers and collagen fibers in the corpus spongiosum; density of the elastic fibers in the tunica albuginea of the corpus cavernosum and the tunica albuginea of the corpus spongiosum; luminal area of the urethra; area of the corpus spongiosum; area of the corpus cavernosum; and thickness of the urethral epithelium. The data were analyzed using the Shapiro–Wilk test to verify the normal distribution, and groups were compared using Student’s t-test; P <0.05 indicated statistically significant differences. Results Significant differences were observed between intact cats and neutered cats in the density of elastic fibers in the tunica albuginea of the corpus cavernosum (8.13% ± 1.38% vs 3.11% ± 0.66%), tunica albuginea of the corpus spongiosum (4.37% ± 1.08% vs 3.30% ± 1.01%) and corpus spongiosum (6.28% ± 3.03% vs 4.10% ± 2.19%), and density of collagen fibers in the corpus spongiosum (34.11% ± 10.86% vs 44.21% ± 12.72%). Conclusions and relevance The results show a significant decrease in the density of the elastic fibers and a significant increase of the density of the collagen fibers in the corpus spongiosum in neutered animals. This suggests that the compliance of the periurethral region is reduced, and these changes could be a predisposing factor for urethral obstructive disease.

scholarly journals Stereological study of the elastic fiber and smooth muscle cell system in the bovine and buffalo penis

2013 ◽  
Vol 33 (suppl 1) ◽  
pp. 107-112 ◽  
Author(s):  
Ilma C.A. Ribeiro ◽  
Marcelo Abidu-Figueiredo ◽  
Fabíola B. Costa ◽  
Marco A. Pereira-Sampaio ◽  
Maurício A. Chagas
Keyword(s):  
Smooth Muscle ◽  
Elastic System ◽  
Tunica Albuginea ◽  
Elastic Fiber ◽  
Corpus Cavernosum ◽  
Volume Density ◽  
Cell System ◽  
Elastic Fibers ◽  
Corpus Spongiosum ◽  
Significant Difference

Samples of ten penises of Mediterranean buffaloes and ten penises of Red Sindhi cattle were used. The thickness of the tunica albuginea (TA), distribution of smooth muscle cells (SMC) and volume density (Vv) of elastic system fibers in TA, corpus cavernosum (CC) and corpus spongiosum (CS) were evaluated. The Vv of elastic system fibers in buffalo and bovine penis was respectively 4.07% ±0.88% and 3.36% ±1.21% in TA; 17.32% ±2.21% and 13.14% ±1.27% (CC), 26.58% ±4.31% and 31.36% ±3.67% (CS). The CC of buffalo presented higher Vv of elastic fibers than bovine, while in the CS the Vv of elastic fibers in buffaloes was smaller than in cattle. The TA thickness showed a significant difference among the species studied. The arrangement of SMC in the bovine penises and in the water buffalo suggests that this pattern is common to animals that have fibroelastic penises.

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