scholarly journals Standardization of the infusion sequence of antineoplastic drugs used in the treatment of breast and colorectal cancers

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Amanda Alves da Silva ◽  
Juliane Carlotto ◽  
Inajara Rotta
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Literature Review ◽  
Antineoplastic Agents ◽  
Tertiary Hospital ◽  
Colorectal Cancers ◽  
Antineoplastic Drugs ◽  
Efficacy And Safety ◽  
Therapeutic Protocols ◽  
Definition Of

ABSTRACT The definition of antineoplastic administration sequences can help planning of therapeutic regimens in a more rational way, and thus optimize chemotherapy effects on patients, increasing efficacy and reducing toxic effects. In this way, this study aimed to evaluate the infusion order of antineoplastic agents of the main therapeutic protocols used in the treatment of colorectal and breast cancer which are used in a tertiary hospital, identifying possible interactions dependent on the infusion sequence. For the definition of protocols adopted in the hospital, medical prescriptions were used in the period of January to March 2016 and a literature review was conducted to search for studies assessing the sequence of administering the selected regimens. The databases used were SciELO, LILACS and MEDLINE, in addition to Micromedex Solutions® and UpToDate®. A total of 19 protocols were identified for antineoplastic therapy, 11 for colorectal cancer and 8 for breast cancer. The selected articles provided evidence for administration order of 19 protocols, and three protocols did no report relevance of infusion sequence. Sequence-dependent interactions were mainly related to toxicity, pharmacokinetics and efficacy of the drug combination. The definition of the infusion sequence has a great impact on the optimization of therapy, increasing efficacy and safety of the protocols containing combined antineoplastic therapies.

Level and Factors Associated with Participation in PopulationBased Cancer Screening in Safranbolu District of Karabuk, Turkey

2020 ◽  
Author(s):  
Raziye ÖZDEMIR ◽  
Fatma TÜRKMEN ÇEVIK ◽  
Duygu KES ◽  
Merve KARACALI ◽  
Simge ÖZGÜNER
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Cervical Cancer ◽  
Cancer Screening ◽  
Fold Increase ◽  
Population Based ◽  
Colorectal Cancers ◽  
Binary Logistic Regression Model ◽  
Cross Sectional ◽  
Factors Associated

Background: Cervix, breast and colorectal cancers are included in the national population-based screening (PBS) program in Turkey. This study aimed to assess participation in PBSs for these cancers and to identify factors associated with participation in screenings in Safranbolu district of Karabuk, Turkey in 2016-2017. Methods: In this cross-sectional study, separate studying groups for cervix, breast and colorectal cancers were identified, taking into account the target age range specified in the national screening standards. The sample size was determined to be 374 for cervical cancer, 371 for breast cancer and 373 for colorectal cancer in the Epi-Info StatCalc program with a prevalence of 50%, a 95% Confidence Interval (CI) and a 5% error margin. The results of the data collected through face-to-face interview using questionnaires were evaluated with Chisquare tests (P<0.05) and included in the binary logistic regression model. Results: Participation in PBS at least once between 2011 and 2016 years was 26.2% for cervical cancer, 27.6% for breast cancer and 31.6% for colorectal cancer, whereas the level of PBS or opportunistic screening at least once was 51.1%, 42.7% and 32.2%, respectively. A 2.9-fold increase in participation for the cervical cancer screening was associated with informing women about cervical cancer by the family physicians. Being married and living in the district center showed associations with a higher rate of participation for colorectal cancer screening. Conclusion: Participation in PBS was low for the 5.5-year period. More effort is needed to increase the effectiveness of the program.

scholarly journals CLINICAL IMPORTANCE OF DEFINITION OF SINGLE NUCLEOTIC POLYMORPHISMS IN PATIENTS WITH BREAST CANCER (LITERATURE REVIEW)

THE BULLETIN ◽  
2019 ◽  
Vol 5 (381) ◽  
pp. 169-174
Author(s):  
V. V. Benberin ◽  
◽  
N. A. Shanazarov ◽  
N. K. Seidalin ◽  
N. Y. Lisovska ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Literature Review ◽  
Clinical Importance ◽  
Definition Of

scholarly journals The impact of episodic screening interruption: COVID-19 and population-based cancer screening in Canada

2020 ◽  
pp. 096914132097471
Author(s):  
Jean HE Yong ◽  
James G Mainprize ◽  
Martin J Yaffe ◽  
Yibing Ruan ◽  
Abbey E Poirier ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
Cancer Screening ◽  
Cancer Incidence ◽  
Population Based ◽  
Colorectal Cancers ◽  
Primary Screening ◽  
Advanced Adenomas ◽  
The Impact ◽  
Over Time

Background Population-based cancer screening can reduce cancer burden but was interrupted temporarily due to the COVID-19 pandemic. We estimated the long-term clinical impact of breast and colorectal cancer screening interruptions in Canada using a validated mathematical model. Methods We used the OncoSim breast and colorectal cancers microsimulation models to explore scenarios of primary screening stops for 3, 6, and 12 months followed by 6–24-month transition periods of reduced screening volumes. For breast cancer, we estimated changes in cancer incidence over time, additional advanced-stage cases diagnosed, and excess cancer deaths in 2020–2029. For colorectal cancer, we estimated changes in cancer incidence over time, undiagnosed advanced adenomas and colorectal cancers in 2020, and lifetime excess cancer incidence and deaths. Results Our simulations projected a surge of cancer cases when screening resumes. For breast cancer screening, a three-month interruption could increase cases diagnosed at advanced stages (310 more) and cancer deaths (110 more) in 2020–2029. A six-month interruption could lead to 670 extra advanced cancers and 250 additional cancer deaths. For colorectal cancers, a six-month suspension of primary screening could increase cancer incidence by 2200 cases with 960 more cancer deaths over the lifetime. Longer interruptions, and reduced volumes when screening resumes, would further increase excess cancer deaths. Conclusions Interruptions in cancer screening will lead to additional cancer deaths, additional advanced cancers diagnosed, and a surge in demand for downstream resources when screening resumes. An effective strategy is needed to minimize potential harm to people who missed their screening.

Colorectal cancer knowledge and screening rates are lower than for breast cancer even in individuals at high risk of cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A741-A741
Author(s):  
P ANG ◽  
D SCHRAG ◽  
K SCHNEIDER ◽  
K SHANNON ◽  
J JOHNSON ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colorectal Cancer ◽  
High Risk ◽  
Cancer Knowledge ◽  
Risk Of Cancer
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