scholarly journals Radiomic features of epicardial adipose tissue in coronary atherosclerosis

2021 ◽  
Vol 10 (4) ◽  
pp. 6-16
Author(s):  
E. V. Popov ◽  
Zh. Zh. Anashbaev ◽  
A. N. Maltseva ◽  
S. I. Sazonova
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Perfusion Defect ◽  
Epicardial Adipose Tissue ◽  
Study Groups ◽  
Control Group ◽  
Computer Tomogram ◽  
Computed Coronary Angiography

Aim. To investigate the association of the radiomic characteristics of epicardial adipose tissue (EAT) on contrast-free computed tomography (CT) of the heart with the severity of obstructive coronary lesion and myocardial ischemia.Methods. The study included 68 patients with coronary heart disease (mean age of 63.5±9.4, 45 men and 23 women), and 15 patients (mean age 30±4.8; 14 men and 1 woman) without cardiovascular disease as a control group. All the patients underwent multispiral computed coronary angiography, coronary calcium scores (CCS) determination and stress myocardial perfusion scintigraphy. Radiomic characteristics of EAT (texture analysis by gradations of gray color) were determined on non-contrast computer tomogram images of the heart using 3D-Sliser software and the SliserRadiomics module (version 4.10.2). The obtained indicators were compared between a control and under the study groups as well as between subgroups of patients divided according to the degree of obstruction of the coronary arteries, the size of the perfusion defect, and the value of the CCS.Results. The comparative analysis of radiomic indicators of EAT between patients with coronary artery disease and the control group showed the presence of statistically significant differences between them. At the same time, the correlation analysis in the study group did not reveal any correlations between the radiomic parameters and the size of the perfusion defect, CCS or degree of stenosis of the lumen of the coronary arteries.Conclusion. The textural characteristics of EAT in patients with coronary heart disease differ from those in individuals without cardiovascular pathology. At the same time, these indicators are not associated with the severity of obstructive lesions of the coronary arteries, the value of the CCS, and the size of the perfusion defect according to scintigraphy.

scholarly journals Correlation analysis of epicardial adipose tissue volume quantified by computed tomography images and coronary heart disease under optimized reconstruction algorithm

2021 ◽  
Vol 37 (6-WIT) ◽  
Author(s):  
Zhenwei Miao ◽  
Hongyan Yang ◽  
Bofen Liu ◽  
Wengui Li
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Risk Factor ◽  
Heart Disease ◽  
Correlation Analysis ◽  
Epicardial Adipose Tissue ◽  
Reconstruction Algorithm ◽  
Control Group ◽  
Computed Tomography Images

Objectives: This paper was aimed to explore the adoption value of low-dose computed tomography (CT) imaging based on optimized ordered subset expectation maximization (OSEM) reconstruction algorithm in the correlation analysis between epicardial adipose tissue (EAT) volume and coronary heart disease (CHD). Methods: A total of 110 patients with CHD were selected for CT angiography (CTA) and coronary arteriography (CAG) examinations from October 2017 to October 2019. The predictive value of EAT for CHD was analyzed via receiver operating characteristic (ROC) curve. Results: The results showed that the iteration time and error of the improved OSEM reconstruction algorithm were better than that of MLEM algorithm under the same number of iterations. Age, smoking, hypertension, diabetes, and EAT in control group were obviously lower in contrast to those in CHD group (P<0.05). EAT in control group was (124.50±26.72) mL, and EAT in the CHD group was (159.41±38.51) mL. EAT (B=0.023, P=0.003) was an independent risk factor for CHD, which was suggested by Multiple linear regression analysis. Moreover, EAT was a risk factor for CHD, and was positively correlated with the degree and NSCV. Conclusion: The optimized OSEM algorithm was used to improve the reconstruction quality of low-dose CT images and used in quantitative measurement of epicardial fat volume. Results showed EAT was an independent risk factor for CHD, and was positively correlated with the number of coronary lesions and Gensini score. It was of great value for the prediction of CHD. doi: https://doi.org/10.12669/pjms.37.6-WIT.4882 How to cite this:Miao Z, Yang H, Liu B, Li W. Correlation analysis of epicardial adipose tissue volume quantified by computed tomography images and coronary heart disease under optimized reconstruction algorithm. Pak J Med Sci. 2021;37(6):1677-1681.  doi: https://doi.org/10.12669/pjms.37.6-WIT.4882 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Ultrasound Detection of Epicardial Adipose Tissue Combined With Ischemic Modified Albumin in the Diagnosis of Coronary Heart Disease

2020 ◽  
Vol 23 (4) ◽  
pp. E461-E464
Author(s):  
Jiandong Xiao ◽  
Yuli Lu ◽  
Xinchun Yang
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Epicardial Adipose Tissue ◽  
Reference Value ◽  
Control Group ◽  
Case Group ◽  
Disease Group ◽  
Vessel Disease ◽  
Single Vessel

Objective: To evaluate the value of epicardial adipose tissue (EAT) thickness combined with serum ischemic modified albumin (IMA) concentration in the diagnosis of coronary heart disease. Methods: A total of 180 patients with coronary heart disease from May 2017 to December 2018 were selected as the case group. After the examination of Judkins coronary angiography, they were grouped according to the results of angiography, including 60 patients in a single-vessel group, 60 patients in a double-vessel group, and 60 patients in a multi-vessel group. Sixty healthy people with physical examinations at our hospital at the same time were selected as the control group. All selected participants were tested for epicardial adipose tissue thickness by echocardiography and serum IMA concentration by albumin cobalt ion binding test. Results: The EAT thickness and IMA concentration in the single-vessel disease group, double-vessel disease group, and multi-vessel disease group significantly were higher than those in the control group (P < .01). The ROC curve shows that the sensitivity is 53.33% and the specificity is 87.6%, when the EAT thickness is 6.12 mm. The sensitivity is 76.0% and the specificity is 72.3%, when the serum IMA concentration is 72 U/L. When the two were combined, the sensitivity was 40.15% and the specificity was 96.89%. In the parallel test, the sensitivity was 88.3% and the specificity was 65.44%. Conclusion: Ultrasound detection of EAT thickness and serum IMA concentration has certain reference value for the diagnosis of coronary heart disease. Combined diagnosis can significantly improve the diagnosis rate and accuracy of coronary heart disease.

Leptin Gene Expression In Males Epicardial Adipose Tissue In Coronary Heart Disease

2019 ◽  
Vol 287 ◽  
pp. e254-e255
Author(s):  
E. Polyakova ◽  
O. Berkovich ◽  
O. Belyaeva ◽  
V. Ionin ◽  
E. Baranova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Epicardial Adipose Tissue

Thickness and an Altered miRNA Expression in the Epicardial Adipose Tissue Is Associated With Coronary Heart Disease in Sudden Death Victims

2019 ◽  
Vol 72 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Josep Marí-Alexandre ◽  
Moises Barceló-Molina ◽  
Jorge Sanz-Sánchez ◽  
Pilar Molina ◽  
Jennifer Sancho ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Sudden Death ◽  
Mirna Expression ◽  
Epicardial Adipose Tissue

Evaluation of subclinical cardiovascular risk and cardiac function in children with vesicoureteral reflux: a prospective study

2021 ◽  
pp. 1-7
Author(s):  
Ahmet Midhat Elmacı ◽  
Hayrullah Alp ◽  
Muhammet İrfan Dönmez
Keyword(s):  
Adipose Tissue ◽  
Vesicoureteral Reflux ◽  
Epicardial Adipose Tissue ◽  
Renal Scarring ◽  
Subclinical Atherosclerosis ◽  
Study Groups ◽  
Tissue Doppler ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Healthy Controls

Abstract Background: Vesicoureteral reflux is a prominent congenital anomaly of the kidney and the urinary tract. Further, renal scarring is known to be related to chronic inflammation. However, there have been limited studies to date regarding the cardiovascular consequences of vesicoureteral reflux. Objective: The aim of this study is to evaluate the possible subclinical atherosclerosis and cardiovascular complications in children with vesicoureteral reflux. Methods: Patients with vesicoureteral reflux and age matched healthy controls were prospectively included in this case-control study. Patients were divided into two groups concerning renal scarring status. To assess cardiac functions, carotid artery intima media, epicardial adipose tissue, and periaortic adipose tissue thicknesses were evaluated. Results: There were 50 patients with vesicoureteral reflux; 26 patients without renal scarring and 24 patients with renal scarring, as well as 40 healthy controls. Myocardial performance indexes (Tei indexes) measured by tissue Doppler echocardiography from septum and left ventricle were significantly increased in study group (for all, p < 0.001). Also, intima media, epicardial adipose tissue, and periaortic adipose tissue thicknesses of the study groups were significantly higher than the control group (for all, p < 0.001). However, no statistical difference was observed between renal scarring (−) and renal scarring (+) groups. Conclusions: Results of our study showed early deterioration of cardiac systolic and diastolic functions in children with vesicoureteral reflux regardless of renal scarring. Also, diagnosis of vesicoureteral reflux is an important risk factor for subclinical atherosclerosis, independent of renal scarring, which should be considered in the follow-up of these patients.

scholarly journals Association between epicardial adipose tissue thickness and coronary heart disease: A metaanalysis

2019 ◽  
Vol 11 (3) ◽  
Author(s):  
Yuan Shuai ◽  
Ai Ke-Qing ◽  
Yang Xin-Quan ◽  
Xiong Ting ◽  
Zhang Rong ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Epicardial Adipose Tissue ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness
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