scholarly journals Regarding the evidence-based use of micronized progesterone

2020 ◽  
Vol 14 (3) ◽  
pp. 374-383
Author(s):  
A. D. Makatsariya ◽  
G. C. Di Renzo ◽  
G. Rizzo ◽  
V. O. Bitsadze ◽  
J. Kh. Khizroeva ◽  
...  
Keyword(s):  
Healthcare Professionals ◽  
Primary Source ◽  
Media Campaign ◽  
Efficacy And Safety ◽  
Treatment Standards ◽  
Data Manipulation ◽  
Scientific Papers ◽  
Source Trust ◽  
Social Importance ◽  
Micronized Progesterone

An issue of habitual miscarriage poses a high social importance especially during COVID-19 pandemic. Meanwhile, healthcareworkers faced a mass media campaign against using micronized progesterone upon habitual miscarriage, which, as viewed by us, displays signs of prejudiced data manipulation and may disorient practitioners. In this Letter we provide objective information on accumulated data regarding gestagenes efficacy and safety. We invoke healthcare professionals to make decisions deserving independent primary source trust presented by original scientific papers published in peer-reviewed journals, clinical recommendations proposed by professional medical communities as well as treatment standards and protocols.

Efficacy and Safety of a COVID-19 Inactivated Vaccine in Healthcare Professionals in Brazil: The PROFISCOV Study

2021 ◽  
Author(s):  
Ricardo Palacios ◽  
Ana Paula Batista ◽  
Camila Santos Nascimento Albuquerque ◽  
Elizabeth González Patiño ◽  
Joane do Prado Santos ◽  
...  
Keyword(s):  
Healthcare Professionals ◽  
Inactivated Vaccine ◽  
Efficacy And Safety

Comparative evaluation of efficacy and safety of micronized progesterone in assisted reproductive technology programs

2018 ◽  
Vol 5_2018 ◽  
pp. 122-126
Author(s):  
Malyshkina A.I. Malyshkina ◽  
Nazarov S.B. Nazarov ◽  
Semenenko S.S. Semenenko ◽  
Kozelkova E.V. Kozelkova E ◽  
Keyword(s):  
Assisted Reproductive Technology ◽  
Comparative Evaluation ◽  
Reproductive Technology ◽  
Efficacy And Safety ◽  
Technology Programs ◽  
Micronized Progesterone

scholarly journals Efficacy and Safety of Oral Micronized Progesterone That Converts to Allopregnanolone as an Adjunctive Treatment in Refractory Status Epilepticus: A Prospective Interventional Phase IIa Study

2020 ◽  
Author(s):  
Pasiri Sithinamsuwan ◽  
Wichai Santimaleeworagun ◽  
Weerayuth Saelim ◽  
Sippanont Samchai ◽  
Puntawat Ruttanajirundorn ◽  
...  
Keyword(s):  
Status Epilepticus ◽  
Statistical Significance ◽  
Intervention Group ◽  
Refractory Status Epilepticus ◽  
T Test ◽  
Trial Registration ◽  
Adjunctive Treatment ◽  
Efficacy And Safety ◽  
Refractory Status ◽  
Micronized Progesterone

Abstract Background: We aimed to study the efficacy and safety of allopregnanolone which convert from oral micronized progesterone as an adjunctive treatment for Thai patients with refractory status epilepticus.Methods: Adults 18–80 years old who diagnosed with either convulsive or non-convulsive refractory status epilepticus receiving standard AED treatment, intravenous midazolam, for longer than 60 minutes were included. The intervention group received Utrogestran® (micronized progesterone, 200 mg/capsule) via enteric feeding every 8 h for five days. Treatments for RSE were continuing along the clinical trial period. Serum allopregnanolone levels were measured by radioimmunoassay (DetectX® Allopregnanolone Immunoassay Kit; Arbor Assays, Michigan, United States). Control patients were randomly selected from our hospital RSE cohort during 2015–2019. Continuous data were presented as the mean and standard deviation. Discrete data were assessed by number and percentage. The changes in laboratories were analyzed by paired t-test. The difference between groups were compared by independent sample t-test. The Mann-Whitney U test, Chi-square test or Fisher’s exact test were used for non-parametric parameters. A p-value < 0.05 indicated statistical significance. All analyses were performed using SPSS version 26 software (IBM Corp., Armonk, NY).Results: The average duration of refractory status epilepticus after treatment with midazolam plus progesterone (intervention group) and without progesterone until status epilepticus termination was 25.5 and 58.4 hours, (p = 0.004), indicated that allopregnanolone significantly shortens the refractory status epilepticus duration in vivo.Conclusions: Allopregnanolone, produced from oral micronized progesterone, demonstrates efficacy and safety in treating refractory status epilepticus as an adjunctive treatment.Trial registration: This trial was registered in Thai Clinical Trials Registry (TCTR) database. The trial registration number was “TCTR20200717002”, 16 July 2020, retrospectively registered.

scholarly journals Clinical Data Mining: a Review

2009 ◽  
Vol 18 (01) ◽  
pp. 121-133 ◽  
Author(s):  
G. Cohen ◽  
A. Depeursinge ◽  
H. Müller ◽  
R. Meyer ◽  
A. Geissbuhler ◽  
...  
Keyword(s):  
Data Mining ◽  
Clinical Data ◽  
Healthcare Professionals ◽  
Primary Source ◽  
Qualitative Evaluation ◽  
Extraction Process ◽  
Medical Data ◽  
Support Vector ◽  
Clinical Databases ◽  
Clinical Data Mining

Summary Objective Clinical data mining is the application of data mining techniques using clinical data. We review the literature in order to provide a general overview by identifying the status-of-practice and the challenges ahead. Methods The nine data mining steps proposed by Fayyad in 1996 [4] were used as the main themes of the review. MEDLINE was used as primary source and 84 papers were retained based on our inclusion criteria. Results Clinical data mining has three objectives: understanding the clinical data, assist healthcare professionals, and develop a data analysis methodology suitable for medical data. Classification is the most frequently used data mining function with a predominance of the implementation of Bayesian classifiers, neural networks, and SVMs (Support Vector Machines). A myriad of quantitative performance measures were proposed with a predominance of accuracy, sensitivity, specificity, and ROC curves. The latter are usually associated with qualitative evaluation. Conclusion Clinical data mining respects its commitment to extracting new and previously unknown knowledge from clinical databases. More efforts are still needed to obtain a wider acceptance from the healthcare professionals and for generalization of the knowledge and reproducibility of its extraction process: better description of variables, systematic report of algorithm parameters including the method to obtain them, use of easy-to-understand models and comparisons of the efficiency of clinical data mining with traditional statistical analyses. More and more data will be available for data miners and they have to develop new methodologies and infrastructures to analyze the increasingly complex medical data.

scholarly journals THE MANAGEMENT OF THE RAILCAR ROLLING STOCK, PROVIDED BEHIND THE SCHEDULE OF MOVEMENT

2014 ◽  
Author(s):  
Dmitro Oleksandrovich Kulagin
Keyword(s):  
Customer Service ◽  
Mathematical Formulation ◽  
Primary Source ◽  
Rolling Stock ◽  
Repair Work ◽  
General Management ◽  
Road Capacity ◽  
Road Condition ◽  
Social Importance

The task execution schedule is one of the priority, since the quality of its decisions ensure the safety ofmovement, more efficient use of rolling stock, freight and road capacity, enhancing customer service and hasimportant economic and social importance. Therefore, the question of overcoming deviations from theschedule of movement with optimal energy consumption during this requires a precise mathematicaldefinition. Depending on the circumstances - the variance of the true weights of the rolling stock ofsettlement, presence of a strong counter or side winds, road condition, failure running time outstrip,infringement of the schedule of suburban trains for boarding and disembarkation of passengers through theovercrowded trains by the issuance depo trains not full line and off-schedule cancellation of suburban trains,delay trains passed by the place of repair work on the stretch, and other factors, the possible deviation fromthe planned schedule. In consequence of this, it is necessary to carry out the adjustment values of theaverage velocity EMU-train to execute a defined timetable. In article on the basis of common methods ofvariational calculus, mathematical formulation of the General management process railcar rolling stock ofRailways in the case backlog from the schedule. The build avtodriving system rolling stock on the basis ofthe proposed mathematical model allows rational way to minimize delays in the schedule of movement withoptimal costs primary source of energy.

scholarly journals Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With Coronavirus Disease 2019 (COVID-19)

2020 ◽  
Author(s):  
Adarsh Bhimraj ◽  
Rebecca L Morgan ◽  
Amy Hirsch Shumaker ◽  
Valery Lavergne ◽  
Lindsey Baden ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Infectious Diseases ◽  
Healthcare Professionals ◽  
Critical Evaluation ◽  
Evidence Based ◽  
Efficacy And Safety ◽  
Assessment Development ◽  
Guideline Panel ◽  
Grade Approach ◽  
Pharmacologic Therapies

Abstract Background There are many pharmacologic therapies that are being used or considered for treatment of coronavirus disease 2019 (COVID-19). There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature. The objective was to develop evidence-based rapid guidelines intended to support patients, clinicians, and other healthcare professionals in their decisions about treatment and management of patients with COVID-19. Methods The Infectious Diseases Society of America (IDSA) formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and gray literature was conducted. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence and make recommendations. Results The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations. Conclusions The panel expressed the overarching goal that patients be recruited into ongoing trials, which would provide much-needed evidence on the efficacy and safety of various therapies for COVID-19, given that we could not make a determination whether the benefits outweigh harms for most treatments.

Factors Affecting IT-Based Knowledge Management Strategy in UK Healthcare System

2004 ◽  
Vol 03 (04) ◽  
pp. 279-289 ◽  
Author(s):  
Matthew W. Guah ◽  
Wendy L. Currie
Keyword(s):  
Web Sites ◽  
Management Strategy ◽  
Healthcare Professionals ◽  
Technological Development ◽  
Medical Knowledge ◽  
Point Of View ◽  
Efficacy And Safety ◽  
Healthcare Organizations ◽  
Factors Affecting ◽  
Set Up

The technological development by the beginning of the 21st century is making it humanly impossible for unaided healthcare professionals to possess all the knowledge needed to deliver medical care with the efficacy and safety made possible by current scientific knowledge. Several healthcare organizations are adopting rigorous methods and technologies for KM as a potential solution to the knowledge predicament. However, awareness and understanding of such methods are not widespread with critics claiming that these technologies are not designed to be compatible with others neither are they interoperable. This paper describes an effort by the NHS for individuals, organizations and partners (commercial companies supplying services to the NHS) to demonstrate their belief in the importance of improving KM in medicine and show that this can be best achieved through collaboration and consensus. It looks at National Knowledge Service, set up to provide a range of services, through one or more open-access web sites. There is an asymmetry in most of the discussion of the field. KM, in this paper, is primarily discussed from the point of view of the user of medical knowledge. The motivation is seen to be the enhancement capabilities, and the utilization of knowledge to increase healthcare effectiveness.

scholarly journals The 1855 Wairarapa, New Zealand, earthquake

1997 ◽  
Vol 30 (4) ◽  
pp. 271-368 ◽  
Author(s):  
Rodney Grapes ◽  
Gaye Downes
Keyword(s):  
New Zealand ◽  
Biological Effects ◽  
Primary Source ◽  
Provincial Government ◽  
Fault Rupture ◽  
Descriptive Account ◽  
Scientific Papers ◽  
Response And Recovery ◽  
Political Conditions ◽  
Historical Accounts

Nearly 200 historical accounts have been examined and analysed in order to determine the effects of the magnitude 8+ 1855 Wairarapa, New Zealand, earthquake. The documents examined include contemporary diaries, letters and journals, newspaper reports and articles, archives, memoranda and reports of the Wellington Provincial Government as well as later reminiscences, extracts from published scientific papers, books and other articles. Other than the published accounts of Sir Charles Lyell, who, in 1856, first recognised the importance of the earthquake as causing the greatest deformation and surface fault rupture then known, there has been no comprehensive account of the effects of the earthquake in the scientific literature until now. Much or the data is presented with extensive quotations from the source material, especially where conflicting accounts on important aspects have been found. All material is analysed with an understanding of the geographical, social and political conditions at the time. The reliability of the material is taken account of so that first-hand accounts, that have been recorded no more than several years after the earthquake, and in which there are no obvious inconsistencies or confusion with other earthquakes, are valued most highly. Using the historical accounts as the primary source of data, but also taking into account the results of more recent geological, geomorphological and seismological investigations of the deformation, many aspects of the earthquake are discussed in detail. These are mainshock magnitude and epicentre; felt intensity distribution: descriptive account of the effects of the mainshock on people (including casualties) and man-made structures by location throughout New Zealand (including a resume of contemporary building techniques): effects on the environment from strong shaking such as fissuring, liquefaction, spreading, subsidence and landslides, and from tectonically produced uplift, subsidence and faulting; biological effects; tsunami and seiche; aftershock occurrence and social response and recovery.

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