Risk factors for perinatal loss - reality or fiction?

Aim: to identify factors predisposing to perinatal losses, assessment of which is available at the first (only) visit of pregnant woman in antenatal clinic.Materials and Methods. A retrospective analysis of the medical records of 964 women who performed delivery in 2009-2019 in 15 obstetric facilities was carried out. The patients were divided into 2 groups: the main group included 457 women with perinatal losses (stillbirth - 328 children, and 129 children with early neonatal death); the control group consisted of 507 women, whose children survived 7 days during postnatal period. We analyzed parameters routinely determined by an obstetrician-gynecologist at the first visit of woman during within ongoing pregnancy (regardless of gestation age), namely, social status, anamnesis, data of initial examination.Results. The following significant differences were revealed in pregnant women from the main group: a younger age of pregnancy; no registered marriage and permanent job as well as primary and secondary education; smoking, alcohol and drug use; concurrent diabetes mellitus, hypertensive disorders, blood contact infections, obesity; older menarche age and younger sexual debut age; medical history contains infectious genital pathology, more often pregnancies and childbirths, two or more abortions before repeated childbirth, premature births.Conclusion. Thus, the anamnestic indicators noted above can be used to create prognostic statistical systems and models to determine high risk of perinatal losses of any nature.

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Improving of treatment of periodontal diseases in workers of the woodworking industry of the Chernivtsi region

SUCHASNA STOMATOLOHIYA ◽

10.33295/1992-576x-2021-2-28 ◽

2021 ◽

Vol 106 (2) ◽

pp. 28-35

Author(s):

V. Batig ◽

◽

O. Tokar ◽

I. Burdenyuk ◽

◽

...

Keyword(s):

Maintenance Therapy ◽

Comparison Group ◽

Periodontal Diseases ◽

Main Group ◽

Control Group ◽

Treatment And Prevention ◽

Group A ◽

Group B ◽

Periodontal Indices

Goal. Improving the scheme of treatment and prevention of periodontal diseases in workers of the woodworking industry of Chernivtsi region, who in the process of professional activity have long-term contact with unfavorable factors of the production environment. Materials and methods. 70 workers of the woodworking industry with diagnosed chronic generalized periodontitis of the I degree were treated (35 people – the main group (A); 35 people – comparison group (B)), age – from 25 to 45 years. To compare the results of laboratory studies, an additional survey of 25 healthy individuals of the same age with an intact periodontium were conducted. They formed the control group (C). Clinical examination of patients was performed according to standart methods: subjective (complaints, medical history, life history) and objective (examination, periodontal indices, determination of the level of gingival attachment). Laboratory methods of research included determination of urease and lysozyme activity in saliva, degree of dysbiosis of oral cavity. As maintenance therapy, patients of the main group were prescribed the proposed composition DEPE. Results. After the treatment, a significant improvement in the hygienic status of patients in both groups was observed, but difference between groups A and B in the indicators of oral hygiene after treatment was no statistically significant (pA2–B2 > 0.05). There was a significant improvement in periodontal indices after treatment in patients of both groups (PMA index according to C. Parma, bleeding index according to Muhlemann in Cowell I. modification, Russell periodontal index, PSR-test), but the indicators in patients of the main group were significantly better – pA2–B2 < 0.05. In patients of the main group (A) the level of attachment loss decreased by 1.83 times, comparison group (B) – by 1.71 times. The difference in levels of attachment loss after treatment between groups A and B is statistically significant (pA2–B2 < 0.05). The activity of the enzyme urease in patients of the main group (A) and comparison group (B) after treatment was significantly reduced (pA1–A2 < 0.001, pB1–B2 < 0.001), but only in the main group it reached the level in the control group (C) (pA2–C > 0.05). The level of lysozyme after treatment was significantly increased in patients of both observation groups (pA1–A2 < 0.001, pB1–B2 < 0.001), and reached the level of lysozyme in patients of the control group (C) (pA2–C > 0.05, pB2–C > 0.05). The degree of oral dysbiosis in patients of the main group (A) was significantly reduced by 5.43 times (pA1–A2 < 0.001), and its difference from the degree of dysbiosis in patients of the control group (C) is statistically insignificant (pA2–C > 0.05 ). The degree of oral dysbiosis in patients of the comparison group (B) was significantly reduced by 3.04 times (pB1–B2 < 0.001), but still remained significantly different from oral dysbiosis in patients of the control group (C) (pB2–C < 0.05). Conclusion. The proposed pharmacological composition DEPE is an effective antiseptic solution and can be used in the phase of maintenance therapy to improve the treatment and prevention of periodontal disease in workers of woodworking industry. Key words: decamethoxine, propolis, ethonium, generalized periodontitis, woodworking industry.

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The role of α-tocopherol and ɷ-3 polyunsaturated fatty acids in miscarriage at early stages of pregnancy with cytomegalovirus infection

Bulletin physiology and pathology of respiration ◽

10.36604/1998-5029-2021-81-98-104 ◽

2021 ◽

pp. 98-104

Author(s):

N. A. Ishutina ◽

I. А. Andrievskaya ◽

I. V. Dovzhikova ◽

N. N. Dorofienko

Keyword(s):

Peripheral Blood ◽

Cytomegalovirus Infection ◽

First Trimester ◽

Main Group ◽

Control Group ◽

Gas Liquid Chromatography ◽

Epa And Dha ◽

Group A ◽

Therapeutic Measures

Introduction. It is now generally acknowledged that cytomegalovirus infection (CMVI) is one of the main causes of miscarriage. However, the mechanism of this effect has not been sufficiently studied. At the same time, the influence of acids of the ɷ-3 family and α-tocopherol (αTP) on the placentation process through a pro-angiogenic action is shown.Aim. To study the concentration of αTP and ɷ-3 family acids in the peripheral blood and establish their role in miscarriage in CMV-seropositive women with CMVI reactivation.Materials and methods. A case-control study included 64 women in the first trimester of pregnancy (7-10 weeks), of which 36 were CMV-seropositive with CMVI reactivation (main group) and 28 were CMV-seronegative (control group). CMVI was diagnosed by the determination of class M and G antibodies by ELISA, as well as CMV DNA detected by PCR. The concentration of ɷ-3 acids of the family (eicosapentaenoic – EPA, docosahexaenoic – DHA) in blood serum was studied by capillary gas-liquid chromatography (J.P.Carreau, J.P.Dubacq). The αTP concentration was determined by the fluorometric method (L.G.Hansen, W.I.Warwich).Results. In women of the main group, a significant (p<0.001) decrease in the concentration of αTP to 1.32±0.025 μg/mL was observed in the peripheral blood compared to the same indicator in the control group (1.49±0.029 μg/mL). At the same time, the levels of EPA and DHA were also statistically significant (p<0.001) lower than the same indicator in the control group and amounted to 1.09±0.012 and 6.09±0.015%, respectively (in the control, 1.29±0.071 and 8.80±0.071%, respectively). Conclusion. The obtained results of the study allow us to establish the important role of disorders in the content of α-TF, EPA and DHA in the pathogenesis of miscarriage during reactivation of CMVI in the early periods of gestation, which can serve as a basis for expanding diagnostic and therapeutic measures in this pathology of pregnant women.

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Clinical efficacy of a screening approach to the differentiated prescription of antibiotic therapy in children with acute tonsilopharyngitis

Kazan medical journal ◽

10.17816/kmj2020-805 ◽

2020 ◽

Vol 101 (6) ◽

pp. 805-811

Author(s):

O I Pikuza ◽

A M Zakirova ◽

T B Moroz

Keyword(s):

Antibiotic Therapy ◽

Respiratory Infections ◽

Main Group ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Practical Implementation ◽

Microbial Culture ◽

Hemolytic Streptococcus ◽

Screening Approach ◽

Group A

Aim. To assess the effectiveness of the screening approach by prescribing a streptotest to verify the etiological cause of tonsillopharyngitis in children. Methods. We observed 67 patients aged 7 to 11 with a history of recurrent respiratory infections. The incidence of acute respiratory infections varied from 8 to 12 times during the year preceding the examination. The main group consisted of 36 children who had tonsillopharyngitis with severe inflammation of the tonsils and plaque on the tonsils. The control group included 31 patients with acute tonsillopharyngitis with inflammatory changes in the tonsils and the absence of plaque. The observation and control groups were comparable and did not have statistically significant differences in gender and age. All patients underwent a common clinical, laboratory, and instrumental examination. Along with microbial culture, the special examinations included an express test (Dectra Pharm, France) for the presence of group A -hemolytic streptococcus. Results. All children underwent an etiological examination. The presence of a viral antigen was confirmed in 71.64% of children. 27.49% of patients in the control group and 30.72% of patients in the main group had positive results of the express test for group A -hemolytic streptococcus, taking into account the requirements for assessing this reaction. It was revealed a reliable direct relationship between the detected viral infection and the negative results of the streptatest test (r=0.86; p=0.03) for the control group, and a positive correlation of the confirmed presence of group A -hemolytic streptococcus in the main group as with both C-reactive protein (r=0.78; p=0.04) and with inflammatory markers in the general blood test. A combination of positive fluorescence of viral antigens based on the results of immunofluorescence and a positive enzyme-linked immunosorbent assay (ELISA) for group A -hemolytic streptococcus was recorded in 7.46% of all patients. Clinical examples are given the justification of practical implementation of the express test for the quick diagnostic information. Conclusion. Differentiated etiological diagnosis of acute tonsillopharyngitis based on clinical symptoms and the levels of markers of bacterial inflammation is extremely difficult therefore laboratory criteria should be the justification for prescribing antibiotic therapy; currently, the most accessible is the streptatest for the detection of group A -hemolytic streptococcus, which allows confirming or denying the presence of group A -hemolytic streptococcus within a few minutes, which means that it is correct to prescribe antibacterial drugs to patients.

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Study of Plasma Metanephrine Level As Biochemical Parameter in Pregnant Women with Preeclampsia

Baghdad Science Journal ◽

10.21123/bsj.11.2.371-377 ◽

2014 ◽

Vol 11 (2) ◽

pp. 371-377

Author(s):

Baghdad Science Journal

Keyword(s):

Pregnant Women ◽

Fetal Death ◽

Protein S ◽

Biochemical Parameter ◽

Mean Value ◽

Control Group ◽

Protein Ratio ◽

Gestation Age ◽

Group A ◽

Group B

Pregnancy- including hypertension(PIH), also known as preeclampsia, is one of the major causes of maternal and fetal death. This study was carried out on 30 pregnant women with preeclampsia and 30 healthy pregnant women as control ranging in age mean ±SD (28.84±3.55) years , BMI (76.80±9.78) Kg/m2 and gestation age(30.82±0.75)week. The aim of this research was studied the plasma Metanephrine level and other biochemical parameters such as Hemoglobin(Hb), serum Protein, S. Albumin, Globulin, Albumin/Globulin ratio (Alb/Glu. ratio), S.Glutamate Pyruvate aminotransferase (GPT), S.Glutamate Oxaloacetate aminotransferase(GOT). The obtained results have been compared with 30 healthy pregnant women as control group. The result showed that there was significant increase in mean value of Hb in group A(pregnant women with preeclampsia) when compared to group B(healthy pregnant women). The present study showed no significant changes was observed in the level of S. Protein, globulin, Alb./Glu. ratio, GPT and GOT as compared to control group. While Albumin showed a significant decrease in group A(pregnant women with preeclampsia) when compared with group B(healthy pregnant women) and significant increase in the levels of metanephrine, metanephrine/protein ratio, metanephrine/Alb ratio in group A (pregnant women with preeclampsia) to group B(healthy pregnant women).The present study conclude that the increase in the levels of metanephrine, metanephrine/protein ratio, metanephrine/Alb ratio in pregnant women with preeclampsia may be used as a marker to evaluate the development of disease. The current study recommend to take more case and measurement metanephrine in plasma and urine.

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Influence of low-frequency ultrasonic cavitation on the severity Of clinical symptoms in complex therapy of exacerbations Of chronic rhinosinusitis

Russian otorhinolaryngology ◽

10.18692/1810-4800-2020-4-39-47 ◽

2020 ◽

Vol 19 (4) ◽

pp. 39-47

Author(s):

M. Yu. Korkmazov ◽

◽

A. M. Korkmazov ◽

I. D. Dubinets ◽

A. A. Smirnov ◽

...

Keyword(s):

Chronic Rhinosinusitis ◽

Clinical Symptoms ◽

Low Frequency ◽

Clinical Effectiveness ◽

Disease Recurrence ◽

Main Group ◽

Ultrasonic Cavitation ◽

Control Group ◽

Recurrence Rates ◽

Group A

The variability of clinical course and frequent exacerbations of chronic rhinosinusitis make it necessary to improve conservative therapy. According to current literature and EPOS 2020 data the main trends are aimed to improve drug treatment, while physiotherapy is rarely applied. The aim of the study was to increase clinical effectiveness of chronic rhinosinusitis exacerbations treatment by using low-frequency ultrasonic cavitation. Clinical examination and treatment of 57 patients with exacerbation of chronic rhinosinusitis and formation of two groups was carried out. The main group (34 patients), in addition to the conventional treatment, received a course of low-frequency ultrasonic cavitation irrigation of the nasal cavity (frequency – 29 kHz, amplitude – 25 µm), and the control group (23 patients) received a course of standard therapy in accordance with clinical recommendations. The treatment resulted in improvement of clinical symptoms and reduced disease recurrence rates in 31 (91,2%) patients in the main group and 16 (69,4%) patients in the control group. A satisfactory result was obtained in 3 (8,8%) patients in the main group and 6 (27,6%) in the control group. An unsatisfactory result was noted in one case in the control group.

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Efficacy of application of a human placenta hydrolysate in prophylaxis of the intestinal anastomoses sutures insufficiency

Klinicheskaia khirurgiia ◽

10.26779/2522-1396.2019.07.09 ◽

2019 ◽

Vol 86 (7) ◽

pp. 9-12

Author(s):

E. K. Aghayev ◽

T. E. Mamedov ◽

E. M. Gasimov ◽

Z. E. Ismayilova

Keyword(s):

Human Placenta ◽

Standard Treatment ◽

Intestinal Anastomosis ◽

Main Group ◽

Experimental Investigations ◽

Control Group ◽

Intestinal Anastomoses ◽

Clinical Investigations ◽

Intestinal Segments ◽

Group A

Objective. Studying of impact of a human placenta hydrolysate on regeneration of intestinal anastomosis and prophylaxis of their sutures insufficiency. Materials and methods. Experimental investigations were conducted on two groups of rabbits. In every group a simulation model of an acute strangulation ileus was created. In a one day a relaparotomy, resection of necrotized intestinal segments with anastomosing in a “side-to-side” fashion were done in rabbits of both groups. After the operation the control group rabbits have obtained a standard treatment, while in the main group the rabbits together with a standard treatment have obtained a human placenta hydrolysate preparation «Laennec». On the days 3, 5, 7 and 15th the according intestinal segments were probed for morpho-histochemical investigations. Clinical investigations were conducted in 122 patients, consisting of resection of intestinal segments with formation of anastomoses. The control group consisted of 60 patients, and the main one – in 62. The data of the control group were studied retrospectively. In the main group the patients, together with a standard treatment, a human placenta hydrolysate in a form of preparation “Laennec” was applied for prophylaxis of insufficiency of the intestinal anastomoses sutures. Results. Basing on experimental results it may be stressed, that application of preparation «Laennec» strengthens regeneration and angiogenesis in zone of anastomosis, because in animals of the main group, comparing with a control one, high mitotic index, good angiogenesis and the motor-evacuation function integrity were noted. In clinical practice the anastomotic sutures insufficiency in the control group have occurred in 13.3% of observations, and in the main group – in 1.6% of observations. Conclusion. Application of the human placenta hydrolysate for prophylaxis of the sutures insufficiency in intestinal anastomoses is affordable due to successive clinical and experimental data obtained.

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Selection of a topical preparation in the basic treatment of chronic hemorrhoids

Ambulatory surgery hospital-replacing technologies ◽

10.21518/1995-1477-2020-3-4-80-88 ◽

2021 ◽

pp. 80-88

Author(s):

A. Ya. Ilkanich ◽

K. Z. Zubailov ◽

S. S. Kurbanov ◽

A. A. Aysanov ◽

Yu. S. Voronin ◽

...

Keyword(s):

Clinical Manifestations ◽

Pain Syndrome ◽

Main Group ◽

Control Group ◽

Topical Drugs ◽

Comparison Groups ◽

Group A ◽

Prevalence Of Pain ◽

Main Components ◽

Rectal Suppositories

Introduction. The vast majority of recommendations for conservative treatment of patients with chronic hemorrhoids contain recommendations for the use of systemic drugs with venotonic and angioprotective properties and the use of topical drugs to treat and prevent exacerbation of the disease. The action of the main components of the topical drugs used is aimed at controlling local inflammation, implemented through various mechanisms. The choice of a drug is mainly subjective.Aim of the study. Comparative clinical evaluation of the effectiveness of topical drugs for the treatment of chronic hemorrhoids.Materials and methods. There are two treatment schemes that are distinguished by the type of the drug that is used. The main group includes patients in treatment of whom a combined preparation based on lidocaine and fluocortolone in the form of rectal suppositories manufactured by Bayer (221 (50.6%) patients) was used. In the control group – a combined preparation on the basis of tribenoside and lidocaine in the form of rectal suppositories by Recordati company (216 (49,4%) people). The rate of suppositories administration and duration of their use was 21 days. Clinical efficacy was estimated by the rate of regression of the main clinical manifestations of the disease: bleeding, pain syndrome, discomfort.Results and discussion. By the 14th day of treatment with Bayer preparation, bleeding as the main sign of disease exacerbation persisted in 15.2% (5) of the main patients against 26.7% (8) of the control group patients. Positive effect was obtained in the majority of patients with the initial prevalence of pain syndrome. On the 14th day the pain remained in 17.0% (8) patients of the main group against 27.9% (12) of the control group. Sense of discomfort was preserved in 10% (4) of the main group patients against 15.8% (6) of the control group patients. Regression of combined clinical manifestations of the disease in the comparison groups showed the fastest elimination of inflammation in the main group in 79.4% of patients against 73.0% in the control group on the 14th day of treatment.Conclusions. Thus, the use of Bayer preparation allowed ensuring the regression of the main clinical manifestations of the disease in a shorter time. This drug can be recommended for use in complex treatment of chronic hemorrhoids in everyday clinical practice.

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APPLICATION OF NEGATIVE PRESSURE IN THE LOCAL TOPICAL TREATMENT OF OPEN SURGICAL WOUNDS IN PATIENTS WITH PYLONIDAL DISEASE

Koloproktologia ◽

10.33878/2073-7556-2016-0-4-42-46 ◽

2016 ◽

pp. 42-46

Author(s):

G. V. Rodoman ◽

O. A. Povarihina ◽

I. R. Cumedy ◽

A. L. Korotaev

Keyword(s):

Wound Healing ◽

Negative Pressure ◽

Topical Treatment ◽

Complete Recovery ◽

Main Group ◽

Control Group ◽

Surgical Wound ◽

Results Of Treatment ◽

Surgical Wounds ◽

Group A

AIM to improve results of treatment of patients pylonidal disease. PATIENTS AND METHODS. Thirty two patients with pylonidal disease had a wide excision with postoperative wounds left open. The patients were allocated into 2 groups: in the main group a local negative pressure was used for management of postoperative wounds, while in the control group ointment dressings was used only. Groups were well matched by age, stage of the process and the area of the surgical wound. RESULTS. The use of local negative pressure in the topical treatment of open surgical wounds allowed to reach complete recovery in the main group on 32 ± 5 POD, while in the control group it lasted 41 ± 7 days. No recurrences of the disease in both group were detected. CONCLUSION. Application of the negative pressure in the local topical treatment of open surgical wounds after excision of pylonidal disease accelerates wound healing, helps to avoid the development of suppuration and provide an earlier recovery.

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CONDITION OF ENDOTHELIAL FUNCTIONS OF VASCULAR WALL IN HYPERTENSIVE PATIENTS DURING DENTAL IMPLANTATION

"Medical & pharmaceutical journal "Pulse" ◽

10.26787/nydha-2686-6838-2020-22-9-6-11 ◽

2020 ◽

pp. 6-11

Author(s):

Dzgoeva M.G. ◽

Remizova A.A. ◽

Dzgoeva Z.G. ◽

Tibilova F.L.

Keyword(s):

Nitric Oxide ◽

Essential Hypertension ◽

Endothelial Dysfunction ◽

Dental Treatment ◽

Vascular Wall ◽

Main Group ◽

Control Group ◽

Initial Examination ◽

Periodontal Status ◽

Dental Implantation

Preoperative correction of periodontal vascular endothelial dysfunction in patients with essential hypertension (HD) can improve the efficiency of dental interventions and reduce the incidence of complications during the implantation process. The periodontal status and functional state of the vascular endothelium were examined in 60 patients with essential hypertension, aged 35 to 45, before and after implantation. The first, main group included 40 people with hypertension, who, in preparation for implantation, along with traditional dental treatment, were prescribed an antioxidant drug Mexidol. Patients of the main group were divided into two subgroups: in subgroup A, a solution of Mexidol was used in the form of applications on the mucous membrane of the gums; in subgroup B, the drug was administered both locally and per os. In the second group, in 20 patients with hypertension, surgical intervention was performed after the traditional complex of therapy. The control group consisted of 10 apparently healthy patients of the same age, with normal blood pressure. Endothelial dysfunction was diagnosed by the level of stable end metabolites of nitric oxide. During the initial examination of patients with hypertension, a significant decrease in the content of nitric oxide metabolites in the blood serum was revealed in comparison with the indicators of patients in the control group. After the course of the therapy, the indicators of nitric oxide in the serum of patients with hypertension increased, more significantly in those who received Mexidol, both locally and orally, which was accompanied by a clear improvement in periodontal status and the absence of complications in the postoperative period.

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Natural mechanism of immunity in the elimination process of virus infection

HEALTH OF WOMAN ◽

10.15574/hw.2017.117.44 ◽

2017 ◽

pp. 44-49

Author(s):

V.V. Bobrytska ◽

◽

O.V. Grishchenko ◽

O.L. Chernyak ◽

◽

...

Keyword(s):

Comparison Group ◽

Clinical Symptoms ◽

Clinical Performance ◽

Cervical Dysplasia ◽

Clinical Manifestations ◽

Main Group ◽

Control Group ◽

Papillomavirus Infection ◽

Group A ◽

Initiation Of Therapy

The objective: optimization of treatment of clinical symptoms and prevention of relapse infetsii virus (HSV, HPV) using immunomodulatory therapy alloferon. Patients and methods. The study included 50 patients aged 20 to 42 years with clinical manifestations of HPV in the form of warts of vulva, vagina, cervix, cervical dysplasia. Patients were divided into two groups according to the treatment received – the main group received Allokin-Alpha 1ml subcutaneous 6 injections, the comparison group – a-2b interferon 3 million 10 injections. Results. The group of patients treated with Allokin-аlfa, showed better clinical performance treatment of genital kondilomas lesions, decrease in the number of lesions in 6–12 days after initiation of therapy, decrease in the degree of dysplastic changes in the cervix, and the absence of relapse (in the control group 32% of patients had a relapse). No side effects as a result of Allokin-alpha has not been registered, while 76% of patients receiving a-interferon-2b expressed flu-like symptoms were observed, requiring additional purpose of detoxification drugs. Test results: in the main group had the elimination of HPV in 92% of cases, 78% in the control group; herpes – elimination of 96% of the cases in the main group and 75% in the comparison group. Conclusion The medicine Allokin-alpha is highly effective in the treatment of HPV and HSV infection, demonstrating good results of therapy, no relapse of infection. The recommended regimen – 6 injections of the drug prior to the electrosurgical treatment. Key words: human papillomavirus infection, herpes, Allokin-alpha, a-interferon-2b.

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