scholarly journals Quantitative determination of Levomepromazine in pharmaceuticals by spectrophotometric method as its sulfoxide

2020 ◽  
Vol 8 (1) ◽  
pp. 117-124
Author(s):  
Olena Mozgova ◽  
Mykola Blazheyevskiy
Keyword(s):  
Sodium Chloride ◽  
Citric Acid ◽  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Present Method ◽  
Limit Of Quantification ◽  
Derivatizing Agent ◽  
Sensitive Method

The oxidative derivatization method using Diperoxyazelaic acid for the indirect spectrophotometric determination of Levomepromazine hydrochloride is presented. Diperoxyazelaic acid is introduced as a derivatizing agent for Levomepromazine, yielding the sulfoxides. This reaction product was successfully used for the spectrophotometric determination of the Levomepromazine hydrochloride. The UV spectroscopic detection of the sulfoxide proved to be a more robust and sensitive method. The elaborated method allowed the determination of Levomepromazine hydrochloride in the concentration range of 3-150 µg/mL. The limit of quantification, LOQ (10S) is 2.85 µg/mL. A new spectrophotometric technique was developed and the possibility of quantitative determination of Levomepromazine in Tisercin Solution for Injection 25mg/mL was demonstrated. The present method is precise, accurate and other excipients: anhydrous citric acid, monothioglycerol, sodium chloride did not interfere. RSD = 1.24 % (δ = –0.02 %).

scholarly journals Difference spectrophotometric method for the determination of Fluphenazine hydrochloride in tablets using peroxomonosulfate

2021 ◽  
Vol 9 (2) ◽  
pp. 64-71
Author(s):  
Mykola Blazheyevskiy ◽  
◽  
Valeriy Moroz ◽  
Olena Mozgova ◽  
◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Present Method ◽  
Molar Absorptivity ◽  
Limit Of Quantification ◽  
Derivatizing Agent ◽  
Sensitive Method

The oxidative derivatization method using potassium hydrogenperoxomonosulfate for the indirect spectrophotometric determination of Fluphenazine hydrochloride is presented. Potassium hydrogenperoxomonosulfate is introduced as a derivatizing agent for Fluphenazine hydrochloride, yielding the sulfoxide. This reaction product was successfully used for the spectrophotometric determination of the Fluphenazine hydrochloride. The UV spectroscopic detection of the sulfoxide proved to be a more robust and sensitive method. The elaborated method allowed the determination of Fluphenazine hydrochloride in the concentration range of 0.2-30 µg mL-1. The molar absorptivity at 349 nm is 5.6×103 (dm3cm-1mol-1). The limit of quantification, LOQ (10S) is 0.24 µg/mL. A new spectrophotometric technique was developed and the possibility of quantitative determination of Fluphenazine hydrochloride in tablets 5.0 mg was demonstrated. The present method is precise, accurate and excipients did not interfere. RSD for Fluphenazine Hydrochloride 5.0 mg tablets was 1.37 %.

scholarly journals The quantitative determination of Perphenazine in tablets by the spectrophotometric method as its sulfoxide obtained with diperoxyazelaic acid

2019 ◽  
Vol 7 (2) ◽  
pp. 96-103
Author(s):  
Mykola Blazheyevskiy ◽  
Myhailo Kucher ◽  
Oleh Shpychak
Keyword(s):  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Present Method ◽  
Derivatizing Agent

The oxidative derivatization method using diperoxyazelaic acid for the indirect spectrophotometric determination of Perphenazine dihydrochloride is presented. Diperoxyazelaic acid is introduced as a derivatizing agent for Perphenazine, yielding sulfoxides. This reaction product was successfully employed for the spectrophotometric determination of Perphenazine dihydrochloride. The UV spectroscopic detection of sulfoxide has been proven to be the more robust and selective. The method developed allowed determination of Perphenazine dihydrochloride in the concentration range of 1–40 µg/mL. The limits of quantification (LOQ=10S) is 3.3 µg·ml-1. A new spectrophotometric method has been developed, and the possibility of the quantitative determination of Perphenazine dihydrochloride in Perphenazine Tablets has been demonstrated. The present method is precise, accurate and other inactive excipients of the drug do not interfere. RSD = 2.00%; δ=( -µ) 100%/µ = – 0.85 %).

scholarly journals Spectrophotometric quantitative analysis of metronidazole and itraconazole in a combined preparation made on the basis of Tizol gel

2020 ◽  
Vol 20 (5-6) ◽  
pp. 157-163
Author(s):  
Anna I. Zamaraeva ◽  
Natalya S. Bessonova ◽  
Tatyana A. Kobeleva ◽  
Alik I. Sichko
Keyword(s):  
Quantitative Analysis ◽  
Quantitative Determination ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Dosage Form ◽  
Statistical Processing ◽  
Ultraviolet Region ◽  
System Of Equations ◽  
Base Materials

Actuality. Nowadays, the problems of effectiveness and accessibility of dermatoprotective therapy and prevention of dermatological diseases are urgent. The complex use of metronidazole in combination with drugs of other pharmacological groups is particularly relevant and promising. The dosage form consisting of 0.1 g of Itraconazole, 0.1 g of metronidazole and Tizol gel up to 10 g, termed by us Metroitraconazole, can be used in dermatology, ophthalmology and gynecology as a bactericidal and antifungal agent. The aim of the study is to develop the method for the quantitative spectrophotometric determination of metronidazole and itraconazole in a soft dosage form on a titanium-containing base. Materials and methods. For the analysis, we used substances, ethanol solutions of Metronidazole and Itraconazole, an ointment with the conditional name Metroitraconazole, containing 1.0% of the preparations in the Tizol gel. The study was carried out by spectrophotometry in the ultraviolet region, using spectrophotometer SF-2000 (Russia). Results. The study of the absorption spectra and statistical processing of the finding demontstrated that spectrophotometric determination of Itraconazole and metronidazole demanded the wavelengths of 262 and 312 nm, with a relative error of 1.52% and 1.67%, respectively. As a result of the analysis of the soft dosage form, it was determined that the content of metronidazole calculated with the use of Firordt method and a simplified system of equations ranged 0.0987-0.1057 g, and Itraconazole ranged 0.0925-0.1055 g. These data conformed the acceptance criteria. Conclusion. The conducted research allowed us to develop and propose a method for the quantitative determination of itraconazole and metronidazole in Metroitraconazole ointment by means of spectrophotometric method. It allowed us to determine the content of drugs in the dosage form with an error not exceeding the standard deviations.

scholarly journals Spectrophotometric determination of neomycin sulphate in tablets form via reaction with ninhydrin reagent

2019 ◽  
Vol 10 (2) ◽  
pp. 1392-1396 ◽  
Author(s):  
Khalaf F Alsamarrai ◽  
Menaa Abdulsalam Al-Abbasi ◽  
Eman Thiab Alsamarrai
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Calibration Curve ◽  
Limit Of Detection ◽  
Basic Medium ◽  
Optimal Conditions ◽  
Limit Of Quantification ◽  
Maximum Absorbance ◽  
Ninhydrin Reagent

A new, sensitive, simple and cheap spectrophotometric method for the determination of Neomycin Sulphate (NEO) in pharmaceutical forms has been developed. The method is based on the reaction between NEO and NIN in basic medium. The maximum absorbance was at 574 nm. The conditions affecting the reaction were optimized. Under the optimal conditions, the calibration curve was linear over the range of 0.0002-0.0011 mol/L. The limit of detection and limit of quantification were 5.423×10-6 mol/L, and 1.643×10-5 mol/L, RSD% of seven replicate was 0.8217- 0.8321% and Rec% was between 99.2168-100.8857%. The proposed method was successfully applied to the determination of NEO tablets form.

Spectrophotometric Determination of Ethchlorvynol in Biologic Specimens

1974 ◽  
Vol 20 (2) ◽  
pp. 159-162 ◽  
Author(s):  
Jack E Wallace ◽  
Horace E Hamilton ◽  
Joel A Riloff ◽  
Kenneth Blum
Keyword(s):  
Quantitative Determination ◽  
Ultraviolet Light ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Product Mixture

Abstract A sensitive, highly specific spectrophotometric method for quantitative determination of ethchlorvynol in biologic specimens is described. The procedure is based on conversion of ethchlorvynol to a product mixture consisting of two major components that strongly absorb ultraviolet light. Results can be obtained within 45 min of receipt of a specimen.

scholarly journals A new oxidative derivatization method for spectrophotometric determination of Periciazine in pharmaceutical preparations

2019 ◽  
Vol 7 (2) ◽  
pp. 52-60 ◽  
Author(s):  
Mykola Blazheyevskiy ◽  
Valeriy Moroz
Keyword(s):  
Spectrophotometric Determination ◽  
Pharmaceutical Preparations ◽  
Drug Dosage ◽  
Official Method ◽  
Limit Of Quantification ◽  
Selective Method ◽  
Derivatizing Agent ◽  
Phenothiazine Drug ◽  
Good Agreement

A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the absorbative Periciazine sulfoxide at λmaх=362 nm is proposed. This reaction product was successfully employed for spectrophotometric determination of the Periciazine. The UV spectrophotometric determination of the Periciazine as its sulfoxide proved to be the more simple and selective method. Limit of quantification (LOQ=10S) is 2.8 µg·mL-1. The common excipients employed do not interfere in the determination of phenothiazine drug. Results of analysis of the drug dosage forms by the proposed method are in good agreement with those of the official method. RSD=1.76 % (δ <RSD).

The acidolysis of p-nitrophenyl sulfate. A kinetic spectrophotometric method for evaluation of pKa

1976 ◽  
Vol 54 (5) ◽  
pp. 673-677 ◽  
Author(s):  
Erwin Buncel ◽  
Claudio Chuaqui
Keyword(s):  
Satisfactory Agreement ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Present Method ◽  
Acid Catalyzed ◽  
Kinetic Spectrophotometric

A kinetic spectrophotometric method for evaluation of pKa has been developed. In the present study this has been utilized towards the pKa determination, in methanol, of the conjugate acids of 4-picoline, aniline, hydroxylamine, methoxyamine, and hydrazinium ion. For the first two cases the pKa values determined by the present method could be compared with the potentiometrically measured values, in a methanol solvent, with satisfactory agreement. Our proposed method involves essentially the spectrophotometric determination of the rate of the acid catalyzed conversion of p-nitrophenyl sulfate to p-nitrophenol in methanol in the presence of the acidic species whose pKa in this medium is required.

scholarly journals A New Oxidative Derivatization Method For The Indirect Spectrofluorimetric Determination Of Prochlorperazine Maleate In Pharmaceutical Preparations

2019 ◽  
Vol 14 (3) ◽  
pp. 140-145
Author(s):  
M.Ye. Blazheyevskiy ◽  
Yu.V. Skrypynets ◽  
A.V. Yegorova ◽  
V.P. Antonovich
Keyword(s):  
Sulfuric Acid ◽  
Acid Solution ◽  
Quantitative Determination ◽  
Calibration Curve ◽  
Pharmaceutical Preparations ◽  
Limit Of Quantification ◽  
Highly Sensitive ◽  
Spectrofluorimetric Determination ◽  
Derivatizing Agent

A new oxidative derivatization method for the indirect spectrofluorimetric determination of Prochlorperazine maleate has been presented. Potassium hydrogenperoxomonosulphate is proposed as a derivatizing agent for Prochlorperazine, yielding the strongly fluorescent sulfoxide. This reaction product was successfully employed for the spectrofluorimetric determination of the Prochlorperazine maleate. A highly sensitive, simple and rapid method has been developed for determining prochlorperazine maleate in tablets by fluorescence of its oxidation product with Oxone solution in 0.01 M sulfuric acid solution (λex = 340 nm; λem = 380 nm). The calibration curve is linear in its concentration range of 0.8–10.0 µg/ml. Limit of quantification (LOQ = 10S) is 0.8 µg/ml. The possibility of quantitative determination of Prochlorperazine maleate in Vertinex® tablets 5 mg has been shown, RSD <2.3% (δ <RSD).

scholarly journals The Oxidative Derivatization Method For The Indirect Spectrophotometric Determination Of Prochlorperazine In Tablets

2020 ◽  
Vol 15 (3) ◽  
pp. 132-136
Author(s):  
M.Ye. Blazheyevskiy ◽  
V.P. Moroz
Keyword(s):  
Spectrophotometric Determination ◽  
Official Method ◽  
Limit Of Quantification ◽  
Selective Method ◽  
Derivatizing Agent ◽  
Potassium Hydrogen ◽  
The Common ◽  
Tablet Dosage ◽  
Good Agreement

The oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Prochlorperazine Maleate is presented. Potassium hydrogen peroxymonosulfate as a derivatizing agent, yielding the Prochlorperazine sulfoxide with λmaх=338 nm is proposed. This reaction product was successfully employed for the spectrophotometric determination of the Prochlorperazine Maleate. The UV spectrophotometric determination of Prochlorperazinе as its sulfoxide proved to be the more robust and selective method. Concentration dependence of the oxidation product remains linear in the range of concentrations from 2 to 40 μg∙mL-1. Limit of quantification (LOQ) is 1.7 μg·mL-1. A new spectrophotometric technique was developed and the possibility of quantitative determination of Prochlorperazine Maleate in 5 mg Vetrinex tablets was demonstrated. The present method is precise and accurate. The common excipients employed do not interfere in the determination. Results of analysis of the tablet dosage form by the proposed method are in good agreement with those of the official method. RSD = 1.34 % (δ = ± 0.57 %).

Collaborative Study of the Spectrophotometric Determination of Procainamide Hydrochloride

1976 ◽  
Vol 59 (4) ◽  
pp. 807-810
Author(s):  
Jeffrey C Hamm
Keyword(s):  
Sodium Hydroxide ◽  
Acid Medium ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Collaborative Study ◽  
Dosage Forms ◽  
Standard Deviations

Abstract The USP analysis for procainamide HCl is titrimetric and relatively nonspecific, capsule and tablet dyes may interfere, and the method is not applicable to coated tablets. In the spectrophotofluorometric method the sample deteriorates when exposed to a xenon source. In the ultraviolet spectrophotometric method reported here, the sample is dispersed in acid medium, possible interferences are extracted in chloroform, base is added, procainamide is extracted in chloroform, the residue is dissolved in sodium hydroxide, and the compound is measured by absorption at 272 nm and comparison with a standard. Recoveries of standards added to capsule, tablet, and injection composites ranged from 99.3 to 102%. Twelve collaborators reported duplicate assay results for all 3 dosage forms with per cent standard deviations for 5 samples ranging from 1.01 to 1.27%. The method has been adopted as official first action.

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