scholarly journals Glutathione detoxication processes in females suffering from sterility

2021 ◽  
Vol 51 (3) ◽  
pp. 98-100
Author(s):  
V. H. Inoyatova
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Tissue Homogenate ◽  
Activity Of Enzymes ◽  
Fertility Disorders ◽  
In The Beginning

Thirty females suffering from sterility were examined. Fertility disorders were accompanied by hyperandrogeny. Hormones FSH, LH, testosterone and progesterone in blood were studied. Besides, an activity of enzymes GPO, GTD, GST, G-6-PD in washed erythrocytes and tissue homogenate of ovary was investigated. Findings obtained demonstrate noticeable disorders in glutathione detoxication processes in females with infertility and they are related to hormones level, in particular androgens. An increase of GPO in females with hyperandrogeny showed deepupdates in metabolism processes of steroid hormones in ovary. It manifests beforehand for development of follicle that is predictive sign of unovulation in the beginning of menstrual cycle.

CHANGES IN THE CONCENTRATION OF PITUITARY AND STEROID HORMONES IN THE FOLLICULAR FLUID OF HUMAN GRAAFIAN FOLLICLES THROUGHOUT THE MENSTRUAL CYCLE

1975 ◽  
Vol 64 (3) ◽  
pp. 555-571 ◽  
Author(s):  
K. P. McNATTY ◽  
W. M. HUNTER ◽  
A. S. McNEILLY ◽  
R. S. SAWERS
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Follicular Fluid ◽  
Follicle Stimulating Hormone ◽  
Secretory Activity ◽  
Follicular Phase ◽  
Hormonal Changes ◽  
Peripheral Plasma ◽  
Before And After ◽  
Late Follicular Phase

SUMMARY The concentrations of FSH, LH, prolactin, oestradiol and progesterone were measured in peripheral plasma and follicular fluid of women throughout the menstrual cycle. With the exception of prolactin, concentrations of pituitary and steroid hormones in follicular fluid correlated with those in peripheral plasma. Follicle-stimulating hormone was present in a greater number of small follicles ( < 8 mm) during or just after the peaks of FSH in peripheral plasma. During the mid-follicular phase the concentration of both FSH and oestradiol in fluid from large follicles ( ≥ 8 mm) was high. During the late follicular phase the large follicles ( ≥ 8 mm) contained high amounts of progesterone in addition to oestradiol, low physiological levels of prolactin, and concentrations of LH and FSH about 30 and 60% respectively of those found in plasma. By contrast no large 'active' follicles ( ≥ 8 mm) were found during the luteal phase although many contained both LH and FSH. Luteinizing hormone was present in a proportion of small follicles ( < 8 mm) during the late follicular and early luteal but not at other stages of the menstrual cycle. It is suggested that a precise sequence of hormonal changes occur within the microenvironment of the developing Graafian follicle; the order in which they occur may be of considerable importance for the growth of that follicle and secretory activity of the granulosa cells both before and after ovulation.

scholarly journals Concentrations of steroid hormones, and of prolactin, in washings of the human uterus during the menstrual cycle

Reproduction ◽  
1986 ◽  
Vol 78 (1) ◽  
pp. 21-25 ◽  
Author(s):  
B. A. Stone ◽  
O. M. Petrucco ◽  
R. F. Seamark ◽  
B. M. Godfrey
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Human Uterus

Platelet 3H-imipramine binding and steroid hormones serum concentrations during the menstrual cycle

1986 ◽  
Vol 88 (1) ◽  
pp. 86-89 ◽  
Author(s):  
Marie-France Poirier ◽  
Chawki Benkelfat ◽  
Anne-Marie Galzin ◽  
Salomon Z. Langer
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Serum Concentrations ◽  
Imipramine Binding

scholarly journals Steroid Diagnostics of 21st Century in the Light of Their New Roles and Analytical Tools

2020 ◽  
pp. S193-S203 ◽  
Author(s):  
M. DUŠKOVÁ ◽  
L. KOLÁTOROVÁ ◽  
M. ŠIMKOVÁ ◽  
M. ŠRÁMKOVÁ ◽  
M. MALÍKOVÁ ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
21St Century ◽  
Reference Values ◽  
Current Technology ◽  
Amount Of Information ◽  
Analytical Phase ◽  
Analytical Tools ◽  
Fertile Women

The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First we focus on specific aspects arising from the pre-analytical phase of steroid determination that need to be considered when planning sampling, whether for diagnostics or research. Then, we provide a brief summary of the characteristics and diagnostic relevance of several steroid hormones and/or their metabolites: pregnenolone, 17α-hydroxy-pregnenolone, dehydroepiandrosterone, hydroxyderivatives of dehydroepiandrosterone, androstenedione, testosterone, estrone, estradiol, estriol, cortisol, cortisone, which in our institute are determined with validated LC-MS/MS methods. For these steroids, we also provide newly calculated reference values in fertile women according to the phase of their menstrual cycle.

Fundamental Frequency Variations Across the Menstrual Cycle and the Use of an Oral Contraceptive Pill

2020 ◽  
Vol 63 (4) ◽  
pp. 1033-1043
Author(s):  
Filipa M. B. Lã ◽  
Nuria Polo
Keyword(s):  
Oral Contraceptive ◽  
Standard Deviation ◽  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Fundamental Frequency ◽  
Oral Contraceptive Pill ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Contraceptive Pill ◽  
The Voice

Purpose Concentrations of sex steroid hormones—estrogens, progesterone, and testosterone—have been associated with premenstrual and menstrual vocal symptoms. However, the extent to which these symptoms may be reflected on acoustical features of the voice is still debated. This study investigates variations in fundamental frequency ( f o ) and related parameters in connected speech across phases of the menstrual cycle and during the use of a combined oral contraceptive pill (OCP). Method Electrolaryngographic recordings were made, and blood samples were collected at three different phases of the menstrual cycle—menstrual, follicular, and luteal—for placebo and OCP use. These two conditions were blindly and randomly allocated in the study. Speaking f o (SFF), SFF standard deviation, SFF rate of change, SFF slope, maximum and minimum f o , and f o range were extracted for nine healthy females while reading a phrase from the Rainbow Passage. Concentrations of sex hormones were analyzed in serum. Nonparametric statistical tests were carried out to assess differences between phases and conditions. Results SFF, its standard deviation, and maximum f o were significantly different between phases of the menstrual cycle for placebo use only. Menstrual phase showed the lowest values. Maximum and minimum f o were significantly different between placebo and OCP use for menstrual and follicular phases, respectively. Conclusions Fluctuations in sex steroid hormones across the menstrual cycle alter f o in speech more than a particular hormonal concentration. OCP use seems to have a stabilizing effect on the voice relative to f o and related parameters in speech.

scholarly journals Molecular mechanisms of cyclic transformation of the endometrium

2019 ◽  
Vol 68 (1) ◽  
pp. 5-12
Author(s):  
Gulrukhsor Kh. Tolibova ◽  
Tatyana G. Tral ◽  
Eduard K. Ailamazyan ◽  
Igor Yu. Kogan
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Structural Transformation ◽  
Molecular Mechanisms ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Biological Interactions ◽  
Genetically Determined

Structural transformation of the endometrium during the menstrual cycle is a genetically determined process and is provided by complex molecular-biological interactions aimed at the onset and development of pregnancy. Sex steroid hormones play a key role in endometrial morphogenesis, which mediate or directly affect angiogenesis and immunogenesis.

scholarly journals Steroid hormones and human choriogonadotropin influence the distribution of alpha6-integrin and desmoplakin 1 in gland-like endometrial epithelial spheroids

2021 ◽  
Author(s):  
V. U. Buck ◽  
M. T. Kohlen ◽  
A. K. Sternberg ◽  
B. Rösing ◽  
J. Neulen ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Culture System ◽  
3D Culture ◽  
Adhesion Protein ◽  
Lateral Membrane ◽  
Matrix Adhesion ◽  
Human Choriogonadotropin ◽  
3D Culture System

AbstractIn human glandular endometrial epithelial cells, desmosomal and adherens junction proteins have been shown to extend from a subapically restricted lateral position to the entire lateral membrane during the implantation window of the menstrual cycle. Similarly, a menstrual cycle stage-dependent redistribution of the extracellular matrix adhesion protein α6-integrin has been reported. These changes are believed to be important for endometrial receptiveness and successful embryo implantation. To prove the hypothesis that steroid hormones and human choriogonadotropin can induce the redistribution of these adhesion molecules, we used the human endometrial cell line Ishikawa in a 3D culture system. Gland-like spheroids were grown in reconstituted basement membrane (Matrigel™). The lumen-bearing spheroids were treated for 2 or 4 days with ovarian steroids or human choriogonadotropin and then assessed by immunofluorescence microscopy. In addition, human endometrial biopsies were obtained from patients, who were in therapy for assisted reproductive technology, and were examined in parallel. Lateral redistribution of the desmosomal plaque protein desmoplakin 1 was observed in the spheroids treated either with progesterone, medroxyprogesterone acetate or human choriogonadotropin. Furthermore, the extracellular matrix adhesion protein α6-integrin showed an increased lateral membrane localization upon gestagen stimulation in the 3D culture system. The results of this study demonstrate that the 3D endometrial Ishikawa cell culture might be suited as an experimental model system to prove the effect of hormonal changes like those occurring during the window of implantation.

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