Association between vitamin d levels and adolescent idiopathic scoliosis

Objective: To compare the levels of 25-hydroxyvitamin D in patients with AIS and a control group. Methods: The patients were recruited from the outpatient clinic of our institution during the year of 2013. Children diagnosed with scoliosis before 10 or after 18 years of age, and those suffering from neurological or muscular disorders, congenital malformations or genetic syndromes were excluded. The 25-OHD levels were determined by a fully automated electrochemiluminescence test. The appropriate level of 25-OHD was defined as greater than 30 ng/mL. The results were compared to a group of healthy individuals. Results: In group 1 (control) 63,3% showed abnormal vitamin D levels, while 91% of patients with AIS presented a low level of vitamin D. The mean BMI was 19.6 kg/m2 for controls and 20.3 kg/m2 for group 2. Statistical analysis showed significant difference (p<0.0001) between the levels of vitamin D. The average and minimum levels of vitamin D were respectively 27 and 13.6 ng/mL for group 1 and 18.8 and 3.13 ng/mL for AIS group. Conclusions: Patients with AIS had statistically significant lower levels of 25-OHD than healthy patients. Further research should be conducted to investigate the actual impact of serum vitamin D levels on the pathophysiology of AIS.

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Do low vitamin D levels facilitate renal parenchymal injury?

Paediatrica Indonesiana ◽

10.14238/pi60.4.2020.205-11 ◽

2020 ◽

Vol 60 (4) ◽

pp. 205-11

Author(s):

Mervan Bekdas ◽

Billur Calıskan ◽

Seyda Karabork ◽

Seher Acar ◽

Nimet Kabakus

Keyword(s):

Vitamin D ◽

Renal Scarring ◽

Serum Vitamin ◽

Control Group ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Tract Infections ◽

Parenchymal Injury

Background Decreased vitamin D levels lead to an increase in infectious diseases, including urinary tract infections (UTIs). Objective To assess serum vitamin D levels in children with renal parenchymal injury secondary to UTIs. Methods Forty-three upper UTI patients and 24 controls, aged 1–15 years, were included. Vitamin D levels and other laboratory tests were obtained when they first admitted to hospital. 99mTc-labeled dimercaptosuccinic acid (DMSA) scans were performed to evaluate renal parenchymal injury. Results Mean serum 25-hydroxyvitamin D (25(OH)D) was lower in the upper UTI group compared to the control group [18 (SD 9) vs. 23 (SD 10.6) ng/mL, respectively; P=0.045]. The upper UTI group was sub-divided into two groups, those with 22 (51.1%) and without 21 (48.8%) renal parenchymal injury. Mean 25(OH)D was significantly lower in patients with renal parenchymal injury [15.1 (SD 7.1) vs. 21 (SD 9.9) ng/mL, respectively; P=0.03]. The renal parenchymal injury cases were further sub-divided into two groups: 8 patients (36.3%) with acute renal parenchymal injury and 14 (63.6%) with renal scarring (RS), but there was no significant difference in 25(OH)D between these two groups [12.5 (SD 8.9) vs. 16.6 (SD 5.7) ng/mL, respectively; P=0.14). Conclusion Decreased vitamin D is associated with renal parenchymal injury in children with upper UTIs. However, vitamin D is not significantly decreased in renal scarring patients compared to acute renal parenchymal injury patients.

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The Relationship between First Trimester 25-Hydroxyvitamin D3 Levels and Second Trimester Femur Length and Their Effects on Birth Weight and Length at Birth: A Preliminary Study

Obstetrics and Gynecology International ◽

10.1155/2019/3846485 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4

Author(s):

Elif Ganime Aydeniz ◽

Umut Sari ◽

Isil Tekin ◽

Talat Umut Kutlu Dilek

Keyword(s):

Vitamin D ◽

Birth Weight ◽

Serum Vitamin ◽

First Trimester ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Group 5 ◽

Group 2 ◽

Term Births

Objective. The main goal of our study was to assess relationships between first trimester 25-hydroxyvitamin D3 levels and infant birthweight and length at birth. Materials and Methods. We conducted a study over our medical records of 154 live-term births at Acibadem Atakent Hospital, Istanbul, Turkey. Subjects were classified into five independent groups. Results. We retrospectively reviewed a total of 154 live birth records. They took vitamin D3 supplement 1000 U/day. We classified the serum vitamin D levels into 5 groups by concentration. Group 1 comprised serum vitamin D levels <10 ng/ml (n = 41); group 2 comprised serum Vitamin D levels between >10–16 ng/ml (n = 33); group 3 comprised serum vitamin D levels >16–20 ng/ml (n = 26); group 4 vitamin D level between >20–30 ng/ml (n = 33) and group 5 comprised vitamin D levels >30 ng/ml. The femurs of infants were found to be longer between the groups, although the differences were not significant (p=0.054). There was also a statistically significant difference in the neonatal birth weight (p=0.048). Conclusion. We observed associations between low and high maternal 25-hydroxyvitamin D3 levels and fetal growth at birth weight but no difference in birth length. We conclude that we always need to conduct further research to be able to predict the effects of vitamin D deficiency.

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VITAMIN D DEFICIENCY IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i11.39653 ◽

2020 ◽

pp. 168-170

Author(s):

JINAN Q MOHAMMED ◽

ABDULSATAR J MATHKHOR ◽

AMER S KHUDHAIRY

Keyword(s):

Vitamin D ◽

Psoriatic Arthritis ◽

Vitamin D Deficiency ◽

Disease Duration ◽

Serum Vitamin ◽

Control Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Lower Vitamin

Objective: The objective of this study is to investigate the association between Vitamin D level and psoriasis, in particular in our city of the long, hot, and sunny weather, in an attempt to add a clarification to this controversial subject. Methods: A case–control study included 120 patients with psoriasis and 38 patients with psoriatic arthritis (PsA); 89 (56.3%) patients were male. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score using 28 joints (DAS28) and erythrocyte sedimentation rate (DAS28) was measured for all patients with PsA. The control group comprised 164 age- and sex-matched participants (91 males and 73 females). Vitamin D serum level was performed for both patients and controls. Results: Vitamin D levels in both patients and controls were 17.4±7.7 and 28.3±5.6, respectively. The level of Vitamin D was lower in a patient with disease duration equal and more than 10 years than those with a disease duration <10 years. There is no significant difference in Vitamin D levels between the two patient subgroups. Lower Vitamin D levels were associated with high PASI and high DAS28 in psoriasis and PsA, respectively. Conclusion: Patients with psoriasis and PsA associated with low levels of serum Vitamin D. Vitamin D deficiency was found to be associated with long disease duration in both psoriasis and PsA. Patients with active disease have lower Vitamin D levels.

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Vitamin D Levels in Children With Recurrent Aphthous Stomatitis

Ear Nose & Throat Journal ◽

10.1177/0145561319882783 ◽

2019 ◽

Vol 99 (7) ◽

pp. 460-463 ◽

Cited By ~ 2

Author(s):

Burçin Nalbantoğlu ◽

Ayşin Nalbantoğlu

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Control Group ◽

Healthy Controls ◽

Vitamin D Status ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference

Background: Recurrent aphthous stomatitis is one of the most prevalent oral mucosa diseases and the etiology is unclear. As a potent anti-inflammatory and immunomodulating agent, vitamin D can significantly affect oral cavity homeostasis. However, to the best of our knowledge, no study has been conducted in pediatric population on the potential role of vitamin D in recurrent aphthous stomatitis to date. The aim of the present study is to determine the vitamin D status in recurrent aphthous stomatitis in children. Methods: This study is conducted retrospectively. Seventy-two patients with minor recurrent aphthous stomatitis and 70 age-matched healthy controls included in the study. 25-Hydroxyvitamin D levels were measured in all patients using enzyme immunoassay. Results: Serum vitamin D levels were 16.4 (8.6) ng/mL in patient group and 23.1 (11.5) ng/mL in healthy controls. There was a statistically significant difference between the groups in terms of serum vitamin D levels ( P = .002). There was no significant correlation between serum vitamin D levels and the severity of the recurrent aphthous stomatitis ( r = 0.54, P = .76). Conclusions: Our study showed a significant difference in vitamin D levels between patients with recurrent aphthous stomatitis and the healthy control group. We also found no correlation between vitamin D status and the severity of the disease.

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Association between Vitamin D and Candida-Associated Denture Stomatitis

Dentistry Journal ◽

10.3390/dj8040121 ◽

2020 ◽

Vol 8 (4) ◽

pp. 121

Author(s):

Miranda Muhvić-Urek ◽

Ema Saltović ◽

Alen Braut ◽

Daniela Kovačević Pavičić

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Hypovitaminosis D ◽

Complete Denture ◽

Host Susceptibility ◽

Control Group ◽

Denture Stomatitis ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference

Candida-associated denture stomatitis (CADS) is a fungal infection affecting 60–65% of denture wearers. Its etiology is complex and multifactorial and often associated with host immunodeficiency. Evidence exists that vitamin D has potential immunomodulatory and anti-inflammatory effects. The aim of this case–control study was to assess the association between vitamin D levels and CADS. The study included 32 complete denture wearers with CADS and 32 sex- and age-matched complete denture wearers without CADS. The patients were clinically examined, and the severity of denture stomatitis was assessed according to Newton’s classification scale. The serum vitamin D level was determined via the use of an electrochemiluminescence assay. The vitamin D level in the CADS group and control group was 54.68 ± 17.07 and 56.82 ± 17.75 nmol/L, respectively. There was no significant difference between the groups (p = 0.622). Univariate logistic regression analysis showed that the presence of CADS was not associated with hypovitaminosis D (odds ratio (OR) = 1.44; 95% confidence interval (CI) = 0.37–5.54). It can be concluded that vitamin D is not associated with CADS and does not play a significant role in host susceptibility to CADS. This finding suggests that vitamin D screening is not indicated routinely in patients with Candida-associated denture stomatitis.

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The Association Between Serum Vitamin D Levels and Benign Paroxysmal Positional Vertigo

Ear Nose & Throat Journal ◽

10.1177/01455613211008561 ◽

2021 ◽

pp. 014556132110085

Author(s):

Kanokporn Sarsitthithum ◽

Tosapohn Wisupagan ◽

Sivaporn Kiatthanabumrung ◽

Chanchai Jariengprasert

Keyword(s):

Vitamin D ◽

Benign Paroxysmal Positional Vertigo ◽

Serum Vitamin ◽

Control Group ◽

P Value ◽

Serum Vitamin D ◽

Positional Vertigo ◽

Vitamin D Levels ◽

Significant Difference ◽

Paroxysmal Positional Vertigo

Objective: This study aimed to evaluate the association between serum vitamin D levels and benign paroxysmal positional vertigo (BPPV). Participants and Methods: This prospective study consisted of 137 participants. There were 69 participants in the BPPV group compared with 68 healthy participants. Blood samples from both groups were collected from all participants to assess serum vitamin D levels. Results: No significant difference in demographic data between BPPV and control groups. The results showed that the mean serum vitamin D levels in the BPPV group was lower than that of the control group ( P value = .001). Among BPPV participants, there was no statistically significant difference between mean serum vitamin D levels of participants with recurrent BPPV, and that of newly diagnosed BPPV participants ( P value = .313). Conclusion: A statistically significant association between lower mean serum vitamin D levels in the BPPV group compared with that of the control group. Therefore, low serum vitamin D levels may be one of the risk factors for BPPV.

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The Association of Serum Vitamin D Levels with Pseudoexfoliation Glaucoma/Syndrome

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530319666181128105911 ◽

2019 ◽

Vol 19 (2) ◽

pp. 166-170 ◽

Cited By ~ 2

Author(s):

Seyhan Dikci ◽

Emrah Öztürk ◽

Penpe G. Fırat ◽

Turgut Yılmaz ◽

Mehmet Ç. Taşkapan ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Glaucoma Surgery ◽

Control Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Glaucoma Group

Objective: To investigate whether serum vitamin D levels have an effect on pseudoexfoliation (PEX) glaucoma/syndrome development and on the control of glaucoma in these cases. </P><P> Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control subjects of similar age and sex were included in the study. Vitamin D levels were compared between the groups and also between the cases where glaucoma surgery was performed or not. Results: PEX glaucoma group consisted of 17 males and 14 females, PEX syndrome group of 27 males and 7 females, and the control group of 27 males and 16 females. The mean age was 70.9±8.9 years, 72.1±7.3 years, and 67.9±9.1 years in PEX glaucoma, syndrome and control group, respectively. Mean vitamin D levels were 9.4±7.7 ng/mL, 7.9±6,1 ng/mL, 11.5±14.2 ng/mL in PEX glaucoma, syndrome and control group, respectively (p>0.05). The mean serum vitamin D level was 8.04±4.7 ng/mL in those who underwent glaucoma surgery and 10.1±8.7 ng/mL in those who didn't undergo glaucoma surgery in PEX glaucoma group (p>0.05). No difference was found between the PEX glaucoma subgroups in terms of the mean deviation when classified according to vitamin D levels (<10 ng/mL, ≥10 ng/mL) (p>0.05). Conclusion: Although we found no statistically significant difference between the PEX syndrome/ glaucoma, and control group in terms of serum vitamin D levels, serum vitamin D levels were lower in PEX syndrome and glaucoma group than control group. Our results indicate that serum vitamin D levels have no effect on the development of PEX glaucoma/syndrome or the control of the disorder in cases with PEX glaucoma. However, these results need to be supported with further studies on a larger number of patients and with longer follow-up.

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Study on Serum Vitamin D in Alopecia Areata Patients

Journal of Nepal Health Research Council ◽

10.33314/jnhrc.v17i01.1475 ◽

2019 ◽

Vol 17 (01) ◽

pp. 21-25

Author(s):

Suchana Marahatta ◽

Sudha Agrawal ◽

Seraj Khan

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Alopecia Areata ◽

Serum Vitamin ◽

Control Group ◽

Healthy Controls ◽

Hydroxyvitamin D ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D

Background: Alopecia areata is the commonest cause of non-scarring alopecia. Few previous studies have found correlation between AA and vitamin D deficiency, suggesting that vitamin D deficiency can be a risk factor for Alopecia areata. To compare serum vitamin D level between Alopecia areata patients and healthy controls; and to assess the relation between serum vitamin D levels and AA disease severity.Methods: This case control study included 30 newly diagnosed Alopecia areata patients. Thorough history was taken, detail examination was done and relevant findings were recorded in the standardized pro-forma. Their serum vitamin D (25-hydroxyvitamin D) levels were determined by competitive chemiluminescence methods; and were compared with that of age and sex matched healthy controls. Chi square test and Spearman’s rho correlation test were used for the inferential statistics using SPSS version 11.5. Results: There were 30 AA patients with mean age 28.37+10.07 years. Mean Severity of Alopecia Tool score was 3.56+3.50. Prevalence of 25-hydroxyvitamin D [25(OH)D] deficiency was significantly higher in AA group (83.3%) compared to the control group (53.3%) (P=0.01). Similarly, serum 25(OH)D level was reduced more in Alopecia areata group (12.84, IQR=8.87-20.47) than the control group (29.5, IQR=19.85-41.27) (P=0.06). There was inverse co-relation between serum 25(OH)D level and SALT score.Conclusions: Prevalence of serum 25(OH)D deficiency was significantly higher in Alopecia areata group compared to the control, with inverse co-relation between its level and Alopecia areata disease severity. Keywords: Alopecia areata; Nepal; SALT Score; Vitamin D.

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Effects of vitamin D on motor symptoms and cognitive functions in people with Parkinson’s disease

GSC Biological and Pharmaceutical Sciences ◽

10.30574/gscbps.2021.15.1.0109 ◽

2021 ◽

Vol 15 (1) ◽

pp. 135-140

Author(s):

Gülbün Asuman Yüksel ◽

Gizem Gürsoy

Keyword(s):

Parkinson’S Disease ◽

Vitamin D ◽

Parkinson's Disease ◽

Serum Vitamin ◽

Control Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

The Relationship ◽

Lower Vitamin

Aim of the study: Parkinson’s disease is the second most common neurodegenerative disorder. The present study investigates the role of vitamin D deficiency thought to be one of the etiopathological and modifying factors in Parkinson’s disease that is known to be multifactorial. Materials and Methods: Designed as a retrospective review of medical records, this study compares the serum vitamin D levels of the idiopathic Parkinson’s disease patients with and without dementia to those of the healthy individuals with no metabolic/degenerative disorders. It also investigates the relationship between the patients’ Standardized Mini-Mental State Examination (SMMSE) and the Unified Parkinson’s Disease Rating Scale (UPDRS) scores and serum vitamin D levels to show the effects of vitamin D on motor symptoms and cognitive functions. Results: In this study, we compared the serum vitamin D levels of 40 Parkinson’s disease patients and 15 Parkinson’s disease patients with dementia to those of the control group comprising 30 healthy individuals. Vitamin D levels were 21,4±15,9 ng/mL in the control group; 16,5±6,4 ng/mL in Parkinson’s disease patients and 13,8±4,5 ng/mL in Parkinson’s disease patients with dementia. All the patient groups had significantly lower vitamin D levels than the control group (p<0,005). Within the Parkinson’s disease group, furthermore, the dementia group had lower vitamin D levels than the non-dementia group. Having examined the relationship between the SMMSE scores and serum vitamin D levels, we found a significant difference in the Parkinson’s disease dementia group (p: 0,020), as well as a relationship of 59,4% in the same direction. On the other hand, there was no significant difference in either patient group in the scores of UPDRS evaluating clinical disability. Conclusion: Consistent with the literature, the present study found that people with Parkinson’s disease had lower mean values of serum vitamin D levels than the control group and showed that serum vitamin D levels were correlated with the cognitive performance. However, the study could not find a relationship between the serum vitamin D levels and the motor performance.

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Relationship between vitamin D levels and brucellosis: a case-control study from Sanandaj, Iran

Iranian Journal of Microbiology ◽

10.18502/ijm.v13i2.5987 ◽

2021 ◽

Author(s):

Behzad Mohsenpour ◽

Amjad Ahmadi ◽

Anvar Mohammadi Baneh ◽

Ebrahim Ghaderi ◽

Shahla Afrasiabian ◽

...

Keyword(s):

Vitamin D ◽

Case Control Study ◽

Serum Vitamin ◽

Case Control ◽

Control Group ◽

Case Group ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Significant Difference ◽

Control Study

Background and Objectives: Brucellosis is a zoonotic disease that is caused by the Brucella species. This disease is common in Iran and its incidence is increasing .This study measures serum vitamin D levels in patients with brucellosis and healthy people. Materials and Methods: This research was conducted as a case-control study at Tohid Hospital, Sanandaj, Iran. The calculated sample size included 90 patients in the case group and 90 patients in the control group. The measurement of vitamin D levels in the case and control groups were performed by ELISA. Results: The mean serum vitamin D level was 19.91 ng/ml in the case group and 22.87 ng/ml in the control group. (Serum vitamin D level <10 ng/mL is accepted as deficiency, 10-30 ng/mL as insufficiency, 30-100 ng/mL as sufficiency, and >100 ng/mL as toxicity). Conclusion: There was no significant difference between the two groups in terms of vitamin D deficiency (p-value=0.097).

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