User's Guide to a Prognostic Study on an Orthopaedic Implant

2007 ◽  
Vol 17 (2) ◽  
pp. 135-144 ◽  
Author(s):  
Daniel Hoppe ◽  
Ryan Degen ◽  
Mohit Bhandari
Keyword(s):  
Orthopaedic Implant

scholarly journals Culture-Independent Genotyping, Virulence and Antimicrobial Resistance Gene Identification of Staphylococcus aureus from Orthopaedic Implant-Associated Infections

2021 ◽  
Vol 9 (4) ◽  
pp. 707
Author(s):  
J. Christopher Noone ◽  
Fabienne Antunes Ferreira ◽  
Hege Vangstein Aamot
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Resistance ◽  
Resistance Genes ◽  
Virulence Gene ◽  
Orthopaedic Implant ◽  
Metagenomic Sequencing ◽  
Gene Detection ◽  
Shotgun Metagenomic Sequencing ◽  
Antimicrobial Resistance Genes ◽  
Culture Independent

Our culture-independent nanopore shotgun metagenomic sequencing protocol on biopsies has the potential for same-day diagnostics of orthopaedic implant-associated infections (OIAI). As OIAI are frequently caused by Staphylococcus aureus, we included S. aureus genotyping and virulence gene detection to exploit the protocol to its fullest. The aim was to evaluate S. aureus genotyping, virulence and antimicrobial resistance genes detection using the shotgun metagenomic sequencing protocol. This proof of concept study included six patients with S. aureus-associated OIAI at Akershus University Hospital, Norway. Five tissue biopsies from each patient were divided in two: (1) conventional microbiological diagnostics and genotyping, and whole genome sequencing (WGS) of S. aureus isolates; (2) shotgun metagenomic sequencing of DNA from the biopsies. Consensus sequences were analysed using spaTyper, MLST, VirulenceFinder, and ResFinder from the Center for Genomic Epidemiology (CGE). MLST was also compared using krocus. All spa-types, one CGE and four krocus MLST results matched Sanger sequencing results. Virulence gene detection matched between WGS and shotgun metagenomic sequencing. ResFinder results corresponded to resistance phenotype. S. aureus spa-typing, and identification of virulence and antimicrobial resistance genes are possible using our shotgun metagenomics protocol. MLST requires further optimization. The protocol has potential application to other species and infection types.

scholarly journals Titanium-Nitride Coating of Orthopaedic Implants: A Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Ruud P. van Hove ◽  
Inger N. Sierevelt ◽  
Barend J. van Royen ◽  
Peter A. Nolte
Keyword(s):  
Titanium Nitride ◽  
Polyethylene Wear ◽  
Ultrahigh Molecular Weight Polyethylene ◽  
Coating Process ◽  
Orthopaedic Implant ◽  
Cohesive Failure ◽  
Orthopaedic Implants ◽  
Tin Coating ◽  
Titanium Nitride Coating ◽  
English Medical Literature

Surfaces of medical implants can be enhanced with the favorable properties of titanium-nitride (TiN). In a review of English medical literature, the effects of TiN-coating on orthopaedic implant material in preclinical studies were identified and the influence of these effects on the clinical outcome of TiN-coated orthopaedic implants was explored. The TiN-coating has a positive effect on the biocompatibility and tribological properties of implant surfaces; however, there are several reports of third body wear due to delamination, increased ultrahigh molecular weight polyethylene wear, and cohesive failure of the TiN-coating. This might be due to the coating process. The TiN-coating process should be optimized and standardized for titanium alloy articulating surfaces. The clinical benefit of TiN-coating of CoCrMo knee implant surfaces should be further investigated.

scholarly journals Plasma d-Dimer Levels in Non-prosthetic Orthopaedic Implant Infection: Can it Aid Diagnosis?

2020 ◽  
Vol 54 (S1) ◽  
pp. 76-80
Author(s):  
Govind Karunakaran ◽  
Jagdish Menon ◽  
Sandeep Nema ◽  
Debadatta Basu
Keyword(s):  
Orthopaedic Implant ◽  
Implant Infection ◽  
D Dimer

Evaluation of Connective Tissue Cell Responses to Orthopaedic Implant Materials

1990 ◽  
Vol 24 (1) ◽  
pp. 77-81 ◽  
Author(s):  
S. R. Goldring ◽  
M. S. Flannery ◽  
K. K. Petrison ◽  
A. E. Evins ◽  
M. J. Jasty
Keyword(s):  
Connective Tissue ◽  
Tissue Cell ◽  
Orthopaedic Implant ◽  
Connective Tissue Cell ◽  
Implant Materials ◽  
Cell Responses

Evaluation of fretting corrosion behaviour of CP-Ti for orthopaedic implant applications

2010 ◽  
Vol 43 (7) ◽  
pp. 1245-1252 ◽  
Author(s):  
Satendra Kumar ◽  
T.S.N. Sankara Narayanan ◽  
S. Ganesh Sundara Raman ◽  
S.K. Seshadri
Keyword(s):  
Corrosion Behaviour ◽  
Orthopaedic Implant ◽  
Fretting Corrosion ◽  
Cp Ti

Phage Therapy in Orthopaedic Implant-Associated Infections

2019 ◽  
pp. 189-211 ◽  
Author(s):  
Paweł Rogóż ◽  
Derek F. Amanatullah ◽  
Ryszard Międzybrodzki ◽  
Robert Manasherob ◽  
Nina V. Tikunova ◽  
...  
Keyword(s):  
Phage Therapy ◽  
Orthopaedic Implant

scholarly journals Orthopaedic implant infections: interplay of associated factors

2019 ◽  
Vol 6 (2) ◽  
pp. 357
Author(s):  
Shazia Benazir ◽  
Umar Nazir ◽  
Shaista Nazir ◽  
Azhar Shafi ◽  
Lenah Bashir ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Onset ◽  
The Body ◽  
Orthopaedic Implant ◽  
Medical Implants ◽  
Tissue Destruction ◽  
Orthopaedic Implants ◽  
Duration Of Surgery ◽  
Hospital Resources ◽  
Standard Techniques

Background: Medical implants are devices that are placed inside or on the surface of the body for functional, cosmetic or therapeutic purposes. Orthopaedic implants are usually associated with infections which lead to devastating complications for the patients. The study was conducted to evaluate the association of various factors considered to affect orthopaedic implant infections.Methods: The 100 patients with orthopaedic implant infections were included. Various patient parameters including risk factors, intervention form and type of onset of infection were recorded. Microbiological workup was done by standard techniques along with biofilm detection.Results: Early onset of infection was prevalent in cases with open fractures. Smoking and tissue destruction were the major risk factors. Longer duration of surgery was associated with early onset and polymicrobial infections. 15.5% of the isolates were strong biofilm producers. Staphylococcus aureus was the predominant biofilm producer. More biofilm producing organisms were recovered from stainless steel implants.Conclusions: Orthopaedic device-related infections lead to extreme morbidity in patients and puts a great encumberance on hospital resources. Various factors affect the outcome of orthopaedic implants. Appropriate infection control and institution specific interventions will help in reducing the magnitude of the problem.

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