scholarly journals Peripheral Vascular Disease Risk Factors among Patients Undergoing Hemodialysis

2002 ◽  
Vol 13 (2) ◽  
pp. 497-503
Author(s):  
Ann M. O’Hare ◽  
Chi-yuan Hsu ◽  
Peter Bacchetti ◽  
Kirsten L. Johansen
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Vascular Disease ◽  
Cardiovascular Risk Factors ◽  
Peripheral Vascular Disease ◽  
The United States ◽  
Left Ventricular ◽  
Peripheral Vascular ◽  
Cross Sectional ◽  
Negatively Associated

ABSTRACT. Peripheral vascular disease (PVD) is common among patients undergoing hemodialysis, but little is known regarding the risk factors for PVD in this population. Data from waves 1, 3, and 4 of the United States Renal Data System Dialysis Morbidity and Mortality Study were used to examine cross-sectional associations of a range of conventional cardiovascular risk factors and uremia- or dialysis-related variables with PVD. Univariate and multivariate logistic regression models were developed using wave 3 and 4 data. Odds ratios for the multivariate model derived using wave 3 and 4 data were then compared with those obtained with the wave 1 data set. For both data sets, PVD was positively associated with the duration of dialysis (vintage) and malnourished status and was negatively associated with serum albumin and parathyroid hormone levels and predialysis diastolic BP. Kt/V was negatively associated with PVD in waves 3 and 4 but not in wave 1. PVD was associated with increasing age, white (versus non-white) race, male gender, diabetes mellitus, coronary artery disease, cerebrovascular disease, smoking, and left ventricular hypertrophy, as for the general population, but not with hypertension or hyperlipidemia. In conclusion, PVD among hemodialysis patients is associated with both dialysis-specific variables and most conventional cardiovascular risk factors other than hypertension and hyperlipidemia. Future studies should prospectively examine the association of these variables identified in cross-sectional analyses with the de novo development of PVD in this population.

scholarly journals Diffuse Dermal Angiomatosis Manifestation of Underlying Severe Peripheral Vascular Disease

2020 ◽  
Author(s):  
Abu Baker Sheikh ◽  
Nismat Javed ◽  
Karl Stoltze
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Vascular Disease ◽  
Cardiovascular Risk Factors ◽  
Peripheral Vascular Disease ◽  
Vascular Disorder ◽  
Peripheral Vascular

Diffuse dermal angiomatosis is a benign vascular disorder suspected in patients with cardiovascular risk factors. We report the case of a 62-year-old woman with a non-healing hip wound but no significant cardiovascular risk factors, who was found to have diffuse dermal angiomatosis on biopsy leading to the diagnosis of severe peripheral vascular disease. Her wound healed after revascularization.

scholarly journals Glucose-6-Phosphate Dehydrogenase Deficiency is Associated with Cardiovascular Disease in U.S. Military Centers

2018 ◽  
Vol 45 (3) ◽  
pp. 144-150 ◽  
Author(s):  
John E. Thomas ◽  
Seungho Kang ◽  
Charles J. Wyatt ◽  
Forest S. Kim ◽  
A. David Mangelsdorff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Medical Records ◽  
Vascular Function ◽  
Oxidant Stress ◽  
The United States ◽  
Cross Sectional ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress—precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, whether the relationship is independent of accepted cardiovascular risk factors. We analyzed the medical records of 737 individuals who had deficient G6PD levels and 16,601 who had normal levels. Everyone had been screened at U.S. military medical centers from August 2004 through December 2007. We evaluated our dependent variable (composite cardiovascular disease) at the individual level, and performed binary logistic regression of our independent variable (G6PD status) and control variables (modifiable cardiovascular risk factors). The adjusted odds ratio of 1.396 (95% CI, 1.044–1.867; P <0.05) indicated that G6PD-deficient individuals have 39.6% greater odds of developing cardiovascular disease than do those with normal levels. Early intervention may reduce the incidence of cardiovascular disease in military personnel and civilians who have deficient G6DP levels.

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