Low-Dose Ionizing Radiation-Induced Blood Plasma Metabolic Response in a Diverse Genetic Mouse Population

2012 ◽  
Vol 178 (6) ◽  
pp. 551-555 ◽  
Author(s):  
Do Yup Lee ◽  
Benjamin P. Bowen ◽  
David H. Nguyen ◽  
Sara Parsa ◽  
Yurong Huang ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Blood Plasma ◽  
Low Dose ◽  
Metabolic Response ◽  
Mouse Population ◽  
Radiation Induced

scholarly journals Extracellular vesicles mediate low dose ionizing radiation-induced immune and inflammatory responses in the blood

2018 ◽  
Vol 95 (1) ◽  
pp. 12-22 ◽  
Author(s):  
Tünde Szatmári ◽  
Eszter Persa ◽  
Enikő Kis ◽  
Anett Benedek ◽  
Rita Hargitai ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Extracellular Vesicles ◽  
Low Dose ◽  
Inflammatory Responses ◽  
Radiation Induced

scholarly journals Low dose ionizing radiation induced acoustic neuroma: A putative link?

2012 ◽  
Vol 01 (01) ◽  
pp. 078-079
Author(s):  
Sachin Borkar ◽  
Deepak Agrawal
Keyword(s):  
Ionizing Radiation ◽  
Brain Tumors ◽  
Acoustic Neuroma ◽  
Cumulative Dose ◽  
Low Dose ◽  
High Dose ◽  
Atomic Reactor ◽  
Radiation Induced

Abstract Although exposure to high dose ionizing radiation (following therapeutic radiotherapy) has been incriminated in the pathogenesis of many brain tumors, exposure to chronic low dose ionizing radiation has not yet been shown to be associated with tumorigenesis. The authors report a case of a 50-year-old atomic reactor scientist who received a cumulative dose of 78.9 mSv over a 10-year period and was detected to have an acoustic neuroma another 15 years later. Although there is no proof that exposure to ionizing radiation was the cause for the development of the acoustic neuroma, this case highlights the need for extended follow-up periods following exposure to low dose ionizing radiation.

scholarly journals Radiation-Induced Cerebro-Ophthalmic Effects in Humans

Life ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 41 ◽  
Author(s):  
Konstantin N. Loganovsky ◽  
Donatella Marazziti ◽  
Pavlo A. Fedirko ◽  
Kostiantyn V. Kuts ◽  
Katerina Y. Antypchuk ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Human Brain ◽  
Neurodegenerative Diseases ◽  
Brain Damage ◽  
Optic Neuropathy ◽  
Radiation Effects ◽  
Low Dose ◽  
Neurocognitive Deficits ◽  
Radiation Induced ◽  
Available Information

Exposure to ionizing radiation (IR) could affect the human brain and eyes leading to both cognitive and visual impairments. The aim of this paper was to review and analyze the current literature, and to comment on the ensuing findings in the light of our personal contributions in this field. The review was carried out according to the PRISMA guidelines by searching PubMed, Scopus, Embase, PsycINFO and Google Scholar English papers published from January 2000 to January 2020. The results showed that prenatally or childhood-exposed individuals are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases. In adulthood and medical/interventional radiologists, the most frequent IR-induced ophthalmic effects include cataracts, glaucoma, optic neuropathy, retinopathy and angiopathy, sometimes associated with specific neurocognitive deficits. According to available information that eye alterations may induce or may be associated with brain dysfunctions and vice versa, we propose to label this relationship “eye-brain axis”, as well as to deepen the diagnosis of eye pathologies as early and easily obtainable markers of possible low dose IR-induced brain damage.

scholarly journals Cellular Mechanisms for Low-Dose Ionizing Radiation–Induced Perturbation of the Breast Tissue Microenvironment

2005 ◽  
Vol 65 (15) ◽  
pp. 6734-6744 ◽  
Author(s):  
Kelvin K.C. Tsai ◽  
Eric Yao-Yu Chuang ◽  
John B. Little ◽  
Zhi-Min Yuan
Keyword(s):  
Ionizing Radiation ◽  
Breast Tissue ◽  
Low Dose ◽  
Cellular Mechanisms ◽  
Tissue Microenvironment ◽  
Radiation Induced

Low dose ionizing radiation‐induced activation of connexin 43 expression

2003 ◽  
Vol 79 (12) ◽  
pp. 955-964 ◽  
Author(s):  
D. Glover ◽  
J. B. Little ◽  
M. F. Lavin ◽  
N. Gueven
Keyword(s):  
Ionizing Radiation ◽  
Connexin 43 ◽  
Low Dose ◽  
Radiation Induced

Low-Dose Ionizing Radiation from Medical Imaging

2016 ◽  
Author(s):  
Christoph I. Lee
Keyword(s):  
Medical Imaging ◽  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Low Dose ◽  
Additional Information ◽  
Radiation Induced Cancer ◽  
Radiation Induced ◽  
Effective Doses ◽  
Study Methodology ◽  
Ionizing Radiation Exposure

This chapter, found in the radiation exposure from medical imaging section of the book, provides a succinct synopsis of a key study examining low-dose ionizing radiation exposure and radiation-induced cancer risks. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. The study reported that a substantial proportion of the nonelderly US population is exposed to medium to very high annual effective doses from medical imaging procedures. Strategies ensuring the appropriate use of medical imaging associated with ionizing radiation should be developed and adopted widely. In addition to outlining the most salient features of the study, a clinical vignette is included in order to provide relevant clinical context.

scholarly journals Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection

2020 ◽  
Vol 21 (17) ◽  
pp. 5993 ◽  
Author(s):  
Mauro Belli ◽  
Maria Antonella Tabocchini
Keyword(s):  
Gene Expression ◽  
Ionizing Radiation ◽  
Radiation Protection ◽  
Low Dose ◽  
Present System ◽  
Epigenetic Effects ◽  
Radiation Induced Cancer ◽  
Radiation Induced ◽  
Hereditary Effects ◽  
The Impact

The present system of radiation protection assumes that exposure at low doses and/or low dose-rates leads to health risks linearly related to the dose. They are evaluated by a combination of epidemiological data and radiobiological models. The latter imply that radiation induces deleterious effects via genetic mutation caused by DNA damage with a linear dose-dependence. This picture is challenged by the observation of radiation-induced epigenetic effects (changes in gene expression without altering the DNA sequence) and of non-linear responses, such as non-targeted and adaptive responses, that in turn can be controlled by gene expression networks. Here, we review important aspects of the biological response to ionizing radiation in which epigenetic mechanisms are, or could be, involved, focusing on the possible implications to the low dose issue in radiation protection. We examine in particular radiation-induced cancer, non-cancer diseases and transgenerational (hereditary) effects. We conclude that more realistic models of radiation-induced cancer should include epigenetic contribution, particularly in the initiation and progression phases, while the impact on hereditary risk evaluation is expected to be low. Epigenetic effects are also relevant in the dispute about possible “beneficial” effects at low dose and/or low dose-rate exposures, including those given by the natural background radiation.

Säugetierspermatogenese als biologischer Indikator für ionisierende Strahlung / Mammalian Spermatogenesis as a Biological Indicator for Ionizing Radiation

1985 ◽  
Vol 40 (11-12) ◽  
pp. 898-907 ◽  
Author(s):  
Ursula Hacker-Klom ◽  
Eva-Maria Meier ◽  
Wolfgang Göhde
Keyword(s):  
Ionizing Radiation ◽  
Cross Sections ◽  
Low Dose ◽  
Inbred Mice ◽  
Biological Indicator ◽  
Ionisierende Strahlung ◽  
Dose Effects ◽  
Radiation Induced ◽  
Low Dose Effects

Abstract We have analysed spermatogenetic cells by flow cytometry to quantify effects of ionizing radiation. The radiation-induced reductions of testicular DNA-synthesizing cells, primary spermatocytes, haploid round and elongated spermatids as well as the increases of numerical chromo­ some aberrations (abnormal diploid spermatids and aneuploidies) in NMRI inbred mice are described. Testicular weights were determined as a parameter of germ cell decrease, and histologic cross sections of the testes were analysed. Since even an exposure of 0.05 Gy (= 5 rad) may be detected by a reduction of DNA-synthesizing cells (Acta Radiol. Oncol. Radiat. Phys. Biol. 21, 349-351 (1982) [1]), the use of the in vivo system “spermatogenesis” as a biological dosimeter to monitor low dose effects and to determine RBE values of different radiation qual­ ities is suggested.

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