scholarly journals Glucose-6-Phosphate Dehydrogenase Deficiency is Associated with Cardiovascular Disease in U.S. Military Centers

2018 ◽  
Vol 45 (3) ◽  
pp. 144-150 ◽  
Author(s):  
John E. Thomas ◽  
Seungho Kang ◽  
Charles J. Wyatt ◽  
Forest S. Kim ◽  
A. David Mangelsdorff ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Medical Records ◽  
Vascular Function ◽  
Oxidant Stress ◽  
The United States ◽  
Cross Sectional ◽  
Glucose 6 Phosphate Dehydrogenase

Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress—precursors to atherosclerosis and cardiovascular disease. Using military medical records, we performed a retrospective, cross-sectional study to investigate whether deficient G6PD levels are associated with a higher prevalence of cardiovascular disease than are normal levels, and, if so, whether the relationship is independent of accepted cardiovascular risk factors. We analyzed the medical records of 737 individuals who had deficient G6PD levels and 16,601 who had normal levels. Everyone had been screened at U.S. military medical centers from August 2004 through December 2007. We evaluated our dependent variable (composite cardiovascular disease) at the individual level, and performed binary logistic regression of our independent variable (G6PD status) and control variables (modifiable cardiovascular risk factors). The adjusted odds ratio of 1.396 (95% CI, 1.044–1.867; P <0.05) indicated that G6PD-deficient individuals have 39.6% greater odds of developing cardiovascular disease than do those with normal levels. Early intervention may reduce the incidence of cardiovascular disease in military personnel and civilians who have deficient G6DP levels.

scholarly journals Risk of Cardiovascular Disease among Diabetic Patients in Manipur, Northeast India

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Mary Grace Tungdim ◽  
T. Ginzaniang ◽  
G. Poufullung Kabui ◽  
Deepali Verma ◽  
Satwanti Kapoor
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Premature Mortality ◽  
Northeast India ◽  
Risk Level ◽  
Diabetic Patients ◽  
Atherosclerotic Cardiovascular Disease ◽  
Cross Sectional

Atherosclerotic cardiovascular disease is the major cause of premature mortality in patients with type 2 diabetes. The present study was conducted to assess cardiovascular risk among diabetic patients of Northeast India. The present cross-sectional study included 81 diabetic patients (39 males and 42 females) aged 36–74 years from the district Imphal of Manipur, Northeast India. Sex-specific Framingham general cardiovascular risk prediction equations were used to calculate the 10-year risk for cardiovascular disease. The probable risk factors were determined by cross-tabulation of cardiometabolic parameters with the 10-year cardiovascular risk level. Males were found to be at higher risk of developing CVD in the future as compared to females with a discernible accumulation of adverse cardiovascular risk factors among them. 38.3% patients were at high risk, 37.0% at moderate risk and 24.7% at low risk for developing CVD in the next 10 years. Systolic blood pressure, total cholesterol, triglyceride, and smoking contributed significantly to high degree of cardiovascular risk. Presence of cardiovascular risk factors among diabetic patients at diagnosis accentuates the need of intensive management of cardiovascular complications, taking into consideration the traditional dietary pattern of the population.

scholarly journals Relationship between Physical Activity and Cardiovascular Risk Factors: A Cross-Sectional Study among Low-Income Housewives in Kuala Lumpur

2021 ◽  
Vol 18 (11) ◽  
pp. 6090
Author(s):  
Nur Zakiah Mohd Saat ◽  
Siti Aishah Hanawi ◽  
Nor M. F. Farah ◽  
Hazilah Mohd Amin ◽  
Hazlenah Hanafiah ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Low Income ◽  
Cross Sectional Study ◽  
Kuala Lumpur ◽  
Sectional Study ◽  
Cross Sectional

Cardiovascular disease is a significant public health concern worldwide, including in Malaysia. Various attempts have been made to resolve this issue. One of the most important methods of controlling cardiovascular risk factors is physical exercise. However, today’s women, especially housewives, are often identified by a lack of physical activity. This is alarming to society, as cardiovascular disease can affect the quality of their life. The aim of this study is to determine the relationship between physical activity and cardiovascular risk factors among low-income housewives in Kuala Lumpur. A total of 63 housewives participated in this cross-sectional study. All participating housewives were asked to fill out a sociodemographic questionnaire and the short version of the International Physical Activity Questionnaire (IPAQ). To evaluate cardiovascular risk factors, anthropometric measurements and blood samples were taken. Findings showed that an average of 70.5 ± 232.4 min/week was spent on moderate-to-vigorous physical activity (MVPA), which indicated a low level of physical activity. Data showed that 90.5% of the subjects had low physical activity, 6.3% were moderate, and 3.2% were considered as having a high level of physical activity. For body mass index (BMI), 58.7% of the respondents were obese, 28.6% were overweight (29.10 ± 5.67 kg m–2), and 81.0% of subjects had a waist circumference (WC) value above the normal range (92.74 ± 16.40 cm). A two-way ANOVA test revealed significant mean differences between systolic blood pressure (mm/Hg) and age groups (p > 0.05). Nevertheless, there was a significant association between MVPA and cardiovascular risk factors using negative binomial regression (p < 0.01). The findings of this study highlight the need for health promotional programs to raise awareness, educate, and engage low-income housewives in lifestyle-enhancing behaviors.

scholarly journals Frequency of subclinical thyroid dysfunction and risk factors for cardiovascular disease among women at a workplace

2010 ◽  
Vol 128 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Rodrigo Diaz-Olmos ◽  
Antônio-Carlos Nogueira ◽  
Daniele Queirós Fucciolo Penalva ◽  
Paulo Andrade Lotufo ◽  
Isabela Martins Benseñor
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Disease ◽  
Thyroid Dysfunction ◽  
Free T4 ◽  
Cross Sectional

CONTEXT AND OBJECTIVE: Subclinical thyroid dysfunction is very common in clinical practice and there is some evidence that it may be associated with cardiovascular disease. The aim here was to evaluate the frequencies of subclinical thyroid disease and risk factors for cardiovascular disease among women at a workplace, and to evaluate the association between subclinical thyroid disease and cardiovascular risk factors among them. DESIGN AND SETTING: Cross-sectional study on 314 women aged 40 years or over who were working at Universidade de São Paulo (USP). METHODS: All the women answered a questionnaire on sociodemographic characteristics and risk factors for cardiovascular disease and the Rose angina questionnaire. Anthropometric variables were measured and blood samples were analyzed for blood glucose, total cholesterol and fractions, high-sensitivity C-reactive protein, thyroid-stimulating hormone (TSH), free thyroxine (free-T4) and anti-thyroperoxidase antibodies (anti-TPO). RESULTS: The frequencies of subclinical hypothyroidism and hyperthyroidism were, respectively, 7.3% and 5.1%. Women with subclinical thyroid disease presented higher levels of anti-TPO than did women with normal thyroid function (P = 0.01). There were no differences in sociodemographic factors and cardiovascular risk factors according to thyroid function status, except for greater sedentarism among the women with subclinical hypothyroidism. Restricting the comparison to women with subclinical hypothyroidism (TSH > 10 mIU/l) did not change the results. CONCLUSION: In this sample of women, there was no association between poor profile of cardiovascular risk factors and presence of subclinical thyroid disease that would justify screening at the workplace.

scholarly journals Knowledge regarding lifestyle and cardiovascular risk factors in rural community

2021 ◽  
Vol 2 (1) ◽  
pp. 062-071
Author(s):  
Priti Lata Mondal ◽  
Jayanta Sadhu ◽  
Abdul Karim ◽  
Beauty Begum
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Rural Community ◽  
Public Health Problem ◽  
Cross Sectional Study ◽  
Good Knowledge ◽  
Major Public Health Problem ◽  
Cross Sectional

Cardiovascular Disease (CVD) is one of the leading causes of death worldwide, making it a major public health problem in Bangladesh also. A descriptive cross-sectional study was carried out in Joykhali village, Batiaghata upazilla in Khulna district from January to December 2019 to assess the level of knowledge regarding lifestyle and cardiovascular risk factors in rural community. A total of 288 people were selected from each house by conveniently. Data were collected by using pre tested semi-structured questionnaire with face-to-face interview. Out of the 288 respondents, 43 (14.9%) had good knowledge while others had average (n=211, 73.3%) and poor (n=34, 11.8%) knowledge regarding risk factors of cardiovascular disease. Only 25 (8.7%) respondents had good knowledge while others had average (n=190, 66.0%) and poor (n=73, 25.3%) knowledge regarding sign and symptoms of cardiovascular disease. Majority of the respondents (61.1%) had good knowledge while others had average (n=105, 36.5%) and poor (n=7, 2.4%) knowledge regarding prevention of cardiovascular disease. There is an apparent need to establish more wide-spread and effective educational intervention, which should be sensitive to the abilities of targeted individuals.

scholarly journals Food habits and risk of cardiovascular disease in schoolchildren from Ouro Preto, Minas Gerais

2015 ◽  
Vol 28 (2) ◽  
pp. 133-142 ◽  
Author(s):  
Lorene Gonçalves Coelho ◽  
Ana Paula Carlos Cândido ◽  
George Luiz Lins Machado-Coelho ◽  
Silvia Nascimento de Freitas
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Food Intake ◽  
Cardiovascular Risk Factors ◽  
Food Habits ◽  
Population Based ◽  
Minas Gerais ◽  
Linear Regression Models ◽  
Cross Sectional

OBJECTIVE: To investigate the relationship between food habits and risk factors for cardiovascular disease in schoolchildren of the city Ouro Preto, Minas Gerais. METHODS: A cross-sectional study was conducted in a population-based sample of 738 schoolchildren aged 6-14 years. A semi-structured questionnaire was used for collecting demographic, socioeconomic, biochemical, clinical, and anthropometric data. Food intake was determined by a food-frequency questionnaire. Food habits were evaluated according to the adapted Recommended Food Score. Multiple linear regression models were constructed to assess how food consumption was associated with cardiovascular risk factors. RESULTS: The schoolchildren presented a dietary pattern characterized by low consumption of healthy foods. Association of cardiovascular risk factors showed that the consumption of foods according to the adapted Recommended Food Score was negatively and significantly associated with tetrapolar percentage of body fat (p=0.030) and systolic blood pressure (p=0.049) in children aged 6-9 years. CONCLUSION: Children's dietary patterns proved to be an important determinant of some of the cardiovascular risk factors studied. Thus, food intake assessment is a primary tool for the prevention and early intervention on cardiovascular risk factors during childhood.

scholarly journals Gaps in Diagnosis and Treatment of Cardiovascular Risk Factors in Patients with Psoriatic Disease: An International Multicenter Study

2018 ◽  
Vol 45 (3) ◽  
pp. 378-384 ◽  
Author(s):  
Lihi Eder ◽  
Paula Harvey ◽  
Vinod Chandran ◽  
Cheryl F. Rosen ◽  
Jan Dutz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Central Obesity ◽  
The United States ◽  
Cross Sectional ◽  
Psoriatic Disease ◽  
Framingham Risk ◽  
International Multicenter Study ◽  
International Multicenter

Objective.We aimed to estimate the proportion of underdiagnosis and undertreatment of cardiovascular risk factors (CVRF) in an international multicenter cohort of patients with psoriasis and psoriatic arthritis (PsA).Methods.A cross-sectional analysis was conducted of patients with psoriatic disease from the International Psoriasis and Arthritis Research Team cohort. The presence of modifiable CVRF [diabetes, hypertension (HTN), dyslipidemia, smoking, elevated body mass index, and central obesity] and the use of appropriate therapies for HTN and dyslipidemia were determined. The 10-year CV risk was calculated according to the Framingham Risk Score. Physician adherence with guidelines for the treatment of dyslipidemia and HTN was assessed. Regression analysis was used to assess predictors of undertreatment of HTN and dyslipidemia.Results.A total of 2254 patients (58.9% PsA, 41.1% psoriasis) from 8 centers in Canada, the United States, and Israel were included. Their mean age was 52 ± 13.8 years and 53% were men. Of the patients, 87.6% had at least 1 modifiable CVRF, 45.1% had HTN, 49.4% dyslipidemia, 13.3% diabetes, 75.3% were overweight or obese, 54.3% central obesity, and 17.3% were current smokers. We found 59.2% of patients with HTN and 65.6% of patients with dyslipidemia were undertreated. Undertreatment was associated with younger age (≤ 50 yrs), having psoriasis, and male sex.Conclusion.In real-world settings, a large proportion of patients with psoriasis and PsA were underdiagnosed and undertreated for HTN and dyslipidemia. Strategies to improve the management of CVRF in psoriatic patients are warranted.

scholarly journals Relationship between Endothelial Function, Antiretroviral Treatment and Cardiovascular Risk Factors in HIV Patients of African Descent in South Africa: A Cross-Sectional Study

2021 ◽  
Vol 10 (3) ◽  
pp. 392
Author(s):  
Benedicta N. Nkeh-Chungag ◽  
Nandu Goswami ◽  
Godwill A. Engwa ◽  
Constance R. Sewani-Rusike ◽  
Vuyolwethu Mbombela ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Vascular Function ◽  
Antiretroviral Treatment ◽  
African Ancestry ◽  
Cd4 Count ◽  
Hiv Positive ◽  
Cross Sectional ◽  
South Africans

Limited information on the effect of antiretroviral treatment (ART) on vascular function in South Africans of African descent living with human immunodeficiency virus (HIV) is available. The relationship between ART, vascular function and cardiovascular risk factors in South Africans of African ancestry with HIV was therefore studied. This cross-sectional study recruited 146 HIV-positive individuals on ART (HIV+ART+), 163 HIV-positive individuals not on ART (HIV+ART−) and 171 individuals without HIV (HIV−) in Mthatha, Eastern Cape Province of South Africa. Flow-mediated dilation (FMD) test was performed to assess endothelial function. Anthropometry and blood pressure parameters were measured. Lipid profile, glycaemic indices, serum creatinine as well as CD4 count and viral load were assayed in blood. Urinary albumin to creatinine ratio (ACR) was determined as a marker of cardiovascular risk. Obesity and albuminuria were positively associated with HIV, and HIV+ART+ participants had significantly higher HDL cholesterol. Dyslipidaemia markers were significantly higher in hypertensive HIV+ART+ participants compared with the controls (HIV+ART− and HIV− participants). FMD was not different between HIV+ART+ participants and the controls. Moreover, HIV+ART+ participants with higher FMD showed lower total cholesterol and LDL cholesterol comparable to that of HIV− and HIV+ART− participants. A positive relationship between FMD and CD4 count was observed in HIV+ART+ participants. In conclusion, antiretroviral treatment was associated with cardiovascular risk factors, particularly dyslipidaemia, in hypertensive South Africans of African ancestry with HIV. Although, ART was not associated with endothelial dysfunction, flow-mediated dilatation was positively associated with CD4 count in HIV-positive participants on ART.

scholarly journals Dietary Quality Index and Cardiometabolic Risk Factors among Adult Women

2021 ◽  
Author(s):  
Behzad Zamani ◽  
Elnaz Daneshzad ◽  
Manije Darooghegi Mofrad ◽  
Nazli Namazi ◽  
Bagher Larijani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Quality Index ◽  
Large Scale ◽  
Health Centers ◽  
Dietary Quality ◽  
Adult Women ◽  
Cross Sectional

Background: The prevalence of cardiovascular disease is dramatically increasing particularly in developing countries. Among the different factors, diet has an important role in the pathogenesis of these diseases. This study aimed to assess the relationship between dietary quality index-international (DQI-I) and cardiovascular risk factors in adult Iranian women. Methods: This was a cross-sectional study of 371 participants, aged 20-50 yr, and recruited from 10 health centers from health centers affiliated with Tehran University of Medical Sciences (TUMS), Tehran, Iran in 2018. Usual dietary intake was evaluated by a validated and reliable 168-items food frequency questionnaire (FFQ). To assess overall quality of diet, the Dietary Quality Index-International (DQI) was used. Anthropometric measurements, blood pressure, and fasting blood of samples were taken to assess biochemical parameters related to cardiovascular disease. Results: The results of linear regression showed that DQI-I score was inversely and directly associated with serum level of total cholesterol (TC) (0.27, confidence interval (CI): 0.13-0.58; P<0.001) and high-density lipoprotein cholesterol (HDL-C) (2.53, CI: 1.42-4.52; P=0.001), respectively. However, there was no significant association between DQI-I and other cardiovascular risk factors. Conclusion: A greater DQI-I score was associated with preferable lipid profile including TC and HDL-C. Future large-scale, prospective cohort or clinical studies are required to confirm these findings.  

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