scholarly journals Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma

Cancers ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2199 ◽  
Author(s):  
Sun-Young Jun ◽  
Joon-Yong Chung ◽  
Nara Yoon ◽  
Eun Sun Jung ◽  
Young-Ha Oh ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Single Cells ◽  
Prognostic Indicator ◽  
Tumor Budding ◽  
High Grade ◽  
Stage Grouping ◽  
Lower Stage ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Small Intestinal

The clinicopathologic and prognostic significances of tumor budding (TB) and poorly-differentiated clusters (PDC) have not been investigated in small intestinal adenocarcinomas (SIACs). In 236 surgically-resected SIACs, we counted TB (single cells or clusters ≤4 tumor cells) and PDC (clusters ≥5 tumor cells) at the peritumoral-invasive front (p) and in the intratumoral area (i) independently to classify as grade-1 (≤4), grade-2 (5–9), or grade-3 (≥10). Consequently, grades-2 and -3 were considered high-grade. High-pTB, -iTB, -pPDC, and -iPDC were observed in 174 (73.7%), 129 (54.7%), 118 (50.0%), and 85 (36.0%) cases, respectively. High-TB/PDCs were more frequently observed in tumors with high-grade, higher T- and N-categories and stage grouping, and perineural or lymphovascular invasion. Patients with high-TB/PDC had a shorter survival than those with low-TB/PDC. In a multivariate analysis, high-pTB, nonintestinal type, high N-category, retroperitoneal seeding, and microsatellite-stable were worse independent-prognostic predictors. Subgroup analysis demonstrated that patients with high-pTB showed worse survival (median: 42.5 months) than those with low-pTB (133.7 months; p = 0.007) in the lower stage (stages I–II) group. High-TB/PDC, both in peritumoral and intratumoral localizations, were associated with aggressive behaviors in SIACs. High-pTB can be used as an adverse prognostic indicator in SIAC patients, especially when patients are in early disease stages.

scholarly journals Comment on Jun, S.Y.; et al. “Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma” Cancers 2020, 12, 2199

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2982 ◽  
Author(s):  
Paolo Giuffrida ◽  
Giovanni Arpa ◽  
Alessandro Vanoli ◽  
Antonio Di Sabatino
Keyword(s):  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Small Intestinal ◽  
Small Intestinal Adenocarcinoma

We read with interest the paper by Jun S [...]

Tu1948 - Poorly Differentiated Clusters High Grade is Associated with Poor Prognosis in Colorectal Cancer

2018 ◽  
Vol 154 (6) ◽  
pp. S-1062
Author(s):  
Takahito Kitajima ◽  
Yuji Toiyama ◽  
Yoshinaga Okugawa ◽  
Yusuke Omura ◽  
Akira Yamamoto ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Poor Prognosis ◽  
High Grade ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

scholarly journals Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas

2021 ◽  
Author(s):  
Aura Jurescu ◽  
Alis Dema ◽  
Adrian Văduva ◽  
Adelina Gheju ◽  
Octavia Vița ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Lymphovascular Invasion ◽  
Tumor Stage ◽  
Nodal Status ◽  
Tumor Budding ◽  
Grading System ◽  
Strongly Correlated ◽  
Colorectal Carcinomas ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently,  we evaluated  associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t)  most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t with other prognostic parameters analyzed, as compared to the conventional grading system. Nodal status, tumor stage, and lymphovascular invasion were strongly correlated with GBd-3t (p=0.0001). Furthermore, we noted that PDCs-G-3t correlated more significantly than the conventional grading system with nodal status (p<0.0001), tumor stage (p=0.0003), lymphovascular invasion (p<0.0001), perineural invasion (p=0.005) and the tumor border configuration (p<0.0001).  High GBd and PDCs-G grades correlate directly with other negative prognostic factors in CRC.Thus, these new parameters/classification methods could be used as additional tools for risk stratification in patients with CRC.

Impact of “poorly differentiated clusters” in primary lesion as a novel prognostic indicator in colorectal liver metastasis.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 3625-3625
Author(s):  
Tsuyoshi Konishi ◽  
Hideki Ueno ◽  
Yuichi Ishikawa ◽  
Masashi Ueno ◽  
Akio Saiura ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Liver Metastasis ◽  
Colorectal Liver Metastasis ◽  
Prognostic Indicator ◽  
Primary Lesion ◽  
Clinicopathological Parameters ◽  
Perioperative Chemotherapy ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
The Impact

3625 Background: Preoperative predictors for survival are needed in colorectal liver metastasis in order to select poor-risk group that truly requires perioperative chemotherapy. This study aimed to elucidate survival predictors in patients undergoing curative hepatectomy for colorectal liver metastasis, particularly focusing on the impact of poorly differentiated clusters (PDC); a novel histologic grading system in primary lesion. Methods: A total of 424 consecutive patients undergoing curative resection of both primary colorectal cancers and metastatic liver lesions at two referral centers were enrolled in the study. Determinants of overall survival (OS) and recurrence free survival (RFS) after hepatectomy were investigated by univariate and multivariate analysis, using detailed clinicopathological parameters in primary and metastatic lesions. Cancer clusters of ≥5 cancer cells and lacking a gland-like structure were counted under a x20 objective lens in a field containing the highest number of clusters at invasive front of primary lesions, and tumors with <5, 5 to 9, and ≥10 clusters were classified as PDC grade (G)1, G2 and G3, respectively (n=65, 132, and 227 tumors, respectively). Results: OS and RFS at 3 years were 59% and 27%, respectively, with average follow up period of 43 months. PDC grade in primary lesion was strongly associated with both 3-year-OS (83%, 62%, and 51%, respectively, p<0.0001) and 3-year-RFS (55%, 30%, and 17%, respectively, p<0.0001). Multivariate analysis revealed that PDC grade in primary lesion was the most potent prognostic factor after hepatectomy independent of T and N of primary lesion and size of liver metastasis. Conclusions: PDC grade in primary lesion is a novel potent prognostic indicator in colorectal liver metastasis, which is independent of T and N. It is noteworthy that PDC grade can bias the survival in clinical studies targeting perioperative chemotherapy in colorectal liver metastasis.

scholarly journals Lymph Node Tumor Burden Correlates With Tumor Budding and Poorly Differentiated Clusters: A New Prognostic Factor in Colorectal Carcinoma?

2021 ◽  
Vol 12 (3) ◽  
pp. e00303
Author(s):  
Ivan Archilla ◽  
Sherley Díaz-Mercedes ◽  
José Javier Aguirre ◽  
Jordi Tarragona ◽  
Isidro Machado ◽  
...  
Keyword(s):  
Lymph Node ◽  
Prognostic Factor ◽  
Colorectal Carcinoma ◽  
Tumor Burden ◽  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

Prognostic significance of poorly differentiated clusters and tumor budding in colorectal liver metastases

2018 ◽  
Vol 117 (7) ◽  
pp. 1364-1375 ◽  
Author(s):  
Gilton M. Fonseca ◽  
Evandro S. de Mello ◽  
Sheila F. Faraj ◽  
Jaime A. P. Kruger ◽  
Fabricio F. Coelho ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Colorectal Liver Metastases ◽  
Prognostic Significance ◽  
Tumor Budding ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated

scholarly journals New morphological risk factors for metastasis to regional lymph nodes in rectal cancer with invasion into the submucosa

2021 ◽  
Vol 20 (4) ◽  
pp. 22-33
Author(s):  
O. A. Maynovskaya ◽  
E. G. Rybakov ◽  
S. V. Chernyshov ◽  
Yu. A. Shelygin ◽  
S. I. Achkasov
Keyword(s):  
Risk Factors ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Lymphovascular Invasion ◽  
Tumor Budding ◽  
Regional Lymph Nodes ◽  
Poorly Differentiated Clusters ◽  
Poorly Differentiated ◽  
Node Metastases

AIM to assess prognostic significance of pathologic features of T1 rectal carcinoma in relation to regional lymph nodes involvement (N+).MATERIAL AND METHODS: surgical specimens (n = 66) from rectal resection for carcinoma pT1 were investigated. Following prognosticators were evaluated: depth of submucosal invasion, grade of differentiation, lymphovascular invasion (LVI), tumor budding (Bd), poorly differentiated clusters (PDC) of tumor and rupture of cancer glands (CGR).RESULTS: lymph nodes metastases were found in 13 (19.7%) specimens. LVI was associated lymphatic spread in great possibility OR 38.0 95% CI 2.1-670 (p < 0.0001). Tumor budding of high grade (Bd3) OR 6.2 95% CI 1.2-31 (p < 0.0001) and poorly differentiated clusters (p = 0,03) also increased risk of lymph node metastases. Depth of submucosal invasion, grade of differentiation, and rupture of cancer glands failed to demonstrate significant association with N+. Logistic regression analysis allowed to determine LVI as independent prognostic factor of lymph node tumor involvement.CONCLUSION: lymphovascular invasion, tumor budding and poorly differentiated clusters of tumor are risk factors of T1 rectal carcinoma lymph node metastases.

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