Single-Dose Pharmacokinetics and Tolerability of Telavancin in Elderly Men and Women

2010 ◽  
Vol 30 (8) ◽  
pp. 806-811 ◽  
Author(s):  
Michael R Goldberg ◽  
Shekman L Wong ◽  
Jeng-Pyng Shaw ◽  
Michael M Kitt ◽  
Steven L Barriere
2005 ◽  
Vol 49 (4) ◽  
pp. 1656-1659 ◽  
Author(s):  
Gopal Muralidharan ◽  
Richard J. Fruncillo ◽  
Marlynne Micalizzi ◽  
Donald G. Raible ◽  
Steven M. Troy

ABSTRACT The pharmacokinetics of tigecycline was evaluated in 46 healthy young and elderly men and women. Except for the volumes of distribution at steady state (approximately 350 liters in women versus 500 liters in men), there were no significant differences in tigecycline pharmacokinetic parameters. Based on pharmacokinetics, no dosage adjustment is warranted based on age or sex.


2002 ◽  
Vol 16 (9) ◽  
pp. 611-620 ◽  
Author(s):  
E Casiglia ◽  
V Tikhonoff ◽  
A Mazza ◽  
A Piccoli ◽  
A C Pessina

2013 ◽  
Vol 72 (OCE1) ◽  
Author(s):  
M. De La Fuente ◽  
O. Hernández ◽  
C. Sanchez ◽  
F. Arnalich ◽  
A. Hernanz

1975 ◽  
Vol 80 (2) ◽  
pp. 262-274 ◽  
Author(s):  
M. Schmidt-Gollwitzer ◽  
B. B. Saxena

ABSTRACT A simple and rapid homologous radioimmunoassay of human prolactin (hPRL), by the use of 66% ethanol containing 6.6% ammonium acetate for the separation of free and bound hormones, has been established. PRL levels showed marked individual and daily variations as well as a circadian periodicity in both men and women. Levels of plasma PRL rose with puberty and decreased during post-menopause and in elderly men (ages 60–73 years). There was no marked change in plasma PRL levels at midcycle; however, in some subjects, luteal levels were slightly higher than follicular levels. Administration of oestradiol-17β caused marked increase in plasma PRL levels during menstrual cycle. During pregnancy, the plasma PRL levels rose as high as 200 ng/ml and decreased within a week or two post-partum. During lactation, the levels were higher and increased with suckling. In a patient with habitual abortion, the plasma PRL level showed a sudden drop prior to abortion. Administration of LH-RH had no effect on the secretion of PRL in human subjects.


2013 ◽  
Vol 4 ◽  
pp. S42
Author(s):  
A.P. Rossi ◽  
V. Mastrandrea ◽  
P. Bertassello ◽  
G. Mazzali ◽  
L. Bissoli ◽  
...  

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