PLASMA TESTOSTERONE IN WOMEN IN LATE PREGNANCY AND AFTER DELIVERY

1968 ◽  
Vol 42 (3) ◽  
pp. 477-481 ◽  
Author(s):  
K. DEMISCH ◽  
J. K. GRANT ◽  
W. BLACK
Keyword(s):  
Protein Binding ◽  
Late Pregnancy ◽  
Plasma Testosterone ◽  
Testosterone Concentration ◽  
Healthy Women ◽  
The Mean

SUMMARY The concentration of testosterone was measured in the plasma of 16 healthy women in late pregnancy and in 14 of these after delivery. The mean testosterone concentration was found to be elevated in late pregnancy, although the range overlapped with the normal. There was a prompt return to normal concentrations after delivery. The significance of the results and of inactivation of testosterone by protein binding are discussed.

TESTOSTERONE AND OESTRADIOL IN DOGS WITH TESTICULAR TUMOURS

1974 ◽  
Vol 77 (2) ◽  
pp. 408-416 ◽  
Author(s):  
F. Comhaire ◽  
D. Mattheeuws ◽  
A. Vermeulen
Keyword(s):  
Plasma Concentration ◽  
Sertoli Cell ◽  
Sex Steroids ◽  
Venous Blood ◽  
Plasma Testosterone ◽  
Testosterone Concentration ◽  
Peripheral Plasma ◽  
Normal Mass ◽  
The Mean ◽  
Sertoli Cell Tumours

ABSTRACT The mean peripheral plasma concentration of oestradiol was found to be increased in 3 dogs with Sertoli cell tumours and in 3 dogs with seminomas, whereas the plasma testosterone showed no difference as compared to a group of dogs without testicular neoplasia. In two thirds of the cases the concentration of oestradiol in the spermatic venous blood draining the neoplastic testes was clearly higher than in the normal dogs. The testosterone concentration in the spermatic venous blood from the tumour bearing testes was lower than in the spermatic venous blood of the contralateral partner testes in the same dogs, though not different from the spermatic venous concentration in the control dogs. There was no correlation between the presence or absence of signs of feminization and the peripheral or spermatic venous concentration of sex steroids. It is concluded that not only Sertoli cell tumours, but also seminomas can secrete increased amounts of oestrogens. This is possibly due to the presence of a larger than normal mass of tissue capable of converting testosterone, or its precursors, to oestradiol.

STIMULATORY EFFECT OF PROSTAGLANDIN F2α ON THE PLASMA CONCENTRATION OF TESTOSTERONE IN BULLS

1975 ◽  
Vol 66 (3) ◽  
pp. 329-338 ◽  
Author(s):  
N. B. HAYNES ◽  
H. D. HAFS ◽  
R. J. WATERS ◽  
J. G. MANNS ◽  
A. RILEY
Keyword(s):  
Plasma Concentration ◽  
Intramuscular Injection ◽  
Prostaglandin F2α ◽  
Plasma Testosterone ◽  
Testosterone Concentration ◽  
Peripheral Plasma ◽  
Prostaglandin F ◽  
The Mean

SUMMARY The concentrations of peripheral plasma testosterone were measured by radioimmunoassay in samples collected from five bulls, each given i.m. injections of 0, 5, 15, 30 and 60 mg prostaglandin F2α (PGF2α). Synchronized peaks in testosterone concentration occurred with maximum values 1–2 h after treatment. These increases of testosterone persisted significantly longer than those observed to occur as natural episodic peaks during two 24 h periods in the same bulls. The mean peak testosterone concentration after PGF2α injection was related to the dose of PGF2α, values after 60 and 30 mg doses being significantly greater than after 15 mg. The response produced by a 5 mg dose was not significant. The results indicate that intramuscular injection of PGF2α acutely stimulates synthesis and release of testosterone in bulls.

Plasma concentrations of testosterone and luteinizing hormone in rutting reindeer bulls (Rangifer tarandrus)

1980 ◽  
Vol 58 (11) ◽  
pp. 2081-2083 ◽  
Author(s):  
K.-A. Stokkan ◽  
K. Hove ◽  
W. R. Carr
Keyword(s):  
Luteinizing Hormone ◽  
Testosterone Level ◽  
Plasma Concentrations ◽  
Plasma Testosterone ◽  
Plasma Samples ◽  
Diurnal Pattern ◽  
Testosterone Concentration ◽  
Peripheral Plasma ◽  
The Mean

Concentrations of plasma testosterone and luteinizing hormone (LH) were measured in peripheral plasma from semidomestic, rutting reindeer bulls. Although the concentrations of plasma testosterone were high and showed large variations, those of LH were low and only a few episodic bursts could be detected in hourly samples taken throughout a 48-h period. The mean testosterone concentration in three bulls differed significantly and ranked the animals according to their position in a fighting hierarchy. The mean concentrations of LH did not differ significantly. Plasma samples from one reindeer bull sampled every 20 min for periods of 3 h indicated that an increment in LH concentration preceded a peak in testosterone. No diurnal pattern in testosterone concentrations could be detected, but testosterone peaks seemed to appear about every 3–4 h. The present study thus demonstrates that a series of plasma samples throughout the day is necessary to determine a true "testosterone level" in the reindeer bull.

THE EFFECT OF MESTEROLONE ADMINISTRATION TO NORMAL MEN ON THE PITUITARY-TESTICULAR FUNCTION

1974 ◽  
Vol 77 (2) ◽  
pp. 380-386 ◽  
Author(s):  
A. Aakvaag ◽  
S. B. Strømme
Keyword(s):  
Protein Binding ◽  
Testosterone Level ◽  
Plasma Levels ◽  
Mean Value ◽  
Plasma Testosterone ◽  
Testicular Function ◽  
Plasma Testosterone Level ◽  
Before And After ◽  
The Mean ◽  
Normal Men

ABSTRACT Mesterolone (1α-methyl-5α-dihydrotestosterone) has been given to 10 normal men, age 24–27 years, and the effect on the plasma levels of ICSH, FSH and testosterone has been studied. No effect on the plasma levels of ICSH and FSH could be detected. After 4 weeks on 75 mg mesterolone per day a significant (P < 0.01) drop in the mean value for plasma testosterone level was observed, 5.2 to 4.0 ng/ml. After another 4 weeks on 150 mg mesterolone per day a further decrease to 3.5 ng/ml was found. During mesterolone administration the protein binding of testosterone in plasma was significantly reduced, and it appeared that the level of free (non-protein bound) testosterone in diluted plasma remained unchanged, 0.37 and 0.41 ng/ml, before and after mesterolone administration respectively. The results suggest that mesterolone given in doses of 75 and 150 mg/day to normal men does not suppress the pituitary ICSH production or the testicular testosterone production.

THE EFFECT OF EPINEPHRINE ON TESTOSTERONE PRODUCTION

1967 ◽  
Vol 55 (1) ◽  
pp. 184-192 ◽  
Author(s):  
Joseph Levin ◽  
Charles W. Lloyd ◽  
Julia Lobotsky ◽  
E. H. Friedrich
Keyword(s):  
Production Rate ◽  
Mean Value ◽  
Constant Infusion ◽  
Plasma Testosterone ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate ◽  
Testosterone Concentration ◽  
The Mean ◽  
Male Subjects ◽  
Double Isotope

ABSTRACT The metabolic clearance rate (MCR) and the production rate (PR) of testosterone were measured in four male subjects by the method of constant infusion of tritiated testosterone. The mean value of the MCR of 1161 ± 80 (SD) liters/24 hours was not altered by the infusion of epinephrine, at the rate of 0.466 mg per hour for three: hours. The plasma testosterone concentration was measured by the double isotope method of Riondel et al. (1963). Epinephrine significantly decreased this concentration (28%) and also the production rate (28%) The effect of epinephrine on plasma testosterone concentration was measured in six additional male subjects, and the results of the total of 10 subjects showed that there was a decrease of (28%) in the concentration. It was concluded that epinephrine significantly diminished the production rate of testosterone.

Protein-Binding Assay for Plasma Testosterone, after Purification by Column Partition Chromatography

1974 ◽  
Vol 20 (4) ◽  
pp. 430-435 ◽  
Author(s):  
E D Horgan ◽  
W J Riley
Keyword(s):  
Protein Binding ◽  
Plasma Testosterone ◽  
Good Precision ◽  
Third Trimester ◽  
Protein Binding Assay ◽  
Competitive Protein Binding ◽  
Menstruating Women ◽  
The Mean ◽  
Normal Men ◽  
Practicable Method

Abstract We describe a relatively simple, specific, and practicable method for measuring plasma testosterone by competitive protein-binding analysis. An ether extract is purified by a single chromatographic step on a micro-scale Celite—ethylene glycol column. Serum from women in the third trimester of pregnancy is used as the binding protein, and an ammonium sulfate precipitation step is used to separate the free and protein-bound testosterone. The method has a consistently low blank [0.59 ± 0.26 (SD) pmol/sample] and shows good precision. The mean testosterone concentration in normal men and menstruating women was 17.1 ± 4.0 (SD) and 1.2 ± 0.4 (SD) nmol/liter, respectively.

scholarly journals Stimulatory Effect of hCG on Male American Mink (Neovison Vison) in the Breeding Season / Wpływ stymulacji hCG na samce norki amerykańskiej (Neovison vison) w okresie kryć

2013 ◽  
Vol 13 (3) ◽  
pp. 563-570
Author(s):  
Bogdan Lasota ◽  
Anna Masłowska ◽  
Lidia Felska-Błaszczyk ◽  
Małgorzata Dziadosz ◽  
Beata Seremak ◽  
...  
Keyword(s):  
Single Dose ◽  
Treatment Group ◽  
Breeding Season ◽  
American Mink ◽  
Neovison Vison ◽  
The Other ◽  
Plasma Testosterone ◽  
Mating Season ◽  
Testosterone Concentration ◽  
The Mean

Abstract The aim of the study was to analyse the effect of a male mink single-dose hCG stimulation on the libido during the mating season and on blood testosterone levels after the season. The material involved males of American mink. The treatment-group males were administered a dose of 100, 150 or 200 U of hCG. Blood was collected twice, approx. 2 weeks prior to and on the completion of the mating season. The group receiving 100 U hCG had the highest percentage of males effectively copulating with females within the first 24 hours after stimulation, whereas males stimulated with a dose of 200 U hCG showed the lowest libido over the same period. On the other hand, males of the group stimulated with 150 U hCG mated to the highest number of females throughout the mating season. The mean plasma testosterone concentration in all the studied males on 18 February was 12.44 ng/ml. The drop in testosterone concentration at the end of the mating season was significant.

EARLY VARIATIONS OF PLASMA CORTISOL AFTER PULSE INTRAVENOUS INJECTION OF DIBUTYRYL CYCLIC ADENOSINE 3′,5′-MONOPHOSPHATE IN NORMAL SUBJECTS

1973 ◽  
Vol 72 (4) ◽  
pp. 753-761 ◽  
Author(s):  
Alberto Angeli ◽  
Giuseppe Boccuzzi ◽  
Roberto Frajria ◽  
Daniela Bisbocci ◽  
Franco Ceresa
Keyword(s):  
Intravenous Injection ◽  
Plasma Cortisol ◽  
Time Course ◽  
Healthy Adult ◽  
Normal Subjects ◽  
Adult Women ◽  
Healthy Women ◽  
Adrenal Steroidogenesis ◽  
The Mean ◽  
Zero Time

ABSTRACT 10 mg/kg of dibutyryl cyclic adenosine 3′,5′-monophosphate (Db-cAMP) was iv pulse injected into twelve healthy adult women. The plasma cortisol levels were determined as 11-OHCS at zero time and then at 2.5, 5, 7.5, 10, 15, 30, 60 and 180 min after the injection. The data were compared with those obtained at the corresponding times in two groups of eleven and seventeen healthy women after the injection of 250 ng and 250 μg of synthetic β-1-24 corticotrophin performed in the same manner as the injection of the nucleotide. The mean increments in plasma cortisol were significantly lower after Db-cAMP than after ACTH. Differences were noted by analyzing the time course of the responses. In the case of stimulation with Db-cAMP the 11-OHCS levels rose progressively to a maximum at 15–30 min. By contrast, a peak of plasma cortisol was evident in most cases within a few min after the injection of ACTH; after a fall, a later rise was then observed starting from 15 min. The differences in the plasma 11-OHCS responses after the two stimuli may also be of interest clinically for the investigation of some aspects of adrenal steroidogenesis.

scholarly journals A non-targeted LC–MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies

Metabolomics ◽  
2021 ◽  
Vol 17 (2) ◽  
Author(s):  
Tiina Jääskeläinen ◽  
◽  
Olli Kärkkäinen ◽  
Jenna Jokkala ◽  
Anton Klåvus ◽  
...  
Keyword(s):  
Large Scale ◽  
Scale Effects ◽  
Late Pregnancy ◽  
Metabolite Profile ◽  
Adverse Outcomes ◽  
Liquid Chromatography Mass Spectrometry ◽  
Targeted Metabolomics ◽  
Serum Samples ◽  
Healthy Women ◽  
Maternal Metabolism

Abstract Introduction Maternal metabolism changes substantially during pregnancy. However, few studies have used metabolomics technologies to characterize changes across gestation. Objectives and methods We applied liquid chromatography–mass spectrometry (LC–MS) based non-targeted metabolomics to determine whether the metabolic profile of serum differs throughout the pregnancy between pre-eclamptic and healthy women in the FINNPEC (Finnish Genetics of Preeclampsia Consortium) Study. Serum samples were available from early and late pregnancy. Results Progression of pregnancy had large-scale effects to the serum metabolite profile. Altogether 50 identified metabolites increased and 49 metabolites decreased when samples of early pregnancy were compared to samples of late pregnancy. The metabolic signatures of pregnancy were largely shared in pre-eclamptic and healthy women, only urea, monoacylglyceride 18:1 and glycerophosphocholine were identified to be increased in the pre-eclamptic women when compared to healthy controls. Conclusions Our study highlights the need of large-scale longitudinal metabolomic studies in non-complicated pregnancies before more detailed understanding of metabolism in adverse outcomes could be provided. Our findings are one of the first steps for a broader metabolic understanding of the physiological changes caused by pregnancy per se.

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