scholarly journals A new oxidative derivatization method for spectrophotometric determination of Periciazine in pharmaceutical preparations

2019 ◽  
Vol 7 (2) ◽  
pp. 52-60 ◽  
Author(s):  
Mykola Blazheyevskiy ◽  
Valeriy Moroz
Keyword(s):  
Spectrophotometric Determination ◽  
Pharmaceutical Preparations ◽  
Drug Dosage ◽  
Official Method ◽  
Limit Of Quantification ◽  
Selective Method ◽  
Derivatizing Agent ◽  
Phenothiazine Drug ◽  
Good Agreement

A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the absorbative Periciazine sulfoxide at λmaх=362 nm is proposed. This reaction product was successfully employed for spectrophotometric determination of the Periciazine. The UV spectrophotometric determination of the Periciazine as its sulfoxide proved to be the more simple and selective method. Limit of quantification (LOQ=10S) is 2.8 µg·mL-1. The common excipients employed do not interfere in the determination of phenothiazine drug. Results of analysis of the drug dosage forms by the proposed method are in good agreement with those of the official method. RSD=1.76 % (δ <RSD).

scholarly journals The Oxidative Derivatization Method For The Indirect Spectrophotometric Determination Of Prochlorperazine In Tablets

2020 ◽  
Vol 15 (3) ◽  
pp. 132-136
Author(s):  
M.Ye. Blazheyevskiy ◽  
V.P. Moroz
Keyword(s):  
Spectrophotometric Determination ◽  
Official Method ◽  
Limit Of Quantification ◽  
Selective Method ◽  
Derivatizing Agent ◽  
Potassium Hydrogen ◽  
The Common ◽  
Tablet Dosage ◽  
Good Agreement

The oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Prochlorperazine Maleate is presented. Potassium hydrogen peroxymonosulfate as a derivatizing agent, yielding the Prochlorperazine sulfoxide with λmaх=338 nm is proposed. This reaction product was successfully employed for the spectrophotometric determination of the Prochlorperazine Maleate. The UV spectrophotometric determination of Prochlorperazinе as its sulfoxide proved to be the more robust and selective method. Concentration dependence of the oxidation product remains linear in the range of concentrations from 2 to 40 μg∙mL-1. Limit of quantification (LOQ) is 1.7 μg·mL-1. A new spectrophotometric technique was developed and the possibility of quantitative determination of Prochlorperazine Maleate in 5 mg Vetrinex tablets was demonstrated. The present method is precise and accurate. The common excipients employed do not interfere in the determination. Results of analysis of the tablet dosage form by the proposed method are in good agreement with those of the official method. RSD = 1.34 % (δ = ± 0.57 %).

scholarly journals Difference spectrophotometric method for the determination of Fluphenazine hydrochloride in tablets using peroxomonosulfate

2021 ◽  
Vol 9 (2) ◽  
pp. 64-71
Author(s):  
Mykola Blazheyevskiy ◽  
◽  
Valeriy Moroz ◽  
Olena Mozgova ◽  
◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Present Method ◽  
Molar Absorptivity ◽  
Limit Of Quantification ◽  
Derivatizing Agent ◽  
Sensitive Method

The oxidative derivatization method using potassium hydrogenperoxomonosulfate for the indirect spectrophotometric determination of Fluphenazine hydrochloride is presented. Potassium hydrogenperoxomonosulfate is introduced as a derivatizing agent for Fluphenazine hydrochloride, yielding the sulfoxide. This reaction product was successfully used for the spectrophotometric determination of the Fluphenazine hydrochloride. The UV spectroscopic detection of the sulfoxide proved to be a more robust and sensitive method. The elaborated method allowed the determination of Fluphenazine hydrochloride in the concentration range of 0.2-30 µg mL-1. The molar absorptivity at 349 nm is 5.6×103 (dm3cm-1mol-1). The limit of quantification, LOQ (10S) is 0.24 µg/mL. A new spectrophotometric technique was developed and the possibility of quantitative determination of Fluphenazine hydrochloride in tablets 5.0 mg was demonstrated. The present method is precise, accurate and excipients did not interfere. RSD for Fluphenazine Hydrochloride 5.0 mg tablets was 1.37 %.

scholarly journals Kinetic spectrophotometric determination of Bi(III) based on its catalytic effect on the oxidation of phenylfluorone by hydrogen peroxide

2009 ◽  
Vol 74 (8-9) ◽  
pp. 977-984
Author(s):  
Sofija Rancic ◽  
Snezana Nikolic-Mandic
Keyword(s):  
Hydrogen Peroxide ◽  
Spectrophotometric Determination ◽  
Reaction Rate ◽  
Catalytic Effect ◽  
Limit Of Detection ◽  
Kinetic Method ◽  
Limit Of Quantification ◽  
Kinetic Spectrophotometric ◽  
Good Agreement

A new reaction was suggested and a new kinetic method was elaborated for determination of Bi(III) in solution, based on its catalytic effect on the oxidation of phenyl-fluorone (PF) by hydrogen peroxide in ammonia buffer. By application of spectrophotometric technique, a limit of quantification (LQ) of 128 ng cm-3 was reached, and the limit of detection (LD) of 37 ng cm-3 was obtained, where LQ was defined as the ratio signal: noise = 10:1 and LD was defined as signal 3:1 against the blank. The RSD value was found to be in the range 2.8-4.8 % for the investigated concentration range of Bi(III). The influence of some ions upon the reaction rate was tested. The method was confirmed by determining Bi(III) in a stomach ulcer drug ('Bicit HP', Hemofarm A.D.). The obtained results were compared to those obtained by AAS and good agreement of results was obtained.

Spectrophotometric Determination of Atropine Sulfate in the Presence of Phenylmercury (II) Acetate

1981 ◽  
Vol 64 (4) ◽  
pp. 855-859
Author(s):  
Abdel Aziz M Wahbi ◽  
Magda Barary
Keyword(s):  
Least Squares ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Atropine Sulfate ◽  
Official Method ◽  
Method Of Least Squares ◽  
Orthogonal Function ◽  
Two Component ◽  
Good Agreement

Abstract Two-component spectrophotometric method of analysis using 2 wavelengths, the method of least squares using absorbances, the method using 2-orthogonal function coefficients, and the method of least squares using orthogonal function coefficients have been applied to the determination of atropine sulfate in the presence of phenylmercury (II) acetate, compounds whose spectra overlap. The first method gave erroneous results; the second method gave satisfactory results for synthetic mixtures. The fourth method was superior, especially in the presence of irrelevant absorption. It has been successfully used for determining atropine sulfate in injection solutions in which a cubic irrelevant absorption was present. Results were in good agreement with those obtained by the official method.

scholarly journals Quantitative determination of Levomepromazine in pharmaceuticals by spectrophotometric method as its sulfoxide

2020 ◽  
Vol 8 (1) ◽  
pp. 117-124
Author(s):  
Olena Mozgova ◽  
Mykola Blazheyevskiy
Keyword(s):  
Sodium Chloride ◽  
Citric Acid ◽  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Present Method ◽  
Limit Of Quantification ◽  
Derivatizing Agent ◽  
Sensitive Method

The oxidative derivatization method using Diperoxyazelaic acid for the indirect spectrophotometric determination of Levomepromazine hydrochloride is presented. Diperoxyazelaic acid is introduced as a derivatizing agent for Levomepromazine, yielding the sulfoxides. This reaction product was successfully used for the spectrophotometric determination of the Levomepromazine hydrochloride. The UV spectroscopic detection of the sulfoxide proved to be a more robust and sensitive method. The elaborated method allowed the determination of Levomepromazine hydrochloride in the concentration range of 3-150 µg/mL. The limit of quantification, LOQ (10S) is 2.85 µg/mL. A new spectrophotometric technique was developed and the possibility of quantitative determination of Levomepromazine in Tisercin Solution for Injection 25mg/mL was demonstrated. The present method is precise, accurate and other excipients: anhydrous citric acid, monothioglycerol, sodium chloride did not interfere. RSD = 1.24 % (δ = –0.02 %).

scholarly journals SPECTROPHOTOMETRIC DETERMINATION OF SOME PHARMACEUTICAL COMPOUNDS USING 2,2-DIPHENYL-1-PICRYLHYDRAZYL

2000 ◽  
Vol 68 (4) ◽  
pp. 403-419 ◽  
Author(s):  
Hesham Salem
Keyword(s):  
Hydrogen Atom ◽  
Spectrophotometric Determination ◽  
Diclofenac Sodium ◽  
Pharmaceutical Preparations ◽  
Standard Addition ◽  
Pharmaceutical Compounds ◽  
Radical Coupling ◽  
Violet Color ◽  
Good Agreement

A simple, rapid and sensitive spectrophotometric procedure for the assay of some drugs has been developed. The method is based on the reaction of the studied drugs with 2,2-diphenyl-1-picrylhydrazyl (DPPH). The latter is employed to abstract a hydrogen atom from the drugs thereby promoting a process of radical coupling. This results in a reduction of the violet color of DPPH with the formation of the yellow colored 2,2-diphenyl-1-picrylhydrazine (DPPH2). The decrease in the intensity of the violet color is used to measure the concentration of the drugs. All measurements are made at λ= 520 nm on methanolic solutions of the reagent and drugs. Beer's law is obeyed in the ranges of 5-30 µg/ml (for aceclofenac, diclofenac sodium and thiaprofenic acid), 2-15 µg/ml (for tenoxicam, furosemide and lansoprazole) and 2-12 µg/ml (for benoxinate hydrochloride and ritodrine). The validity of the method was tested by carrying out standard addition procedure analyzing the studied drugs in pure form as well as in their pharmaceutical preparations without interference from common additives. Results of the proposed methods are in good agreement with those of the official or reported methods.

Spectrophotometric Determination of Some Benzene Sulfonamides with 7,7,8,8-Tetracyanoquinodimethane

1989 ◽  
Vol 72 (6) ◽  
pp. 885-889 ◽  
Author(s):  
Abdel-Maboud I Mohamed
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Analytical Data ◽  
Pharmaceutical Preparations ◽  
Pure Form ◽  
Wide Range ◽  
Beer's Law ◽  
Beer’S Law ◽  
Good Agreement

Abstract A new spectrophotometric method for the determination of some unsubstituted benzene sulfonamides is presented. The method is based on the interaction of these derivatives with 7,7,8,8-tetracyanoquinodimethane at pH 9.0-9.5 to produce intense blue products. The quantitation of the products was carried out at 578 nm. Beer’s law was obeyed over a wide range of concentrations for all sulfonamide compounds studied. Optimum analytical conditions were determined, and the color produced was stable for at least 90 min at 25 °C. Analytical data for determination of sulfonamide compounds in pure form are presented together with application of the proposed method for analysis of some commercially available pharmaceutical preparations. The results are in good agreement with those obtained by official procedures.

scholarly journals A New Oxidative Derivatization Method For The Indirect Spectrofluorimetric Determination Of Prochlorperazine Maleate In Pharmaceutical Preparations

2019 ◽  
Vol 14 (3) ◽  
pp. 140-145
Author(s):  
M.Ye. Blazheyevskiy ◽  
Yu.V. Skrypynets ◽  
A.V. Yegorova ◽  
V.P. Antonovich
Keyword(s):  
Sulfuric Acid ◽  
Acid Solution ◽  
Quantitative Determination ◽  
Calibration Curve ◽  
Pharmaceutical Preparations ◽  
Limit Of Quantification ◽  
Highly Sensitive ◽  
Spectrofluorimetric Determination ◽  
Derivatizing Agent

A new oxidative derivatization method for the indirect spectrofluorimetric determination of Prochlorperazine maleate has been presented. Potassium hydrogenperoxomonosulphate is proposed as a derivatizing agent for Prochlorperazine, yielding the strongly fluorescent sulfoxide. This reaction product was successfully employed for the spectrofluorimetric determination of the Prochlorperazine maleate. A highly sensitive, simple and rapid method has been developed for determining prochlorperazine maleate in tablets by fluorescence of its oxidation product with Oxone solution in 0.01 M sulfuric acid solution (λex = 340 nm; λem = 380 nm). The calibration curve is linear in its concentration range of 0.8–10.0 µg/ml. Limit of quantification (LOQ = 10S) is 0.8 µg/ml. The possibility of quantitative determination of Prochlorperazine maleate in Vertinex® tablets 5 mg has been shown, RSD <2.3% (δ <RSD).

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