scholarly journals Bone remodeling in patients with type I and type II diabetes mellitus in pre- and postmenopausal periods

2020 ◽  
Vol 14 (5) ◽  
pp. 611-618
Author(s):  
S. S. Safarova ◽  
S. S. Safarova
Keyword(s):  
Diabetes Mellitus ◽  
Lumbar Spine ◽  
Bone Remodeling ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Type I ◽  
Type Ii ◽  
Reparative Osteogenesis ◽  
T Score

Aim: to perform structural and functional analysis of the activity of reparative osteogenesis processes at pre- and postmenopausal women with diabetes mellitus (DM).Materials and Methods. There were enrolled 142 pre- and postmenopausal patients with type I and type II diabetes mellitus type (DM-1 and DM-2) as well as 43 females in control group. Subjects taking medicines acting on bone metabolism comorbid with chronic diseases were excluded from the study. All patients underwent Dual-energy X-ray Absorptiometry (DXA) to assess bone mineral density (BMD, T-score). Serum markers of bone remodeling (alkaline phosphatase, ALP; procollagen type I N propeptide, PINP; beta-Cross laps, b-CTx), metabolic and hormone parameters (glycated hemoglobin, parathyroid hormone, calcitonin, vitamin D, electrolytes) were also measured.Results. A positive correlation was found between the duration of DM-1 and DM-2 and b-CTx level (DM-1: г = 0.349, р = 0.08; DM-2: г = 0.214, р = 0.04). A negative correlation was found between the lumbar spine T-score and the duration of diabetes (DM-1: r = -0.568, p = 0.001; DM-2: r = -0.267, p = 0.04). A statistically significant correlation was found between the lumbar spine T-score and b-CTx levels (DM-1: r = -0.452, p = 0.002; DM-2: r = -0.357, p = 0.09).Conclusion. The results of current study suggest that reparative osteogenesis in patients with post-menopausal DM-1 vs. DM-2 and the control group was moderately increased. In patients with DM-2, a less pronounced change in BMD was determined in parallel with inconsistent bone remodeling processes, which casts doubt on the ability of DXA to predict fractures in these patients. Such changes contribute to decreased bone quality, which distinguishes diabetic osteopathy from traditional menopausal osteoporosis manifested mainly by low BMD. 

Knowledge of Hypoglycemic Symptoms and their Self-Management among patients with Type II Diabetes Mellitus

2021 ◽  
Vol 15 (11) ◽  
pp. 2961-2962
Author(s):  
Aneel Kumar ◽  
Zahid Ali Shaikh ◽  
Sham Lal Prithiani ◽  
Bashir Ahmed Shaikh ◽  
Imdad Ali Ansari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Self Management ◽  
Type I ◽  
Type Ii ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Adequate Knowledge

Aim: To determine knowledge of hypoglycaemic symptoms & their self-management among pts with type II diabetes mellitus. Study Design: Descriptive, cross-sectional. Place and duration of study: OPD Clinic of Department of Medicine, Chandka Medical College Hospital Larkana from 23rd May 2019 to 22nd November 2019. Methodology: One hundred and thirty five patients with type II diabetes mellitus of age 35- 60 years were selected. Patients with type I DM and neuro-psychiatric illness were excluded. The symptoms of hypoglycemia and their responses to those symptoms were recorded. Results: The mean age of 47.07±6.04years and majority of the patients 83 (61.48%) were between 46-60 years of age. Seventy two (53.33%) were male and 63 (46.67%) were females. Mean duration of diabetes mellitus was 6.90±3.86 years. Adequate knowledge of hypoglycemic symptoms and their self-management among patients with type II diabetes mellitus was found in 62 (56.9%) patients. Conclusion: Hypoglycemic patients are significantly unaware of their condition and have a very low knowledge about hypoglycemia and its self-management. Keywords: Type II diabetes, Hypoglycemic symptoms, Knowledge

scholarly journals Evaluation of the Relationship between Type II Diabetes Mellitus and the Prevalence of Apical Periodontitis in Root-Filled Teeth Using Cone Beam Computed Tomography: An Observational Cross-Sectional Study

2019 ◽  
Vol 28 (6) ◽  
pp. 533-538
Author(s):  
Selen Nihal Sisli
Keyword(s):  
Diabetes Mellitus ◽  
Computed Tomography ◽  
Glycemic Control ◽  
Cone Beam Computed Tomography ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Apical Periodontitis ◽  
Cone Beam ◽  
Control Group ◽  
Type Ii

Objective: This study aimed to investigate the prevalence of apical periodontitis (AP) in patients with type II diabetes mellitus (DM) with either optimal glycemic control (OGC) or poor glycemic control (PGC) compared with nondiabetics using cone beam computed tomography (CBCT). Subjects and Methods: The periapical status of 75 teeth with adequate root canal treatment performed at least 1 year ago that could be visualized in the field of view of CBCT images of 43 DM patients (29 females, 14 males) was compared with a control group consisting of 162 teeth of 86 nondiabetics (56 females, 30 males). In addition, the DM group was divided into subgroups according to the patients’ mean glycated hemoglobin level as either having OGC or PGC. The periapical status of the teeth was evaluated using the CBCT periapical index (CBCTPAI), and AP was diagnosed as a CBCTPAI ≥1. χ2, Fisher’s exact test, and independent-samples t tests were used for the statistical analysis, and p < 0.05 was considered significant. Results: Significant differences between the DM group and the control group were observed (p< 0.05) in terms of AP (the frequencies of both CBCTPAI ≥1 and CBCTPAI ≥3) and the frequency of cardiovascular disease, while there were no significant differences between the DM subgroups (p > 0.05). Conclusion: The prevalence of AP and severe bone destruction in periapical tissues was significantly higher in the DM patients compared with the nondiabetic patients.

To Study the Effect of Type II Diabetes Mellitus and Its Duration on Hearing

2017 ◽  
Vol 2 (3) ◽  
pp. 140-143
Author(s):  
Sameer Aggarwal ◽  
Vikas Kakkar ◽  
Chandni Sharma ◽  
Surender Bishnoi ◽  
Ankit Gulati ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Hearing Loss ◽  
Type Ii Diabetes ◽  
Pure Tone Audiometry ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Diabetic Patients ◽  
Age Group ◽  
Type Ii ◽  
Group I

ABSTRACT Objective This study has been undertaken to study the effect of type II diabetes mellitus (T2DM) and its duration on hearing. Materials and methods The present study was conducted on 100 persons of age group 20 to 45 years. All subjects included in the study were divided into two groups. Group I: 50 patients suffering from T2DM (fasting blood sugar ≥ 126 mg/dL and postprandial ≥ 200 mg/dL) of either sex, in the age group of 20 to 45 years. Group II: 50 healthy volunteers in the age group of 20 to 45 years, of either sex were included in control group. Hearing assessment was done by using pure tone audiometry (PTA). Results In diabetic patients, the mean threshold in the PTA was higher at all frequencies as compared with healthy controls, and there was a positive correlation between the duration of diabetes and hearing loss. Conclusion Various audiological investigations have revealed that there is a strong association of diabetes with sensorineural part. The prevalence of sensorineural hearing loss (SNHL) in type II diabetics observed was 64%. In the majority of the patients, the hearing loss was bilateral, affecting mid and higher frequencies from 2 to 8 kHz. Hence, to conclude, we can say that the high prevalence of hearing loss in T2DM supports the importance of audiometric evaluation in such patients. How to cite this article Gulati A, Kakkar V, Aggarwal S, Sharma C, Panchal V, Pareek M, Bishnoi S. To Study the Effect of Type II Diabetes Mellitus and Its Duration on Hearing. Int J Adv Integ Med Sci 2017;2(3):140-143.

Differential Alterations of Spontaneous and Stimulated 45Ca2+ Uptake by Platelets from Patients with Type I and Type II Diabetes Mellitus

1999 ◽  
Vol 13 (5-6) ◽  
pp. 271-276 ◽  
Author(s):  
Jasvinder K Gill ◽  
Vivian Fonseca ◽  
Paresh Dandona ◽  
Dimitri P Mikhailidis ◽  
Gianni D Angelini ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type I ◽  
Type Ii

scholarly journals Euglycaemic hyperinsulinaemia does not affect gastric emptying in Type I and Type II diabetes mellitus

Diabetologia ◽  
1999 ◽  
Vol 42 (3) ◽  
pp. 365-372 ◽  
Author(s):  
M.-F. Kong ◽  
P. King ◽  
I. A. Macdonald ◽  
P. E. Blackshaw ◽  
M. Horowitz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gastric Emptying ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type I ◽  
Type Ii

scholarly journals Diastolic dysfunction in cases with Type II diabetes mellitus.

2019 ◽  
Vol 26 (12) ◽  
pp. 2040-2043
Author(s):  
Munir Ahmed ◽  
Abdul Hayee ◽  
Shahla Afsheen Memon ◽  
Ismail Salim Memon ◽  
Abdul Qayoom Memon
Keyword(s):  
Diabetes Mellitus ◽  
Diastolic Dysfunction ◽  
Type Ii Diabetes ◽  
Female Gender ◽  
Type Ii Diabetes Mellitus ◽  
P Value ◽  
Type I ◽  
Type Ii ◽  
Cross Sectional ◽  
Significant Difference

Objectives: To determine the frequency of diastolic dysfunction in patients presenting with type II Diabetes Mellitus. Study Design: Cross sectional study. Setting: Sheikh Zayed Hospital, Rahim Yar Khan. Period: From 01-01-2017 to 30-06-2017. Material & Methods: In this study the cases were selected via non probability consecutive sampling of both male and female gender with age more than 40 years having type II DM of at least more than 2 years were included. The cases suffering from type I DM, gestational DM and those with HTN, end stage kidney and liver failure were excluded. Trans thoracic echocardiography was done to label diastolic dysfunction and was labelled as yes when the E/A ratio was <0.8. The data was analysed using chi square test and p value less than 0.05 was taken as significant. Results: In this study, 100 cases of type II DM were included with mean age of 51.31±7.89 years at presentation. There were 61% males and 39% females. Diastolic dysfunction was observed in 53% of the cases. There was no significant difference in terms of gender where it affected 56.41% of females with p= 0.92. Diastolic dysfunction was more in cases that had duration of DM more than 3 years affecting 48 (70.58%) cases with p= 0.001 and it was also significantly high in cases that had BMI more than 30 where it was seen in 40 (70.17%) of cases with p= 0.001. Conclusion: Diastolic dysfunction seen in half of the cases suffering from type II DM and it is significantly high in cases that had duration of DM more than 3 years and BMI more than 30.

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