scholarly journals Posterior colpotomy (colpotomia posterior) with inflammation of the uterine appendages and neoplasms in them

2020 ◽  
Vol 11 (9) ◽  
pp. 902-909
Author(s):  
Yv. M. Lvov
Keyword(s):  
Clinical Data ◽  
German Literature ◽  
Surgical Method ◽  
Clinical Observations ◽  
Critical Note ◽  
Posterior Colpotomy ◽  
Posterior Fornix

In 1892, in The Doctor, I published my first article the removal of the uterine appendages and their neoplasms through the vagina. In this article, on the basis of my clinical observations, I recommended for some cases a new surgical method for removing large appendages of the uterus and their neoplasms through the posterior fornix. This article of mine caused only one critical note by Dr. Tipyakov in the same "Doctor" in which he spoke out against this operation. I replied to this article with a second article, also in Physician for the same 1892, in which I proved with new clinical observations the relevance and superiority of this operation before gluttony in certain cases. Then, until 1895, no attention was paid to my proposal, and only from that time, when the question of vaginae fixatio uteri began to be developed in German literature, and then when prof. Dhrssen's proposal to remove uterine appendages and some neoplasms of the uterus using colpotomiae anterior, since that time the question of the significance of colpotomiae anterior et posterior for removing diseased uterine appendages and their neoplasms has become fashionable on the pages of the special medical press. At the present time, the literature on this issue is quite large and I will not expound it here, since this issue will be examined in detail in a special work of my friend Dr. P. Ya. Teplov, which will soon appear in print. I currently wish only to summarize my clinical data on posterior colpotomia.

Cure of Interstitial Cystitis and Non-Ulcerating Hunner’s Ulcer by Cardinal/Uterosacral Ligament Repair

2021 ◽  
pp. 1-4
Author(s):  
Kay Scheffler ◽  
Oliver W. Hakenberg ◽  
Peter Petros
Keyword(s):  
Interstitial Cystitis ◽  
Uterine Prolapse ◽  
English Literature ◽  
German Literature ◽  
Uterosacral Ligament ◽  
Original Intention ◽  
Uterosacral Ligaments ◽  
Bladder Symptoms ◽  
Posterior Fornix ◽  
The Relationship

A serendipitous cure in a 73-year-old woman of Hunner’s ulcer, urge, nocturia, apical prolapse by a tissue fixation system tensioned minisling (TFS) which reinforced the cardinal, and uterosacral ligaments (USLs) led us to analyse the relationship between Hunner’s ulcer and known pain conditions associated with USL laxity. The original intention was to cure the “posterior fornix syndrome” (PFS), uterine prolapse, and associated pain and bladder symptoms by USL repair. A speculum inserted preoperatively into the posterior fornix alleviated pain and urge symptoms, by mechanically supporting USLs. Hunner’s ulcer, along with pain and other PFS symptoms were cured by USL repair. The concept of USL laxity causing chronic pelvic pain and bladder problems is not new. It was published in the German literature by Heinrich Martius in 1938 and by Petros in the English literature in 1993. These findings raise important questions. As PFS symptoms are identical with those of interstitial cystitis (IC), are PFS and IC similar conditions? If so, then patients with IC who have a positive speculum test are at least theoretically, potentially curable by USL repair. These questions need to be explored.

Online orthodontic advice: a protocol for a pilot teledentistry system

2001 ◽  
Vol 7 (6) ◽  
pp. 324-333 ◽  
Author(s):  
J Cook ◽  
C Mullings ◽  
R Vowles ◽  
R Ireland ◽  
C Stephens
Keyword(s):  
Expert System ◽  
Clinical Data ◽  
Data File ◽  
The Internet ◽  
Radiographic Images ◽  
Dental Practitioner ◽  
Clinical Observations ◽  
General Dental Practitioner

A prototype teledentistry service was established that incorporated a PC-based expert system designed to assist in orthodontic cases. It guided the general dental practitioner (GDP) through the assessment of a patient's malocclusion and helped ensure that all relevant clinical observations were made and details recorded. The resulting data file, containing radiographic images and clinical data, was then transferred via the Internet to a dental specialist. The specialist's recommendations were returned by the same route or, where appropriate, a realtime videoconference was conducted. During an eight-month trial, six GDPs referred 158 cases through the teledentistry system; another 24 cases were referred directly to a local consultant. The protocol used during the trial worked satisfactorily. The GDPs found that it was straightforward and covered all aspects of the cases they submitted.

Mathematical modelling of malaria chemotherapy: combining artesunate and mefloquine

Parasitology ◽  
2002 ◽  
Vol 124 (1) ◽  
pp. 9-15 ◽  
Author(s):  
M. B. HOSHEN ◽  
W. D. STEIN ◽  
H. GINSBURG
Keyword(s):  
Combination Therapy ◽  
Mathematical Modelling ◽  
Clinical Data ◽  
Drug Combinations ◽  
Human Populations ◽  
Pharmacokinetic Data ◽  
Pharmacodynamic Interaction ◽  
Treatment Regimens ◽  
Lower Resistance ◽  
Clinical Observations

Clinical data on the use of artesunate combined with mefloquine in a variety of treatment regimens and parasite loads in Thailand were modelled on the basis of experimentally determined pharmacokinetic data. The model assumed no pharmacodynamic interaction between artesunate and mefloquine, but that the parasites were already resistant to mefloquine. Predictions of the model accorded well with the data. In particular, in accordance with clinical observations, the model showed that monotherapy with either drug failed to cure at moderate parasitaemia, yet such patients could be treated effectively with the combination of 3 days of artesunate + mefloquine. For high levels of parasitaemia, 5 days of artesunate+mefloquine were needed. Simulations were also performed for situations of lower resistance to mefloquine and for the immune human populations found in Africa. The importance of mathematical modelling of combination therapy is borne out by this study and suggests its wider application for other drug combinations.

scholarly journals The blood parameters and liver function changed inconsistently among children between burns and traumatic injuries

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6415 ◽  
Author(s):  
Chan Nie ◽  
Tao Wang ◽  
Huiting Yu ◽  
Xue Wang ◽  
Xueqin Zeng ◽  
...  
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Clinical Data ◽  
Traumatic Injury ◽  
Blood Parameters ◽  
Blood Cell Count ◽  
Traumatic Injuries ◽  
Routine Blood ◽  
Acute Response ◽  
Clinical Observations

Objective Burn and traumatic injury are two kinds of injury by modality. They cause acute phase response and lead to a series of pathological and physiological changes. In this study, we explored whether there are differences in routine blood parameters and liver enzyme levels between burned and traumatically injured children. Methods Patients under 18 years old with injuries were recruited. Their demographic and clinical data were recorded. Collected clinical data included routine blood parameters (white blood cell count (WBC), red blood cell count (RBC), platelets (PLT), hemoglobin (HB)), serological enzyme levels (alanine aminotransferase (ALT), aspartate transaminase (AST), glutamyltransferase (GGT), alkaline phosphatase (ALP), cholinesterase (CHE)), and total protein (TP) levels (albumin (ALB), globulin (GLB)). A generalized linear model and multivariate analysis of variance were used to conduct comparisons. Results A total of 162 children (109 with burns and 53 with traumatic injuries) with a mean age of 4.36 ± 4.29 years were enrolled in the study. Burned children had higher levels of RBC, HB, WBC, AST and lower levels of TP, CHE, ALB than traumatically injured children (P < 0.05). Moreover, the concentration of WBC and HB was higher in males compared to females (P < 0.001). Conversely, the level of AST and TP in males was lower, AST levels were significantly lower in males (P = 0.005). Age positively correlated with the levels of HB, AST and TP (P < 0.001), and negatively correlated with WBC (P < 0.001). With decreasing body mass index (BMI), the levels of WBC, HB, AST and TP significantly increased in both groups of injured children (P < 0.001). In addition, ISS was positively correlated with WBC and HB levels (P < 0.001), but negatively correlated with AST and TP levels (P < 0.001). Conclusions Children with burn injuries suffered a greater acute response and liver damage than traumatically injured children. This may in part underlie clinical observations of differences in children morbidity and mortality in response to different injury types.

Integrating Imaging and Clinical Data for Decision Support

2009 ◽  
pp. 18-33 ◽  
Author(s):  
William Hsu ◽  
Alex A.T. Bui ◽  
Ricky K. Taira ◽  
Hooshang Kangarloo
Keyword(s):  
Graphical Models ◽  
Clinical Data ◽  
Data Model ◽  
Medical Knowledge ◽  
Bayesian Belief Networks ◽  
Routine Care ◽  
Medical Decision ◽  
Disease Models ◽  
Open Problems ◽  
Clinical Observations

Though an unparalleled amount and diversity of imaging and clinical data are now collected as part of routine care, this information is not sufficiently integrated and organized in a way that effectively supports a clinician’s ability to diagnose and treat a patient. The goal of this chapter is to present a framework for organizing, representing, and manipulating patient data to assist in medical decision-making. We first demonstrate how probabilistic graphical models (specifically, Bayesian belief networks) are capable of representing medical knowledge. We then propose a data model that facilitates temporal and investigative organization by structuring and modeling clinical observations at the patient level. Using information aggregated into the data model, we describe the creation of multi-scale, temporal disease models to represent a disease across a population. Finally, we describe visual tools for interacting with these disease models to facilitate the querying and understanding of results. The chapter concludes with a discussion about open problems and future directions.

scholarly journals Clinical Observations of a Surgical Method Comprising a Combination of Cross Flap and Autologous Auricular Cartilage Transplantation in the Treatment of Type I to III Congenital Concha-Type Microtia

2021 ◽  
pp. 014556132110380
Author(s):  
Pengfei Sun ◽  
Meng Lu ◽  
Changchen Wang ◽  
Bo Pan ◽  
Haiyue Jiang
Keyword(s):  
Retrospective Study ◽  
Surgical Approach ◽  
Type I ◽  
Medical Sciences ◽  
Auricular Cartilage ◽  
Ischemic Necrosis ◽  
Cartilage Transplantation ◽  
Surgical Method ◽  
Satisfaction Rate ◽  
Clinical Observations

Objectives: The present study attempted to investigate the clinical efficacy of a surgical method involving a combination of cross flap with autologous auricular cartilage transplantation in the treatment of type I to III congenital concha-type microtia. Methods: The present retrospective study was conducted on the clinical and postoperative data of 50 patients with unilateral type I to III concha-type microtia treated with a combination of cross flap and autologous auricular cartilage transplantation at the Plastic Surgery Hospital of Chinese Academy of Medical Sciences from January 2018 to December 2021. Results: The postoperative perimeters of malformed ears were significantly larger than the preoperative perimeters ( P < .05). Of the total, 2 patients exhibited incision dehiscence, 3 patients exhibited incision infection, 2 patients exhibited flap hematoma, and 1 patient exhibited ischemic necrosis at the flap tip. The satisfaction rate of the patients and their families was 100%. Conclusions: The surgical method involving a combination of cross flap and autogenous auricular cartilage transplantation was effective in treating patients with type I to III congenital concha-type microtia, and therefore, this surgical approach can be applied widely to correct this deformity.

scholarly journals Клінічнi спостереження автотрансплантації зубів як альтернативи імплантації

2018 ◽  
Author(s):  
N. S. Hutor ◽  
N. O. Tverdokhlib ◽  
O. V. Avdeev
Keyword(s):  
Third Molar ◽  
Cost Effective ◽  
Diagnostic Methods ◽  
Third Molars ◽  
X Ray ◽  
Surgical Method ◽  
Clinical Observations ◽  
Patient Health Status ◽  
Patient Health ◽  
Somatic Diseases

Summary. Study of the tooth range defect area, the post-extraction alveolar socket, the state of the transplanted tooth by using an X-ray examination is relevant nowadays.The aim of the study – to increase the efficiency of complex treatment of patients with defects in the tooth range by using dental autotransplantation for their restoration.Materilas and Methods. 10 patients without somatic diseases were examined: 7 women and 3 men, aged 23 to 30, residents of Ternopil town. Using clinical and radiological methods of examination, they had found by ones periodontitis tooth that was not subject to therapeutic treatment, the presence of intact third molars. Autotransplantation and clinical observations were performed on 2 patients.Results and Discussion. According to clinical and radiological examination data, autotransplantation in patients, as a surgical method of treatment, is sufficiently effective. Clinical observations have proven that one way to restore the integrity of the tooth range can be autotransplantation. For its conduct, indications for surgical treatment with the use of modern diagnostic methods should be determined, patients’ consent is required. Conclusions. To conduct autotransplantation one should begin with indications for its implementation: the presence of intact third molars; presence of the first molars not subject to conservative treatment; age of the patient; health status; good hygiene of the oral cavity; preliminary careful X-ray examination. Autotransplantation of the third molar as a surgical method of treatment is a sufficiently effective, accessible, cost-effective operation for patients in the absence of the first molar.

Sentence-Based Experience Logging in New Hearing Aid Users

2020 ◽  
Vol 29 (3S) ◽  
pp. 631-637
Author(s):  
Katja Lund ◽  
Rodrigo Ordoñez ◽  
Jens Bo Nielsen ◽  
Dorte Hammershøi
Keyword(s):  
Hearing Aid ◽  
Patient Experiences ◽  
Online Tool ◽  
Rehabilitation Process ◽  
Hearing Rehabilitation ◽  
Clinical Observations ◽  
Hearing Aid Use ◽  
Wide Range ◽  
Insight Into ◽  
Shed Light

Purpose The aim of this study was to develop a tool to gain insight into the daily experiences of new hearing aid users and to shed light on aspects of aided performance that may not be unveiled through standard questionnaires. Method The tool is developed based on clinical observations, patient experiences, expert involvement, and existing validated hearing rehabilitation questionnaires. Results An online tool for collecting data related to hearing aid use was developed. The tool is based on 453 prefabricated sentences representing experiences within 13 categories related to hearing aid use. Conclusions The tool has the potential to reflect a wide range of individual experiences with hearing aid use, including auditory and nonauditory aspects. These experiences may hold important knowledge for both the patient and the professional in the hearing rehabilitation process.

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