scholarly journals Ultrasound Detection of Epicardial Adipose Tissue Combined With Ischemic Modified Albumin in the Diagnosis of Coronary Heart Disease

2020 ◽  
Vol 23 (4) ◽  
pp. E461-E464
Author(s):  
Jiandong Xiao ◽  
Yuli Lu ◽  
Xinchun Yang
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Epicardial Adipose Tissue ◽  
Reference Value ◽  
Control Group ◽  
Case Group ◽  
Disease Group ◽  
Vessel Disease ◽  
Single Vessel

Objective: To evaluate the value of epicardial adipose tissue (EAT) thickness combined with serum ischemic modified albumin (IMA) concentration in the diagnosis of coronary heart disease. Methods: A total of 180 patients with coronary heart disease from May 2017 to December 2018 were selected as the case group. After the examination of Judkins coronary angiography, they were grouped according to the results of angiography, including 60 patients in a single-vessel group, 60 patients in a double-vessel group, and 60 patients in a multi-vessel group. Sixty healthy people with physical examinations at our hospital at the same time were selected as the control group. All selected participants were tested for epicardial adipose tissue thickness by echocardiography and serum IMA concentration by albumin cobalt ion binding test. Results: The EAT thickness and IMA concentration in the single-vessel disease group, double-vessel disease group, and multi-vessel disease group significantly were higher than those in the control group (P < .01). The ROC curve shows that the sensitivity is 53.33% and the specificity is 87.6%, when the EAT thickness is 6.12 mm. The sensitivity is 76.0% and the specificity is 72.3%, when the serum IMA concentration is 72 U/L. When the two were combined, the sensitivity was 40.15% and the specificity was 96.89%. In the parallel test, the sensitivity was 88.3% and the specificity was 65.44%. Conclusion: Ultrasound detection of EAT thickness and serum IMA concentration has certain reference value for the diagnosis of coronary heart disease. Combined diagnosis can significantly improve the diagnosis rate and accuracy of coronary heart disease.

scholarly journals Correlation analysis of epicardial adipose tissue volume quantified by computed tomography images and coronary heart disease under optimized reconstruction algorithm

2021 ◽  
Vol 37 (6-WIT) ◽  
Author(s):  
Zhenwei Miao ◽  
Hongyan Yang ◽  
Bofen Liu ◽  
Wengui Li
Keyword(s):  
Computed Tomography ◽  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Risk Factor ◽  
Heart Disease ◽  
Correlation Analysis ◽  
Epicardial Adipose Tissue ◽  
Reconstruction Algorithm ◽  
Control Group ◽  
Computed Tomography Images

Objectives: This paper was aimed to explore the adoption value of low-dose computed tomography (CT) imaging based on optimized ordered subset expectation maximization (OSEM) reconstruction algorithm in the correlation analysis between epicardial adipose tissue (EAT) volume and coronary heart disease (CHD). Methods: A total of 110 patients with CHD were selected for CT angiography (CTA) and coronary arteriography (CAG) examinations from October 2017 to October 2019. The predictive value of EAT for CHD was analyzed via receiver operating characteristic (ROC) curve. Results: The results showed that the iteration time and error of the improved OSEM reconstruction algorithm were better than that of MLEM algorithm under the same number of iterations. Age, smoking, hypertension, diabetes, and EAT in control group were obviously lower in contrast to those in CHD group (P<0.05). EAT in control group was (124.50±26.72) mL, and EAT in the CHD group was (159.41±38.51) mL. EAT (B=0.023, P=0.003) was an independent risk factor for CHD, which was suggested by Multiple linear regression analysis. Moreover, EAT was a risk factor for CHD, and was positively correlated with the degree and NSCV. Conclusion: The optimized OSEM algorithm was used to improve the reconstruction quality of low-dose CT images and used in quantitative measurement of epicardial fat volume. Results showed EAT was an independent risk factor for CHD, and was positively correlated with the number of coronary lesions and Gensini score. It was of great value for the prediction of CHD. doi: https://doi.org/10.12669/pjms.37.6-WIT.4882 How to cite this:Miao Z, Yang H, Liu B, Li W. Correlation analysis of epicardial adipose tissue volume quantified by computed tomography images and coronary heart disease under optimized reconstruction algorithm. Pak J Med Sci. 2021;37(6):1677-1681.  doi: https://doi.org/10.12669/pjms.37.6-WIT.4882 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals The relationship between arterial stiffness index and coronary heart disease and its severity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Longjian Gao ◽  
Dasheng Lu ◽  
Guangwei Xia ◽  
Hao Zhang
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Arterial Stiffness ◽  
Roc Analysis ◽  
Stiffness Index ◽  
Control Group ◽  
Disease Group ◽  
Vessel Disease ◽  
Arterial Stiffness Index

Abstract Background Arterial stiffness index (ASI) is closely related to coronary atherosclerosis. This study aims to explore whether ASI can predict coronary heart disease (CHD) and its severity. Methods In this study, a total of 726 patients with suspected CHD were recruited. Based on coronary angiography results, the subjects were assigned into three groups: the control group (without obvious coronary artery disease), single-vessel disease group, and multi-vessel disease group (the number of vessels diseased ≥ 2). At the same time, according to the results of angiography, myocardial enzyme spectrum, electrocardiogram, color Doppler echocardiography and clinical manifestations, these patients were divided into four groups: the control group, stable angina (SA) Group, unstable angina (UA) group, and acute myocardial infarction (AMI) group. We have compared whether there were differences in ASI and related baseline data between groups. Receiver operating curve (ROC) analysis was conducted to determine whether ASI could predict CHD and evaluate the severity. Results ASI was positively correlated with the number of diseased branches of coronary artery. The value of ASI was increased as the number of the diseased branches increased. The ASI value in the SA group was significantly higher compared with the control group. Furthermore, the ASI value in the UA and AMI groups was remarkably increased compared with the control and SA groups. The results of ROC analysis indicated that the sensitivity and specificity of ASI was 71.0% and 85.4% in diagnosing CHD, respectively. While ASI was used in predicting the severity of CHD, the sensitivity was 72.1% and specificity 57.9%. Conclusion ASI is of great value in the diagnosis of coronary heart disease and the prediction of its severity.

scholarly journals Radiomic features of epicardial adipose tissue in coronary atherosclerosis

2021 ◽  
Vol 10 (4) ◽  
pp. 6-16
Author(s):  
E. V. Popov ◽  
Zh. Zh. Anashbaev ◽  
A. N. Maltseva ◽  
S. I. Sazonova
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Perfusion Defect ◽  
Epicardial Adipose Tissue ◽  
Study Groups ◽  
Control Group ◽  
Computer Tomogram ◽  
Computed Coronary Angiography

Aim. To investigate the association of the radiomic characteristics of epicardial adipose tissue (EAT) on contrast-free computed tomography (CT) of the heart with the severity of obstructive coronary lesion and myocardial ischemia.Methods. The study included 68 patients with coronary heart disease (mean age of 63.5±9.4, 45 men and 23 women), and 15 patients (mean age 30±4.8; 14 men and 1 woman) without cardiovascular disease as a control group. All the patients underwent multispiral computed coronary angiography, coronary calcium scores (CCS) determination and stress myocardial perfusion scintigraphy. Radiomic characteristics of EAT (texture analysis by gradations of gray color) were determined on non-contrast computer tomogram images of the heart using 3D-Sliser software and the SliserRadiomics module (version 4.10.2). The obtained indicators were compared between a control and under the study groups as well as between subgroups of patients divided according to the degree of obstruction of the coronary arteries, the size of the perfusion defect, and the value of the CCS.Results. The comparative analysis of radiomic indicators of EAT between patients with coronary artery disease and the control group showed the presence of statistically significant differences between them. At the same time, the correlation analysis in the study group did not reveal any correlations between the radiomic parameters and the size of the perfusion defect, CCS or degree of stenosis of the lumen of the coronary arteries.Conclusion. The textural characteristics of EAT in patients with coronary heart disease differ from those in individuals without cardiovascular pathology. At the same time, these indicators are not associated with the severity of obstructive lesions of the coronary arteries, the value of the CCS, and the size of the perfusion defect according to scintigraphy.

scholarly journals Platelet Aggregation in Heart Disease

1977 ◽  
Author(s):  
K. Oversohl ◽  
W. Theiss ◽  
C.S. So ◽  
K.F. Seidl
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Platelet Aggregation ◽  
Cardiac Catheterization ◽  
Valvular Heart Disease ◽  
Platelet Adhesion ◽  
Control Group ◽  
Vessel Disease ◽  
Platelet Adhesion And Aggregation ◽  
Spontaneous Aggregation

Increased platelet adhesion and aggregation has been reported in patients suffering from rheumatic valvular heart disease and from atherosclerotic heart disease. We therefore measured spontaneous aggregation “PAT III” (Breddin) and ADP-induced platelet aggregation (Born) in 141 patients who underwent cardiac catheterization. There were 50 patients with coronary heart disease, 41 with valvular heart disease, 18 with cardiomyopathy; 32 with normal findings at catheterization served as control group.In comparison to controls, patients with coronary heart disease had significantly increased aggregation. Subdivision into 1, 2, or 3 vessel disease revealed no significant differences. Patients with valvular heart disease also had significantly increased aggregation. This appears to be particularly the case after valvular grafting. Cardiomyopathies were not associated with increased platelet aggregation.

Leptin Gene Expression In Males Epicardial Adipose Tissue In Coronary Heart Disease

2019 ◽  
Vol 287 ◽  
pp. e254-e255
Author(s):  
E. Polyakova ◽  
O. Berkovich ◽  
O. Belyaeva ◽  
V. Ionin ◽  
E. Baranova ◽  
...  
Keyword(s):  
Gene Expression ◽  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Epicardial Adipose Tissue

scholarly journals Activity of coagulation processes with comorbid hypertension and coronary heart disease

2021 ◽  
pp. 35-38
Author(s):  
A. I. Pastushyna
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Protein C ◽  
Stage Ii ◽  
Stage Iii ◽  
Control Group ◽  
Disease Group ◽  
Hypertensive Patients ◽  
Coronary Heart Disease Group ◽  
The Difference

Purpose – determine the characteristics of changes of procoagulant, anticoagulant and fibrinolytic links of the hemostatic system in patients with hypertension in combination with coronary heart disease. Materials and methods. 127 people were examined - 14 healthy (control), 61 patients with stage II hypertension with concomitant coronary heart disease (group 2), 52 hypertensive patients with stage III with concomitant coronary heart disease (group 3). There were evaluated indicators of hemostasis system: thrombin time, activated partial thromboplastin time, prothrombin index, soluble fibrin monomer complex, fibrinogen, protein C, antithrombin III of, and the time of XII-dependent fibrinolysis. Results. Patients on both study groups SFMC content significantly higher than the control group. SFMC content in patients with stage II hypertension with concomitant coronary heart disease exceed normative value of 3 times, and in the group of hypertensive patients with stage III with with concomitant coronary heart disease of 3.65 times. The content of fibrinogen in the third group of patients exceeded the indicators of the control group by 27.6%, the difference was significant (p<0,001). Also valid was the difference between the two comparable groups (p<0,001). The content of protein C in hypertensive patients stage III was lower than the control values at 28,7% (p<0,001). The difference between comparable groups also were significantly (p<0,001). At the same time, and XII-dependent fibrinolysis in patients with stage II hypertension in combination with coronary heart disease was 3.54 times longer than the standard values (p<0,001), and the combination of hypertension III stage with CAD - 4.7 times longer than the norm (p< 0.001). Conclusions. Patients with hypertension stage II and III with concomitant coronary heart disease characterized by increased blood clotting activity in the background suppression of the anticoagulant and fibrinolytic components of hemostasis. The largest contribution to the formation of thrombophilic changes in patients of both treatment groups belongs to inhibition of fibrinolysis, which is more pronounced when hypertension stage III combined with coronary heart disease.

Thickness and an Altered miRNA Expression in the Epicardial Adipose Tissue Is Associated With Coronary Heart Disease in Sudden Death Victims

2019 ◽  
Vol 72 (1) ◽  
pp. 30-39 ◽  
Author(s):  
Josep Marí-Alexandre ◽  
Moises Barceló-Molina ◽  
Jorge Sanz-Sánchez ◽  
Pilar Molina ◽  
Jennifer Sancho ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Sudden Death ◽  
Mirna Expression ◽  
Epicardial Adipose Tissue

Can Epicardial Adipose Tissue be Defined as an Early Marker of Treatment Decisions of Subclinical Hypothyroidism in Childhood?

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Asik G ◽  
◽  
Ergur AT ◽  
Sanli C ◽  
◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Medical Treatment ◽  
Subclinical Hypothyroidism ◽  
Epicardial Adipose Tissue ◽  
Treated Group ◽  
Control Group ◽  
Overt Hypothyroidism ◽  
Case Group ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness

Introduction and Aim: Childhood overt hypothyroidism is a chronic disease that affect many system adversely and requires treatment. However, Subclinical Hypothyroidism (SH), defined obvious cases, impacts on other systems are unknown and there is no common approach to be treated. Moreover, SH may continue for many years, before they become overt hypothyroidism. Cardiovascular System (CVS) is one of the host system, which hypothyroidism adversely affects. Epicardial Adipose Tissue Thickness (EAT) is known to be an important marker in terms of the cardiovascular risks. We aimed to determine the effects on CVS in children with SH. Material and Methods: The study included were 100 cases, which are 1-18 years had categorized in two groups; control group (50 children), who had no signs of thyroidal dysfunction and case group (50 children) who had diagnosed with SH, are recruited in the study. SH was diagnosed according to the slightly higher TSH than the upper limit (4.2M/L), normal free T4 and T3 levels. Medical treatment (LT4) was decided according to the levels of TSH, sT3, sT4 and clinical status. EAT was determined by transthoracic echocardiographic measurements in millimeters. The SH cases were classified into two groups in terms of medical treatment. EAT thickness was measured in patients with treated group (SH1) and non-treated group (SH2) at admission (EAT0) and at 6 months (EAT 6). Results: Epicardial adipose tissue thickness was significantly higher in SH children, than the children without thyroid dysfunction. The mean value of the EAT in control group was 2,11±0,52 mm. Mean of EAT0 was 4,08±1,41 in group SH1, mean of EAT0 was 4,31±1,09 mm in group SH2. In addition, mean of EAT6 was 3.65±1,27 mm in group SH1 and mean of EAT6 was 4,16±1,10 in group SH2. Although there were a decrease in both group SH1 and SH2, at EAT6 compared to the EAT0, and this decrease was more significant in group SH1.

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