Organic Hallucinosis in Non-Hemorrhagic Stroke Caused by Thrombosis Process: A Case Report

Background/aim: Hallucinations are the special ability to experience phenomena that are not visible to normal individuals. Hallucinations, delusions, and confabulations are common symptoms between neurology and psychiatry. Nervous disease that manifests with hallucinatory symptoms like this is one of them due to right hemispheric stroke. The authors report cases of new-onset organic hallucinosis. and stroke in brain regions similar to the salience network (insular cortex, parietal cortex, and striatum). Case: A 43-year-old man comes to the ER Sanglah Hospital Denpasar, Bali Indonesia with complaints of slurred speech using an incomprehensible language, and repeating the same words. Talking about seeing a shadow following him but actually not there. Patients often experience sleep disorders, from the results of neurological physical examination found right eye ptosis, pupil anisokor, nerve III dextra complete lesion, supranuclear left NVII paresis, supranuclear left NXII paresis, left flaccid hemiparesis. Psychiatric status obtained unnatural appearance, looks confused, verbal and visual contact is sufficient, mood dysphoric, confused affect and there is no harmony. The thought process obtained realistic, coherent, preoccupation with pain. Perceptual disturbances in the form of visual and auditory hallucinations. Insomnia mixed type and there is hypobulia. Psychomotor calm on examination, history increases. Narcissistic personality traits and defense mechanisms of ego repression. Grade 4 view. CT scan of the head with and without contrast shows subacute ischemic cerebral infarction in the right internal capsule to the right thalamus and midbrain. Conclusion: Organic hallucinosis occur in non-hemorrhagic stroke caused by thrombosis process if an infarction is found in the right hemisphere. Keywords: organic hallucinations, ischemic cerebral infarction, non-hemorrhagic stroke, right hemisphere.

Clinical and Genetic Characteristics of ABCC8 Nonneonatal Diabetes Mellitus: A Systematic Review

Objectives. Diabetes mellitus (DM) is a major chronic metabolic disease in the world, and the prevalence has been increasing rapidly in recent years. The channel of KATP plays an important role in the regulation of insulin secretion. The variants in ABCC8 gene encoding the SUR1 subunit of KATP could cause a variety of phenotypes, including neonatal diabetes mellitus (ABCC8-NDM) and ABCC8-induced nonneonatal diabetes mellitus (ABCC8-NNDM). Since the features of ABCC8-NNDM have not been elucidated, this study is aimed at concluding the genetic features and clinical characteristics. Methods. We comprehensively reviewed the literature associated with ABCC8-NNDM in the following databases: MEDLINE, PubMed, and Web of Science to investigate the features of ABCC8-NNDM. Results. Based on a comprehensive literature search, we found that 87 probands with ABCC8-NNDM carried 71 ABCC8 genetic variant alleles, 24% of whom carried inactivating variants, 24% carried activating variants, and the remaining 52% carried activating or inactivating variants. Nine of these variants were confirmed to be activating or inactivating through functional studies, while four variants (p.R370S, p.E1506K, p.R1418H, and p.R1420H) were confirmed to be inactivating. The phenotypes of ABCC8-NNDM were variable and could also present with early hyperinsulinemia followed by reduced insulin secretion, progressing to diabetes later. They had a relatively high risk of microvascular complications and low prevalence of nervous disease, which is different from ABCC8-NDM. Conclusions. Genetic testing is essential for proper diagnosis and appropriate treatment for patients with ABCC8-NNDM. And further studies are required to determine the complex mechanism of the variants of ABCC8-NNDM.

Corpus-based Analysis of Lexicosemantic Behaviour of Nervous System Diseases Names

Terminology represents a significant factor in healthcare communication between specialists and patients. The present paper deals with the lexicosemantic characteristics of multi-word lexical units multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, epidural abscess, Huntington’s chorea, and carpal tunnel syndrome. The research questions focus on collocations, word combinations, and concordances in which they regularly appear; the first lemma to the left and the first lemma to the right from the studied lexeme demonstrate the principal positions of our interest. Simultaneously, the researcher considers their semantic restrictions, semantic prosody, and grammatical relations that influence their lexical features. The whole linguistic material is investigated in the framework of the text corpus English Web 2015 (enTenTen15) with the help of the search tool Sketch Engine. To begin the research, the frequencies of these lexical units are elaborated. The researcher also looks into the morphological classification of the studied words as these two factors affect them from the lexicological perspective. The research outcomes confirm that the nervous disease names appear in a wide range of structures, and they considerably contribute to successful communication in the medical surroundings. Moreover, the results indicate that the lexicosemantic behaviour of the terms reflects extralinguistic factors (psychological, social) of individual communication acts. The phenomenon is to be further examined and interpreted within the corpus analyses of other chosen lexical units, not only from the field of medicine. Eventually, the researcher outlines possible pedagogical implications of the research results in the process of teaching English.

Science: Entropy, Degeneration, and Decadent Self-Destruction

This chapter considers the relationship between decadence, individualism, and science at the end of the nineteenth century. Individualism was considered key to the decadent style, yet it was also widely understood by sociologists and scientists to be symptomatic of nervous disease and social decline. This chapter argues that the overly civilized, nervous, and exhausted heroes of decadent literature result from the widespread understanding of the human being as an energy system, subject to the recently formulated laws of thermodynamics. As isolated systems, these characters use up their energy in increasing disorder, “continually suffering deductions, [until] these unceasing deductions finally result in the cessation of motion” (Herbert Spencer, “Progress: Its Law and Cause,” 1880). Thus, many decadent texts can only end with nothing other than the death of their protagonist.

Corpus-based Analysis of Lexicosemantic Behaviour of Nervous System Diseases Names

Terminology represents a significant factor in healthcare communication between specialists and patients. The present paper deals with the lexicosemantic characteristics of multi-word lexical units multiple sclerosis, amyotrophic lateral sclerosis, Parkinson’s disease, Alzheimer’s disease, epidural abscess, Huntington’s chorea, and carpal tunnel syndrome. The research questions focus on collocations, word combinations, and concordances in which they regularly appear; the first lemma to the left and the first lemma to the right from the studied lexeme demonstrate the principal positions of our interest. Simultaneously, the researcher considers their semantic restrictions, semantic prosody, and grammatical relations that influence their lexical features. The whole linguistic material is investigated in the framework of the text corpus English Web 2015 (enTenTen15) with the help of the search tool Sketch Engine. To begin the research, the frequencies of these lexical units are elaborated. The researcher also looks into the morphological classification of the studied words as these two factors affect them from the lexicological perspective. The research outcomes confirm that the nervous disease names appear in a wide range of structures, and they considerably contribute to successful communication in the medical surroundings. Moreover, the results indicate that the lexicosemantic behaviour of the terms reflects extralinguistic factors (psychological, social) of individual communication acts. The phenomenon is to be further examined and interpreted within the corpus analyses of other chosen lexical units, not only from the field of medicine. Eventually, the researcher outlines possible pedagogical implications of the research results in the process of teaching English.

Epileptic Seizure Prediction

Epilepsy is a nervous disease which causes seizures. Electroencephalography (EEG) gives complex information about the brain dynamics but its visual inspection is difficult and requires skilled interpreters. Source localization means identifying the area of the brain where a seizure can occur. In general, source localization is necessary for patients with a special condition in epilepsy, i.e. when their disease is resistant to drugs. One-third of the people having epilepsy are drug resistant and the latest anti-epileptic drugs cannot stop the seizures completely. Unexpected occurrence of seizure disturbs the quality of life and causes physical damage and thus epilepsy should be predicted. This study will use various signal processing methods to extract features by studying the pre-ictal and inter-ictal periods, localize the source and then finally predict epilepsy with the help of Artificial Neural Networks. The knowledge thus derived can help in preparing a wearable brain - computer interface.

Towards the modern doctrine of Landry paralysis

Pri opredѣleni kazhdago nervnago zabolѣvanya, kak" otdѣl'noy nozologicheskoy yedinitsy, sovremennaya nevropatologya kladet" v" osnovu tri glavnykh" printsipa: anatomo-fizologichesky, patologo-anatomichesky i etologichesky. Na osnovani pervago printsipa nevropatolog", pol'zuyas' faktami normal'noy anatomi i fizologi nervnoy sistemy, opredѣlyayet" v" klinicheskoy kartinѣ zabolѣvanya uklonenya v" proyavleni dѣyatel'nosti otdѣl'nykh" nervnykh" sistem", nervnykh" yedinits"nevronov". Opredѣlyaya, kakya sistemy i kakya chasti ikh" porazheny, on" stavit" topicheskuyu dagnostiku zabolѣvanya. Na osnovani dannykh" patologicheskoy anatomi nevropatolog" opredѣlyayet" kharakter" porazhenya, lezhashchago v" osnovѣ zabolѣvanya, i nakonets" opredѣlyayet" prichinu, vyzvavshuyu dannoye zabolѣvane, obuslovivshuyu bystrotu ili medlennost' yego razvitya, pol'zuyas' v" ostrykh" sluchayakh" dannymi bakterologi i toksikologi. No ne smotrya na uspѣkhi nevrapotologi, sushchestvuyet" mnogo zabolѣvany, gdѣ vsѣ tri printsipa ne mogut" byt' strogo provedeny, tak" kak" predstavlyayut' mnogo yeshche spornago. Eti zabolѣvanya predstavlyayutsya simptomokompleksom", v" osnovѣ kotorago mogut" lezhat' porazhenya, chrezvychayno raznoobraznyya po svoyey lokalizatsi, po kharakteru patologo-anatomicheskago protsessa i po etologi. K" chislu podobnago roda zabolѣvany prinadlezhit" bolѣzn', izvѣstnaya pod" imenem" ostrago voskhodyashchago paralicha Landry. Развернуть 1371/5000 When defining each nervous disease, as a separate nosological unit, modern neuropathology lays in the basis of three main principles: anatomical-physiological, pathological-anatomical and ethiological. On the basis of the first principle, the neuropathologist, using the facts of normal anatomy and physiology of the nervous system, determines in the clinical picture of the disease, the evasion in the manifestation of the activity of individual nervous systems, nervous units - neurons. Determining which systems and which parts of them are affected, he sets the topical diagnosis of the disease. Based on the data of the pathological anatomy, the neuropathologist determines the nature of the lesion underlying the disease, and finally determines the cause that caused this disease, which caused the rapidity or slowness of its development, using the data of toxicology and toxicology in acute cases. But in spite of the successes of neuropathology, there are many diseases where all three principles cannot be strictly followed, since they represent a lot more controversial. These diseases are presented as a symptom complex, in the basis of which there may be lesions, extremely diverse in their localization, in the nature of the pathological-anatomical process and in ethiology. To the number of such kind of diseases belongs the disease, known under the name of acute ascending paralysis of Landry.

Exosomes: Potential Therapies for Disease via Regulating TLRs

Exosomes are small membrane vesicles that retain various substances such as proteins, nucleic acids, and small RNAs. Exosomes play crucial roles in many physiological and pathological processes, including innate immunity. Innate immunity is an important process that protects the organism through activating pattern recognition receptors (PRRs), which then can induce inflammatory factors to resist pathogen invasion. Toll-like receptor (TLR) is one member of PRRs and is important in pathogen clearance and nervous disease development. Although exosomes and TLRs are two independent materials, abundant evidences imply exosomes can regulate innate immunity through integrating with TLRs. Herein, we review the most recent data regarding exosome regulation of TLR pathways. Specifically, exosome-containing materials can regulate TLR pathways through the interaction with TLRs. This is a new strategy regulating immunity to resist pathogens and therapy diseases, which provide a potential method to cure diseases.

Association Between Anemia and Dementia: A Nationwide, Populationbased Cohort Study in Taiwan

Background: In addition to the traditional risk predictors, whether anemia is an early biomarker of dementia, needs to be confirmed. Objective: This population-based cohort study aimed to investigate the dementia risk in patients with newly diagnosed anemia using data from the Taiwan National Health Insurance Research Database. Methods: All newly diagnosed anemia patients (n = 26,343) with no history of stroke hospitalization, central nervous disease other than dementia, psychiatric disorders, traumatic brain injury, major operations, or blood loss diseases, were enrolled. A group of non-anemic controls, 1:4 matched with anemic patients on the basis of demographics and comorbidities, was also included. A competing risk analysis was used to evaluate the dementia risk in anemic patients compared to that of their matched controls. Results: The adjusted subdistribution hazard ratio (SHR) of dementia risk in anemic patients was 1.14 (95% confidence interval [CI]: 1.08~1.21, p<0.001). Patients with iron supplements tended to exhibit a lower dementia risk (adjusted SHR: 0.84; 95% CI: 0.75~0.94, p=0.002) compared to patients without iron supplement. A subgroup analysis showed that a positive association between dementia and anemia existed in females, those aged 70 years and older, and patients without hypertension, diabetes, or hyperlipidemia. Conclusion: The present population-based cohort study identified that newly diagnosed anemia is a risk factor for dementia and also that iron supplementation was able to reduce the risk of dementia in people with iron deficiency anemia.