Evaluation of subclinical cardiovascular risk and cardiac function in children with vesicoureteral reflux: a prospective study

2021 ◽  
pp. 1-7
Author(s):  
Ahmet Midhat Elmacı ◽  
Hayrullah Alp ◽  
Muhammet İrfan Dönmez
Keyword(s):  
Adipose Tissue ◽  
Vesicoureteral Reflux ◽  
Epicardial Adipose Tissue ◽  
Renal Scarring ◽  
Subclinical Atherosclerosis ◽  
Study Groups ◽  
Tissue Doppler ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Healthy Controls

Abstract Background: Vesicoureteral reflux is a prominent congenital anomaly of the kidney and the urinary tract. Further, renal scarring is known to be related to chronic inflammation. However, there have been limited studies to date regarding the cardiovascular consequences of vesicoureteral reflux. Objective: The aim of this study is to evaluate the possible subclinical atherosclerosis and cardiovascular complications in children with vesicoureteral reflux. Methods: Patients with vesicoureteral reflux and age matched healthy controls were prospectively included in this case-control study. Patients were divided into two groups concerning renal scarring status. To assess cardiac functions, carotid artery intima media, epicardial adipose tissue, and periaortic adipose tissue thicknesses were evaluated. Results: There were 50 patients with vesicoureteral reflux; 26 patients without renal scarring and 24 patients with renal scarring, as well as 40 healthy controls. Myocardial performance indexes (Tei indexes) measured by tissue Doppler echocardiography from septum and left ventricle were significantly increased in study group (for all, p < 0.001). Also, intima media, epicardial adipose tissue, and periaortic adipose tissue thicknesses of the study groups were significantly higher than the control group (for all, p < 0.001). However, no statistical difference was observed between renal scarring (−) and renal scarring (+) groups. Conclusions: Results of our study showed early deterioration of cardiac systolic and diastolic functions in children with vesicoureteral reflux regardless of renal scarring. Also, diagnosis of vesicoureteral reflux is an important risk factor for subclinical atherosclerosis, independent of renal scarring, which should be considered in the follow-up of these patients.

scholarly journals The evaluation of epicardial adipose tissue and carotid intima media thickness in patients with Behçet’s disease

2021 ◽  
pp. 95-95
Author(s):  
Gonca Sağlam ◽  
Mehmet Turgut ◽  
Oktay Gülcü
Keyword(s):  
Adipose Tissue ◽  
Disease Activity ◽  
Epicardial Adipose Tissue ◽  
Subclinical Atherosclerosis ◽  
Laboratory Data ◽  
Clinical Manifestations ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Control Group ◽  
Media Thickness

Objective: Epidemiological studies indicate that cardiovascular disease is common in almost all patients diagnosed with autoimmune disease. This study aimed to examine whether Epicardial adipose tissue (EAT) and carotid intima media thickness (CIMT) differ among patients with Beh?et?s Disease (BD) and healthy individuals. Methods: A total of 40 healthy subjects as controls and 40 BD patients with musculoskeletal complaints were enrolled in this cross-sectional prospective study. Socio-demographic, clinical and laboratory data were obtained and compared between groups. Beh?et?s Disease Current Activity Form was used to assess disease activity. Both groups underwent echocardiography to measure EAT and CIMT. Results: The mean thickness of EAT (5.70?1.05; 2.50?0.61, respectively, p<0.001) and CIMT (0.68?0.05; 0.63?0.06, respectively, p: 0.002) were significantly increased in BD patients compared to the control group. A positive correlation was observed between EAT thickness and age (r:0.500, p:0.001), the duration of the disease (r:0.330, p<0.001), waist circumference (r:0.316, p: 0.013), and disease activity (r: 0.31, p<0.001) in the patient group. The CIMT was positively correlated with age (r: 0.594, p: 0.001) and the duration of the disease (r: 0.585, p: 0.001). Use of glucocorticoids or clinical manifestations (joint involvements, genital ulcer, skin lesions, inflammatory back pain and major organ involvement) of the patients were not found to be associated with EAT or CIMT. Conclusion: The thickness of EAT and CIMT are increased in patients with BD that are associated with disease activity. Echocardiographic measurement of EAT and CIMT is an objective, noninvasive and available method that can evaluate the risk of subclinical atherosclerosis in patients with BD.

scholarly journals Radiomic features of epicardial adipose tissue in coronary atherosclerosis

2021 ◽  
Vol 10 (4) ◽  
pp. 6-16
Author(s):  
E. V. Popov ◽  
Zh. Zh. Anashbaev ◽  
A. N. Maltseva ◽  
S. I. Sazonova
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Perfusion Defect ◽  
Epicardial Adipose Tissue ◽  
Study Groups ◽  
Control Group ◽  
Computer Tomogram ◽  
Computed Coronary Angiography

Aim. To investigate the association of the radiomic characteristics of epicardial adipose tissue (EAT) on contrast-free computed tomography (CT) of the heart with the severity of obstructive coronary lesion and myocardial ischemia.Methods. The study included 68 patients with coronary heart disease (mean age of 63.5±9.4, 45 men and 23 women), and 15 patients (mean age 30±4.8; 14 men and 1 woman) without cardiovascular disease as a control group. All the patients underwent multispiral computed coronary angiography, coronary calcium scores (CCS) determination and stress myocardial perfusion scintigraphy. Radiomic characteristics of EAT (texture analysis by gradations of gray color) were determined on non-contrast computer tomogram images of the heart using 3D-Sliser software and the SliserRadiomics module (version 4.10.2). The obtained indicators were compared between a control and under the study groups as well as between subgroups of patients divided according to the degree of obstruction of the coronary arteries, the size of the perfusion defect, and the value of the CCS.Results. The comparative analysis of radiomic indicators of EAT between patients with coronary artery disease and the control group showed the presence of statistically significant differences between them. At the same time, the correlation analysis in the study group did not reveal any correlations between the radiomic parameters and the size of the perfusion defect, CCS or degree of stenosis of the lumen of the coronary arteries.Conclusion. The textural characteristics of EAT in patients with coronary heart disease differ from those in individuals without cardiovascular pathology. At the same time, these indicators are not associated with the severity of obstructive lesions of the coronary arteries, the value of the CCS, and the size of the perfusion defect according to scintigraphy.

Evaluation of Epicardial Adipose Tissue in Patients of Type 2 Diabetes Mellitus by Echocardiography and its Correlation with Intimal Medial Thickness of Carotid Artery

2017 ◽  
Vol 125 (09) ◽  
pp. 598-602 ◽  
Author(s):  
Zihang Wang ◽  
Yuhong Zhang ◽  
Weiwei Liu ◽  
Benli Su
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Carotid Artery ◽  
Epicardial Adipose Tissue ◽  
Control Group ◽  
Intimal Medial Thickness ◽  
Type 2 Diabetic

AbstractThe present study aimed to evaluate the diagnostic value of echocardiography in measuring the thickness of epicardial adipose tissue (EAT) of the patients of type 2 diabetes mellitus (T2DM) and its correlation with the intimal-medial thickness of the carotid artery (cIMT) to investigate the relationship between EAT and cIMT. 68 patients of T2DM were enrolled and were divided into 2 groups: group of T2DM with duration≤10 years (35 cases) and group of T2DM with duration>10 years (33 cases). And 30 healthy subjects were enrolled as the control group. The thickness of EAT and cIMT were measured by echocardiography and high-frequency ultrasonography. The thickness of EAT and IMT of the carotid artery of 2 type 2 diabetic groups (duration≤10 years and>10 years) were significantly higher than that of the control group (all p<0.05), and the thickness of EAT and cIMT of the group of T2DM with duration>10 years were significantly higher than that of the group of T2DM with duration≤10 years (p<0.05). In univariate analysis, the thickness of EAT was positively and significantly associated with age (r=0.412, p<0.05), BMI (r=0.566, p<0.05), waist circumference (r=0.475, p<0.05), LDL (r=0.425, p<0.05), TG (r=0.496, p<0.05), duration of diabetes (r=0.384, p<0.05) and cIMT (r=0.456, p<0.05). In multiple stepwise regression analyses, age, BMI and IMT of carotid artery were appeared to be significantly associated with EAT (p<0.05 for all). In conclusion, routine screening of EAT and cIMT by ultrasonography in type 2 diabetic patients helps us to predict cardiovascular risks and prevent further development of cardiovascular complications.

scholarly journals The Relationship between Epicardial Adipose Tissue Thickness and Serum Interleukin-17a Level in Patients with Isolated Metabolic Syndrome

Biomolecules ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 97 ◽  
Author(s):  
Esra Demir ◽  
Nazmiye Harmankaya ◽  
İrem Kıraç Utku ◽  
Gönül Açıksarı ◽  
Turgut Uygun ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Control Group ◽  
Model Assessment ◽  
Tissue Thickness ◽  
The Metabolic Syndrome ◽  
Epicardial Adipose Tissue Thickness ◽  
The Relationship

In this study, it was aimed to investigate the relationship between the epicardial adipose tissue thickness (EATT) and serum IL-17A level insulin resistance in metabolic syndrome patients. This study enrolled a total of 160 subjects, of whom 80 were consecutive patients who applied to our outpatient clinic and were diagnosed with metabolic syndrome, and the other 80 were consecutive patients who were part of the control group with similar age and demographics in whom the metabolic syndrome was excluded. The metabolic syndrome diagnosis was made according to International Diabetes Federation (IDF)-2005 criteria. EATT was measured with transthoracic echocardiography (TTE) in the subjects. IL-17A serum levels were determined using the ELISA method. Fasting blood glucose, HDL, triglyceride, and fasting insulin levels were significantly higher in the metabolic syndrome group compared to the control group. In addition, the metabolic syndrome group had significantly higher high-sensitivity C-reactive protein (hs-CRP) and Homeostatic Model Assessment Insulin Resistance (HOMA-IR) levels than the control group. Similarly, serum IL-17A levels were significantly elevated in the metabolic syndrome group compared to the control group statistically (p < 0.001). As well, EATT was higher in the metabolic syndrome than the control group. Conclusion: By virtue of their proinflammatory properties, EATT and IL-17 may play an important role in the pathogenesis of the metabolic syndrome.

scholarly journals Can Epicardial Adipose Tissue be Defined as an Early Marker of Treatment Decisions of Subclinical Hypothyroidism in Childhood?

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Gaye Asik ◽  
◽  
Ayça Törel Ergür ◽  
Cihat Sanli ◽  
◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Medical Treatment ◽  
Cardiovascular System ◽  
Subclinical Hypothyroidism ◽  
Epicardial Adipose Tissue ◽  
Treated Group ◽  
Control Group ◽  
Overt Hypothyroidism ◽  
Tissue Thickness ◽  
Epicardial Adipose Tissue Thickness

Introduction and Aim: Childhood overt hypothyroidism is a chronic disease that affect many system adversely and requires treatment. However, Subclinical Hypothyroidism (SH) ,defined obvious cases, impacts on other systems are unknown and there is no common approach to be treated. Moreover, SH may continue for many years, before they become overt hypothyroidism. Cardiovascular System (CVS) is one of the host system, which hypothyroidism adversely affects. Epicardial Adipose Tissue thickness (EAT) is known to be an important marker in terms of the cardiovascular risks. We aimed to determine the effects on CVS in children with SH. Material and Methods: The study included were 100 cases, which are 1-18 years had categorized in two groups; control group (50 children), who had no signs of thyroidal dysfunction and case group (50 children) who had diagnosed with SH, are recruited in the study. SH was diagnosed according to the slightly higher TSH than the upper limit (4.2M/L), normal free T4 and T3 levels. Medical Treatment (LT4) was decided according to the levels of TSH, sT3, sT4 and clinical status. EAT was determined by transthoracic echocardiographic measurements in millimeters. The SH cases were classified into two groups in terms of medical treatment. EAT thickness was measured in patients with treated group (SH1) and non-treated group (SH2) at admission (EAT0) and at 6. months (EAT 6). Results: Epicardial adipose tissue thickness was significantly higher in SH children, than the children without thyroid dysfunction. The mean value of the EAT in control group was 2,11 ± 0,52mm. Mean of EAT0 was 4,08 ± 1,41 in group SH1, mean of EAT0 was 4,31 ± 1,09mm in group SH2. In addition, mean of EAT6 was 3.65 ± 1,27mm in group SH1 and mean of EAT6 was 4,16 ± 1,10 in group SH2. Although there were a decrease in both group SH1 and SH2, at EAT6 compared to the EAT0, and this decrease was more significant in group SH1. Discussion: This study suggests that subclinical hypothyroidism effects adversly the cardiovascular system in children before hypothyroidism become overt. In future this data may be marker at the begining of LT4 treatment in children with SH.

scholarly journals Cardiovascular risk rate in hypertensive patients attended in primary health care units: the influence of pharmaceutical care

2015 ◽  
Vol 51 (3) ◽  
pp. 617-627 ◽  
Author(s):  
Paulo Yuri Milen Firmino ◽  
Tainá Osterno Vasconcelos ◽  
Caroline Carneiro Ferreira ◽  
Larissa Mendonça Moreira ◽  
Nirla Rodrigues Romero ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Pharmaceutical Care ◽  
Intervention Group ◽  
Study Groups ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Pharmacological Interventions ◽  
Hypertensive Patients ◽  
Clinical Assay ◽  
Risk Rate

Cardiovascular complications are relevant due to their frequency and severity on the hypertension scenario. Studies refer Pharmaceutical Care (PC) as capable of decreasing cardiovascular risk rate (%CVR) on hypertensive patients. This study aimed to investigate, through a randomized clinical assay, the influence of PC service on the %CVR of hypertensive patients assisted in a health primary care unit from Fortaleza-Ceará. Two study groups were formed: i. Intervention Group (IG), which received orientation about taking medicines, actions aiming to prevent/solve medicine interactions and adverse effects and non-pharmacological interventions for 9 months and, ii. Control Group (CG), which received traditional assistance of the unit and was monitored during the same period. It was observed a statistically significant reduction on %CVR (10.76 to 7.86; p=0.04) and systolic blood pressure levels (SBP) (137.69 to 131.54; p<0.01) in the IG, while, in the CG, there was no significant alteration. 151 Drug Related Problem (DRP) were identified and it was realized 124 pharmaceutical interventions, with 89.2% of them resulting on solution/prevention of the problem. Our findings indicated that the inclusion of the PC service in the hypertensive health assistance was more effective at the %CVR and the SBP reduction in comparison to the traditional assistance offered.

Sign in / Sign up

Export Citation Format

Share Document