Evaluation of Serum Interleukin 36 in Egyptian Acne Vulgaris Patients versus Controls

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Maha Mohamed Adel Shahin ◽  
Marwa Yassin Ahmed Soltan ◽  
Esraa Mahmoud Awaad
Keyword(s):  
Acne Vulgaris ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
University Hospitals ◽  
Innate And Adaptive Immunity ◽  
Dermatology Clinic ◽  
Probable Role ◽  
Sebum Production ◽  
High Degree ◽  
Control Study

Abstract Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, and it is one of the most common dermatological conditions worldwide. Some of the key mechanisms of pathogenesis are the disturbed sebaceous gland activity associated with excess sebum production and alterations in sebum fatty acid composition, dysregulation of the hormone microenvironment, interaction with neuropeptides, follicular hyperkeratinization, and induction of inflammation and dysfunction of the innate and adaptive immunity. Objectives We aimed to evaluate the serum IL36 levels in acne vulgaris patients in comparison with healthy controls and to correlate its level to different severities of acne vulgaris. Patients and Methods This is a case control study which included 30 acne vulgaris patients who were recruited from the Outpatient Dermatology Clinic at Ain Shams University Hospitals during the period between September 2018 and December 2018. Results The study revealed a highly significant increase in IL-36 serum levels which can differentiate cases form controls with a high degree of specificity of the test according to the ROC curve However, there was no association between IL-36 and the disease severity. Expression of high levels of IL-36 in all acne cases including mild cases suggests a probable role in early inflammatory stage of the disease. Furthermore, duration of the disease, body mass index, family history and sex were all insignificant factors on affecting IL-36 levels. Conclusion We found that IL-36 is involved in acne pathogenesis and its serum levels are elevated even in mild cases with comedonal lesions suggesting the possible involvement in the early events of acne vulgaris. Further studies are required to demonstrate more detailed explanation of IL-36 pathogenic role in acne.

scholarly journals Clinical profile of acne vulgaris in semiurban patients

2018 ◽  
Vol 4 (1) ◽  
pp. 23
Author(s):  
Kshitij Saxena ◽  
Yogesh M. Shah ◽  
K. K. Singh ◽  
Shobhit Dutt ◽  
Meenal Agrawal ◽  
...  
Keyword(s):  
Age Of Onset ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Clinical Profile ◽  
Acne Lesion ◽  
Dermatology Clinic ◽  
Common Skin ◽  
Associated Conditions ◽  
Acne Scarring ◽  
Grade 3

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Acne is a chronic inflammatory disease of the pilosebaceous unit, mainly affecting face and frequently followed by scarring. It is the most common skin disease in an urban dermatology clinic in India. Adult acne is more common in women and may be a marker of hyperandrogenism.The present study was carried out to study the clinical profile of acne vulgaris in semiurban patients.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">The study was conducted for 1 year on all eligible patients of acne vulgaris attending dermatology OPD of a hospital catering to semiurban patients. Data including grade of acne, markers of androgenicity and post-acne scarring was collected. Statistical analysis was done using SPSS 15 software</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Frequency of acne vulgaris patients in the dermatology OPD was 2.8% with 429 acne patients out of 15,322 new patients. Female to male ratio was 1.44:1. The mean age of onset in males was 16.24 and in females, 14.84 years. Grade 2 acne (66%) was commonest followed by grade 3 (5.1%) and grade 4 (3.7%). Associated conditions seen were seborrhea (60.8%), alopecia (18.9%), acanthosis (4.9%) and PCOD (2.3%). Markers of androgenicity were more frequently seen in grade 2 acne which was statistically significant. Atrophic scars were commonest including icepick scars (80.2%), rolling scars (67.4%) and box scars (57.8%). </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">In our study females had an earlier onset and closed comedones were the most common acne lesion. Grade 2 acne vulgaris formed majority of patients. Grade 4 acne vulgaris was more common in males.</span></p>

scholarly journals Serum levels of Asprosin in patients diagnosed with coronary artery disease (CAD): a case-control study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Nariman Moradi ◽  
Fatima Zahraa Fouani ◽  
Akram Vatannejad ◽  
Abbas Bakhti Arani ◽  
Soraya Shahrzad ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Type Ii Diabetes Mellitus ◽  
Chronic Inflammatory Disease ◽  
Increased Risk ◽  
Tnf Α ◽  
Artery Disease ◽  
Control Study

Abstract Background Coronary artery disease (CAD) is considered as a multi-faceted chronic inflammatory disease involving reduced blood supply to the myocardium as a result of accumulating lipids in the atrial walls. Visceral adiposity with disrupted release of adipokines play a key role in its pathogenesis. Asprosin is a newly identified fasting-induced glucogenic adipokine that has been related with metabolic disorders such as type II diabetes mellitus and polycystic ovary syndrome. The preset study sought to assess circulating asprosin in context of CAD. Methods In this study, serum levels of asprosin were determined in 88 CAD patients and 88 non-CAD healthy controls. Serum IL-6, TNF-α, asprosin and adiponectin were assessed using ELISA kits. Results: Serum asprosin was found to be higher in CAD patients when compared to non-CAD subjects (7.84 ± 2.08 versus 5.02 ± 1.29 μg/mL, p <  0.001). Similarly, serum TNF-α, and IL-6 elevated in CAD group significantly (p <  0.001). However, circulating adiponectin diminished in CAD group when compared with non-CAD subjects (p < 0.001). Moreover, serum asprosin levels directly correlated with BMI, FBG, HOMA-IR, TG and TC. Logistic regression analyses showed that asprosin levels were associated with increased risk of developing CAD (odds ratio: 3.01, 95% CI: 2.16, 4.20 and p < 0.001), after adjusting for potential confounders (age, sex and BMI). Conclusions The present study findings suggested a possible relation of serum asprosin with the pathogenesis of CAD, in particular through insulin resistance and dyslipidemia.

scholarly journals PROFIL AKNE VULGARIS DI RSUP Prof. Dr. R. D. KANDOU MANADO PERIODE 2009-2011

e-CliniC ◽  
2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Muhammad Mizwar ◽  
Marlyn Grace Kapantow ◽  
Pieter Levinus Suling
Keyword(s):  
Medical Records ◽  
Acne Vulgaris ◽  
Educational Status ◽  
Chronic Inflammatory Disease ◽  
Age Group ◽  
Student Group ◽  
Dermatology Clinic ◽  
The Face ◽  
Key Words Acne ◽  
Akne Vulgaris

Abstract: Acne vulgaris is a chronic inflammatory disease of pilosebaceous follicles that commonly occurs in adolescence and can heal itself. The purpose of this study was to determine the profile of acne vulgaris in Dermatovenereology of Prof. Dr. R. D. Kandou Manado in 2009-2011. This study was conducted retrospectively in patients with acne vulgaris who came to the Dermatology clinic in 2009-2011. The data were recorded from  medical records of the amounts of patients, gender, age, occupation / education, lesion location, and the type of acne. The results showed that of a total of 10003 visits in 2009-2011 there of 121 patients (3.59%) were new cases of acne vulgaris, acne vulgaris in patients dominance of female patients by 75 patients (61.9%), the age group most at 15-24 years old is 76 patients (62.8%), the highest educational status on the student group is 73 patients (60.3%), the most lesions location are on the face, most types of acne is papulopustular. Key words: acne vulgaris, inflammation, pilosebaceous    Abstrak: Akne vulgaris adalah penyakit peradangan menahun folikel pilosebasea yang umumnya terjadi pada masa remaja dan dapat sembuh sendiri. Tujuan dari penelitian ini untuk mengetahui profil akne vulgaris di poliklinik Kulit dan Kelamin RSUP Prof Dr R. D. Kandou Manado pada tahun 2009–2011. Penelitian ini dilakukan secara retrospektif pada pasien dengan akne vulgaris yang datang ke poliklinik  Kulit dan Kelamin pada tahun 2009–2011. Dilakukan pencatatan data dari catatan medik mengenai jumlah pasien, jenis kelamin, usia, pekerjaan/pendidikan, lokasi lesi, dan jenis akne. Hasil yang diperoleh menunjukkan bahwadari total 10003 kunjungan pada tahun 2009–2011 terdapat 121pasien (3,59%) merupakan penderita baru akne vulgaris, pasien akne vulgaris di dominasi pasien perempuan sebanyak 75 pasien (61,9%), kelompok usia terbanyak pada usia 15 – 24 tahun yaitu 76 pasien (62,8%), status pendidikan terbanyak  pada kelompok pelajar yaitu 73 pasien (60,3%), lokasi lesi terbanyak yaitu di bagian wajah, jenis akne terbanyak yaitu papulopustuler. Kata kunci: akne vulgaris, pilosebasea, radang

scholarly journals Nobiletin Reduces Lipid Accumulation in Sebocytes and Inhibits PPAR Delta Activation in Epidermal Tissue Models

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Fedorova E ◽  
Li S ◽  
Gusella GL ◽  
Mosoian A
Keyword(s):  
Inflammatory Disease ◽  
Lipid Accumulation ◽  
Bacterial Colonization ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Ppar Delta ◽  
Epidermal Tissue ◽  
Sebum Production ◽  
Polymethoxylated Flavones ◽  
Tissue Models

Background: Acne vulgaris is a chronic inflammatory disease that affects the majority of the population at some point in their lifetime. Acne pathogenesis is multifactorial with four primary contributors that play a pivotal role in the formation of acne lesions: inflammation, androgeninduced sebum production, abnormal keratinization, and bacterial colonization. Recent studies have demonstrated the anti-inflammatory, anticarcinogenic, anti-diabetic, and anti-lipid properties of certain Polymethoxylated Flavones (PMF) derivatives.

Anti muellerian hormone serum levels in women with endometriosis: A case-control study

2009 ◽  
pp. 1-4 ◽  
Author(s):  
Omar Shebl ◽  
Thomas Ebner ◽  
Michael Sommergruber ◽  
Andreas Sir ◽  
Gernot Tews
Keyword(s):  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Control Study

Dietary and serum vitamin D and preeclampsia risk in Chinese pregnant women: a matched case–control study

2021 ◽  
pp. 1-26
Author(s):  
Xue-min Huang ◽  
Yan-hua Liu ◽  
Han Zhang ◽  
Yuan Cao ◽  
Wei-feng Dou ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dietary Intake ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Serum Concentrations ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

Abstract The effect of vitamin D (VD) on the risk of preeclampsia (PE) is uncertain. Few of previous studies focused on the relationship between dietary VD intake and PE risk. Therefore, we conducted this 1:1 matched case-control study to explore the association of dietary VD intake and serum VD concentrations with PE risk in Chinese pregnant women. A total of 440 pairs of participants were recruited during March 2016 to June 2019. Dietary information was obtained using a 78-item semi-quantitative food frequency questionnaire. Serum concentrations of 25(OH)D2 and 25(OH)D3 were measured by liquid chromatography–tandem mass spectrometry. Multivariate conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines (RCS) were plotted to evaluate the dose-response relationship of dietary VD intake and serum VD concentrations with PE risk. Compared with the lowest quartile, the ORs of the highest quartile were 0.45 (95%CI: 0.29-0.71, Ptrend = 0.001) for VD dietary intake and 0.26 (95%CI: 0.11-0.60, Ptrend = 0.003) for serum levels after adjusting for confounders. In addition, the RCS analysis suggested a reverse J-shaped relationship between dietary VD intake and PE risk (P-nonlinearity = 0.02). A similar association was also found between serum concentrations of total 25(OH)D and PE risk (P-nonlinearity = 0.02). In conclusion, this study provides evidence that higher dietary intake and serum levels of VD are associated with the lower risk of PE in Chinese pregnant women.

Serum otolin-1 as a biomarker for benign paroxysmal positional vertigo: a case-control study

2021 ◽  
pp. 1-4
Author(s):  
D V K Irugu ◽  
A Singh ◽  
H Yadav ◽  
H Verma ◽  
R Kumar ◽  
...  
Keyword(s):  
Serum Level ◽  
Benign Paroxysmal Positional Vertigo ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Control Group ◽  
Positional Vertigo ◽  
The Difference ◽  
Control Study ◽  
Paroxysmal Positional Vertigo

Abstract Objectives This study aimed to evaluate serum otolin-1 levels in patients with benign paroxysmal positional vertigo and to compare these levels with healthy individuals. Method This was a case-control study. After obtaining institutional ethical committee clearance, the serum level of otolin-1 was calculated in adult individuals (18–75 years old) who were divided into group 1 (patients presenting with benign paroxysmal positional vertigo) and group 2 (healthy patients without benign paroxysmal positional vertigo as the control group). Data analysis was carried out to compare the serum levels in the cases and controls. A p-value less than 0.05 was considered significant. Results A total of 70 age-matched individuals (cases, n = 40; controls, n = 30) were included in the study. The mean serum level of otolin-1 was 636.8 pg/ml (range, 259–981 pg/ml) in the group of patients with benign paroxysmal positional vertigo and 236.2 pg/ml (range, 189–370 pg/ml) in the control group. The difference was statistically significant (p = 0.0000). Conclusion The serum levels of otolin-1 in patients with benign paroxysmal positional vertigo are significantly higher compared with individuals without benign paroxysmal positional vertigo.

scholarly journals Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Danielle Perez-Bercoff ◽  
Hélène Laude ◽  
Morgane Lemaire ◽  
Oliver Hunewald ◽  
Valérie Thiers ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cell Death ◽  
Lupus Erythematosus ◽  
Immunosuppressive Treatment ◽  
Elevated Serum ◽  
Serum Levels ◽  
Chronic Inflammatory Disease ◽  
Mrna Levels ◽  
Systemic Lupus ◽  
Inflammatory Conditions

AbstractAPOBEC3 (A3) enzymes are best known for their role as antiviral restriction factors and as mutagens in cancer. Although four of them, A3A, A3B, A3F and A3G, are induced by type-1-interferon (IFN-I), their role in inflammatory conditions is unknown. We thus investigated the expression of A3, and particularly A3A and A3B because of their ability to edit cellular DNA, in Systemic Lupus Erythematosus (SLE), a chronic inflammatory disease characterized by high IFN-α serum levels. In a cohort of 57 SLE patients, A3A and A3B, but also A3C and A3G, were upregulated ~ 10 to 15-fold (> 1000-fold for A3B) compared to healthy controls, particularly in patients with flares and elevated serum IFN-α levels. Hydroxychloroquine, corticosteroids and immunosuppressive treatment did not reverse A3 levels. The A3AΔ3B polymorphism, which potentiates A3A, was detected in 14.9% of patients and in 10% of controls, and was associated with higher A3A mRNA expression. A3A and A3B mRNA levels, but not A3C or A3G, were correlated positively with dsDNA breaks and negatively with lymphopenia. Exposure of SLE PBMCs to IFN-α in culture induced massive and sustained A3A levels by 4 h and led to massive cell death. Furthermore, the rs2853669 A > G polymorphism in the telomerase reverse transcriptase (TERT) promoter, which disrupts an Ets-TCF-binding site and influences certain cancers, was highly prevalent in SLE patients, possibly contributing to lymphopenia. Taken together, these findings suggest that high baseline A3A and A3B levels may contribute to cell frailty, lymphopenia and to the generation of neoantigens in SLE patients. Targeting A3 expression could be a strategy to reverse cell death and the generation of neoantigens.

scholarly journals Vitiligo and Rise in Blood Pressure – a Case–Control Study in a Referral Dermatology Clinic in Southern Iran

2020 ◽  
Vol Volume 13 ◽  
pp. 425-430
Author(s):  
Mohammad Reza Namazi ◽  
Shekoofe Rouhani ◽  
Alireza Moarref ◽  
Mahsa Kiani ◽  
Seyed Sajjad Tabei ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Case Control Study ◽  
Case Control ◽  
Southern Iran ◽  
Dermatology Clinic ◽  
Control Study

How matrix metalloproteinase (MMP)-9 (rs3918242) polymorphism affects MMP-9 serum concentration and associates with autism spectrum disorders: A case-control study in Iranian population

2021 ◽  
pp. 1-7
Author(s):  
Javid Rezaei Lord ◽  
Farhad Mashayekhi ◽  
Zivar Salehi
Keyword(s):  
Serum Concentration ◽  
Matrix Metalloproteinase ◽  
Serum Levels ◽  
Autism Spectrum ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mmp9 Expression ◽  
Relationship Of ◽  
The Relationship ◽  
Metalloproteinase 9 ◽  
Control Study

Abstract The aim of this project was to evaluate the relationship of matrix metalloproteinase-9 (MMP-9) genetic variation and its serum concentration with autism spectrum disorder (ASD). One hundred ASD and 120 controls were enrolled in this study. Genomic DNA was extracted from blood and MMP-9 polymorphism was determined by polymerase chain reaction restriction fragment length polymorphism and serum levels were measured by enzyme-linked immunosorbent assay. The frequencies of CC, CT, and TT genotypes were 72%, 26%, and 2% in controls and 31%, 57%, and 12% in ASD, respectively. The frequencies of C and T alleles in ASD were 59.5% and 40.5%, and controls were 86% and 14%, respectively. There is a significant increase in serum MMP-9 levels in ASD as compared to controls. We have also shown that TT genotype is significantly associated with increase serum MMP-9 levels in patients (TT, CT, and CC serum levels were 91.77 ± 10.53, 70.66 ± 7.21, and 38.66 ± 5.52 and in controls were 55.55 ± 11.39, 42.66 ± 7.85, and 30.55 ± 6.34 ng/ml, respectively). It is concluded that there is a significant association between rs3918242 MMP-9 polymorphism and its serum concentration with autism. We also suggest that TT genotype is associated with increased MMP9 expression and may be a risk factor for ASD.

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