scholarly journals Alterations of pancreatic functions and lipid profiles in dairy cows with left displacement of the abomasum

2019 ◽  
Vol 64 (No. 5) ◽  
pp. 204-208
Author(s):  
Z Ismail ◽  
AM Al-Majali ◽  
O Al-Rawashdeh ◽  
M Daradka ◽  
M Mohaffel
Keyword(s):  
High Density Lipoprotein ◽  
Dairy Cows ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Reactive Protein

The objectives of this study were to determine the serum activities of the pancreatic enzymes amylase, lipase, trypsinogen 1 and trypsinogen 2, serum concentrations of total cholesterol, high density lipoprotein, low-density lipoprotein and triglycerides and serum inflammatory indicators, namely C-reactive protein and procalcitonin, in Holstein-Friesian dairy cows with left displacement of the abomasum (LDA). A total of 60 cows (30 LDA-affected and 30 healthy) were included in the study. Laboratory analyses were performed using commercially available ELISA kits and chemical reagents according to the manufacturers’ recommendations. There was a significant increase (P ≤ 0.05) in the activities of lipase, trypsinogen 1 and trypsinogen 2 in LDA-affected cows compared to healthy cows. Amylase concentrations, however, remained unchanged. The serum concentrations of total cholesterol and high-density lipoprotein were significantly (P ≤ 0.05) increased in LDA-affected cows while the concentrations of low-density lipoprotein and triglycerides were significantly (P ≤ 0.05) decreased compared to healthy cows. Procalcitonin and C-reactive protein concentrations were significantly (P ≤ 0.05) increased in LDA-affected cows compared to healthy cows. This study indicates that displacement of the abomasum may be associated with significant pathological effects in the pancreas that may affect cows in the post-operative period.

scholarly journals Η επίδραση της υπολιπιδαιμικής αγωγής - είτε με αναστολείς της σύνθεσης της χοληστερόλης είτε με αναστολείς της απορρόφησης της χοληστερόλης - στους δείκτες φλεγμονής και θρομβωτικούς και ιστικούς παράγοντες σε ασθενείς με δυσλιπιδαιμία

2009 ◽  
Author(s):  
Παναγιώτα Κωστάκου
Keyword(s):  
High Density Lipoprotein ◽  
Tissue Factor ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Von Willebrand

Οι στατίνες έχουν ευνοϊκή επίδραση στο λιπιδαιμικό προφίλ, μειώνουν την ολική θνησιμότητα και παρουσιάζουν επίσης πολλές πλειοτροπικές δράσεις. Ο σκοπός της παρούσας εργασίας ήταν να προσδιοριστούν και να συγκριθούν οι πλειοτροπικές δράσεις ενός αναστολέα της σύνθεσης της χοληστερόλης και συγκεκριμένα της σιμβαστατίνης (Σ) και ενός αναστολέα της απορρόφησης της χοληστερόλης και συγκεκριμένα της εζετιμίμπης (Ε), σε ασθενείς με δυσλιπιδαιμία. Σε 44 ασθενείς (24 άνδρες και 20 μεταεμμηνοπαυσιακές γυναίκες) με χαμηλής πυκνότητας λιποπρωτεΐνη (low density lipoprotein-LDL) > 130 mg/dl ή LDL > 100 mg/dl σε ασθενείς με στεφανιαία νόσο ή ανάλογο αυτής, χορηγήθηκαν 10 mg Σ (η=21) ημερησίως ή 10 mg E (η=23) ημερησίως. Ελήφθησαν δείγματα αίματος στην αρχή και τρεις μήνες μετά την έναρξη της θεραπείας. Σε όλα τα δείγματα μετρήθηκαν τα επίπεδα της ολικής χοληστερόλης, των τριγλυκεριδίων, της υψηλής σε πυκνότητα λιποπρωτεΐνης (high density lipoprotein-HDL), της LDL, της απολιποπρωτεΐνης [apolipoprotein (apo)] A, της apoB, της λιποπρωτεΐνης [Lipoprotein (lp)] (a), της ομοκυστεΐνης , του ‘tissue factor’ (TF), του παράγοντα von Willebrand (vW) και της C αντιδρώσας πρωτεΐνης (C-reactive protein, CRP). Οι αρχικές τιμές των λιπιδίων και των αιματολογικών παραμέτρων ανάμεσα στις δύο ομάδες ήταν παρόμοιες. Η Σ και η Ε μείωσαν την ολική χοληστερόλη (262 mg/dl σε 189 mg/dl, p<0,001 και 268 mg/dl σε 220 mg/dl, p=0,001, αντίστοιχα, την LDL (177 mg/dl σε 114 mg/dl, p<0,001 και 196 mg/dl σε 146 mg/dl, p<0,001, αντίστοιχα). Επίσης, η Σ ελάττωσε τα επίπεδα της apoB (125 mg/dl σε 93 mg/dl, p<0,001). Κανένα από τα φάρμακα δεν επηρέασε τις συγκεντρώσεις της lp(a), του TF, του vW και της ομοκυστεϊνης. Και τα δύο φάρμακα βελτίωσαν το λιπιδαιμικό προφίλ των ασθενών και τα επίπεδα της CRP. Παρόλ’ αυτά, δε διαπιστώθηκε καμία επίδραση στους TF και vW. Τα αποτελέσματά μας δεν υποδεικνύουν κάποια επιπρόσθετη πλειοτροπική αντιφλεγμονώδη δράση των στατινών πέραν της μείωσης της ολικής και της LDL χοληστερόλης.

Effectiveness of generic rosuvastatin in patients with ischaemic cerebrovascular disease

2012 ◽  
Vol 153 (22) ◽  
pp. 857-860 ◽  
Author(s):  
László Szapáry ◽  
Gergely Fehér
Keyword(s):  
High Density Lipoprotein ◽  
Cerebrovascular Disease ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Lipid Lowering Agent

Statin therapy is the cornerstone of anti-atherosclerotic treatment, and it considered obligatory in the secondary prevention of atherosclerotic diseases. Rosuvastatin is well-known and efficacious lipid-lowering agent. Generic drugs are more frequently used instead of its ancestors. Generic rosuvastatin forms have been aproved recently to the Central European market, but their safety and efficacy have not been previously examined in cerebrovascular patient populations. Patients and methods: 109 patients with documented ischaemic cerebrovascular events were included in our study. 20 mg generic rosuvastatin significantly decreased total cholesterol (5.47 vs. 3.88 mmol/l, p<0.01), low-density lipoprotein (3.16 vs. 1.84 mmol/l, p<0.01) and trigliceride levels (1.77 vs. 1.33 mmol/l, p<0.05, and there was a non-significant high-density lipoprotein increasing tendency (1.27 vs. 1.36 mmol/l, p = 0.08). There was also a significant decrease in high-sensitive C-reactive protein levels (3.73 vs. 2.82 mg/l, p<0.05). Overall, 30% decrease in total cholesterol, 42% decrease in low-density lipoprotein, 25% decrease in trigliceride and high-sensitive C-reactive protein and 9% increase in high-density lipoprotein levels were observed. Conclusions: The generic rosuvastatin studied by the authors proved to be safe and efficacious lipid-lowering agent. Based on these short term results, in daily practice, generic rosuvastatin treatment seems to be cost-effective for the treatment of patients with ischemis cerebrovascular disease. Orv. Hetil., 2012, 153, 857–860.

scholarly journals Hubungan indeks massa tubuh dengan profil lipid pada pasien diabetes melitus tipe 2

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Pradika H. Koampa ◽  
Karel Pandelaki ◽  
Marthen C.P. Wongkar
Keyword(s):  
Body Mass Index ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Body Mass ◽  
Pearson Correlation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Diabetes Melitus

Abstract: Body Mass Index (BMI) is a measurement of nutritional status by calculating the ratio of height and weight. Type 2 Diabetes Mellitus (T2DM) is more common in a person with a BMI of more than normal. In patients with T2DM, there is lipid metabolism disorder, dyslipidaemia. Changes in lipid profiles consist of increased levels of total cholesterol, Low Density Lipoprotein (LDL), and triglycerides, and decreased levels of High Density Lipoprotein (HDL). This study aimed to obtain the correlation between body mass index and lipid profile in T2DM patients in Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study using patients’ medical record in Endocrine Clinic Prof. Dr. R. D. Kandou Hospital Manado from September to November 2015. The Pearson correlation test showed correlations between BMI and total cholesterol levels with r=0.037and p=0.763; between BMI and HDL levels with r=-0.249 and p=0.039; between BMI and LDL levels with r=0.091 and p=0,455; and between BMI and triglyceride levels with r=0.179 and p=0.142. Conclusion: Among T2DM patients, there were no significant correlations between body mass index and total cholesterol, LDL cholesterol, as wello as triglyceride levels. However, there was a significant correlation between body mass index and HDL levels. Keywords: body mass index, total cholesterol, HDL, LDL, triglycerides, T2DM Abstrak: Indeks Massa Tubuh (IMT) merupakan salah satu pengukuran status gizi dengan menghitung perbandingan tinggi badan dan berat badan. Diabetes Melitus Tipe 2 (DMT2) lebih sering terjadi pada individu dengan IMT lebih dari normal. Pada pasien DMT2 terjadi gangguan metabolisme lipid yaitu dislipidemia. Perubahan profil lipid yang terjadi yaitu peningkatan kadar Kolesterol Total, Low Density Lipoprotein (LDL), dan trigliserida, serta penurunan kadar High Density Lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dengan profil lipid pada pasien DMT2di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. Dr. R. D. Kandou Manado periode September – November 2015. Hasil uji korelasi Pearson memperlihatkan nilai hubungan antara IMT dan kadar kolesterol total r = 0,037 dan p = 0,763 ; nilai hubungan antara IMT dan kadar HDL r = -0,249 dan p = 0,039 ; nilai hubungan antara IMT dan kadar LDL r = 0,091 dan p = 0,455; serta nilai hubungan antara IMT dan kadar trigliserida r = 0,179 dan p = 0,142. Simpulan: Pada pasien DMT2 tidak dijumpai hubungan bermakna antara IMT dengan kadar kolesterol total, kadar LDL, dan kadar trigliserida, namun terdapat hubungan bermakna antara IMT dengan kadar HDL.Kata kunci: IMT, kolesterol total, HDL, LDL, trigliserida, DMT2

scholarly journals Relationship between C-reactive protein and features of the metabolic syndrome in military pilots in the Serbia and Montenegro

2005 ◽  
Vol 62 (11) ◽  
pp. 811-819
Author(s):  
Aleksandra Jovelic ◽  
Goran Radjen ◽  
Stojan Jovelic ◽  
Marica Markovic
Keyword(s):  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
C Reactive Protein ◽  
Low Density Lipoprotein Cholesterol ◽  
Reactive Protein

Background/Aim. C-reactive protein is an independent predictor of the risk of cardiovascular events and diabetes mellitus in apparently healthy men. The relationship between C-reactive protein and the features of metabolic syndrome has not been fully elucidated. To assess the cross-sectional relationship between C-reactive protein and the features of metabolic syndrome in healthy people. Methods. We studied 161 military pilots (agee, 40?6 years) free of cardiovascular disease, diabetes mellitus and active inflammation on their regular annual medical control. Age, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, fasting glucose, glycosylated hemoglobin, blood pressure, smoking habit, waist circumference and body mass index were evaluated. Plasma C-reactive protein was measured by the immunonephelometry (Dade Behring) method. Metabolic syndrome was defined according to the National Cholesterol Education Program Expert Panel. Results. The mean C-reactive protein concentrations in the subjects grouped according to the presence of 0, 1, 2 and 3 or more features of the metabolic syndrome were 1.11, 1.89, 1.72 and 2.22 mg/L, respectively (p = 0.023) with a statistically, significant difference between those with 3, and without metabolic syndrome (p = 0.01). In the simple regression analyses C-reactive protein did not correlate with the total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, body mass index and blood pressure (p > 0.05). In the multiple regression analysis, waist circumference (? = 0.411, p = 0.000), triglycerides to high density lipoprotein cholesterol ratio (? = 0.774, p = 0.000), smoking habit (? = 0.236, p = 0.003) and triglycerides (? = 0.471, p = 0.027) were independent predictors of C-reactive protein. Conclusions. Our results suggested a cross-sectional independent correlation between the examined cardiovascular risk factors as the predominant features of metabolic syndrome and C-reactive protein in the group of apparently healthy subjects. The lack of correlation of C-reactive protein with the total cholesterol and low density lipoprotein cholesterol in our study may suggest their different role in the process of atherosclerosis and the possibility to determine C-reactive protein in order to identify high-risk subjects not identified with cholesterol screening.

scholarly journals COMPARISON OF SDLDL-C ANALYSIS USING SRISAWASDI METHOD AND HOMOGENEOUS ENZYMATIC ASSAY METHOD ON HYPERTRIGLYCERIDEMIA CONDITION (Perbandingan Analisa sdLDL-C metode Srisawasdi dan Homogeneous Enzymatic Assay di Kondisi Hipertrigliseridemia)

2018 ◽  
Vol 23 (1) ◽  
pp. 74
Author(s):  
Gilang Nugraha ◽  
Soebagijo Poegoeh Edijanto ◽  
Edhi Rianto
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Enzymatic Assay ◽  
Assay Method ◽  
Low Density

Small Dense Low Density Lipoprotein (sdLDL) merupakan fraksi terkecil dari partikel Low Density Lipoprotein (LDL) yang memilikidiameter ≤25,5 nm. Partikel sdLDL merupakan lipoprotein sangat aterogenik bahkan telah dilaporkan meningkatkan kebahayaanPenyakit Jantung Koroner (PJK) hingga tiga kali lipat. Pengukuran sdLDL dilakukan dengan alat dan teknik yang rumit sehinggakurang cocok diterapkan dalam praktek klinis sehari-hari. Tahun 2011, Srisawasdi dkk mengembangkan teknik pengukuran perkiraansdLDL-cholesterol (sdLDL-C) menggunakan persamaan dengan menghitung profil lipid rutin. Dilaporkan bahwa peningkatan kepekatantrigliserida (TG) menurunkan kenasaban perkiraan sdLDL-C Srisawasdi. Penurunan nilai kenasaban dapat mempengaruhi ketepatanyang mengakibatkan penurunan mutu pemeriksaan laboratorium. Diambil 88 sampel yang dilakukan pengukuran Total Cholesterol(TC), TG, high density lipoprotein-cholesetrol (HDL-C) dan direk low density lipoprotein-cholesetrol (dLDL-C) di RSUD Dr. Soetomo,sdLDL-C metode homogeneous enzymatic assay dilakukan di Laboratorium Parahita Dharmawangsa. Hasil analisis menunjukkan, tidakada perbedaan hasil periksaan sdLDL-C formula Srisawasdi dkk dengan metode homogeneous enzymatic assay (P=0,000). Penurunannilai kenasaban ditemukan di kelompok kepekatan TG <100 mg/dL sampai dengan kelompok kepekatan TG 200-299 mg/dL. Perbedaannilai kenasaban di setiap kelompok TG tidak mempengaruhi ketepatan pemeriksaan sdLDL-C formula Srisawasdi (P=0,720) hinggakepekatan TG <400 mg/dL, dengan nilai bias pada seluruh sampel yaitu 34,15%. Keterbatasan sdLDL-C formula Srisawasdi dkk hanyadapat digunakan di kepekatan TG kurang dari 200 mg/dL dengan pemantapan mutu intralaboratorium yang terkendali baik. Saranpenelitian, perlu diteliti lebih lanjut untuk menentukan nilai normal sdLDL-C formula Srisawasdi.

The Effects of Low-Density Lipoprotein and High-Density Lipoprotein on Blood Viscosity Correlate with their Association with Risk of Atherosclerosis in Humans

1997 ◽  
Vol 92 (5) ◽  
pp. 473-479 ◽  
Author(s):  
Gregory D. Sloop ◽  
David W. Garber
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Blood Viscosity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

1. Increased blood or plasma viscosity has been observed in almost all conditions associated with accelerated atherosclerosis. Cognizant of the enlarging body of evidence implicating increased viscosity in atherogenesis, we hypothesize that the effects of low-density lipoprotein and high-density lipoprotein on blood viscosity correlate with their association with risk of atherosclerosis. 2. Blood viscometry was performed on samples from 28 healthy, non-fasting adult volunteers using a capillary viscometer. Data were correlated with haematocrit, fibrinogen, serum viscosity, total cholesterol, high-density lipoprotein-cholesterol, triglycerides and calculated low-density lipoprotein-cholesterol. 3. Low-density lipoprotein-cholesterol was more strongly correlated with blood viscosity than was total cholesterol (r = 0.4149, P = 0.0281, compared with r = 0.2790, P = 0.1505). High-density lipoprotein-cholesterol levels were inversely associated with blood viscosity (r = −0.4018, P = 0.0341). 4. To confirm these effects, viscometry was performed on erythrocytes, suspended in saline, which had been incubated in plasma of various low-density lipoprotein/high-density lipoprotein ratios. Viscosity correlated directly with low-density lipoprotein/high-density lipoprotein ratio (n = 23, r = 0.8561, P < 0.01). 5. Low-density lipoprotein receptor occupancy data suggests that these effects on viscosity are mediated by erythrocyte aggregation. 6. These results demonstrate that the effects of low-density lipoprotein and high-density lipoprotein on blood viscosity in healthy subjects correlate with their association with risk of atherosclerosis. These effects on viscosity may play a role in atherogenesis by modulating the dwell or residence time of atherogenic particles in the vicinity of the endothelium.

scholarly journals Profil Lipid, Peroksidasi Lipid, dan Status Inflamatif Wanita Penderita Sindrom Metabolik

2011 ◽  
Vol 5 (5) ◽  
pp. 212
Author(s):  
Hery Winarsi ◽  
Siwi P.M. Wijayanti ◽  
Agus Purwanto
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein

Prevalensi sindrom metabolik (SM) di Indonesia (13,13%) tergolong tinggi dengan kecenderungan terus meningkat. Salah satu akibat SM adalah disfungsi endotel, sebagai awal penyakit kardiovaskuler yang diinduksi oleh stres oksidatif dan inflamatif. Penelitian ini bertujuan untuk mengeksplorasiprofil lipid, peroksidasi lipid, dan marker inflamasi pada wanita penderita SM di Purwokerto. Sebanyak 30 wanita dengan kadar gula darah diatas normal, obesitas body mass index (BMI) > 25 kg/m2, dan berusia 40-65 tahun dilibatkan sebagai responden yang dipilih melalui survei di PoliklinikPenyakit Dalam Rumah Sakit Margono Soekarjo. Kadar kolesterol total, trigliserida, high density lipoprotein, low density lipoprotein, malondialdehid, dan plasma C-reactive protein ditentukan dalam darah responden yang mempunyai kadar gula sewaktu > 200 mg/dL. Ditemukan bahwa wanitadengan SM rata-rata berumur 50,4 tahun; BMI 31,89 kg/m2; kadar gula darah 219,4 mg/dL; kolesterol total 216,73 mg/dL; trigliserida 218,13 mg/dL; HDL 46,59 mg/dL; LDL 146,27 mg/dL; MDA 2943,4 pmol/mL; C-RP 7,62 mg/L; dan tekanan darah 153/103 mmHg. Hasil ini menunjukkan bahwapenderita SM mengalami dislipidemia disertai dengan status antioksidan rendah dan inflamasi.Kata kunci: Wanita sindrom metabolik, profil lipid, lipid peroksida, malondialdehid, C-reactive proteinAbstractPrevalence of metabolic syndrome (MS) in Indonesia (13,13%) is high and tends to increase. One of the consequences of MS is endothelial dysfunction leading to cardiovascular disease which is inducted by oxidative stressand inflammation. The aim of the present research is to explore lipid profile, lipid peroxidation, and inflammatory marker level on metabolic syndrome women in Purwokerto. Thirty women with blood glucose level greater than normal, body mass index (BMI) > 25 kg/m2, 40-65 years of age were recruited as respondent through selection by a survey in Internal Medicine Polyclinic of Margono Soekarjo Hospital in Purwokerto. In respondents with blood glucose level > 200 mg/dL, total blood cholesterol level, high density lipoprotein, low density lipoprotein, malondialdehid, and plasma C-reactive protein were determined. It was found that the MS women were 50,4 years of age; BMI 31,89 kg/m2; blood glucose 219,4 mg/dL; total cholesterol 216,73 mg/dL; triglyceride 218,13 mg/dL; HDL 46,59 mg/dL; LDL 146,27mg/dL; MDA 2943,4 pmol/mL; C-RP 7,62 mg/L; and blood pressure 153/103 mmHg. It indicates that SM women experience dyslipidemia with low antioxidant and inflammation.Key words: Metabolic syndrome women, lipid profile, peroxide lipid, malondialdehid, C-reactive protein

scholarly journals Uji Toksisitas Ekstrak Metanolik Kombinasi Daun Benalu Teh Dan Daun Benalu Mangga Terhadap Profil Lipid Tikus Betina (Rattus norvegicus) pada Paparan Sub-Kronik 28 Hari

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Tengku Anggun Lestari ◽  
Nour Athiroh ◽  
Nurul Jadid Mubarakati
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Rattus Norvegicus ◽  
Toxicity Test ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
One Way Anova

Tea Benalu (Scurrula atropurpurea [Bl.] Dans.) and Mango Benalu (Dendrophthoe pentandra L. miq.) containssecondary metabolites with potential antioxidant potential. Antioxidants can inhibit the oxidation process and reduce Total Cholesterol, Triglycerides, Low-Density Lipoprotein (LDL) and increase High-Density Lipoprotein (HDL). The safety of the preparations for the combination of parasites of tea and mango leaves was tested to obtain toxic effects after repeated treatment tests over some time. The purpose of this study was to determine the toxic effects of a combination of methanolic extracts of a combination of tea parasites and mangoes in female rats (Rattus norvegicus) subchronically for 28 days by looking at the results of the clinical biochemical examination on lipid profiles, namely total cholesterol levels, triglycerides, high-density lipoproteins (28%). HDL), and Low-Density Lipoprotein (LDL). The method of this study was experimental with a combination dose of methanol extract of tea parasite leaves and mango parasite leaves at a dose of 250 mg / KgBB, 500 mg / KgBB and 1000 mg / KgBB with 5x replications each treatment. The subjects used white rats (Rattus norvegicus) female Wistar strains aged 6-8 weeks with a minimum body weight of 100 grams. The treatment in this study was in the form of each dose given 5 times a week for 28 days (subchronic toxicity test) orally. Lipid profile levels were analyzed using the one-way ANOVA test. The results showed that the level of control blood lipid profile with a treatment dose of 250 mg / KgBW, 500 mg / KgBW, and 1000 mg / KgBW was not significantly different. The toxicity test of combined extracts of tea leaves and mango parasite leaves of female rat Rattus novergicus on subchronic exposure 28 days with those doses showed no difference tangible between treatments of controls. This means it is safe and does not cause toxic properties in the lipid profile of female wistar rats.Keywords: Lipid Profile, Scurrula atropurpurea, Dendophthoe pentandra, Sub-Chronic Toxicity, Rattus norvegicus ABSTRAKBenalu Teh (Scurrula atropurpurea [Bl.] Dans.) dan  Benalu Mangga (Dendrophthoe pentandra L. miq.) mengandung metabolit sekunder berpotensi sebagai antioksidan. Antioksidan dapat memperhambat proses oksidasi dan menurunkan Cholesterol Total, Trigliserida, Low Density Lipoprotein (LDL) dan menaikkan High Density Lipoprotein (HDL). Keamanan sediaan kombinasi daun benalu teh dan mangga diuji memperoleh tentang efek toksik setelah uji perlakuan berulang dalam jangka waktu tertentu. Tujuan dari penelitian ini untuk mengetahui efek toksik kombinasi ekstrak metanolik kombinasi daun benalu teh dan mangga pada tikus betina (Rattus norvegicus) secara subkronik selama 28 hari dengan melihat hasil pemeriksaan biokimia klinis pada profil lipid, yaitu kadar Cholesterol Total, Trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL). Metode penelitian ini adalah eksperimental dengan perlakuan dosis kombinasi ekstrak metanol daun benalu teh dan daun benalu mangga dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB dengan ulangan 5x tiap perlakuan. Subjek menggunakan tikus putih (Rattus norvegicus) betina strain wistar yang berumur 6-8 minggu dengan berat badan minimal 100 gram. Perlakuan dalam penelitian ini berupa setiap dosis  diberikan 5 kali seminggu selama 28 hari (uji toksisitas subkronik) secara per-oral. Kadar profil lipid dianalisis menggunakan uji One-way ANOVA. Hasil penelitian menunjukkan bahwa kadar profil lipid darah kontrol dengan perlakuan dosis 250 mg/KgBB, 500 mg/KgBB dan 1000 mg/KgBB tidak berbeda nyata. Uji”toksisitas”ekstrak kombinasi daun benalu teh dan daun benalu mangga  tikus betina Rattus novergicus pada paparan subkronik 28 hari dengan”dosis”tersebut menunjukkan hasil tidak”beda”nyata antara perlakuan terhadap”kontrol. ”Hal ini berarti aman dan tidak menimbulkan sifat toksik pada profil lipid tikus wistar betina.Kata Kunci : Profil Lipid, Scurrula atropurpurea, Dendophthoe pentandra, Subkronik, Rattus norvegicus

scholarly journals Effect of Unsaturated Fatty Acid Omega-3 on Some Biochemical Criteria in White New Zealand Rabbits Administrated with Cyclosporine Drug

2021 ◽  
Vol 2 (1) ◽  
pp. 15-24
Author(s):  
Murtadha M. Jawad
Keyword(s):  
Fatty Acid ◽  
Side Effects ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Unsaturated Fatty Acid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Low Density ◽  
Omega 3

The present study was aimed efficiency to evaluate the unsaturated fatty acid omega-3 in reducing the side effects that resulted from the administration of cyclosporine drug in white rabbits. (60) white males' rabbits were used in this study, divided into four groups contain (15) rabbits per group and its subdivision into three groups (5) rabbits per group. The first group is orally administered with normal saline, the second group was administered cyclosporine (25mg/kg) only. Third groups were administered cyclosporine on the first day and omega-3 (500mg/kg) on the second day, while Fourth groups were administered cyclosporine on the first day and omega-3 (1000mg/kg) on the second day for periods (21,30,60) days respectively. After ending study periods, the animals were sacrificed and the blood was collected and the results were shown the following:  Administration with cyclosporine (25mg/kg)only and for periods were led to a significant increase(P<0.05) in total cholesterol, triglycerides and low-density lipoprotein(LDL) and a significant decrease(P<0.05) in high-density lipoprotein(HDL).whereas interaction with (500&1000mg/kg) of omega-3 and to all periods showed a significant decrease (p<0.05) in the total cholesterol, triglycerides and low-density lipoprotein(LDL) and significant decrease(p<0.05) in high-density lipoprotein(HDL), while the non-significant difference in high-density lipoprotein(HDL). This study concluded that omega-3 has an important role in reducing biochemistry side effects that result from the administration of cyclosporine drugs in white rabbits.

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