scholarly journals Prehospital sudden death from acute myocardial infarction in Tomsk (1984 and 2018): what has changed for 34 years

2020 ◽  
Vol 9 (4) ◽  
pp. 6-11
Author(s):  
S. A. Okrugin ◽  
A. B. Lvova ◽  
A. N. Repin

Aim. To compare the circumstances of the prehospital deaths among patients with acute myocardial infarction (AMI) in Tomsk in 1984 and 2018.Methods. Population-level data were collected from the WHO project “Acute Myocardial Infarction Registry”. In 1984, 739 cases of AMI were recorded, in 2018 - 924 ones. 262 (35.5%) and 359 (38.9%) deaths occurred in the acute phase, respectively. Of them, 158 (60.3%) and 148 (41.2%) patients died in the prehospital setting. 66 (41.8%) and 46 (31.1%) cases of deaths were selected for further analysis.Results. In 2018, the number of patients who did not receive timely medical care decreased from 74.2% to 52.2%, compared to 1984 (p <0.05). The number of cases when patients failed to call the ambulance due to a rapid loss of consciousness (cardiac arrest) or managed to call, but died before the ambulance arrived, was similar. The number of death among patients who received emergency medical services (EMS) increased from 25.8% to 47.9% (p <0.05).Conclusion. Prehospital mortality from AMI in Tomsk has improved over thirty years, but not drastically. Despite the number of patients who died before the first medical contact has decreased, they still make up about half of all cases. Every 4th-5th patient fails to contact EMS. In terms of reducing prehospital mortality, measures focused on the regular clinical examination of patients with cardiovascular diseases seem to be more promising for effective secondary prevention of coronary artery disease and AMI.

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110196
Author(s):  
Heyu Meng ◽  
Jianjun Ruan ◽  
Xiaomin Tian ◽  
Lihong Li ◽  
Weiwei Chen ◽  
...  

Objective This study aimed to investigate whether differential expression of the retinoic acid receptor-related orphan receptor A ( RORA) gene is related to occurrence of acute myocardial infarction (AMI). Methods This was a retrospective study. White blood cells of 93 patients with acute myocardial infarction and 74 patients with stable coronary artery disease were collected. Reverse transcription quantitative polymerase chain reaction and western blotting were used to measure RORA mRNA and protein expression, respectively. Results RORA mRNA expression levels in peripheral blood leukocytes in patients with AMI were 1.57 times higher than those in patients with stable coronary artery disease. Protein RORA levels in peripheral blood of patients with AMI were increased. Binary logistic regression analysis showed that high expression of RORA was an independent risk factor for AMI, and it increased the risk of AMI by 2.990 times. Conclusion RORA expression levels in patients with AMI is significantly higher than that in patients with stable coronary artery disease. High expression of RORA is related to AMI and it may be an independent risk factor for AMI.


Author(s):  
Sifat Jubaira ◽  
Forhadul Haque Mollah ◽  
Tahrim Mehdi ◽  
M Iqbal Arslan

The study was designed to explore serum copper as a risk factor for coronary artery disease (CAD). In this case-control study 30 healthy controls and 60 diagnosed cases of acute myocardial infarction (AMI) were enrolled. Serum copper concentration and serum lipid profile were measured in all study subjects. Serum copper level was significantly higher in AMI as compared to controls. The concentrations of serum TC, TG, LDL-C level were found to be significantly higher in cases as compared to controls. The concentration serum HDL-C was found to be significantly lower in cases as compared to controls. CAD leads to raised serum copper level and it has positive correlation with TC, TG and LDL-C but negative correlation with HDL-C in males.Keywords: Coronary artery disease; serum copper; acute myocardial infarction; total cholesterol; triglyceride; low density lipoprotein cholesterol. DOI: 10.3329/bjpp.v24i1.5730Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 7-9


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