CORRELATION OF WATER AND ELECTROLYTE DISTRIBUTION IN THE THYROID GLAND WITH ITS FUNCTIONAL STATE IN RATS AND GUINEA-PIGS

1971 ◽  
Vol 50 (4) ◽  
pp. 577-588 ◽  
Author(s):  
S. Y. CHOW ◽  
D. M. WOODBURY
Keyword(s):  
Thyroid Gland ◽  
Guinea Pigs ◽  
Thyroid Stimulating Hormone ◽  
Fluid Volume ◽  
Follicular Cell ◽  
Adult Rats ◽  
Interstitial Fluid Volume ◽  
Term Administration ◽  
Hypophysectomized Rats

SUMMARY In the thyroid gland of rats and guinea-pigs, follicular cell fluid volume was increased and luminal fluid volume was decreased after a single injection of thyroid-stimulating hormone (TSH) (1 i.u./animal) or long-term administration of propylthiouracil (PTU) (0·1% in drinking water for 2 weeks). In rats, follicular cell fluid volume was decreased and luminal fluid volume was increased after hypophysectomy. Interstitial fluid volume remained fairly constant in different functional states of the thyroid gland in both species. As a result of the decrease in luminal colloid content by TSH and PTU treatments, the Cl− concentration in the luminal compartment of the thyroid gland was increased. Luminal Cl− concentration decreased in hypophysectomized rats. In the cellular compartment of the thyroid gland, TSH and PTU treatments caused an increase in K+ and Cl− concentrations and a decrease in Na+ concentration, whereas hypophysectomy caused a decrease in K+ and Cl− and an increase in Na+ concentrations. Water and electrolytes in the thyroid gland of rats younger than 5 weeks were distributed in the same pattern as that of adult guinea-pigs and hypophysectomized adult rats; all these animals probably had lower TSH activity than intact adult rats.

Long-term administration of high-dose methylphenidate-induced cerebellar morphology and function damage in adult rats

2020 ◽  
Vol 103 ◽  
pp. 101712 ◽  
Author(s):  
Amir Raoofi ◽  
Abass Aliaghaei ◽  
Mohammad-Amin Abdollahifar ◽  
Mahdi Eskandarian Boroujeni ◽  
Sara Sadat Javadinia ◽  
...  
Keyword(s):  
High Dose ◽  
Adult Rats ◽  
Term Administration ◽  
And Function

Effects of oestradiol-17β on testicular microcirculation in rats

1987 ◽  
Vol 115 (3) ◽  
pp. 489-495 ◽  
Author(s):  
A. Widmark ◽  
J. E. Damber ◽  
A. Bergh
Keyword(s):  
Blood Vessels ◽  
Interstitial Fluid ◽  
Fluid Volume ◽  
Polymorphonuclear Leucocytes ◽  
Testosterone Production ◽  
Interstitial Fluid Volume ◽  
Before And After ◽  
Testicular Steroidogenesis ◽  
Hypophysectomized Rats ◽  
Intact Rats

ABSTRACT The effect of oestradiol-17β on testicular micro-circulation in intact and hypophysectomized rats was studied before and after treatment with human chorionic gonadotrophin (hCG). Treatment of intact rats with oestradiol-17β for 5 days did not influence vasomotion but decreased testicular interstitial fluid volume (IFV). Treatment of intact rats with 50 IU hCG 8 h before the experiment began induced an increase in testicular IFV, abolished vasomotion and increased the accumulation of polymorphonuclear leucocytes in the testicular venules and interstitium. These changes were unaffected by pretreatment with oestradiol-17β, despite the decreased testosterone production. However, pretreatment with oestradiol-17β potentiated the hCG-induced migration of polymorphonuclear leucocytes to the interstitium. The interstitial fluid volume and number of polymor phonuclear leucocytes in blood vessels were decreased in hypophysectomized rats, and vasomotion was abolished. Daily treatment with 5 IU hCG increased the IFV and the number of polymorphonuclear leucocytes in blood vessels, and preserved vasomotion. Treatment of hypophysectomized rats with oestradiol-17β decreased testosterone production but did not influence basal IFV, vasomotion or the changes in IFV and vasomotion induced by 5 IU hCG. The present study shows that the regulation of testicular vascular permeability and vasomotion may not be directly related to testicular steroidogenesis, and that oestrogens are probably not involved as a mediator of the hCG-induced changes in testicular microcirculation. J. Endocr. (1987) 115, 489–495

Effects of long-term administration of the 5-hydroxytryptamine 1B receptor antagonist AR-A000002 to guinea pigs

2004 ◽  
Vol 172 (3) ◽  
pp. 333-340 ◽  
Author(s):  
Carina Stenfors ◽  
Charlotte Ahlgren ◽  
Hong Yu ◽  
Maria Wed�n ◽  
Lars-Gunnar Larsson ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Guinea Pigs ◽  
Term Administration

scholarly journals Effect of Short- and Long-Term Administration of Baclofen on Spatial Learning and Memory in Rats

2018 ◽  
pp. 133-141 ◽  
Author(s):  
M. HOLAJOVA ◽  
M. FRANEK
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Receptor Agonist ◽  
Gabab Receptor ◽  
Spatial Learning And Memory ◽  
Adult Rats ◽  
Treatment Groups ◽  
Term Administration ◽  
Short And Long Term

Baclofen is the only clinically available metabotropic GABAB receptor agonist. In our experiment, we tested the hypothesis that long-term baclofen administration can impair learning and memory in rats. The experiment consisted of three parts. In the first part of the study the drug was administered simultaneously with the beginning of the behavioral tests. In the second and third part of the experiment baclofen was administered daily for 14 days and for one month before the tests. In each part of the experiment, adult rats were randomly divided into four treatment groups. Three groups were given an injection of baclofen at doses of 1 mg/kg, 5 mg/kg, 10 mg/kg, while the fourth group was injected with saline. The injections were given after each session. Spatial learning and memory were tested using the Morris water maze, involving three types of tests: Acquisition, Probe, and Re-acquisition. This work reveals that baclofen did not affect spatial learning at any of the tested doses and regardless of the length of administration. Memory was observed to be affected, but only at the highest dose of baclofen and only temporarily. This conclusion is in line with previously published clinical cases.

scholarly journals Some experimental data on the etiology of uterine fibroids

2021 ◽  
Vol 43 (2) ◽  
pp. 77-78
Author(s):  
M. S. Todortseva
Keyword(s):  
Experimental Data ◽  
Nervous System ◽  
Tumor Growth ◽  
Guinea Pigs ◽  
Morphological Changes ◽  
Uterine Fibroids ◽  
Nervous Apparatus ◽  
Term Administration

Taking into account the great interest in identifying the role of the nervous system in the processes of tumor growth and the insufficient study of morphological changes in the nervous apparatus of neoplasms, in our clinic (Head - Prof. AM Foy), since 1955, work has been carried out to study the effect of prolonged hyperestrogenism on the nervous apparatus of the uterus during the development of experimental fibroids in it. Experiments with long-term administration of estrogenic hormones were carried out on 120 non-castrated female guinea pigs weighing from 150.0 to 250.0, which were divided into 4 groups.

Effect of prepubertal and postpubertal long-term exposure to the mild dose of soybean seeds on the tissue and function of thyroid gland in albino rat

2019 ◽  
Vol 7 (3) ◽  
pp. 213-222
Author(s):  
Siham M. Abdul-Ridha ◽  
Abed H. Baraaj
Keyword(s):  
Body Weight ◽  
Thyroid Gland ◽  
Life Stage ◽  
Significant Decline ◽  
Follicular Cell ◽  
Soybean Seeds ◽  
Life Stages ◽  
And Function ◽  
Significant Increment

The aim of this study is to investigate the effect of long-term exposure to the mild dose of soybean seeds on the tissue and some physiological parameters of the thyroid gland in the prepubertal and postpubertal life stages. Twenty four Sprague-Dawley albino male rats were divided into four groups (n=6); control rats at the prepubertal life stage; prepubertal rats treated with 20% soybean seeds of daily diet for 40 days after the weaning; normal control rats, at the postpubertal stage; and postpubertal rats, were treated with 20% soybean seeds. Morphmetrical, histological and physiological changes were examined. Consumption of mild dose of soybean seeds along the prepubertal life stage showed significant decrease (P<0.05) in the height of follicular cell, significant increase (P<0.05) in the diameter of follicular lumen and ratio of cold follicles, slightly non-significant decline in (T3 and T4) hormones levels and significant increment (P<0.05) in body weight, while at postpuberty, long-term exposure for the same dose of soybean seeds showed significant increase in the height of follicular cell (P<0.05), significant decrease (P<0.05) in the diameter of follicular lumen and ratio of cold follicles caused hyperactivity of the thyroid, significant decline (P<0.05) in (T3 and T4) hormones levels and slightly non-significant increment (P<0.05) in body weight. We concluded that the long-term exposure to the mild dose of the soybean affect adversely the tissue and function of the thyroid at both life stages, pre- and postpuberty.

Gold nanoparticles alter parameters of oxidative stress and energy metabolism in organs of adult rats

2015 ◽  
Vol 93 (6) ◽  
pp. 548-557 ◽  
Author(s):  
Gabriela Kozuchovski Ferreira ◽  
Eria Cardoso ◽  
Francieli Silva Vuolo ◽  
Monique Michels ◽  
Elton Torres Zanoni ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gold Nanoparticles ◽  
Energy Metabolism ◽  
Acute Administration ◽  
Sod Activity ◽  
Adult Rats ◽  
Protein Levels ◽  
Carbonyl Protein ◽  
Term Administration

This study evaluated the parameters of oxidative stress and energy metabolism after the acute and long-term administration of gold nanoparticles (GNPs, 10 and 30 nm in diameter) in different organs of rats. Adult male Wistar rats received a single intraperitoneal injection or repeated injections (once daily for 28 days) of saline solution, GNPs-10 or GNPs-30. Twenty-four hours after the last administration, the animals were killed, and the liver, kidney, and heart were isolated for biochemical analysis. We demonstrated that acute administration of GNPs-30 increased the TBARS levels, and that GNPs-10 increased the carbonyl protein levels. The long-term administration of GNPs-10 increased the TBARS levels, and the carbonyl protein levels were increased by GNPs-30. Acute administration of GNPs-10 and GNPs-30 increased SOD activity. Long-term administration of GNPs-30 increased SOD activity. Acute administration of GNPs-10 decreased the activity of CAT, whereas long-term administration of GNP-10 and GNP-30 altered CAT activity randomly. Our results also demonstrated that acute GNPs-30 administration decreased energy metabolism, especially in the liver and heart. Long-term GNPs-10 administration increased energy metabolism in the liver and decreased energy metabolism in the kidney and heart, whereas long-term GNPs-30 administration increased energy metabolism in the heart. The results of our study are consistent with other studies conducted in our research group and reinforce the fact that GNPs can lead to oxidative damage, which is responsible for DNA damage and alterations in energy metabolism.

scholarly journals Behavioral Changes in Guinea Pigs Treated with Long-Term Administration of Methamphetamine and Immunohistochemical Changes in Their Brains

1996 ◽  
Vol 1 (1) ◽  
pp. 21-26
Author(s):  
Satoshi Kubota ◽  
Sachio Miyasaka ◽  
Mineo Yoshino ◽  
Ken Tanaka ◽  
Takako Inoue ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Behavioral Changes ◽  
Term Administration
Sign in / Sign up

Export Citation Format

Share Document