scholarly journals NEUROPSYCHOLOGICAL ASSESSMENT OF COMPENSATORY RESPONSE TO COGNITIVE IMPAIRMENT IN AGING AT CHRONIC CEREBRAL ISCHEMIA

2017 ◽  
pp. 102-118
Author(s):  
Yulia G. Novikova ◽  
◽  
Nataliya G. Ermakova ◽  
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Neuropsychological Assessment ◽  
Chronic Cerebral Ischemia ◽  
Compensatory Response

scholarly journals Vascular cognitive impairment and chronic cerebral ischemia (dyscirculatory encephalopathy)

2019 ◽  
Vol 11 (3S) ◽  
pp. 61-67 ◽  
Author(s):  
V. A. Parfenov
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Emotional Disorders ◽  
Blood Lipid ◽  
Vascular Cognitive Impairment ◽  
Considerable Proportion ◽  
Secondary Headache ◽  
Chronic Cerebral Ischemia ◽  
Dyscirculatory Encephalopathy ◽  
Blood Clots

The paper reviews the literature on vascular cognitive impairment (VCI), the diagnosis widely used in foreign neurological practice, as well as chronic cerebral ischemia (CCI) and dyscirculatory encephalopathy (DEP), the common diagnoses in Russian neurological practice. According to the etiology, risk factors, and manifestations, Stages I and II DEP largely corresponds to moderate VCI; Stage III DEP does to severe VCI. The results of the author’s studies show that a considerable proportion of patients followed up with a diagnosis of CCI, DEP, have no signs of chronic cerebrovascular disease (CVD), but suffer from primary or secondary headache, vertigo of various origins, emotional disorders, and other diseases. The diagnosis of CCI, DEP should be based on the presence of CCI, the reliable neuroimaging signs of chronic CVD, and the ruling out of other diseases. When treating and preventing VCI, CCI, and DEP, a premium is placed upon both non-drug (regular physical activity, smoking cessation, rational nutrition) and drug therapy aimed at normalizing blood pressure and blood lipid spectrum, preventing blood clots, and improving cognitive functions.

scholarly journals Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Shu Zhu ◽  
Dongyu Min ◽  
Jianhong Zeng ◽  
Yetao Ju ◽  
Yao Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Neuronal Apoptosis ◽  
Deciduous Teeth ◽  
Stem Cell Population ◽  
Chronic Cerebral Ischemia ◽  
Nervous Disease ◽  
Human Exfoliated Deciduous Teeth

Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population with high self-renewal ability that originates from the cranial neural crest. Since SHED are homologous to the central nervous system, they possess superior capacity to differentiate into neural cells. However, whether and how SHED ameliorate degenerative central nervous disease are unclear. Chronic cerebral ischemia (CCI) is a kind of neurological disease caused by long-term cerebral circulation insufficiency and is characterized by progressive cognitive and behavioral deterioration. In this study, we showed that either systemic transplantation of SHED or SHED infusion into the hippocampus ameliorated cognitive impairment of CCI rats in four weeks after SHED treatment by rescuing the number of neurons in the hippocampus area. Mechanistically, SHED transplantation decreased the apoptosis of neuronal cells in the hippocampus area of CCI rats through downregulation of cleaved caspase-3. In summary, SHED transplantation protected the neuronal function and reduced neuronal apoptosis, resulting in amelioration of cognitive impairment from CCI. Our findings suggest that SHED are a promising stem cell source for cell therapy of neurological diseases in the clinic.

FEATURES OF COGNITIVE IMPAIRMENT DEPENDING ON THE STAGE OF CHRONIC CEREBRAL ISCHEMIA

2021 ◽  
Vol 2 (1) ◽  
pp. 56-61
Author(s):  
Munis Dilshod qizi Fayzieva ◽  
◽  
Durdona Djurabaevna Usmanova
Keyword(s):  
Adverse Effect ◽  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Neurological Disorders ◽  
Cognitive Disorders ◽  
Chronic Cerebral Ischemia ◽  
Common Cause ◽  
Local Factors ◽  
Atherosclerotic Stenosis ◽  
Stenosis And Occlusion

The article presents the results of the analysis of literature sources on chronic cerebral ischemia, etiology and pathogenetic mechanisms of the development of cognitive impairment. In the pathogenesis of chronic cerebral ischemia, systemic and local factors are important, leading to disorders of cerebral hemodynamics, the most adverse effect is exerted by their combination. The most common cause of local disorders of cerebral blood flow is atherosclerotic stenosis and occlusion of intracerebral and extracranial vesselsthat perform transport and distribution functions.Keywords: chronic cerebral ischemia, cognitive disorders, neurological disorders

scholarly journals Clinical manifestations and issues of diagnosis of chronic cerebrovascular disease (chronic cerebral ischemia) at an early (pre-dementia) stage

2021 ◽  
Vol 13 (1) ◽  
pp. 4-12
Author(s):  
A. A. Kulesh ◽  
A. Yu. Emelin ◽  
A. N. Bogolepova ◽  
O. B. Doronina ◽  
V. V. Zakharov ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Cerebrovascular Disease ◽  
Emotional Disorders ◽  
Clinical Manifestations ◽  
Primary Headache ◽  
Chronic Cerebral Ischemia ◽  
Common Diagnosis ◽  
Long Time ◽  
Vestibular Vertigo

The paper presents experts' opinion on the clinical manifestations and diagnosis of chronic cerebrovascular disease (CVD) (chronic cerebral ischemia (CCI) and dyscirculatory encephalopathy (DEP)) at the pre-dementia stage. It is noted that DEP/CCI is a common diagnosis in Russian neurological practice, the criteria for which have not been updated for a long time. DEP/CCI most often develops in the presence of cerebral small artery (CSA) disease (cerebral microangiopathy (CMA)), the severity of which can be quantified by magnetic resonance imaging. The main clinical manifestation of DEP/CCI is cognitive impairment that may be subjective or moderate at the pre-dementia stage. Emotional disorders (apathy, depression, anxiety) and instability are considered as possible manifestations of CSA disease. It is noted that headache and vestibular vertigo are not caused by chronic CVD; while in patients with CMA, they are usually associated with other diseases (primary headache, peripheral vestibular vertigo, and vestibular migraine). The diagnosis of DEP/CCI should be based on the presence of cognitive impairment, reliable neuroimaging signs of CVD, and the exclusion of another cause of cognitive impairment.

scholarly journals Balneotherapy and physiotherapy in treatment of cognitive and psychoemotional disorders in patients with chronic cerebral ischemia

2020 ◽  
Vol 17 (4) ◽  
pp. 178-184
Author(s):  
Lyubov A. Cherevaschenko ◽  
Artem A. Serebryakov ◽  
Nikolay N. Kulikov ◽  
Anatolii T. Tereshin ◽  
Igor A. Cherevashchenko
Keyword(s):  
Quality Of Life ◽  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Electrostatic Field ◽  
Low Frequency ◽  
Chronic Cerebral Ischemia ◽  
Health Resort ◽  
Treatment Methods ◽  
Treatment Stage

Background. Chronic cerebral ischemia, or discirculatory encephalopathy, is one of the most common neurological diagnosis in Russia. This condition is defined as a chronic, progressive, non-stroke-related vascular lesion of the brain, which is manifested predominantly by cognitive impairment. Therapeutic measures for cognitive impairment include, first of all, the prevention of acute cerebrovascular accidents and chronic vascular cerebral insufficiency. The development and implementation of highly effective non-drug treatment methods, having few side effects, is an urgent problem in contemporary medicine. Such treatment methods can include balneotherapy and physiotherapy. Aim: to justify the possibility and expediency of applying at the health resort treatment stage the combined use of iodine-bromine baths and a pulsed low-frequency electrostatic field in patients with chronic cerebral ischemia in order to correct cognitive and psychoemotional disorders and improve the quality of life. Methods. The study included 90 patients with chronic cerebral ischemia, who were randomly divided into 3 treatment groups. The control group patients received iodine-bromine baths, the comparison group patients received exposure to an alternating pulsed low-frequency electrostatic field using the HIVAMAT-200 apparatus, and the main group patients received iodine-bromine baths and exposure to a pulsed low-frequency electrostatic field. The cognitive and emotional-volitional sphere was studied using standard neuropsychological techniques, namely the minimum cognitive deficit scale Mini Mental State Examination (MMSE); Lurias test, the Clock Drawing test, Schulte tables, and Yu.L. Hanins anxiety scales. The study of quality of life was performed using the Russian version of the general questionnaire MOS SF 36 Iterm Short-Form Health Survey. Results. It has been proved that as a result of treatment, disorders of memory and attention are reduced, the general cognitive status of patients is improved, which slows down the disease progression, reduces the risk of vascular catastrophes and dementia. Conclusion. New medical technologies developed for the treatment of patients with chronic cerebral ischemia at the health resort treatment stage are highly effective, pathogenetically substantiated, and can be recommended for widespread use in a network of health resort institutions and rehabilitation and preventive institutions of practical health care.

scholarly journals Tooth loss, cognitive impairment and chronic cerebral ischemia

2020 ◽  
Vol 15 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Qian Pang ◽  
Qianqian Wu ◽  
Xingxue Hu ◽  
Jianjun Zhang ◽  
Qingsong Jiang
Keyword(s):  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Tooth Loss ◽  
Chronic Cerebral Ischemia

scholarly journals Longitudinal tracing of neurochemical metabolic disorders in working memory neural circuit and optogenetics modulation in rats with vascular cognitive impairment

2020 ◽  
Author(s):  
Huawei Lin ◽  
Tingting Jin ◽  
Lewen Chen ◽  
Yaling Dai ◽  
Weiwei Jia ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Impairment ◽  
Cerebral Ischemia ◽  
Gray Matter ◽  
Metabolic Disorders ◽  
Neural Circuit ◽  
Vascular Cognitive Impairment ◽  
Chronic Cerebral Ischemia ◽  
Mediodorsal Thalamus ◽  
Ischemia Time

Abstract Objective: Chronic cerebral ischemia leads to vascular cognitive impairment (VCI) that exacerbates along with ischemia time and eventually develops into dementia. Recent advances in molecular neuroimaging contribute to understand its pathological characteristics. We previously traced the anisotropic diffusion of water molecules suggests that chronic cerebral ischemia leads to irreversible progressive damage to white matter integrity. However, the abnormalities of gray matter activity following chronic cerebral ischemia remains not entirely understood.Methods: In this study, in vivo hydrogen proton magnetic resonance spectroscopy (1H-MRS) was applied to longitudinally track the neurochemical metabolic disorder of gray matter associated with working memory, and optogenetics modulation of neurochemical metabolism was performed for targeted treatment of VCI. Results: The results showed that the concentration of N-acetylaspartate (NAA) in the right hippocampus, left hippocampus, right medial prefrontal cortex (mPFC) and mediodorsal thalamus was decreased as early as 7 days after chronic cerebral ischemia, subsequently gamma-aminobutyric acid (GABA) declined whereas myo-inositol (mI) and glutamate (Glu) increased at 14 days, as well as choline (Cho) lost at 28 days, concurrently the change of Glu and GABA in the mPFC and hippocampus was ischemia time-dependent manner within 1 month. Behaviorally, working memory and object recognition memory were impaired at 14 days, 28 days that significantly correlated with neurochemical metabolic disorders. Interestingly, using optogenetics modulation of PV neurons in the mPFC, the metabolic abnormalities of NAA and GABA in working memory neural circuit could be repaired after chronic cerebral ischemia, together with behavior improvements. Conclusions: These findings suggested that as early as 1~4 weeks after chronic cerebral ischemia, the metabolism of NAA, Glu, mI and Cho was synchronously impaired in neural circuit of hippocampus-mediodorsal thalamus-mPFC, and the loss of GABA delayed in the hippocampus, and optogenetics modulation of parvalbumin (PV) neurons in the mPFC can improve the neurochemical metabolism of working memory neural circuit and enhance working memory.

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