scholarly journals The role of ZIP proteins in zinc assimilation and distribution in plants: current challenges

2019 ◽  
Vol 55 (No. 2) ◽  
pp. 45-54 ◽  
Author(s):  
Juan Daniel Lira-Morales ◽  
Nancy Varela-Bojórquez ◽  
Magaly Berenice Montoya-Rojo ◽  
J. Adriana Sañudo-Barajas
Keyword(s):  
Family Members ◽  
Zn Deficiency ◽  
Mineral Concentration ◽  
Regulation Of Expression ◽  
Zip Family ◽  
Zn Homeostasis ◽  
Homeostasis Regulation ◽  
Zn Status ◽  
Nutritional Imbalance

Soils with mineral deficiencies lead to nutritional imbalance in crops worldwide. Zinc (Zn) is a micronutrient that is fundamental for plant growth and development, being essential for the proper functioning of a range of enzymes and transcription factors. Zn transporters tightly regulate Zn homeostasis. Plants contain a large number of Zn-responsive genes that are specifically expressed under Zn deficiency to ensure the coordination of assimilatory pathways and meet the physiological requirements. This review brings together a range of studies that have been undertaken to investigate the effects of Zn status on the regulatory mechanisms involved in plant mineral nutrition. The ZIP (ZRT, IRT-like Protein) family is especially implicated in Zn transport and in the maintenance of cellular Zn homeostasis. Regulation of expression in relation to plant tissue, mineral concentration, and species has been determined for several ZIP family members. In the omic era, genomic and proteomic approaches have facilitated a rapid increase in our understanding of the roles of ZIP family members and their regulation, though significant knowledge gaps remain. A comprehensive understanding of ZIP proteins could lead to many potential molecular applications to improve crop management and food quality.  

scholarly journals Arabidopsis thaliana zinc accumulation in leaf trichomes is correlated with zinc concentration in leaves

2020 ◽  
Author(s):  
Felipe K. Ricachenevsky ◽  
Tracy Punshon ◽  
David E. Salt ◽  
Janette P. Fett ◽  
Mary Lou Guerinot
Keyword(s):  
Arabidopsis Thaliana ◽  
Spatial Distribution ◽  
Growth And Yield ◽  
Zn Deficiency ◽  
Model Species ◽  
Nutritional Disorder ◽  
Leaf Trichomes ◽  
Zn Accumulation ◽  
Zn Homeostasis ◽  
Zn Status

AbstractZinc (Zn) is a key micronutrient. In humans, Zn deficiency is a common nutritional disorder, and most people acquire dietary Zn from eating plants. In plants, Zn deficiency can decrease plant growth and yield. Understanding Zn homeostasis in plants can improve agriculture and human health. While root Zn transporters in plat model species have been characterized in detail, comparatively little is known about shoot processes controlling Zn concentrations and spatial distribution. Previous work showed that Zn hyperaccumulator species such as Arabidopsis halleri accumulate Zn and other metals in leaf trichomes. The model species Arabidopsis thaliana is a non-accumulating plant, and to date there is no systematic study regarding Zn accumulation in A. thaliana trichomes. Here, we used Synchrotron X-Ray Fluorescence mapping to show that Zn accumulates at the base of trichomes of A. thaliana, as had seen previously for hyperaccumulators. Using transgenic and natural accessions of A. thaliana that vary in bulk leaf Zn concentration, we demonstrated that higher leaf Zn increases total Zn found at the base of trichome cells. Furthermore, our data suggests that Zn accumulates in the trichome apoplast, likely associated with the cell wall. Our data indicates that Zn accumulation in trichomes is a function of the Zn status of the plant, and provides the basis for future studies on a genetically tractable plant species aiming at understanding the molecular steps involved in Zn spatial distribution in leaves.

scholarly journals The Arabidopsis bZIP19 and bZIP23 transcription factors act as zinc-sensors to control plant zinc status

2020 ◽  
Author(s):  
Grmay H. Lilay ◽  
Daniel P. Persson ◽  
Pedro Humberto Castro ◽  
Feixue Liao ◽  
Ross D. Alexander ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Control Plant ◽  
Zn Deficiency ◽  
In Planta ◽  
Zn Homeostasis ◽  
Food And Feed ◽  
Zn Status ◽  
And Storage

AbstractZinc (Zn) is an essential micronutrient for plants and animals because of its structural and catalytic roles in many proteins. Zn deficiency affects ca. two billion people, mainly those living on plant-based diets that rely on crops from Zn deficient soils. Plants maintain adequate Zn levels through tightly regulated Zn homeostasis mechanisms, involving Zn uptake, distribution and storage, but it was not known how they sense Zn status. We use in vitro and in planta approaches to show that the Arabidopsis thaliana F-group bZIP transcription factors bZIP19 and bZIP23, which are the central regulators of the Zn deficiency response, act as Zn sensors by binding Zn2+ ions to a Zn sensor motif (ZSM). Deletions or modifications of this ZSM disrupts Zn binding, leading to a constitutive transcriptional Zn deficiency response, which causes a significant increase in plant and seed Zn accumulation. Since the ZSM is highly conserved in F-bZIPs across land plants, the identification of the first plant Zn-sensor will promote new strategies to improve the Zn nutritional quality of plant-derived food and feed, and contribute to tackle the global Zn deficiency health problem.

scholarly journals Zinc as a Biomarker of Cardiovascular Health

2021 ◽  
Vol 8 ◽  
Author(s):  
Marija Knez ◽  
Maria Glibetic
Keyword(s):  
Cardiovascular Diseases ◽  
Cardiovascular Health ◽  
Zn Deficiency ◽  
Population Groups ◽  
Common Features ◽  
Significant Relationships ◽  
Zn Homeostasis ◽  
Zn Status

The importance of zinc (Zn) for cardiovascular health continuously gains recognition. As shown earlier, compromised Zn homeostasis and prolonged inflammation are common features in various cardiovascular diseases (CVDs). Similarly, Zn biochemistry alters several vascular processes, and Zn status is an important feature of cardiovascular health. Zn deficiency contributes to the development of CVDs; thus, Zn manipulations, including Zn supplementation, are beneficial for preventing and treating numerous cardiovascular (CV) disorders. Finally, additional long-term, well-designed studies, performed in various population groups, should be pursued to further clarify significant relationships between Zn and CVDs.

scholarly journals The Evolving Role for Zinc and Zinc Transporters in Cadmium Tolerance and Urothelial Cancer

Stresses ◽  
2021 ◽  
Vol 1 (2) ◽  
pp. 105-118
Author(s):  
Soisungwan Satarug ◽  
David A. Vesey ◽  
Glenda C. Gobe
Keyword(s):  
Stress Responses ◽  
Cell Model ◽  
Family Members ◽  
Gene Families ◽  
Arable Soils ◽  
Cd Uptake ◽  
Aberrant Expression ◽  
Cd Toxicity ◽  
Zip Family ◽  
Zn Homeostasis

Cadmium (Cd) is an environmental toxicant with serious public health consequences due to its persistence within arable soils, and the ease with which it enters food chains and then, accumulates in human tissues to induce a broad range of adverse health effects. The present review focuses on the role of zinc (Zn), a nutritionally essential metal, to protect against the cytotoxicity and carcinogenicity of Cd in urinary bladder epithelial cells. The stress responses and defense mechanisms involving the low-molecular-weight metal binding protein, metallothionein (MT), are highlighted. The efflux and influx transporters of the ZnT and Zrt-/Irt-like protein (ZIP) gene families are discussed with respect to their putative role in retaining cellular Zn homeostasis. Among fourteen ZIP family members, ZIP8 and ZIP14 mediate Cd uptake by cells, while ZnT1 is among ten ZnT family members solely responsible for efflux of Zn (Cd), representing cellular defense against toxicity from excessively high Zn (Cd) intake. In theory, upregulation of the efflux transporter ZnT1 concomitant with the downregulation of influx transporters such as ZIP8 and ZIP14 can prevent Cd accumulation by cells, thereby increasing tolerance to Cd toxicity. To link the perturbation of Zn homeostasis, reflected by the aberrant expression of ZnT1, ZIP1, ZIP6, and ZIP10, with malignancy, tolerance to Cd toxicity acquired during Cd-induced transformation of a cell model of human urothelium, UROtsa, is discussed as a particular example.

The Role of Family Members in Safer/Unsafe Injection Drug Use Practices

2011 ◽  
Author(s):  
L. Jackson ◽  
M. Dykeman ◽  
J. Gahagan ◽  
J. Karabanow ◽  
J. Parker
Keyword(s):  
Drug Use ◽  
Injection Drug Use ◽  
Family Members ◽  
Injection Drug ◽  
Unsafe Injection

Pembinaan Semula Peradaban Komuniti Cina Muslim Berasaskan Dialog Antara Agama: Pengalaman di Terengganu dan Brunei

Sains Insani ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 77-84
Author(s):  
Azarudin Awang ◽  
Azman Che Mat ◽  
Sophian Ramli
Keyword(s):  
Cultural Practices ◽  
Family Members ◽  
Interfaith Dialogue ◽  
Chinese Community ◽  
Cultural Life ◽  
Muslim Communities ◽  
Muslim Family

Bagi sesebuah negara yang mempunyai etnik pelbagai anutan kepercayaan dan perbezaan amalan budaya, dialog antara agama berperanan membetulkan semula kekaburan dalam kehidupan beragama dan berbudaya. Melalui peranan Saudara Baru, dialog antara agama mampu menjadi medan bagi menjelaskan kebenaran tentang agama Islam kepada masyarakat bukan Muslim dan pelaksanaan amalan budaya asal kepada Muslim asal. Objektif kajian ini ialah melihat pengalaman pelaksanaan dialog antara agama di Terengganu dan relevansi dalam kehidupan beragama di negara Brunei. Metode kajian ini menggunakan kajian dokumen yang menyentuh komuniti Cina Muslim di Terengganu dan Brunei. Pengalaman pelaksanaan dialog antara agama di Terengganu dan negara Brunei memperlihatkan dialog antara agama mampu membetulkan salah faham dan selanjutnya mengendurkan ketegangan hubungan antara agama dan budaya antara komuniti Saudara Baru, ahli keluarga bukan Muslim dan masyarakat Muslim asal. Biarpun begitu, adalah dicadangkan agar kajian yang menyentuh dialog antara agama perlu diperkukuhkan sebagai medium membina semula peradaban memandangkan penduduk di kedua-dua lokasi ini terdiri daripada berbilang etnik dan agama sedangkan pada masa yang sama masalah yang menyentuh hubungan antara agama sentiasa timbul. Abstract: For a country with diverse ethics of beliefs and cultural practices, interfaith dialogue plays a role to redefine ambiguity in religious and cultural life. Through the role of the New Muslim (Muslim Convert), interfaith dialogue can become a medium to explain the truth about Islam to the non-Muslims and the implementation of real cultural practices to the others Muslim. The objective of this study is to examine the experience of interfaith dialogue in Terengganu and in Brunei. The method of this study is being conducted in document research that related with the Muslim Chinese community in Terengganu and Brunei. In addition, interviews with people involved in the management of New Muslims also carried out. The experience of interfaith dialogue in Terengganu and Brunei shows that dialogue capable explains misunderstandings and further loosening the tension between religion and culture among New Muslims, non-Muslim family members and Muslim communities. However, it is recommended that studies on interfaith dialogue should be strengthened as a medium for rebuilding civilization as the residents of both locations are multi-ethnic and religious while at the same time the problem of interreligious persists.

“Consideration of patients as networked units to identify opportunities and motivation to enhance capability”: A mixed methods study to explore a personalised Digital Health Hub Model of Care for hip fractures in South Australia (Preprint)

2021 ◽  
Author(s):  
Lalit Yadav ◽  
Tiffany K Gill ◽  
Anita Taylor ◽  
Jen DeYoung ◽  
Mellick J Chehade
Keyword(s):  
Hip Fractures ◽  
Digital Health ◽  
Family Members ◽  
South Australia ◽  
Aged Care ◽  
Mixed Methods Study ◽  
Residential Aged Care ◽  
Model Of Care ◽  
Factors Influencing

UNSTRUCTURED Introduction Majority of older people with hip fractures once admitted to acute hospital care are unable to return to their pre-fracture level of independence and a significant number are either newly admitted or return to residential aged care. Patient education involves family members and/or residential aged care staff as networked units, crucial for empowerment through improving health literacy. Advancement of digital technology has led to evolving solutions around optimising health care including self-management of chronic disease conditions and telerehabilitation. The aim of this study is to understand perspectives of older patients with hip fractures, their family members and residential aged carers, to inform the development of a digitally enabled model of care using a personalised digital health hub (pDHH). Methods A mixed methods study was conducted at a public tertiary care hospital in South Australia involving patients aged 50 years and above along with their family members and residential aged carers. Quantitative data, including basic demographic characteristics, access to computers and Internet were analysed using descriptive statistics. Spearman’s Rank Order Correlation was used to examine correlations between the perceived role of a pDHH in improving health and likelihood of subsequent usage. Whereas qualitative data included series of open-ended questions and findings were interpreted using constructs of capability, opportunity and motivation to help understand the factors influencing the likelihood of potential pDHH use Results Overall, 100 people were recruited in the study, representing 55 patients, 13 family members and 32 residential aged carers. The mean age of patients was 76.4 years (SD-8.4, age range 54-88) and females represented 60% of patients. Although a moderate negative correlation existed with increasing age and likelihood of pDHH usage (ρ= -0.50, p<0.001) the perceived role of the DHH in improving health had a strong positive correlation with the likelihood of pDHH usage by self (ρ=0.71, p<0.001) and by society, including friends and family members (ρ=0.75, p<0.001). Of particular note, almost all the patients (98%) believed they had a family member or friend /carer who would be able to help them to use a digital health platform. Whereas our qualitative findings suggest emphasising on complex interplay of capability, opportunity and motivation as crucial factors while designing a pDHH enabled model of care for hip fractures at a local context level. Conclusion Findings from this study contributed to understand the dynamics around capabilities, motivation and opportunities of patients, family members and formal carers as a “patient networked unit”. Future research recommendation must involve co-creation guided by iterative processes through improving understanding of factors influencing development and successful integration of complex digital healthcare interventions in real-world scenarios.

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