scholarly journals Nobiletin Reduces Lipid Accumulation in Sebocytes and Inhibits PPAR Delta Activation in Epidermal Tissue Models

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Fedorova E ◽  
Li S ◽  
Gusella GL ◽  
Mosoian A
Keyword(s):  
Inflammatory Disease ◽  
Lipid Accumulation ◽  
Bacterial Colonization ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Ppar Delta ◽  
Epidermal Tissue ◽  
Sebum Production ◽  
Polymethoxylated Flavones ◽  
Tissue Models

Background: Acne vulgaris is a chronic inflammatory disease that affects the majority of the population at some point in their lifetime. Acne pathogenesis is multifactorial with four primary contributors that play a pivotal role in the formation of acne lesions: inflammation, androgeninduced sebum production, abnormal keratinization, and bacterial colonization. Recent studies have demonstrated the anti-inflammatory, anticarcinogenic, anti-diabetic, and anti-lipid properties of certain Polymethoxylated Flavones (PMF) derivatives.

scholarly journals Very Severe (4th Grade) Closed Comedonal Acne Vulgaris That was Complicated by Staphylococcus Epidermidis and Pityrosporum Ovale Folliculities in 16th Years Old Atopic Hystory Girl that was Treated with 4x Tca 10% Chemical Peeling at 2 Weeks Intervals

2019 ◽  
Vol 4 (1) ◽  
Keyword(s):  
Staphylococcus Epidermidis ◽  
Bacterial Colonization ◽  
Acne Vulgaris ◽  
Acne Scar ◽  
Laboratory Examination ◽  
First Line ◽  
Pityrosporum Ovale ◽  
Acne Therapy ◽  
Chemical Peeling ◽  
Sebum Production

Acne vulgaris was very common self limitting disease, affected approximately 85% of adolesence, that was defined as a chronic inflammation of pilosebaceous units. It was characterized (diagnosed) by the formation of comedones (as primarily acne lession), erythemathous papules and pustules, less frequently nodules and pseudocyst, and was accompanied by scarring in some cases that caused psychosocial problems. Cunliffe classified the severity of acne vulgaris into 4 types based on the kind and number of acne lessions : mild, moderate, severe, very severe. Four major factors were involved in the etiopathogenesis: follicular hyperkeratinization, increased sebum production, abnormality of microbial flora and inflammation process. The goal of therapy were : removed plugging of the pilar drainage, reduced sebum production, treated bacterial colonization, prevented from scaring. The complications were acne scar, persistent hyperpigmentation, pyogenic granuloma formation, persistent swelling, gram negative bacteria folliculitis, bacterial and fungal folliculitis as secondary infection, resistances to antibiotics. The purpose of this case report was to share experience in treating very severe comedonal acne vulgaris because of the chronicity course of acne vulgaris was difficult to be eradicated and there were many resistances problems to antibiotics in some literatures and journals. Case Presentation: It was a very severe (4th grade) closed comedonal acne vulgaris that was complicated by Staphylococcus epidermidis and Pityrosporum ovale folliculitis in 16th years old atopic hystory girl based on anamnesis, clinical finding and laboratory examination. And this case was treated by 4x TCA 10% chemical peeling at 2 weeks intervals, 2 weeks antibiotic and 10 days ketokonazole after the result of culture and laboratory examination were positive. And the result was good. There was significant improvement in clinical stage (4th grade to 1st grade acne vulgaris), decreased the count of comedones, diminished papules-pustules and inflammation, no scar and post inflamatory hyperpigmentation were occured Discussion: TCA 10% was superficial chemical peeling, considered as adjunctive therapy to the first line acne therapy retinoids and antibiotic, and TCA was the first line therapy for acne scar and skin rejuvenation. TCA was cheap and save because no systemic absorbtion, had keratolytic effect (comedolytic action) and anti inflammatory effect (bactericidal action). It could be combined to antibiotics and antifungal therapy and solved resistance problems to antibiotic and antifungal in acne therapy

Evaluation of Serum Interleukin 36 in Egyptian Acne Vulgaris Patients versus Controls

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Maha Mohamed Adel Shahin ◽  
Marwa Yassin Ahmed Soltan ◽  
Esraa Mahmoud Awaad
Keyword(s):  
Acne Vulgaris ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
University Hospitals ◽  
Innate And Adaptive Immunity ◽  
Dermatology Clinic ◽  
Probable Role ◽  
Sebum Production ◽  
High Degree ◽  
Control Study

Abstract Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, and it is one of the most common dermatological conditions worldwide. Some of the key mechanisms of pathogenesis are the disturbed sebaceous gland activity associated with excess sebum production and alterations in sebum fatty acid composition, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinization, and induction of inflammation and dysfunction of the innate and adaptive immunity. Objectives We aimed to evaluate the serum IL36 levels in acne vulgaris patients in comparison with healthy controls and to correlate its level to different severities of acne vulgaris. Patients and Methods This is a case control study which included 30 acne vulgaris patients who were recruited from the Outpatient Dermatology Clinic at Ain Shams University Hospitals during the period between September 2018 and December 2018. Results The study revealed a highly significant increase in IL-36 serum levels which can differentiate cases form controls with a high degree of specificity of the test according to the ROC curve However, there was no association between IL-36 and the disease severity. Expression of high levels of IL-36 in all acne cases including mild cases suggests a probable role in early inflammatory stage of the disease. Furthermore, duration of the disease, body mass index, family history and sex were all insignificant factors on affecting IL-36 levels. Conclusion We found that IL-36 is involved in acne pathogenesis and its serum levels are elevated even in mild cases with comedonal lesions suggesting the possible involvement in the early events of acne vulgaris. Further studies are required to demonstrate more detailed explanation of IL-36 pathogenic role in acne.

Therapeutic glucocorticoids prevent local and systemic bone loss in the TNF-tg model of chronic inflammatory disease

2018 ◽  
Author(s):  
Chloe Fenton ◽  
Syeda Fareed ◽  
Amy Naylor ◽  
Dominika Nanus ◽  
Mark Cooper ◽  
...  
Keyword(s):  
Bone Loss ◽  
Inflammatory Disease ◽  
Chronic Inflammatory Disease ◽  
Systemic Bone Loss

A Critical Review on Tamaka Shwasa (Bronchial Asthma) - An Ayurvedic View

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Sandip R. Baheti ◽  
Deepa Sharma ◽  
Saroj Devi ◽  
Amit Rai
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Critical Review ◽  
Modern Science ◽  
Modern Medicine ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Natural Immunity ◽  
Shortness Of Breath ◽  
Asthma Symptoms

Difficulty in breathing or shortness of breath may be simply termed as Shwasa (Asthma), As per Ayurveda, Shwasa is mainly caused by the Vata and Kapha Doshas. Shwasa is broadly classified into five types in Maha Shwasa (Dyspnoea major), Urdhawa Shwasa (Expiratory Dyspnoea), Chinna Shwasa (Chyne-stroke respiration), Kshudra Shwasa (Dyspnoea minor), Tamaka Shwasa (Bronchial Asthma). In modern science Tamaka Shwasa can be correlated with Asthma, Asthma which is a chronic inflammatory disease of airway. In modern medicine there is no cure for Asthma, symptoms can typically be improved. In Ayurveda, Asthma can be effectively and safely manage the condition without inducing any drug dependency where Pachakarma procedures and use of internal medication detoxifies the body, provides nutrition and increases the elasticity of lung tissue it also develops natural immunity of the body thus decreasing episodic recurrence of the disease.

Intermammary Hidradenitis Suppurativa: Considerations on a Unique Presentation

2021 ◽  
pp. 1-4
Author(s):  
Ana Luísa João ◽  
Nélia Cunha ◽  
Joana Cabete
Keyword(s):  
Surgical Approach ◽  
Inflammatory Disease ◽  
Pilonidal Sinus ◽  
Hidradenitis Suppurativa ◽  
Chronic Inflammatory Disease ◽  
Pilonidal Sinus Disease ◽  
Sinus Disease ◽  
Case Presentation ◽  
Overweight Women

Introduction: Hidradenitis suppurativa (HS) is a potentially disabling chronic inflammatory disease. The intermammary location, not clearly specified in the usual phenotypic classifications, entails significant functional and cosmetic compromise. Case Presentation: Eleven cases of predominantly intermammary disease with multiple fistulization and disfiguring scarring were observed at our Department between January 2016 and March 2020. They were young (mean age = 22 years) obese or overweight women, in which the medical-surgical approach has led to variable results. Discussion/Conclusion: Intermammary HS possibly represents a unique phenotypic presentation, likely to be fistulizing and severe. We believe that anatomo-functional considerations, which can be paralleled to pilonidal sinus disease, contribute to its pathophysiology and striking appearance, and further emphasize the importance of multidisciplinary endeavor to reduce the morbidity associated with this seemingly overlooked location.

708 FREQUENCY OF HYPERTENSION IN PATIENTS WITH CHRONIC INFLAMMATORY DISEASE S IS UNDERESTIMATED

2012 ◽  
Vol 30 ◽  
pp. e205-e206
Author(s):  
Ingrid Prkacin ◽  
Diana Balenovic ◽  
Andrija Jurina ◽  
Luka Šantek ◽  
Dino Kasumović ◽  
...  
Keyword(s):  
Inflammatory Disease ◽  
Chronic Inflammatory Disease
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