scholarly journals Ginzburg. Artificial legal miscarriage according to the Peltzer method in case of severe bleeding in pregnant women. (Weekly, 1894, No. 10)

2020 ◽  
Vol 8 (10) ◽  
pp. 922

The author describes 2 cases of bleeding during pregnancy (5 months and 4 months), where, after unsuccessful attempts to stop the bleeding, he miscarried according to the method proposed by Peltzer. This method, as is known, consists in the fact that glycerin is poured through a catheter inserted a few centimeters between the walls of the uterus and the membranes. (Glycerin, having properties to irritate the mucous membrane of the uterus, acts more surely than water).

Author(s):  
V. Ya. Ivankiv ◽  
I. M. Malanchyn ◽  
N. I. Tkachuk

Background. The threat of preterm birth is one of the most topical issues in the world medicine. According to the statistics, from 12-13 to 25-35 % of all pregnancies end prematurely. One of the causes of preterm labour is chronic inflammatory processes of female genital organs and disorder of microbiocenosis. Timely diagnosis and adequate treatment will reduce the risk of premature labour and avoid perinatal loss.Objective. We examined and analysed the microflora of the skin of mammary glands and mucous membrane of vagina in healthy pregnant women and patients with threat of preterm labour.Materials and methods. The examination of the pregnant was conducted at the TRMPC “Mother and Child” in several stages. First of all, we rinsed the skin of mammary glands and smeared from mucous membrane the posterior vault of vagina with sterile swabs pre-moistened in physiological solution. After that, the tampons were placed in sterile tubes and delivered to laboratory. Sowing was carried out on Petri dishes with sterile medium: ZHSA, bloods MPA, Endo, Saburo, thioglycolic medium.Conclusions. As a result of the research we found saprophytic Gram-positive and Gram-negative microorganisms (in women with a physiological course of pregnancy). In pregnant women with preterm labour, there was the increase in the number of St. haemolyticus from 13% to 87%, appearance of representatives of pathogenic flora – St. aureus (in 20%).


Blood ◽  
2016 ◽  
Vol 128 (22) ◽  
pp. 2552-2552
Author(s):  
Thibault Comont ◽  
Guillaume Moulis ◽  
Karen Delavigne ◽  
Pierre Cougoul ◽  
Olivier Parant ◽  
...  

Abstract Immune thrombocytopenia (ITP) is an autoimmune disease that occurs in young women. Pregnancy is a well-known risk factor for developing newly diagnosed ITP as well as for inducing disease flares in patients with current ITP. However, the impact of pregnancy in women with an old history of ITP, considered as cured, has not been assessed. The aim of this study was to describe the course of ITP in pregnant women with an ITP in complete remission (platelets count >100x109/L and absence of bleeding symptoms) for at least 5 years without any ITP treatment. We retrospectively selected all pregnant women with delivery at Toulouse University Hospital, South of France, between 2010 and 2015 with a hospital discharge code of ITP (international classification of diseases; version 10 code D69.3). This code has a sensitivity of 81.2% and a positive predictive value of 89.8% in this database. All medical charts were reviewed to confirm the diagnosis of ITP. We included adult women (≥18 years) with a diagnosis of primary ITP according to French guidelines (platelet count <150 x 109 /L and exclusion of other causes of thrombocytopenia, especially other causes of thrombocytopenia during pregnancy) in complete remission for at least 5 years. We identified 50 pregnancies in 39 ITP patients during the study period. Eleven pregnancies occurred in 10 patients in long-term complete remission of ITP at the time of pregnancy onset. Baseline characteristics were: median age at ITP diagnosis: 21 years (range: 4-29); median age at pregnancy onset:32 years (range: 26-34; history of ITP during a previous pregnancy: 1; history of bleeding: 4 (36.4%); previous treatment for ITP: 8 (72.7%), corticosteroids-CS (5), CS and intravenously immunoglobulin-IVIg (3), splenectomy (4), dapsone (1); last median platelet count before pregnancy: 170x109/L (range: 118-363). Platelets count decreased below 100x109/L in 3 pregnancies (27.2%) from the first trimester for one patient, from the second trimester for one other and from the third trimester for the last one, with a nadir of 3, 39 and 87 (x109/L) respectively. One of them experienced a severe bleeding (grade 3 according to the International Working Group bleeding classification). All thrombocytopenic patients required treatment during pregnancy: CS+IVIg for 2 (one for bleeding and one to allow epidural analgesia) and IVIg for the other (to allow epidural analgesia). For these 3 women, the median platelet count at delivery was 128 (range: 38-159) and consequently only 2 of them could have epidural analgesia. No bleeding during delivery was observed. Transient thrombocytopenia occurred in 2 newborns. Primary ITP considered as cured may relapse during pregnancy and may induce severe bleeding requiring specific treatment. A tight monitoring should be proposed to all pregnant women with a history of primary ITP, even after several years of complete remission. Disclosures Récher: Celgene, Sunesis, Amgen, Novartis, Chugai: Membership on an entity's Board of Directors or advisory committees, Research Funding.


2021 ◽  
Vol 6 (1) ◽  
pp. 69-76
Author(s):  
E. N. Vaulina ◽  
N. V. Artymuk ◽  
O. A. Zotova

Here we analysed rare and acute complications of endometriosis in pregnant women by searching Cochrane, HINARY, and PubMed databases. Keywords were “rare”, “causes”, “acute”, “complications”, “endometriosis”, and “pregnancy”. The search depth was 10 years (2011−2021). In total, we found 126 publications, 41 of which met the selection criteria. The course of pregnancy and childbirth in patients with endometriosis is insufficiently studied. Yet, it is characterised by a higher risk of complications including those rarely occurring: haemoperitoneum, intestinal perforation, appendicitis, torsion and rupture of the endometrioid cyst, and thoracic endometriosis. Because of major hormonal changes occurring during the pregnancy, endometriosis undergoes a significant progression or decidualisation. As endometrioid tissue is characterised by a resistance to progesterone, its defciency during the pregnancy can lead to necrosis, perforation of decidualised foci, and severe bleeding. Progesterone deficiency provokes hypervascularisation of the endometrioid tissue, which is the most common cause of spontaneous haemoperitoneum and most frequently occurs in the third trimester of pregnancy and after in vitro fertilisation. Pregnancy increases the risk of endometriosis-related intestinal perforation of different localisation: small intestine, caecum, appendix, and rectosigmoid colon. Limited information about the pregnancy-related complications of endometriosis leads to their underestimation, albeit they can be life-threatening and significantly impact the health of the mother and fetus. The results of this review indicate the need for the further studies of the pregnancy course in patients with endometriosis, especially after the use of assisted reproductive technology. Development of specific clinical guidelines would contribute to the efficient prevention of obstetric and perinatal complications in patients with endometriosis.


Author(s):  
Shapla Akter ◽  
Tarazul Islam ◽  
Al Mamun Sarker ◽  
Md. Shohel Rana ◽  
Ashrafi Alim Roki

The rate of maternal mortality of Bangladesh is increasing day by day. Among many reasons early marriage, unplanned impregnation or lack of antenatal care are the major causes of those maternal deaths. Antenatal care is significantly effective for the mother and their newborns during pregnancy period especially from severe bleeding, high blood pressures, infections or complications during delivery. Several researches have conducted in various countries about the antenatal care service factors affecting pregnant women during pregnancy period but have not been organized information collectively. Hence, further research need to accomplish a literature review for finding organized information about the antenatal care service factors affecting pregnant women in Bangladesh. This is a descriptive analysis based on the information extracted from different literature review, primary and secondary data sources by using a specific methodology. The study found that 60.87 percent pregnant women have adequate information about the ANC services and 39.13 percent have partial knowledge about the ANC services. The major outcomes of this special review study might help the respective authorities and interested groups to make plan and improvement existing approaches for application of ANC factors affecting pregnant women in Bangladesh.


2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Barna Babik ◽  
Szilvia Kupcsulik ◽  
János Fazakas

AbstractEarly goal-directed treatment is an evidence-based approach to guide hemostatic therapy during major periprocedural bleeding. If viscoelastic coagulation tests are not available, an algorithm, termed the pyramid of hemostatic interventions, can help manage severe bleeding. Pregnant women accumulate huge reserves of prothrombotic and antifibrinolytic hemostatic elements to avoid peripartum blood loss. We provide comparison of therapeutic hemostatic approaches and natural gestational process and identified remarkable analogy between early goal-directed management of bleeding and hemostatic adaptation of pregnant woman. Therefore, gestational hemostasis serves as a natural model for goal-directed hemostasis resuscitation and can foster understanding of hemostatic management of periprocedural bleeding.


Author(s):  
I. N. Gorikov ◽  
V. P. Kolosov ◽  
L. G. Nakhamchen ◽  
A. N. Odireev ◽  
I. A. Andrievskaya ◽  
...  

Author(s):  
A. W. Fetter ◽  
C. C. Capen

Atrophic rhinitis in swine is a disease of uncertain etiology in which infectious agents, hereditary predisposition, and metabolic disturbances have been reported to be of primary etiologic importance. It shares many similarities, both clinically and pathologically, with ozena in man. The disease is characterized by deformity and reduction in volume of the nasal turbinates. The fundamental cause for the localized lesion of bone in the nasal turbinates has not been established. Reduced osteogenesis, increased resorption related to inflammation of the nasal mucous membrane, and excessive resorption due to osteocytic osteolysis stimulated by hyperparathyroidism have been suggested as possible pathogenetic mechanisms.The objectives of this investigation were to evaluate ultrastructurally bone cells in the nasal turbinates of pigs with experimentally induced atrophic rhinitis, and to compare these findings to those in control pigs of the same age and pigs with the naturally occurring disease, in order to define the fundamental lesion responsible for the progressive reduction in volume of the osseous core.


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