scholarly journals Splenic malignant mesenchymoma in a dog – immunophenotypic features and clinicopathological ramifications: a case report

2014 ◽  
Vol 59 (No. 1) ◽  
pp. 55-61 ◽  
Author(s):  
Z. Dokic ◽  
W. Pirog ◽  
J. Benak ◽  
D. Lorinson
Keyword(s):  
Smooth Muscle ◽  
Retrospective Studies ◽  
Smooth Muscle Actin ◽  
Abdominal Distension ◽  
Alpha Smooth Muscle Actin ◽  
Abdominal Ultrasonography ◽  
Tumor Entity ◽  
The Common ◽  
Well Differentiated

A 13-year-old spayed bitch was referred for evaluation of an abdominal distension with a palpable, continuously growing mass. Abdominal ultrasonography revealed a 30 × 20 cm mass directly connected to the spleen. Surgical exploration confirmed the sonographic diagnosis with adhesions to the omentum and the liver. Pathohistological samples revealed well differentiated adipose tissue and variably differentiated collagenous and myxomatous tissue. Immunohistochemically, vimentin and in some regions alpha smooth muscle actin were expressed indicating smooth muscle differentiation. The results support the diagnosis of a malignant mesenchymoma composed of liposarcoma, mixosarcoma and leiomyosarcoma. No local recurrence or metastasis occurred during a nine month follow-up. So far, only two pathological retrospective studies describing the common prevalence and properties of canine splenic malignant mesenchymomas were found in the literature. However, this rare tumor entity has to be considered as a differential diagnosis in cases of large splenic masses.  

scholarly journals Benign mixed Müllerian (duct) vaginal tumor in a 12-y-old goat

2022 ◽  
pp. 104063872110693
Author(s):  
Svenja Hartung ◽  
Elfi K. Schlohsarczyk ◽  
Alexandra Jost ◽  
Marlene Sickinger ◽  
Kernt Köhler
Keyword(s):  
Smooth Muscle ◽  
Case Reports ◽  
Smooth Muscle Actin ◽  
Female Genital Tract ◽  
Alpha Smooth Muscle Actin ◽  
Distinct Cell ◽  
Well Differentiated ◽  
Vaginal Neoplasms ◽  
Gross Examination ◽  
Female Genital

In human and veterinary medicine, mixed Müllerian tumors (MMTs) are rarely diagnosed neoplasms of the tubular female genital tract. Although there are case reports of malignant MMTs in various species, benign MMTs have only been described once in a macaque. Here we present a case of benign MMT in a 12-y-old goat, and review the literature on uterine, cervical, and vaginal neoplasia in goats. The doe was presented with vaginal discharge and was euthanized because of the high suspicion of intraabdominal neoplasia. On gross examination, an ulcerated vaginal mass was identified. Histologically, 2 distinct cell populations were present: smooth muscle cells that were well differentiated and positive for alpha–smooth muscle actin, and ciliated columnar epithelial cells that lined ductal structures and had no signs of malignancy. These findings led to the diagnosis of neoplasia of Müllerian origin. Benign MMT should be considered as a differential diagnosis for uterine and vaginal neoplasms in goats.

Expression of alpha-smooth muscle actin, TGF-β1 and TGF-β type II receptor during connective tissue contraction

1997 ◽  
Vol 33 (8) ◽  
pp. 622-627 ◽  
Author(s):  
M. Reza Ghassemifar ◽  
Roy W. Tarnuzzer ◽  
Nasser Chegini ◽  
Erkki Tarpila ◽  
Gregory S. Schultz ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Connective Tissue ◽  
Smooth Muscle Actin ◽  
Type Ii ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Tissue Contraction ◽  
Tgf Β1

scholarly journals Orthodontic mechanical tension effects on the myofibroblast expression of alpha-smooth muscle actin

2010 ◽  
Vol 80 (5) ◽  
pp. 912-918 ◽  
Author(s):  
Yao Meng ◽  
Xianglong Han ◽  
Lan Huang ◽  
Ding Bai ◽  
Hongyou Yu ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Mechanical Tension ◽  
Alpha Smooth Muscle Actin

A Step Forward Toward the Understanding of the Long-Term Pathogenesis of Double Capsule Formation in Macrotextured Implants: A Prospective Histological Analysis

2018 ◽  
Vol 39 (11) ◽  
pp. 1191-1199 ◽  
Author(s):  
Caroline A Glicksman ◽  
Michel A Danino ◽  
Johnny I Efanov ◽  
Arij El Khatib ◽  
Monica Nelea
Keyword(s):  
Smooth Muscle ◽  
Histological Analysis ◽  
Incidental Finding ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Level Of Evidence ◽  
Staining Techniques ◽  
Hematoxylin And Eosin ◽  
Mechanical Shearing

Abstract Background Although increasingly reported in the literature, most plastic surgeons cannot define the etiology of double capsules. Often an incidental finding at implant exchange, double capsules are frequently associated with macrotextured devices. Several mechanisms have been proposed, including at the forefront that shearing causes a delamination of the periprosthetic capsule into a double capsule. Objectives This study was designed to confirm the hypothesis that mechanical forces are involved in formation of double capsules by histological analysis. Methods A prospective analysis of consecutive implants with double capsules removed over 2 years was performed. Data collected at the time of surgery included Baker classification, reason for explant, implant manufacturer and style, and any presence of a seroma associated with the capsule. Specimens were sent for analysis by histology utilizing hematoxylin and eosin and alpha-smooth muscle actin staining techniques. Results Eight double capsules were collected for specimen analysis. All capsules demonstrated evidence of granulation tissue, alpha-smooth muscle actin positive myofibroblasts, and folds with embedded texture. Fibrosis surrounded weak areas with presence of layering and splitting, creating a potential space that is prone to separation. Tears and folds from granulomatous reaction are also present within the outer layer of the double capsule, which can only be explained by a mechanical shearing force as a pathogenic mechanism. Conclusions Understanding the pathogenesis of double capsules may allow plastic surgeons to refine their indications for macrotextured implants while providing guidance to patients on avoidance of activities that produce shear-forces. The findings support the hypothesis that shearing forces delaminate the capsule into 2 separate distinct capsules. Level of Evidence: 5

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