A Randomized Controlled Trial on the Effect of VCO in Reducing Glucose and Body Weight in Post-Acute Coronary Syndrome Patients: A Pilot Study

The aims of this paper were to determine the effect of virgin coconut oil (VCO) on bodyweight and serum glucose level among acute coronary syndrome (ACS) patients. Various clinical trials on animal studies have found that the VCO has many beneficial effects on health. However, there have been limited published human studies on the pharmacological properties of VCO. Investigation on human subjects is extremely required in order to provide more empirical evidence to show the effect of VCO for ACS patients. Randomised single blind study conducted between March 2018 and April 2018. RCT was conducted among 70 ACS patients for 30 days. Participants in group A received their bottles containing 100 pieces of virgin coconut oil soft gels and were required to ingest 10 capsules per day (5 mL/5 gm) and continue routine treatment (diabetic diet and diabetic medication). Group B participants continued receiving routine treatment. Changes in serum fating blood sugar and body weight were identified using a paired t-test and independent t-test. A total of 70 patients participated with ages of 51 years old and older and were mostly male. The serum FBS and body weight of the intervention group that received VCO were reduced about 13.6% on day 30, from the baseline on day 1. They also had body weight reduction of about 2% with p value of less than 0.05. In contrast, the control group that only received routine treatment showed an increment of 12.1% in their serum FBS and had no changes in body weight. These reductions were noted within 30 days of consuming a daily dose of VCO (5 g every day). The properties of lauric acid and antioxidants present in the VCO composition were key players in the reduction of serum glucose levels and body weight. VCO can reduce serum glucose levels and body weight with 5 mL (5 g) of VCO per day for 30 days. Also, VCO may have a positive effect towards the glucose level and other cardiovascular risk factors.

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Abstract 165: In-hospital Serum HbA1c and Glucose Levels and 30-Day Hospital Readmissions Among Adults Hospitalized with an Acute Coronary Syndrome: TRACE-CORE

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.8.suppl_2.165 ◽

2015 ◽

Vol 8 (suppl_2) ◽

Author(s):

Nathaniel A Erskine ◽

Molly E Waring ◽

Joel M Gore ◽

Jerry H Gurwitz ◽

Darleen M Lessard ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Medical Center ◽

Hospital Readmissions ◽

Significant Proportion ◽

Serum Glucose ◽

Day Hospital ◽

Glucose Levels ◽

Coronary Syndrome ◽

Study Results ◽

Hba1c Levels

Objective: Abnormalities in glucose metabolism may worsen the prognosis of patients hospitalized with an acute coronary syndrome (ACS). We examined the association of in-hospital serum glucose and glycated hemoglobin (HbA1c) levels with the occurrence of 30-day hospital readmissions among adults discharged from the hospital after an ACS. Methods: Using data from the Transitions, Risks, and Action in Coronary Events - Center for Outcomes Research and Education (TRACE-CORE) study, we reviewed the medical records of 2,187 patients discharged from 6 hospitals in MA and GA after an ACS between 2011 and 2013. We stratified patients according to diabetes mellitus (DM) status at baseline, as defined by medical history of DM, admission medications, or a serum HbA1c > 6.5%. Using logistic regression models, we calculated crude and adjusted odds ratios to estimate the association between serum HbA1c and glucose levels during hospitalization with 30-day all-cause readmissions. We controlled for prior and inpatient insulin use, age, body mass index, ACS classification, length of stay, and hospital site. Results: Data on serum HbA1c and glucose levels were available for 1,102 (50%) participants. This study sample had a mean age of 60 (SD: 11) years, 68% were male, 77% were non-Hispanic white, and 52% had DM. The mean in-hospital serum HbA1c and maximum and minimum serum glucose levels were 8.2%, 277 mg/dL, and 101 mg/dL, respectively, for those with known DM (n = 526) and 5.7%, 155 mg/dL, and 92 mg/dL for those without known DM (n = 576). A higher, but non-significant, proportion of patients with DM (14%) were readmitted to an area medical center within 30 days of discharge compared to those without DM (11%, p = 0.27). Neither serum HbA1c levels, nor minimum or maximum glucose values during hospitalization were associated with all-cause 30-day readmissions among those with and without DM (Table). Conclusions: In this prospective study of adults with an ACS, we found no significant association between serum HbA1c or glucose levels with the occurrence of 30-day hospital readmissions. The low proportion of subjects with serum HbA1c testing may have biased the study results. Further investigation should examine the in-hospital management of ACS patients with varying serum glucose and HBA1C levels and their post-discharge outcomes.

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The Prognostic Significance of Serum Glucose Levels After the Onset of Ventricular Arrhythmia on In-Hospital Mortality of Patients with Acute Coronary Syndrome

The Review of Diabetic Studies ◽

10.1900/rds.2008.5.47 ◽

2008 ◽

Vol 5 (1) ◽

pp. 47-51 ◽

Cited By ~ 2

Author(s):

Vassilios N. Nicolaou ◽

John E. Papadakis ◽

Christina Chrysohoou ◽

Demosthenes B. Panagiotakos ◽

Xenofon Krinos ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Ventricular Arrhythmia ◽

Hospital Mortality ◽

Prognostic Significance ◽

Serum Glucose ◽

Glucose Levels ◽

Coronary Syndrome

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PEMANFAATAN VCO (Virgin Coconut Oil) SEBAGAI BAHAN PENURUN KADAR GLUKOSA PADA NASI SEBAGAI MAKANAN PENDERITA DIABETIS MELITUS

Jurnal Kesehatan Kusuma Husada ◽

10.34035/jk.v10i2.348 ◽

2019 ◽

pp. 122-126

Author(s):

S Suharyanto ◽

Rian Dianto

Keyword(s):

Glucose Level ◽

Coconut Oil ◽

Average Level ◽

Virgin Coconut Oil ◽

Rice Sample ◽

Glucose Determination ◽

Glucose Levels ◽

Average Glucose

Makanan penduduk Indonesia sebagaian besar adalah nasi, disamping sagu dan jagung. Penderita Diabetus Melitus, nasi merupakan sumber glukosa yang pantas diwaspadai sehingga asupan nasi harus dibatasi. Virgin Coconut Oil (VCO) merupakan minyak yang berasal dari buah kelapa (Cocos mucifera L) tua segar yang diolah pada suhu 100C-150C dan dimasak tidak sampai matang. Tujuan penelitian ini adalah untuk mengetahui penurunan kadar glukosa pada nasi yang dicampur VCO (Virgin Cocot Oil). Pada penelitian ini sampel dari nasi tanpa penambahan VCO dibandingkan dengan nasi dengan penambahan VCO 3%, 4%, dan 5% dari jumlah beras yang akan dinanak. Uji kuatitatif penentuan Glukosa menggunakan metode Anthrone Sulfat sedang analisisnya dengan metode Spektrofotometri. Hasil penelitian menunjukkan kadar rata-rata glukosa pada sampel nasi tanpa penambahan VCO sebesar 30,65%b/b, kadar rata-rata glukosa pada sampel nasi yang ditambahkan VCO dengan kadar 3% sebesar 28,46%b/b, kadar rata-rata glukosa pada sampel nasi yang ditambahkan VCO dengan kadar 4% sebesar 28,31%b/b, kadar rata-rata glukosa pada sampel nasi yang ditambahkan VCO dengan kadar 5% sebesar 18,78%b/b. Dari hasil penelitian dapat disimpulkan bahwa kadar Glukosa nasi terbaik adalah nasi yang ditambah VCO kadar 5%b/b. The majority of Indonesian population's food is rice, besides sago and corn. Diabetus Melitus sufferers, rice is a source of glucose that must be watched out so that rice intake must be limited. Virgin Coconut Oil (VCO) is oil derived from fresh old coconut (Cocos mucifera L) which is processed at a temperature of 100C-150C and not cooked until cooked. The purpose of this study was to determine the decrease in glucose levels in rice mixed with VCO (Virgin Cocot Oil). In this study samples from rice without the addition of VCO were compared with rice with the addition of VCO 3%, 4%, and 5% of the amount of rice to be cooked. Quantitative testing of Glucose determination using the Anthrone Sulfate method is being analyzed using the Spectrophotometry method. The results showed that the average glucose level in the rice sample without the addition of VCO was 30.65% b / b, the average glucose level in the rice sample added with VCO at 3% was 28.46% b / b, the average level The average glucose in the rice sample which was added by VCO at 4% level was 28.31% b / b, the average glucose level in the rice sample added with VCO at 5% level was 18.78% b / b. From the results of the study it can be concluded that the best rice glucose level is rice which is added to the VCO level of 5% b / b.

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The Prevalence and Outcome of Excess Body Weight Among Middle Eastern Patients Presenting With Acute Coronary Syndrome

Angiology ◽

10.1177/0003319709355801 ◽

2009 ◽

Vol 61 (5) ◽

pp. 456-464 ◽

Cited By ~ 8

Author(s):

Hadi A. R. Hadi ◽

Mohammad Zubaid ◽

Wael Al Mahmeed ◽

Ayman A. El-Menyar ◽

Alawi A. Alsheikh-Ali ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Body Weight ◽

Middle Eastern ◽

Excess Body Weight ◽

Coronary Syndrome

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Dexamethasone Administration in Mice Leads to Less Body Weight Gain over Time, Lower Serum Glucose, and Higher Insulin Levels Independently of NRF2

Antioxidants ◽

10.3390/antiox11010004 ◽

2021 ◽

Vol 11 (1) ◽

pp. 4

Author(s):

Fotini Filippopoulou ◽

George I. Habeos ◽

Vagelis Rinotas ◽

Antonia Sophocleous ◽

Gerasimos P. Sykiotis ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

Molecular Mechanisms ◽

Inflammatory Diseases ◽

Body Weight Gain ◽

Serum Glucose ◽

Dexamethasone Treatment ◽

Insulin Levels ◽

Glucose Levels ◽

High Insulin

Glucocorticoids are used widely on a long-term basis in autoimmune and inflammatory diseases. Their adverse effects include the development of hyperglycemia and osteoporosis, whose molecular mechanisms have been only partially studied in preclinical models. Both these glucocorticoid-induced pathologies have been shown to be mediated at least in part by oxidative stress. The transcription factor nuclear erythroid factor 2-like 2 (NRF2) is a central regulator of antioxidant and cytoprotective responses. Thus, we hypothesized that NRF2 may play a role in glucocorticoid-induced metabolic disease and osteoporosis. To this end, WT and Nrf2 knockout (Nrf2KO) mice of both genders were treated with 2 mg/kg dexamethasone or vehicle 3 times per week for 13 weeks. Dexamethasone treatment led to less weight gain during the treatment period without affecting food consumption, as well as to lower glucose levels and high insulin levels compared to vehicle-treated mice. Dexamethasone also reduced cortical bone volume and density. All these effects of dexamethasone were similar between male and female mice, as well as between WT and Nrf2KO mice. Hepatic NRF2 signaling and gluconeogenic gene expression were not affected by dexamethasone. A 2-day dexamethasone treatment was also sufficient to increase insulin levels without affecting body weight and glucose levels. Hence, dexamethasone induces hyperinsulinemia, which potentially leads to decreased glucose levels, as well as osteoporosis, both independently of NRF2.

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Effect of metformin on the expression of SNAER proteins in the skeletal muscle of rats with type 2 diabetes

Journal of Birjand University of Medical Sciences ◽

10.32592/jbirjandunivmedsci.2021.28.3.105 ◽

2021 ◽

pp. 270-278

Keyword(s):

Type 2 Diabetes ◽

Skeletal Muscle ◽

Body Weight ◽

Serum Insulin ◽

Serum Glucose ◽

Snare Complex ◽

Snare Proteins ◽

Glucose Levels ◽

Male Wistar Rats

Background and Aims: SNARE proteins are composed of a combination of SNAP-23, Stx-4, and VAMP-2 isoforms that are significantly expressed in skeletal muscle. These proteins control the transport of GLUT4 to the cell membranes. The modifications in the expression of SNARE proteins can cause Type 2 diabetes. The present study aimed to assess the effect of metformin on the expression of these proteins in rats. Materials and Methods: For the purpose of the study, 40 male Wistar rats were randomly selected. Streptozotocin and Nicotinamide were used for the induction of type 2 diabetes. The animals were assigned to five groups (n=8), including healthy and diabetic groups as control, as well as three experimental groups which were treated with different doses of metformin (100, 150, and 200 mg/kg body weight) for 30 days. The quantitative reverse transcription PCR (RT-qPCR) method was applied to evaluate the expression of SNARE complex proteins.. Results: Based on the results, metformin (100, 150, and 200 mg/kg body weight) decreased serum glucose levels and increased serum insulin levels. This difference in dose of 200 mg/kg body weight was statistically significant (P<0.05). Moreover, all three doses of metformin increased the expression of SNAP- 23, syntaxin-4, and VAMP-2 proteins in skeletal muscle tissue. Metformin at a dose of 200 mg/kg body weight demonstrated the most significant effects (P<0.05). Conclusion: As evidenced by the results of the current study, another anti-diabetic mechanism of metformin is to increase the expression of SNARE proteins, which effectively improves insulin resistance and lowers blood glucose.

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Enoxaparin in cardiovascular disease: how to improve effectiveness and safety?

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2011-6-112-123 ◽

2011 ◽

Vol 10 (6) ◽

pp. 112-123

Author(s):

I. S. Yavelov

Keyword(s):

Atrial Fibrillation ◽

Cardiovascular Disease ◽

Acute Coronary Syndrome ◽

Body Weight ◽

Standard Treatment ◽

Decision Strategy ◽

Elderly Age ◽

Treatment Protocols ◽

Coronary Syndrome ◽

Optimal Balance

The review analyses the specifics of enoxaparin therapy in the most prevalent cardiovascular diseases, such as acute coronary syndrome, venous thromboembolism, and atrial fibrillation. The decision strategy is presented for difficult and non-standard clinical situations (renal dysfunction, elderly age, heparin medication change, or abnormal body weight), when the optimal balance between effectiveness and safety requires modifying the standard treatment protocols.

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Blood Glucose Levels May Aid the Decision for CT Scan in Minor Head Trauma

Disease Markers ◽

10.1155/2019/1065254 ◽

2019 ◽

Vol 2019 ◽

pp. 1-4 ◽

Cited By ~ 5

Author(s):

George A. Alexiou ◽

Athanasios Sotiropoulos ◽

Georgios D. Lianos ◽

Andreas Zigouris ◽

Dimitrios Metaxas ◽

...

Keyword(s):

Blood Glucose ◽

Glucose Level ◽

Head Trauma ◽

Serum Glucose ◽

Common Mechanism ◽

Roc Curve Analysis ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Ct Findings ◽

Mechanism Of Trauma

Traumatic brain injury has been associated with increased blood glucose levels. In the present study, we set out to investigate if blood glucose level in mild head trauma could predict the need for CT. One hundred fifty-nine patients with minor TBI (GCS 13-15) and a mean age of44.8±23.8years were included in the study. The most common mechanism of trauma was falls. Patients with positive CT findings had significantly higher glucose levels than patients with negative CT findings. Using ROC curve analysis, serum glucose levels higher than 120 mg dl-1were the optimal cutoff value for the detection of patients with positive CT findings with a sensitivity of 74.4% and a specificity of 90.7%. Serum glucose level evaluation at presentation in the emergency department may aid CT decision-making in mild TBI.

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