scholarly journals A systematic analysis of vascular paroxysm pathophysiology in perimenopause: methods for nutritional correction

2020 ◽  
Vol 14 (3) ◽  
pp. 361-373
Author(s):  
O. A. Gromova ◽  
I. Yu. Torshin ◽  
O. A. Limanova ◽  
N. I. Tapilskaya
Keyword(s):  
Insulin Resistance ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Gaba Receptors ◽  
Large Data ◽  
Hot Flushes ◽  
Serotonin Metabolism ◽  
Systematic Analysis ◽  
Autonomic Nervous ◽  
Large Data Analysis

Materials and Methods. A systematic analysis of publications retrieved from PubMed/MEDLINE database as well as in the list of primary sources of the identified scientific papers was carried out by using current methods for large data analysis within the framework of topological and metric approaches applied for data recognition/classification. A map of molecular-pathophysiological processes was compiled followed by performing analysis of metric condensations.Results. Three clusters of terms describing an impact of various biological processes into the pathophysiology of hot flushes were identified: inflammation combined with insulin resistance (cluster 1), the presence of chronic comorbid pathologies in patients (cluster 2), and disorders of serotonin metabolism (cluster 3). The use of menopausal hormone therapy (MHT) is not accepted for all patients. A promising direction in treatment of mild and moderate hot flushes is based on using nutraceuticals: vitamins, trace elements and substances obtained from plant extracts (isoflavones, phytoestrogens, etc.). Here, this set of interactions between pathophysiology of hot flushes and deficiency of certain micronutrients, inflammation, insulin resistance, chronic comorbid pathologies and disorders of serotonin metabolism is described. Replenished deficiency of vitamins C, E, A, B2, PP, B6, B12, and folates aids to reduce chronic inflammation, insulin resistance and normalize functioning of the autonomic nervous system. Natural and synthetic agonists of GABA receptors and tryptophan derivatives are necessary for serotonin biosynthesis and elimination of other neurotransmitter imbalances in order to normalize activity of the hypothalamic thermoregulatory region.Conclusion. Plant isoflavones (including phytoestrogens) together with vitamins and other micronutrients help to overcome estrogen-dependent withdrawal symptoms and eliminate dysfunction of autonomic nervous system

scholarly journals Is Active Lifestyle Related to Autonomic Nervous System Function and Lipid Profile in People with Overweight? A Study Pilot

2021 ◽  
Vol 13 (5) ◽  
pp. 2439
Author(s):  
Alexis Espinoza-Salinas ◽  
Edgardo Molina-Sotomayor ◽  
Johnattan Cano-Montoya ◽  
Jose Antonio Gonzalez-Jurado
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Lipid Profile ◽  
Model Assessment ◽  
System Function ◽  
Autonomic Nervous System Function ◽  
Autonomic Nervous ◽  
Nervous System Function

Autonomic nervous system function is an important predictor of physical fitness. The objective of this study was to find out the associations of autonomic activity parameters, lipid profile, insulin concentrations, and insulin resistance in overweight men with the level of physical activity. A descriptive and correlational study was carried out in 28 overweight men: 14 physically active (PA) and 14 physically inactive (PI). The following variables were assessed: Level of physical activity, HRV (heart rate variability), basal insulin, HOMA-IR index (Homeostasis Model Assessment Insulin-Resistance), and lipid profile. The main results show a positive correlation between the spectral parameters of the HRV and total cholesterol (r = 0.24), LDL (r = 0.59), VLDL (r = 0.86), and insulin (r = 0.88) of sedentary people, evidencing a directly proportional correlation with BMI. We conclude that weight gain and a sedentary lifestyle are associated with an increase in sympathetic discharge, which, in turn, is associated with an increase in lipid profile and insulin levels.

Dysregulation of the Autonomic Nervous System Can Be a Link between Visceral Adiposity and Insulin Resistance

2005 ◽  
Vol 13 (4) ◽  
pp. 717-728 ◽  
Author(s):  
Stina Lindmark ◽  
Lars Lönn ◽  
Urban Wiklund ◽  
Magnus Tufvesson ◽  
Tommy Olsson ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Visceral Adiposity ◽  
Autonomic Nervous

scholarly journals HORMONAL AND VEGETATIVE FACTORS OF INSULIN RESISTANCE IN PATIENTS WITH HYPERTENSION

2021 ◽  
Vol 77 (3) ◽  
pp. 91-98
Author(s):  
Sergii Shevchuk ◽  
Володимир Корчинський
Keyword(s):  
Insulin Resistance ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Parathyroid Hormone ◽  
Angiotensin Ii ◽  
Arterial Hypertension ◽  
Plasma Renin ◽  
Activity Levels ◽  
Central Hemodynamics ◽  
Autonomic Nervous

The combination of arterial hypertension (AH) and insulin resistance (IR) significantly increases the risk of cardiovascular complications. Research objective: Studying indices of carbohydrate metabolism, activity of renin-angiotensin-aldosterone system, calcium-regulating hormones, adrenal glucocorticoid function, the condition of the autonomic nervous system and their possible interrelation with hemodynamic parameters in AH patients with different insulin sensitivity. A comprehensive study of hormonal profile was held with use of radio immune method and that of central hemodynamics with use of echocardiography in 72 patients with arterial hypertension stage II, 1-2 degrees, male (mean age – 54.1±3.4 years), with a body mass index up to 30 kg / mІ and verified insulin resistance (IR), in 32 patients of which insulin resistance (IR) was revealed, and in 40 patients its absence was fixed. Insulin resistance was verified by the value of HOMA-IR in excess of 2,77. To assess the condition of the autonomic nervous system, studies of heart rate variability were performed. It is established that patients with hypertension with IR had increased level of plasma renin activity, levels of angiotensin II, cortisol, insulin, parathyroid hormone, decreased parasympathetic and increased sympathetic tonus. According to the results of factor analysis, AH with insulin resistance has a distinctive structure of neurohumoral regulation of the main indicators of central hemodynamics and interhormonal interactions; the direct regulatory effects of angiotensin II, insulin, progesterone, parathyroid hormone on the indicators of central hemodynamics, modulation of presorption action increases. The study not only revealed peculiarities of neurohumoral profiles in patients with hypertension depending on insulin resistance, but also determined distinctive features in structure of the regulatory process of central hemodynamics and interhormonal interactions. This should be taken into account when prescribing antihypertensive therapy.

scholarly journals Hypothalamic Orexin Prevents Hepatic Insulin Resistance via Daily Bidirectional Regulation of Autonomic Nervous System in Mice

Diabetes ◽  
2014 ◽  
Vol 64 (2) ◽  
pp. 459-470 ◽  
Author(s):  
Hiroshi Tsuneki ◽  
Emi Tokai ◽  
Yuya Nakamura ◽  
Keisuke Takahashi ◽  
Mikio Fujita ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Hepatic Insulin Resistance ◽  
Autonomic Nervous ◽  
Bidirectional Regulation

scholarly journals Autonomic Nervous System Function in Newly Diagnosed Multiple Sclerosis: Association With Lipid Levels and Insulin Resistance

2021 ◽  
pp. 875-882
Author(s):  
M. Hardoňová ◽  
P. Šiarnik ◽  
M. Siváková ◽  
B. Suchá ◽  
M. Vlček ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Insulin Resistance ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Sympathetic Activity ◽  
Whole Body ◽  
Sensitivity Index ◽  
Positive Correlation ◽  
Autonomic Nervous ◽  
Significant Difference

Autonomic nervous system (ANS) disorders are common in multiple sclerosis (MS). Previous studies showed differences in insulin resistance (IR) and lipoprotein levels in MS subjects compared to controls. Lipolysis caused by increased sympathetic activity could be one of the possible linking mechanisms leading to dyslipidemia in MS. Our study aimed to evaluate ANS activity in the context of glucose and lipid metabolism in people with MS. We prospectively measured short-term heart rate variability (HRV), fasting lipoprotein concentrations, and calculated IR indices based on plasma glucose and insulin levels during oral glucose tolerance test (oGTT) in 32 patients with MS and 29 healthy controls matched for age, sex and body mass index in our study. There was no significant difference in HRV parameters and lipoprotein levels between MS and controls. A significant positive correlation was found between low/high-frequency power ratio (LF/HF) and triglycerides (r=0.413, p=0.021) in MS subjects but not in controls. A significantly lower whole-body insulin sensitivity index (ISIMat) was found in patients with MS compared to the control group (7.3±3.7 vs. 9.8±5.6, p=0.041). No significant correlations were found between LF/HF and IR parameters. In MS subjects, the positive correlation of LF/HF with triglycerides could reflect the effects of sympathetic activity on lipolysis. Positive correlations of sympathetic activity with increased lipoprotein levels could rather reflect processes associated with immune system activation/inflammation, than processes involved in glucose homeostasis maintenance.

Gender differences in the relationship between leptin, insulin resistance and the autonomic nervous system

2007 ◽  
Vol 140 (1-2) ◽  
pp. 37-42 ◽  
Author(s):  
Daniel E. Flanagan ◽  
Julian C. Vaile ◽  
Graham W. Petley ◽  
David I. Phillips ◽  
Ian F. Godsland ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gender Differences ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Autonomic Nervous ◽  
The Relationship

scholarly journals DYSREGULATION OF THE AUTONOMIC NERVOUS SYSTEM IN THE MECHANISMS OF METABOLIC SYNDROME DEVELOPMENT

2019 ◽  
Vol 33 (4) ◽  
pp. 119-124
Author(s):  
S. I. Kseneva ◽  
E. V. Borodulina ◽  
O. Yu. Trifonova ◽  
V. V. Udut
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Cardiac Autonomic Neuropathy ◽  
Autonomic Nervous ◽  
High Incidence

The concept of metabolic syndrome as a cluster of risk factors for type 2 diabetes and cardiovascular diseases has undergone a number of evolutionary transformations over the past years. Incorporation of autonomic nervous system dysfunction into the pathogenesis of metabolic syndrome opens an opportunity for inclusion of a number of clinical entities in the cluster of metabolic syndrome as they mutually affect the course and clinical manifestations of pathologies involved in metabolic syndrome. To confirm this notion, a cross-sectional transverse study of a continuous sample of 158 patients with metabolic syndrome was performed. The study showed that, in the presence of metabolic syndrome, the incidence of cardiac autonomic neuropathy reaches 37.5%. A number of features of gastroesophageal reflux disease in patients with metabolic syndrome were found in the structure of complaints where regurgitation predominated. Fibrogastroduodenoscopy demonstrated endoscopically negative form of the disease in 38%, and, according to high DeMeester index by daily pH-metry, the alkaline reflux was present in patients in lying position over 25% of time. Young men with metabolic syndrome had high incidence of prostatic enlargement (increased prostate size and volume) as well as high incidence of the IPSS questionnaire  score corresponding to the initial manifestations of prostatic hyperplasia in the presence of insulin resistance and normal androgen levels. The study showed that dysfunction of the autonomic nervous system (along with insulin resistance) was the main converging point in the development of metabolic syndrome. This suggests that cardiac autonomic neuropathy, lower urinary tract symptoms, and gastroesophageal reflux disease may be included in the metabolic syndrome cluster. 

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