Magnesium-containing composition influencing morphological parameters and gelatinase B activity in endometrial tissues in experimental chronic endometrial inflammation

Aim: to assess an effect of medicinal magnesium-containing composition on gelatinase B expression intensity and morphological parameters of chronic experimental endometrial inflammation.Materials and Methods. There were conducted experiments with 60 sexually mature female Wistar rats to determine an effect of medicinal magnesium-containing composition (contains magnesium chloride – a natural polymineral Bischofite) on gelatinase B activity in endometrial tissues (counting number of gelatinase-B-positive cells and intensity of gelatinase B expression), morphological parameters of cell infiltration, as well as amount of magnesium in red blood cell mass collected from the inferior vena cava and subclavian vein. All such parameters were assessed in experimental animals from 4 groups: group 1 – animals in baseline state, group 2 – control, group 3 – experimental chronic endometritis (CE), group 4 – experimental CE after treatment with medicinal magnesium-containing composition. Results. It was found that use of medicinal magnesium-containing composition increased amount of erythrocyte magnesium up to the baseline level and increased both number and expression intensity of stromal gelatinase B-positive cells. In addition, magnesium level in erythrocyte mass from the inferior vena cava was increased and accompanied with restored eosinophil-plasmacyte as well as significantly elevated macrophage-lymphocyte infiltration in endometrial tissues compared to CE animals lacking therapy. Conclusion. The results of this study allow us to conclude about importance of gelatinase B in pathogenesis of experimental chronic endometrial inflammation as well as an opportunity of regulating gelatinase B activity by applying medicinal magnesium containing drug in pathogenetic therapy of experimental CE.

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Optimization of proper diagnosis of thromboses associated with high risk of embolism in patients with neoplasms

Kazan medical journal ◽

10.17816/kmj1589 ◽

2013 ◽

Vol 94 (2) ◽

pp. 202-207

Author(s):

I A Kamalov ◽

I R Agliullin ◽

M G Tukhbatullin

Keyword(s):

Pulmonary Embolism ◽

High Risk ◽

Inferior Vena Cava ◽

Distal Part ◽

Inferior Vena ◽

Vena Cava ◽

Main Group ◽

Control Group ◽

Proper Diagnosis ◽

Antineoplastic Treatment

Aim. To optimize a proper diagnosis of thromboses associated with high risk of embolism and pulmonary embolism prevention in patients with neoplasms. Methods. Ultrasonography of veins of lower extremities, iliac veins and the distal part of inferior vena cava was performed in patients with and without neoplasms in a prospective study to detect thromboses associated with high risk of embolism and thrombophlebitis. Ultrasonography was performed once in control group subjects, and before and during specialized antineoplastic treatment (surgical, chemotherapy, radiotherapy) in patients of the main group, the results were compared. A detection of a new thrombus in previously intact venous segment of inferior vena cava system was assessed as a high risk for pulmonary embolism. Results. Thromboses associated with high risk of embolism and thrombophlebitis were found in 6 patients of control group, in 5 patients of the main group before and in 27 patients of the main group while at specialized antineoplastic treatment. Specific measures for pulmonary embolism prevention were taken immediately in all of the cases according to ultrasonography results after the detection of thromboses associated with high risk of embolism. No fatal cases of pulmonary embolism were registered both in main (before and while at treatment) and control groups. Conclusion. Ultrasonography of veins of lower extremities, iliac veins and the distal part of inferior vena cava in patients with neoplasms before the start of specialized antineoplastic treatment allows to optimize the choice of prevention measures for pulmonary embolism and thus significantly decreases mortality from pulmonary embolism.

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Infrahepatic Inferior Vena Cava Clamping does not Increase the Risk of Pulmonary Embolism Following Hepatic Resection

World Journal of Surgery ◽

10.1007/s00268-021-06159-4 ◽

2021 ◽

Author(s):

Emrullah Birgin ◽

Arianeb Mehrabi ◽

Dorothée Sturm ◽

Christoph Reißfelder ◽

Jürgen Weitz ◽

...

Keyword(s):

Pulmonary Embolism ◽

Inferior Vena Cava ◽

Hepatic Resection ◽

Inferior Vena ◽

Venous Pressure ◽

Vena Cava ◽

Bile Leakage ◽

Perioperative Outcomes ◽

Control Group ◽

The Impact

Abstract Background Infrahepatic inferior vena cava (IVC) clamping reduces central venous pressure. However, controversies remain regarding its impact on postoperative complications, particularly, the incidence of postoperative pulmonary embolism (PE). The aim of the study was to determine the impact of IVC clamping on the incidence of PE in patients undergoing hepatectomy. Methods A pooled analysis of five prospective trials on patients who underwent hepatic resection over a period of 10 years was performed. Patients with infrahepatic IVC clamping were compared to patients without infrahepatic IVC clamping. Outcomes were studied by univariate and multivariate analyses. Results Of 505 included patients, 141 patients had IVC clamping and 364 patients served as control group. The rate of postoperative PE was comparable between groups (3% vs. 3%; P = 0.762), as were postoperative morbidity (P = 0.932), bile leakage (P = 0.272), posthepatectomy hemorrhage (P = 0.095), and posthepatectomy liver failure (P = 0.605), respectively. No clinicopathological and intraoperative risk factors were found to predict the onset of PE. Subgroup analyses of patients with major hepatectomy and vascular resections confirmed no adverse perioperative outcomes to be associated with IVC clamping. Conclusions Infrahepatic IVC clamping does not increase the incidence of postoperative PE.

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Prevention of Contrast-Induced Nephropathy by Inferior Vena Cava Ultrasonography-Guided Hydration in Chronic Heart Failure Patients

Cardiology ◽

10.1159/000512434 ◽

2021 ◽

pp. 1-8

Author(s):

Yuanming Yan ◽

Mingfang Ye ◽

Xianfeng Dong ◽

Qin Chen ◽

Huashan Hong ◽

...

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Coronary Angiography ◽

Inferior Vena Cava ◽

Inferior Vena ◽

Vena Cava ◽

Control Group ◽

Contrast Induced Nephropathy ◽

Heart Failure Patients ◽

Significant Difference

Introduction: Contrast-induced nephropathy (CIN) is a common complication resulting from the administration of contrast media. This study was designed to determine whether inferior vena cava (IVC) ultrasonography (IVCU)-guided hydration can reduce the risk of CIN in chronic heart failure patients undergoing coronary angiography or coronary angiography with percutaneous coronary intervention compared with standard hydration. Methods: This prospective clinical trial enrolled 207 chronic heart failure patients from February 2016 to November 2017, who were randomly assigned to either the IVCU-guided hydration group (n = 104) or the routine hydration group (n = 103). In the IVCU-guided group, the hydration infusion rate was set according to the IVC diameter determined by IVCU, while the control group received intravenous infusion of 0.9% saline at 0.5 mL/(kg·h). Serum Cr was measured before and 48–72 h after the procedure. All patients were followed up for 18 months. The incidence of nephropathy and major adverse cardiovascular or cerebrovascular events (MACCEs) was also compared between the 2 groups. Results: Statistically significant difference between the 2 groups regarding the occurrence of CIN was observed (12.5 vs. 29.1%, p = 0.004). The hydration volume of the IVCU-guided group was significantly higher than that of the routine group (p < 0.001). In addition, patients receiving IVCU-guided hydration had significantly lower risk of developing MACCEs than patients in the control group during the 18-month follow-up (14.4 vs. 27.2%, p = 0.027). Conclusion: Our findings support that IVCU-guided hydration is superior to standard hydration in prevention of CIN and may substantially reduce longtime composite major adverse events.

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Required frequency of ultrasonography for detection of thrombosis with high risk for embolism in patients with malignancies

Kazan medical journal ◽

10.17816/kmj2180 ◽

2013 ◽

Vol 94 (3) ◽

pp. 335-339

Author(s):

I A Kamalov ◽

I R Agliullin ◽

M G Tukhbatullin ◽

I R Safin

Keyword(s):

Pulmonary Embolism ◽

High Risk ◽

Inferior Vena Cava ◽

Inferior Vena ◽

Vena Cava ◽

Clinical Signs ◽

Lower Extremities ◽

Main Group ◽

Control Group ◽

Venous Blood Flow

Aim. To determine the optimal terms for detection of thrombosis with high risk for embolism in patients with malignancies receiving specialized treatment. Methods. 117 patients (50 males, 67 females - the main group) with malignancies were randomly picked out (using the random numbers tables) underwent daily ultrasonography of inferior vena cava tributaries for detection of thrombosis with high risk for embolism. Ultrasonography of inferior vena cava distal part, both common iliac veins and veins of lower extremities was done in patients while on surgical treatment, chemotherapy or radiotherapy. The control group consisted of 130 patients (58 males, 72 females) with malignancies in whom ultrasonography was performed only if clinical signs of venous thrombosis were present. Results. Ultrasonic features of venous blood flow decrease (spontaneous contrast phenomenon) in veins of lower extremities were found in 27 out of 117 main group patients on the second day. On the third day features of saphenous veins thrombosis were found in 13 patients. On the fourth day, 4 patients were diagnosed with iliofemoral thrombosis. 5 more patients developed ultrasonic features of venous blood flow decrease (spontaneous contrast phenomenon) on the fourth and fifth day. Signs of thrombosis progression and floating thrombus were found in 6 patients on the 6th and 7th day. No fatal cases of pulmonary embolism were registered in the main group. 10 patients of the control group had clinical signs of inferior vena cava tributaries and underwent distal part of inferior vena cava, both common iliac veins and veins of lower extremities ultrasonography while on specialized treatment. 5 cases of pulmonary embolism were reported in the rest of the control group patients (120 patients). Conclusion. Inferior vena cava tributaries thrombosis with high risk for embolism in patients with malignancies can be reliably detected by repeating ultrasonography every 3-4 days; Reliable diagnosis of thrombosis with high risk for embolism by means of ultrasonography during the post-surgical period allows to prevent pulmonary embolism in a timely and targeted manner.

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Improved Removal Rates for Retrievable Inferior Vena Cava Filters with the Use of a ‘Filter Registry’

The American Surgeon ◽

10.1177/000313481207800143 ◽

2012 ◽

Vol 78 (1) ◽

pp. 94-97 ◽

Cited By ~ 13

Author(s):

Michael Kalina ◽

Marilyn Bartley ◽

Mark Cipolle ◽

Glen Tinkoff ◽

Scott Stevenson ◽

...

Keyword(s):

Logistic Regression ◽

Inferior Vena Cava ◽

Inferior Vena ◽

Vena Cava ◽

Control Group ◽

Stepwise Logistic Regression ◽

Removal Rates ◽

Inferior Vena Cava Filters ◽

Vena Cava Filters ◽

Significant Difference

The American Association for the Surgery of Trauma challenged the trauma community to improve a 22 per cent average removal rate for retrievable inferior vena cava filters (r-IVCFs). Since 2006, we maintained a “filter registry” documenting all IVCFs placed in trauma patients. Our goal was to improve removal rates for r-IVCF. Patients receiving an IVCF before implementation of filter registry, 2003–2005, comprised the control group. Patients receiving an IVCF after implementation of filter registry, 2006–2009, comprised the study group. Data obtained included age, gender, Injury Severity Score (ISS), length of stay (LOS), mortality, filter inserted, placement indication, removal rates, and reasons why removal did not occur. Fisher exact test and chi square were used for nominal variables. Stepwise logistic regression analysis was used to define predictors of removing and not removing an IVCF. Three hundred seven patients received an IVCF, 142 preregistry and 165 post-registry. No significant difference existed between groups in age, gender, ISS, placement indication, or mortality. A significant difference existed between groups in LOS and presence of deep vein thrombosis (DVT) and pulmonary embolism. A total of 98.2 per cent of postregistry patients received a Günther Tulip filter and all retrievals were performed by Interventional Radiology. Retrieval rates improved, 15.5 to 31.5 per cent post registry ( P < 0.001). No differences existed in lost to follow-up (LTF) between groups. Univariate analysis identified age, IVC clot, DVT, and LTF as predictors for not removing a filter. Stepwise logistic regression revealed the filter registry independently predicts the removal of an r-IVCF. A filter registry is effective in improving rates of removal for r-IVCFs.

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A multidisciplinary quality improvement program increases the inferior vena cava filter retrieval rate

Vascular Medicine ◽

10.1177/1358863x16676658 ◽

2016 ◽

Vol 22 (1) ◽

pp. 51-56 ◽

Cited By ~ 12

Author(s):

John P Winters ◽

Christopher S Morris ◽

Chris E Holmes ◽

Patricia Lewis ◽

Anant D Bhave ◽

...

Keyword(s):

Inferior Vena Cava ◽

Inferior Vena ◽

Control Period ◽

Vena Cava ◽

Controlled Study ◽

Control Group ◽

Ivc Filter ◽

Improvement Program ◽

Filter Retrieval ◽

Ivc Filters

Published reports indicate low retrieval rates for retrievable inferior vena cava (IVC) filters. We performed a historic-controlled study of a 5-year intervention (March 2007 to February 2012) to improve IVC filter retrieval rates at a university medical center serving a rural area. All adults with a retrievable filter placed were included, except those with a life expectancy <6 months. The intervention included initial verbal counseling and printed educational materials, correspondence after discharge, and a hematology consultation. The control group included patients with retrievable filters placed in the 15 months preceding study initiation. In the control group, 116 filters were placed and 27 (23%) were removed, compared to 378 filters placed and 169 (45%) removed during the intervention. Adjusting for patient characteristics, the odds ratio of retrieval during the intervention was 3.03 (95% CI 1.85–4.27) compared to the control period. An intervention including patient education and hematology follow-up appeared to significantly improve IVC filter retrieval rates.

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Pulmonary embolism prevention in out-patients with malignancies during the first year of follow-up

Kazan medical journal ◽

10.17750/kmj2015-013 ◽

2015 ◽

Vol 96 (1) ◽

pp. 13-16

Author(s):

R Sh Khasanov ◽

I A Kamalov

Keyword(s):

Pulmonary Embolism ◽

High Risk ◽

Inferior Vena Cava ◽

Venous Thrombosis ◽

Inferior Vena ◽

Vena Cava ◽

Clinical Manifestations ◽

Main Group ◽

Control Group ◽

Very High

Aim. To decrease the one-year mortality rate in out-patients with malignancies undergoing periodic health examination.Methods. The study included 270 patients, who were examined and followed up. The main group included 140 patients, who monthly underwent ultrasonography of inferior vena cava branches during the first year of follow-up. The control group included 130 patients, in whom ultrasonography of inferior vena cava branches was performed only if clinical manifestations of venous thrombosis were registered.Results. Venous thrombosis was diagnosed in 35 patients of the main group, including 21 cases of venous thrombosis at very high risk for embolism. In control group, ultrasonography of inferior vena cava branches was performed in 13 patients who developed clinical manifestations of venous thromboembolic events, in whom 6 patients were diagnosed with deep vein thrombosis of the lower limbs, in 3 patients venous thrombosis was assessed as at very high risk for embolism. In 24 patients (21 in the main group and 3 in the control group), targeted measures to prevent pulmonary embolism were administered, including cava filter implantation, vein ligation above the venous thrombosis at very high risk for embolism site, and crossectomy. The rest of the patients were administered conservative prevention of thromboembolism. In the main group, no deaths associated with pulmonary embolism were registered. In the control group, 19 patients died due to developing pulmonary embolism.Conclusion. Preventive measures for pulmonary embolism, selected according to the results of timely ultrasound diagnosis of venous thrombosis, may reduce the one-year mortality rate in patients with cancer.

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Fluid administration guided by inferior vena cava ultrasound before spinal anaesthesia may reduce post procedural hypotension rate

10.1101/2021.06.20.21258944 ◽

2021 ◽

Author(s):

Mathieu Favre ◽

Samuele Ceruti ◽

Maira Biggiogero ◽

Michele Musiari ◽

Andrea Glotta ◽

...

Keyword(s):

Inferior Vena Cava ◽

Arterial Pressure ◽

Spinal Anesthesia ◽

Inferior Vena ◽

Reduction Rate ◽

Vena Cava ◽

Clinical Signs ◽

Test Group ◽

Control Group ◽

Group I

PURPOSE: This study was conducted to estimate the incidence of hypotension after spinal anesthesia after inferior vena cava ultrasound (IVCUS) guided volaemic optimization compared with a control group in patients undergoing elective surgery. According to ESICM guidelines, hypotension was defined as two systolic arterial pressure (SAP) measurements < 80 mmHg and / or a mean arterial pressure (MAP) < 60 mmHg, or a drop in SAP of more than 50 mmHg or more than 25% from baseline, or a decrease in MAP by more than 30% from baseline and / or clinical signs/symptoms of inadequate perfusion. MATERIALS AND METHODS: From May 2014 to February 2019, a prospective, controlled, randomised, three-arm, parallel-group trial was performed in our tertiary hospital. In the IVCUS group (I, 132 patients) and passive leg raising test group (L, 148 patients), a pre-anaesthesia volume optimization was achieved following a fluid response protocol. In control group (C, 149 patients), no specific intervention was performed. RESULTS: 474 patients were collected. In group I, hypotension rate was 35%. In group L hypotension rate was 44%. In group C hypotension rate was 46%. An 11% reduction rate in hypotension (95% CI -1 to -24%, P=0.047) was observed between the group I and the group C. A 2% reduction rate in hypotension (95% CI -3 to -5%, P=0.428) was observed between group L and the group C. Total fluid amount administered was greater in the I group I than in the group C (593 ml versus 453 ml, P=0.015) and greater in the group L than the group C (511 ml versus 453 ml, P=0.11). CONCLUSION: IVCUS guided fluid optimization decrease the incidence of arterial hypotension after spinal anesthesia.

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Abstract 14936: Prevention of Contrast-induced Nephropathy by Inferior Vena Cava Ultrasonography-guided Hydration in Chronic Heart Failure Patients

Circulation ◽

10.1161/circ.142.suppl_3.14936 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Yuanming Yan ◽

Mingfang Ye ◽

qin chen ◽

yukun luo

Keyword(s):

Heart Failure ◽

Chronic Heart Failure ◽

Coronary Angiography ◽

Inferior Vena Cava ◽

Inferior Vena ◽

Vena Cava ◽

Control Group ◽

Contrast Induced Nephropathy ◽

Heart Failure Patients ◽

Significant Difference

Introduction: Contrast-induced nephropathy (CIN) is a common complication resulting from the administration of contrast media. This study was designed to determine whether inferior vena cava ultrasonography (IVCU)-guided hydration can reduce the risk of CIN in chronic heart failure patients undergoing coronary angiography or coronary angiography with percutaneous coronary intervention (PCI) than standard hydration. Methods: This prospective clinical trial enrolled 207 chronic heart failure patients from February 2016 to November 2017, who were randomly assigned to either IVCU-guided hydration group (n = 104) or the routine hydration group (n = 103). In the IVCU-guided group, the hydration infusion rate was set according to inferior vena cava diameter (IVC-D) determined by IVCU; while the control group received intravenous infusion of 0.9% saline at 0.5 ml/((kg·h)). Serum creatinine (SCr) was measured before and 48-72 hours after procedure. All patients were followed up for 18 months. The incidence of nephropathy and major adverse cardiovascular or cerebrovascular events (MACCE) were also compared between two groups. Results: Statistically significant difference between two groups regarding the occurrence of CIN were observed (12.5% vs. 29.1%, p = 0.003); The hydration volume of the IVCU-guided group is significantly higher than routine group (p<0.001). In addition, patients receiving IVCU-guided hydration had significantly lower risk of developing MACCE compared with patients in control group during 18 months follow-up (14.4% vs. 27.2%, p = 0.027). Conclusions: IVCU-guided hydration is superior to standard hydration in prevention of CIN and substantially reduce longtime composite major adverse events.

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