Determination and occurrence of bisphenol A, bisphenol A diglycidyl ether, and bisphenol F diglycidyl ether, including their derivatives, in canned foodstuffs’ from the Czech retail market

A several-year survey (2000–2006) documents a continuing occurrence of bisphenol A (BPA), bisphenol A diglycidyl ether (BADGE), and bisphenol F diglycidyl ether (BFDGE), including their derivatives, migrating from packaging into food. A wide range of bisphenols levels (from traces up to hundreds µg/kg) in canned foodstuffs available at the Czech retail market was found. An analytical procedure suitable for routine monitoring of bisphenols in various matrices was validated. Crude extracts (obtained by dichloromethane extraction in ultrasonic bath) were purified by gel permeation chromatography (GPC), identification/quantification was carried out by HPLC/FLD method. Optimised procedure allowed to measure trace levels of the target analytes (LODs – 3 µg/kg) with good repeatability (RSDs – 3% at level 100 µg/kg) and recoveries exceeding 75%.

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High-performance liquid chromatographie determination of bisphenol a diglycidyl ether and bisphenol F diglycidyl ether in water

Journal of Chromatography A ◽

10.1016/s0021-9673(00)91673-x ◽

1986 ◽

Vol 360 ◽

pp. 266-270 ◽

Cited By ~ 14

Author(s):

B. Crathorne ◽

C.P. Palmer ◽

J.A. Stanley

Keyword(s):

Bisphenol A ◽

High Performance ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Bisphenol A Diglycidyl Ether

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Multiple-stage mass spectrometry analysis of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether and their derivatives

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.4801 ◽

2010 ◽

Vol 24 (23) ◽

pp. 3469-3477 ◽

Cited By ~ 23

Author(s):

H. Gallart-Ayala ◽

E. Moyano ◽

M.T. Galceran

Keyword(s):

Mass Spectrometry ◽

Bisphenol A ◽

Diglycidyl Ether ◽

Mass Spectrometry Analysis ◽

Spectrometry Analysis ◽

Bisphenol F ◽

Bisphenol A Diglycidyl Ether

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Chlorination and chloramination of bisphenol A, bisphenol F, and bisphenol A diglycidyl ether in drinking water

Water Research ◽

10.1016/j.watres.2015.04.014 ◽

2015 ◽

Vol 79 ◽

pp. 68-78 ◽

Cited By ~ 37

Author(s):

Rachael F. Lane ◽

Craig D. Adams ◽

Stephen J. Randtke ◽

Ray E. Carter

Keyword(s):

Drinking Water ◽

Bisphenol A ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Bisphenol A Diglycidyl Ether

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Stabilities of bisphenol A diglycidyl ether, bisphenol F diglycidyl ether, and their derivatives under controlled conditions analyzed using liquid chromatography coupled with tandem mass spectrometry

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-019-02016-5 ◽

2019 ◽

Vol 411 (24) ◽

pp. 6387-6398 ◽

Cited By ~ 4

Author(s):

Natalia Szczepańska ◽

Paweł Kubica ◽

Błażej Kudłak ◽

Jacek Namieśnik ◽

Andrzej Wasik

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Bisphenol A ◽

Diglycidyl Ether ◽

Tandem Mass ◽

Bisphenol F ◽

Controlled Conditions ◽

Bisphenol A Diglycidyl Ether

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Investigation of bisphenol a diglycidyl ether, bisphenol f diglycidyl ether and their hydroxy and chlorohydroxy derivatives stability in water-based food simulants

Czech Journal of Food Sciences ◽

10.17221/10679-cjfs ◽

2004 ◽

Vol 22 (SI - Chem. Reactions in Foods V) ◽

pp. S272-S275

Author(s):

I. Poustková ◽

J. Dobiáš ◽

J. Poustka ◽

M. Voldřich

Keyword(s):

Acetic Acid ◽

Bisphenol A ◽

Epoxy Resins ◽

High Performance ◽

Diglycidyl Ether ◽

Phase Gradient ◽

Bisphenol F ◽

Food Simulants ◽

Bisphenol A Diglycidyl Ether ◽

Food Simulant

Varnishes used as the inner coatings of food cans are often based on epoxy resins or vinylic organosols. The epoxy resins can be produced from bisphenol A (BPA) and bisphenol F (BPF) and they also contain bisphenol A diglycidyl ether (BADGE) of bisphenol F diglycidyl ether (BFDGE) as stabilising components. These compounds may break down during storage and also by influence of food simulants. The stability of BADGE and BFDGE was studied using reverse-phase gradient high performance liquid chromatography (RP-HPLC) with fluorescence detection (FLD). Four experiments were compared: (i) BPA solution at the concentration 3 μg/ml of each food simulant, (ii) BADGE solution at the concentration 3 μg/ml of each food simulant, (iii) BFDGE solution at the concentration 3 μg/ml of each food simulant and (iv) mixture of all bisphenols solution at the concentration 3 μg/ml of each food simulant. Distilled water, 10% ethanol, 95% ethanol and 3% acetic acid were used as food simulants. It was observed that BPA, BADGE and BFDGE were most stabile in 95% ethanol and least stabile in 3% acetic acid. Creation of hydroxy and chlorohydroxy derivatives was in each food simulant different so it cannot be predicted.

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Study on anti-androgenic effects of bisphenol a diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives using cells stably transfected with human androgen receptor, AR-EcoScreen

Food and Chemical Toxicology ◽

10.1016/j.fct.2004.02.011 ◽

2004 ◽

Vol 42 (6) ◽

pp. 983-993 ◽

Cited By ~ 101

Author(s):

K. Satoh ◽

K. Ohyama ◽

N. Aoki ◽

M. Iida ◽

F. Nagai

Keyword(s):

Androgen Receptor ◽

Bisphenol A ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Bisphenol A Diglycidyl Ether ◽

Human Androgen Receptor

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Simultaneous determination of bisphenol A-diglycidyl ether, bisphenol F-diglycidyl ether and their hydrolysis and chlorohydroxy derivatives in canned foods

European Food Research and Technology ◽

10.1007/s002170050026 ◽

2000 ◽

Vol 211 (3) ◽

pp. 211-217 ◽

Cited By ~ 30

Author(s):

J. Lintschinger ◽

Walfried Rauter

Keyword(s):

Bisphenol A ◽

Simultaneous Determination ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Bisphenol A Diglycidyl Ether ◽

Canned Foods

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Migration of BADGE (bisphenol A diglycidyl-ether) and BFDGE (bisphenol F diglycidyl-ether) in canned seafood

Food and Chemical Toxicology ◽

10.1016/j.fct.2008.01.006 ◽

2008 ◽

Vol 46 (5) ◽

pp. 1674-1680 ◽

Cited By ~ 40

Author(s):

Ana G. Cabado ◽

Susana Aldea ◽

Corina Porro ◽

Gonzalo Ojea ◽

Jorge Lago ◽

...

Keyword(s):

Bisphenol A ◽

Diglycidyl Ether ◽

Bisphenol F ◽

Bisphenol A Diglycidyl Ether

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Determination of bisphenol A, bisphenol F, bisphenol A diglycidyl ether and bisphenol F diglycidyl ether migrated from food cans using Gas Chromatography-Mass Spectrometry

Czech Journal of Food Sciences ◽

10.17221/3481-cjfs ◽

2011 ◽

Vol 21 (No. 3) ◽

pp. 85-90 ◽

Cited By ~ 10

Author(s):

I. Jordáková ◽

J. Dobiáš ◽

M. Voldřich ◽

J. Postka

Keyword(s):

Gas Chromatography ◽

Bisphenol A ◽

Epoxy Resins ◽

Diglycidyl Ether ◽

Gas Chromatography Mass Spectrometry ◽

Simple Method ◽

Bisphenol F ◽

Mass Spectrometric Detector ◽

Bisphenol A Diglycidyl Ether

Varnishes used for the inner coatings of food cans are mostly based on epoxy resins or vinylic organosols. The epoxy resins are produced from bisphenol A and bisphenol F and they also contain BADGE or BFDGE as stabilising components. A simple method for the quantitative determination of bisphenol A (BPA), bisphenol F (BPF), bisphenol A diglycidyl ether (BADGE), and bisphenol F diglycidyl ether (BFDGE) migrated from food packaging materials was optimised. The can sample was extracted with acetonitrile or with food simulants (distilled water, 3% acetic acid and 10% ethanol) and the extract obtained was analysed by gas chromatography coupled with mass spectrometric detector. The limits of detection and quantification ranged between 0.15–0.86 and 0.51–2.77 µg/dm2, respectively. The migrating levels of bisphenols found in various can samples were for BPA and for BADGE in the range from 0.63 × 10–3 to 0.34 mg/dm2, and from 1.49 × 10–3 to 3.67 mg/dm2, respectively. BPF and BFDGE were practically not detected in the can samples.

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