scholarly journals Steroid Diagnostics of 21st Century in the Light of Their New Roles and Analytical Tools

2020 ◽  
pp. S193-S203 ◽  
Author(s):  
M. DUŠKOVÁ ◽  
L. KOLÁTOROVÁ ◽  
M. ŠIMKOVÁ ◽  
M. ŠRÁMKOVÁ ◽  
M. MALÍKOVÁ ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
21St Century ◽  
Reference Values ◽  
Current Technology ◽  
Amount Of Information ◽  
Analytical Phase ◽  
Analytical Tools ◽  
Fertile Women

The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First we focus on specific aspects arising from the pre-analytical phase of steroid determination that need to be considered when planning sampling, whether for diagnostics or research. Then, we provide a brief summary of the characteristics and diagnostic relevance of several steroid hormones and/or their metabolites: pregnenolone, 17α-hydroxy-pregnenolone, dehydroepiandrosterone, hydroxyderivatives of dehydroepiandrosterone, androstenedione, testosterone, estrone, estradiol, estriol, cortisol, cortisone, which in our institute are determined with validated LC-MS/MS methods. For these steroids, we also provide newly calculated reference values in fertile women according to the phase of their menstrual cycle.

scholarly journals A study on influence of different phases of menstrual cycle on hematological parameters

2021 ◽  
Vol 38 (3) ◽  
pp. 308-311
Author(s):  
Vijayashri Basavaraj HANCHINAL ◽  
Ambhuja SAMBRANI ◽  
Vineet BALJOSHI
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Hematological Parameters ◽  
Endocrine System ◽  
Sex Steroid Hormones ◽  
Sex Steroid ◽  
Monocyte Count ◽  
Significant Difference ◽  
The Impact ◽  
Fertile Women

Menstruation is the most common phenomenon observed in fertile women. Menstrual cycle (MC) is of 3 phases: proliferative phase, secretory phase and menstruation phase. It is controlled by endocrine system. Natural fluctuations in sex steroid hormones during MC causes changes in hematological parameters. The aim of the present study to assess the impact of different phases of MC on hematological parameters. The study was conducted in KIMS, Hubli, from 01st March 2011 to 31st March 2012. Women aged between 20-30 years with regular menstrual cycle of 27-30 days were included in the study. During each visit, the subjects’ blood was collected and analyzed using KX-21 SYSMEX for various hematological parameters. A total of 50 healthy young women were included in the study. On statistical comparing of hematological parameters, hematocrit, hemoglobin, neutrophil count and eosinophil count showed a significant difference while no statistically significant difference was observed in RBC, leucocyte count, lymphocyte count, monocyte count, erythrocyte sedimentation rate (ESR) and platelet count between different phases of MC. To conclude, the hematological parameters during the MC are highly dependent on the phasic changes in the immune response mechanism and sex steroid hormones.

1258: Normative Androgens Values Throughout the Menstrual Cycle in Healthy Fertile Women with Normal Sexual Function

2005 ◽  
Vol 173 (4S) ◽  
pp. 341-341
Author(s):  
Andrea Salonia ◽  
Marina Pontillo ◽  
Fabio Fabbri ◽  
Giuseppe Zanni ◽  
Rita Daverio ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Sexual Function ◽  
Fertile Women

UNTERSUCHUNGEN ÜBER DIE EXTRAKTION DES ROTEN KOBER-FARBSTOFFS DURCH ORGANISCHE LÖSUNGSMITTEL ZUR ÖSTROGENBESTIMMUNG IM HARN

1960 ◽  
Vol XXXV (I) ◽  
pp. 34-48 ◽  
Author(s):  
Gerd Ittrich
Keyword(s):  
Menstrual Cycle ◽  
Organic Solvents ◽  
Urine Sample ◽  
Phenol Derivatives ◽  
Organische Lösungsmittel ◽  
Colour Complex

ABSTRACT A series of organic solvents and phenol derivatives have been examined for the extraction of the pink Kober-colour complex. Optimal results could be achieved for fluorimetry by a solution of 2 % (w/v) p-nitrophenol and 1 % (v/v) ethanol in acetylenetetrabromide, when the green mercury line (546 mμ was used as primary light. The sensitivity, stability and specificity have been improved, compared with the previously described reaction. By changing the sequence of purification steps and by reducing the volume of the urine sample (5 ml) the method for the determination of total oestrogens has been simplified. Approximately 10 determinations can be done within 3–4 hours by one person. Recovery experiments and comparative determinations with a previously described method have been carried out. The excretion of total oestrogens in a complete menstrual cycle is determined with the described method.

ANALYTICAL TOOLS AND MANAGEMENT METHOD OF CASH FLOWS AT THE ENTERPRISE

2017 ◽  
pp. 93-105
Author(s):  
Olha NIPIALIDI
Keyword(s):  
Financial Stability ◽  
Cash Flows ◽  
Sustainable Growth ◽  
Financial Health ◽  
Traditional Assessment ◽  
Financial Condition ◽  
Efficient Management ◽  
Expert Assessments ◽  
Analytical Tools

Introduction. The most important factors for “financial health” of the company are effectively structured cash flows, precondition for sustainable growth and achievement of high end results of economic activity as a whole. Knowledge and practical use of modern methods of organization and efficient management of cash flows enables transition of the company to a new quality of economic development. Purpose. The aim of the article is the research and development of theoretical, methodological and practical recommendations concerning the organization of the management process of cash flows at the enterprise. Results. Methodology of traditional assessment of financial stability of the enterprise, its elements and the factors influencing it can significantly complement and improve through the use of advanced mathematical models that allow to analyze the accuracy and objectivity of expert assessments for determination the level of the financial condition of the enterprise. Conclusion. The system of indicators used in the analysis of cash flows at the enterprises is investigated and systematized. It is advisable to choose those indicators from the total aggregate of indicators that are the most attracted to specific users of accounting information. Methods for analyzing cash flow is supplemented as regards the determination of the integral index of financial stability, which makes it possible to install ranked of the investigated enterprise. Proposals for amendments the methodological approaches to estimating of future cash flows will allow more effectively increase usefulness and reliability of accounting and analytical information for making management decisions.

If things go South: The renewed policy of sport mega events allocation and its implications for future research

2021 ◽  
pp. 101269022098134
Author(s):  
Billy Graeff ◽  
Jorge Knijnik
Keyword(s):  
21St Century ◽  
Public Expenditure ◽  
Global South ◽  
International Olympic Committee ◽  
Future Research ◽  
Construction Costs ◽  
Mega Events ◽  
The Past ◽  
Global North ◽  
Analytical Tools

The past few decades have seen an increase of sport mega events (SMEs) held outside the Global North. This tendency has been accompanied by a growing public expenditure in these events. This paper employs selected Global South SMEs to discuss this trend. By critically analysing public documents, biddings and reports, the study traces comparisons between 21st-century Global South and Global North SMEs expenditures, in the revenue of franchise owners (FIFA and the International Olympic Committee), in construction costs within the budgets and in the costs related to security. This comprehensive and intertwined investigation shows the need for new analytical tools – such as the Renewed Policy of Sport Mega Events Allocation, a concept developed here - to better capture the central questions posed by the challenges of ‘SMEs going South’.

CHANGES IN THE CONCENTRATION OF PITUITARY AND STEROID HORMONES IN THE FOLLICULAR FLUID OF HUMAN GRAAFIAN FOLLICLES THROUGHOUT THE MENSTRUAL CYCLE

1975 ◽  
Vol 64 (3) ◽  
pp. 555-571 ◽  
Author(s):  
K. P. McNATTY ◽  
W. M. HUNTER ◽  
A. S. McNEILLY ◽  
R. S. SAWERS
Keyword(s):  
Menstrual Cycle ◽  
Steroid Hormones ◽  
Follicular Fluid ◽  
Follicle Stimulating Hormone ◽  
Secretory Activity ◽  
Follicular Phase ◽  
Hormonal Changes ◽  
Peripheral Plasma ◽  
Before And After ◽  
Late Follicular Phase

SUMMARY The concentrations of FSH, LH, prolactin, oestradiol and progesterone were measured in peripheral plasma and follicular fluid of women throughout the menstrual cycle. With the exception of prolactin, concentrations of pituitary and steroid hormones in follicular fluid correlated with those in peripheral plasma. Follicle-stimulating hormone was present in a greater number of small follicles ( < 8 mm) during or just after the peaks of FSH in peripheral plasma. During the mid-follicular phase the concentration of both FSH and oestradiol in fluid from large follicles ( ≥ 8 mm) was high. During the late follicular phase the large follicles ( ≥ 8 mm) contained high amounts of progesterone in addition to oestradiol, low physiological levels of prolactin, and concentrations of LH and FSH about 30 and 60% respectively of those found in plasma. By contrast no large 'active' follicles ( ≥ 8 mm) were found during the luteal phase although many contained both LH and FSH. Luteinizing hormone was present in a proportion of small follicles ( < 8 mm) during the late follicular and early luteal but not at other stages of the menstrual cycle. It is suggested that a precise sequence of hormonal changes occur within the microenvironment of the developing Graafian follicle; the order in which they occur may be of considerable importance for the growth of that follicle and secretory activity of the granulosa cells both before and after ovulation.

Association of serum progesterone level and endometrial estradiol & progesterone receptors in women with unexplained recurrent miscarriage

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Ihab Found Alam ◽  
Sherif Ahmed Ashoush ◽  
Ihab Adel Gomaa ◽  
Ahmed Sabry AbdEl-Hafeez
Keyword(s):  
Menstrual Cycle ◽  
Recurrent Miscarriage ◽  
Progesterone Receptors ◽  
First Trimester ◽  
Endometrial Biopsy ◽  
Serum Progesterone ◽  
Normal Endometrium ◽  
History Of ◽  
Unexplained Recurrent Miscarriage

Abstract This study investigated the endometrial tissue to study the fluctuation of estrogen receptors (ERs) and progesterone receptors (PRs) in women with recurrent miscarriage compared with normal endometrium of fertile women. Forty women were divided into two groups: 20 non-pregnant women with history of recurrent miscarriage (who had three or more first- trimester miscarriages) and 20 controls. Both groups had regular ovulatory menses and proven fertility. Endometrial biopsy was taken in the two groups during the luteal phase of the menstrual cycle, between the 8th and the 10th postovulatory days using an endometrial biopsy curette for determination of estrogen (E2) and progesterone (P4) hormones levels and their receptors. On the same day as the biopsy, a blood sample was taken for determination of estradiol (E2) and progesterone (P4) levels. The obtained results showed no significant differences between both groups regarding age, BMI, menarche, menstrual cycle & menstruation, significant decrease in E2 and P4 levels in the serum and endometrial biopsy of recurrent miscarriage women versus control. In control and recurrent miscarriage; ER levels in cytoplasm and salt extracted nucleus were higher than PR levels. ER and PR values were higher in the nuclear compartment than in the cytoplasmic compartment. The women with early recurrent miscarriage showed lower levels of both ER and PR significantly. All types of endometrial receptors (ER &PR) and hormones (E2 &P4) in serum and endometrium showed correlation relating to number of previous miscarriages.

Determination of Normal Electrocardiographic Reference Values in Long-Eared Hedgehogs (Hemiechinus auritus)

2016 ◽  
Vol 25 (3) ◽  
pp. 237-241
Author(s):  
Masoud Selk Ghaffari ◽  
Nima Mohseni Abbas abadi ◽  
Iman Azhari ◽  
Seyed Mehdi Rajaei
Keyword(s):  
Reference Values
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