Ereptic enzymes and agglutinins in urine in septic diseases and their prognostic value

1934 ◽  
Vol 30 (6) ◽  
pp. 633-633
Author(s):  
Е. Freund ◽  
К. Кadnа
Keyword(s):  
Prognostic Value ◽  
Fatal Outcome ◽  
Definite Relationship

In a study of the agglutination ability and the ability to digest urinary peptone aa. we found a definite relationship between the severity of the case and the amount of enzymes in the urine. Of the 18 cases with no normal agglutinins and ereptic enzymes in the urine, 16 ended fatally, the remaining 2 had a prolonged febrile course. In cases with normal enzymes there was no fatal outcome.

scholarly journals Oxid Comparative Analysis of the Significance of BISAP and MEWS Score for an Early Assessment of Illness Severity and Treatment Outcome of Acute Pancreatitis

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Olivera Marinkovic ◽  
Slađana Trpkovic ◽  
Ana Sekulic ◽  
Aleksandra N. Ilic ◽  
Nataša Zdravkovc ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Intensive Care ◽  
Treatment Outcome ◽  
Prognostic Value ◽  
Fatal Outcome ◽  
High Specificity ◽  
Early Assessment ◽  
Time Points ◽  
Additional Costs ◽  
Vital Parameters

Abstract The aim of this study was to determine the significance of the use of the BISAP score, which is specific for patients with AP, in relation to the application of the MEWS score that is important for assessing the condition of critically ill patients in intensive care units, but is not specific for patients with AP. The research was conducted as a cohort prospective study and included patients of both sexes, older than 18 and diagnosed with AP. BISAP and MEWS score were monitored at least at four time points: on admission to the hospital (zero), 48 hours, 72 hours and 7 days after admission to the hospital. High levels of discrimination between patients with fatal outcome and cured patients are determined in both cases, with discrimination at MEWS being somewhat higher than BISAP score. The BISAP0 had the best discrimination for BISAP score, AUROC (0.807) and also MEWS0 for MEWS score, AUROC (0.899). In our research, the highest sensitivity was shown by BISAP7d (92.1%) and MEWS48 (88.1%), and a high specificity of 87.5% had BISAP score, 48h, 72h and MEWS score at all four points of measurement. BISAP score has a better prognostic value in relation to the form of pancreatitis, the development of complications and the outcome. However, the calculation of the MEWS score is based on monitoring the basic vital parameters so that its application is much simpler and does not require additional costs.

scholarly journals Mathematical modeling of ischemic stroke

2019 ◽  
Vol 11 (4) ◽  
pp. 38-43
Author(s):  
V. I. Ershov ◽  
A. N. Chirkov ◽  
A. P. Gonchar-Zaykin ◽  
S. N. Lyashchenko ◽  
T. Yu. Lozinskaya ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Mortality Rate ◽  
Diabetes Insipidus ◽  
Prognostic Value ◽  
Hormone Secretion ◽  
Fatal Outcome ◽  
Electrolyte Imbalance ◽  
Electrolyte Balance ◽  
Plasma Osmolarity ◽  
The Impact

Objective: to determine the prognostic value of the indicators of fluid and electrolyte balance in the acutest period of severe ischemic stroke (IS). Patients and methods. A total of 150 patients with severe IS of various locations and pathogenetic subtypes were examined. The impact of plasma osmolarity or sodium levels on the course and prognosis of IS was studied on day 1 of the disease. Results and discussion. It has been established that in patients with severe IS, the most common type of fluid and electrolyte imbalance is hyperosmolar hypernatremic syndrome that develops at the onset of severe IS, serves as a factor for poor outcome, and is accompanied by high mortality. The rate of fatal outcomes in hypoosmolar syndromes is higher than that in normal plasma osmolarity, but significantly lower than that in hyperosmolar syndromes. Cerebral salt wasting (CSW) is associated with a higher mortality rate than syndrome of inappropriate antidiuretic hormone secretion (SIADH), which confirms a worse prognostic value in hypovolemia than in normo- and hypervolemia. The development of diabetes insipidus at the onset of IS reflects the degree of brainstem structural destruction and, accordingly, is associated with the highest rate of fatal outcomes. The cardioembolic pathogenetic subtype of IS is characterized by a more severe course and a higher probable mortality rate in both hypoosmolar and normosmolar conditions.Conclusion. Impaired fluid and electrolyte homeostasis is of significant prognostic value for the outcome of IS. In this case, the leading role is played by the hyperosmolar hypernatremic syndrome, in which the probability of a fatal outcome is highest and there is a need for continuous patient health monitoring and high-speed decision-making aimed to correct this condition. Therapeutic policy for diabetes insipidus depends on the duration of IS. The risk for fatal outcome in the cardioembolic pathogenetic subtype of IS is higher than that in atherothrombotic stroke, at any plasma osmolarity and sodium levels.

scholarly journals Comparison of the Main Staging Systems for Assessing the Severity of Lung Injury in Patients with COVID-19 and Evaluation of Their Predictive Value

2021 ◽  
Vol 102 (5) ◽  
pp. 296-303
Author(s):  
Y. S. Kudryavtsev ◽  
M. M. Beregov ◽  
A. B. Berdalin ◽  
V. G. Lelyuk
Keyword(s):  
Lung Tissue ◽  
Predictive Value ◽  
Prognostic Value ◽  
Time Course ◽  
Fatal Outcome ◽  
Chest Ct ◽  
Viral Pneumonia ◽  
Maximum Magnitude ◽  
Predictive Values ◽  
Staging Systems

Objective: to compare the results of staging the severity of viral pneumonia in patients with COVID-19 based on the results of chest computed tomography (CT) using the empirical visual scale CT 0–4 and chest CT severity score (CT-SS) point scale, as well as to assess their prognostic value.Material and methods. Chest CT scans and anamnestic data in patients hospitalized to a non-specialized center repurposed for the treatment of new coronavirus infection, were analyzed. Chest CT analysis was performed by two radiologists using CT 0–4 and CT-SS scales.Results. The time course of changes in the severity of lung parenchymal lesions, by using both scales, was found to be similar: the maximum magnitude of lung tissue changes was recorded on day 5 of the disease. In cases of death, there was a significantly more extensive lung parenchymal involvement at admission to the center than in recovered patients, which was also true for both CT data assessment systems. Bothscales demonstrated comparable diagnostic and prognostic value: there were no statistically significant differences in sensitivity, specificity, and predictive value of a fatal outcome. Both the CT 0–4 scales and the CT-SS are based on the estimation of the volume of the affected lung tissue, but when the CT 0–4 scale was employed, additional criteria were used in some cases: the presence of hydrothorax and the determination of the maximum score for the most affected lung. Not all patients with a pronounced CT picture of viral pneumonia had a fatal outcome, which may indicate the presence of other factors that increase its risk.Conclusion. Both CT 0–4 and CT-SS scales have similar predictive values. The greater severity of parenchymal damage assessed by these CT scales was associated with the higher mortality rate.

scholarly journals Evaluation of NAB2-STAT6 Fusion Variants and Other Molecular Alterations as Prognostic Biomarkers in a Case Series of 83 Solitary Fibrous Tumors

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5237
Author(s):  
Carmen Salguero-Aranda ◽  
Paula Martínez-Reguera ◽  
David Marcilla ◽  
Enrique de Álava ◽  
Juan Díaz-Martín
Keyword(s):  
Prognostic Value ◽  
Gene Fusion ◽  
Fatal Outcome ◽  
Case Series ◽  
Tumor Location ◽  
P53 Mutation ◽  
Clinicopathological Parameters ◽  
Late Relapse ◽  
Biological Knowledge ◽  
Molecular Alterations

Risk stratification of solitary fibrous tumor (SFT) patients based on clinicopathological features has limited efficacy, especially in predicting late relapse or metastasis. The hallmark alteration of SFT is the gene fusion NAB2-STAT6, whose prognostic value remains controversial. As biological knowledge of this entity has increased in recent years, new molecular alterations have emerged that could be helpful to refine current risk models. Here, we evaluated NAB2-STAT6 fusion variants and other molecular alterations in a series of 83 SFTs that are enriched in progressing cases. Gene fusion variants were identified by targeted RNA-seq in the whole series, whereas TERT promoter (pTERT) mutations were inspected by Sanger sequencing in a subset of 18 cases. Immunohistochemical assays were performed to assess BCOR and NTRK expression as well as P53 mutation status in 45, 44, and 44 cases, respectively. While confirming the associations of gene fusion variants with clinicopathological parameters, our results do not prove their prognostic value. Pan-TRK immunoexpresion correlated with recurrence/progression, P53 staining associated with higher mitotic counts, and pTERT mutations were enriched in cases with fatal outcome. An intriguing correlation was found for BCOR protein expression with gene fusion variants, size, and tumor location.

scholarly journals Prognostic Value of ECG in Patients with Pulmonary Embolism

2019 ◽  
Vol 15 (1) ◽  
pp. 63-68
Author(s):  
I. S. Mullova ◽  
T. V. Pavlova ◽  
S. M. Khokhlunov ◽  
D. V. Duplyakov
Keyword(s):  
Pulmonary Embolism ◽  
Prognostic Value ◽  
Ventricular Dysfunction ◽  
Fatal Outcome ◽  
Right Ventricular Dysfunction ◽  
Pulmonary Angiography ◽  
Cardiac Biomarkers ◽  
St Segment Elevation ◽  
T Wave ◽  
St Segment

Aim. To study the significance of electrocardiography (ECG) signs for determining the hospital prognosis in patients with pulmonary embolism (PE).Material and methods. 472 consecutive patients (49.6% men; average age 58.06±14.28 years) with PE, hospitalized to our center from 23.04.2003 to 18.09.2014 were enrolled into the study. In all cases PE was confirmed by computed tomographic pulmonary angiography and rarely by pulmonary angiography, or by pathology. Patients management was in accordance with appropriate European guidelines. Data of patients' history, clinical symptoms, biochemical markers and instrumental methods (ECG, echocardiography) were analyzed by one-dimensional logistic regression. The end points were: death, shock and hypotension, right ventricular dysfunction and pulmonary hypertension, positive cardiac biomarkers.pulmonary embolism, electrocardiography, prognosis, collapse, hypotension, dysfunction of the right ventricle. 443 patients (93.9%) without fatal outcome were the first group and 29 patients (6.1%) with a fatal outcome – the second group. SIQIII pattern (33 vs 55.2%; p=0.015), non-complete right bundle branch block (RBBB) (16.3 vs 37.9%; p=0.001), ST segment elevation in lead III (9.7 vs 20.7%, p=0.034), atrial fibrillation (12.9 vs 37.9%, p=0.048) were observed more frequently among patients of group 2. Multivariate analysis revealed that SIQIII pattern (odds ratio [OR] 2.26; 95% confidence interval [95%CI] 1.046-4.868; p=0.038) and RBBB (OR 2.84; 95%CI 1.272-6.327; p=0.011) were associated with worse prognosis. The SIQIII pattern was significantly associated with a fatal outcome with a sensitivity of 55% and a specificity of 33% (AUC=0.611) according to ROC-analysis. Risk of hypotension was related to the following ECG-signs: the p-pulmonale (OR 1.76; 95%CI 1.001-3.088; p=0.049), negative T-wave in lead III (OR 1.8; 95%CI 1.035-3.144; p=0.037). Inversion of the T wave in lead III was associated with the development of shock (OR 1.98; 95%CI 0.891-4.430; p=0.043).ECG-signs were also associated with the development of right ventricular dysfunction and pulmonary hypertension: right axis deviation (OR 1.035; 95%CI 1.008-1.062; p=0.01), ST-segment elevation in the AVR lead (OR 3.769; 95%CI 1.018-13.955; p=0.047), negative T wave in leads III, V1-V3 (OR 1.015; 95%CI 1.008-1.023; p=0.001 and OR 1.014; 95%CI 1.005-1.022; p=0.001, respectively), RBBB (OR 1.013; 95%CI 1.003- 1.024; p=0.012), p-pulmonale (OR 1.015; 95%CI 1.007-1.023; p=0.001), deep S in leads V5-V6 (OR 1.015; 95%CI 1.006-1.024; p=0.001). However, there was no significant relationship between ECG signs and cardiac biomarkers (troponin I and BNP).Conclusions. SIQIII pattern, RBBB and inversion of the T wave in lead III have prognostic value in unselected population of patients with PE. 

scholarly journals MARKERS OF ENDOTHELIAL DYSFUNCTION AND THEIR PROGNOSTIC VALUE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

2020 ◽  
Vol 7 (1) ◽  
pp. 10-16
Author(s):  
Yu. Odinets ◽  
T. Kondratiuk ◽  
M. Koida
Keyword(s):  
Nitric Oxide ◽  
Acute Lymphoblastic Leukemia ◽  
Endothelial Dysfunction ◽  
Prognostic Value ◽  
Lymphoblastic Leukemia ◽  
Fatal Outcome ◽  
Cardiac Monitoring ◽  
Oxide Content ◽  
Healthy Children

MARKERS OF ENDOTHELIAL DYSFUNCTION AND THEIR PROGNOSTIC VALUE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA Y.V. Odinets, T.O. Kondratiuk, M.L. Koida Acute lymphoblastic leukemia (ALL) in children is associated with the development of a large number of serious complications. Inflammatory and pro-aggregation activation of endothelial cells accompanies the course of leukemia. Endothelial dysfunction (ED) is believed to be an integral part of the pathogenic link of ALL and its complications. Materials and methods. The content of nitric oxide in serum with the concentration of its stable metabolites - NO₂, NO₃ was determined in 73 patients with ALL and 19 healthy children. Determination of nitric oxide was performed at different stages of the presentation of ALL: 49 children were examined during the manifestation of leukemia (group 1A), of whom 36 children (group 1B) were re-examined during the first course of treatment – induction of remission. Also 8 children (group 2) were examined during supportive therapy and 16 children (group 3) who underwent complete chemotherapy treatment. Results. The study showed nitrite increases and nitrate reductions secondary to reduced total nitric oxide content during all treatment periods in children with ALL. In addition, signs of endothelial dysfunction were recorded in patients after treatment. ROC analysis showed that a reduction in NO₂ content lower than 12.31 µmol/l and a sum of NO₂ + NO₃ lower than 32.99 µmol/l significantly had a negative effect on the survival of children with ALL. Conclusions. ED accompanies the course of ALL in children. Determination of nitric oxide is of diagnostic and prognostic importance in patients with leukemia. The critical fall in the concentration of NO and NO₂ accompanies the development of multiple organ failure with fatal outcome in children with ALL. Preservation of signs of ED after the end of the treatment of leukemia indicates the need for cardiac monitoring of patients with ALL in history. Keywords: acute leukemia, children, endothelial dysfunction, nitric oxide Резюме. МАРКЕРИ ЕНДОТЕЛІАЛЬНОЇ ДИСФУНКЦІЇ ТА ЇХ ПРОГНОСТИЧНЕ ЗНАЧЕННЯ У ДІТЕЙ, ХІОРИХ НА ГОСТРУ ЛІМФОБЛАСТНУ ЛЕЙКЕМІЮ Ю.В. Одинець, Т.О. Кондратюк, М.Л. Койда. Гостра лімфобластна лейкемія (ГЛЛ) у дітей асоціюється з виникненням великої кількості тяжких ускладнень. Прозапальна та проагрегаційна активація ендотеліальних клітин супроводжує перебіг лейкемії. Вважається, що ендотеліальна дисфункція (ЕД) являються невід’ємливою частиною патогенетичної ланки ГЛЛ та її ускладнень. Mateріали та методи. Досліджено вміст оксиду азоту в сироватці крові за концентрацією його стабільних метаболітів – NO₂, NO₃ у 73 дітей, хворих на ГЛЛ та 19 здорових дітей. Визначення оксиду азоту проводили на різних етапах перебігу ГЛЛ: 49 дітей досліджено під час маніфестації лейкемії (група 1А), з них 36 дітей (група 1Б) повторно досліджено під час першого курсу лікування – індукції ремісії. Також 8 дітей (група 2) було досліджено під час проведення підтримуючої терапії і 16 дітей (група 3), які закінчили хіміотерапевтичне лікування. Результати. Ми отримали збільшення нітритів та зменшення нітратів на фоні зниженого загального вмісту оксиду азоту у продовж всіх періодів лікування та ремісії при ГЛЛ у дітей. Окрім того, ознаки ендотеліальної дисфункції фіксувались у хворих після закінчення лікування. ROC-аналіз продемонстрував, що  зниження вмісту NO₂ нижче ніж 12.31 мкмоль/л та суми NO₂+ NO₃ нижче, ніж 32.99 мкмоль/л  - достовірно впливає на негативний результат виживання дітей з ГЛЛ. Висновки. ЕД супроводжує перебіг ГЛЛ у дітей. Визначення оксиду азоту має діагностичну та прогностичну значущість у пацієнтів з лейкемією. Критичне падіння концентрації NO та NO₂ супроводжує виникнення поліорганної недостатності з летальним результатом у дітей, хворих на ГЛЛ.Збереження ознак ЕД після закінчення лікування у дітей, які перенесли ГЛЛ вказують на необхідність кардіологічного спостереження за даними хворими у катамнезі. Ключові слова: гостра лейкемія, діти, ендотеліальна дисфункція, оксид азоту   Резюме. МАРКЕРЫ ЭНДОТЕЛИАЛЬНОЙ ДИСФУНКЦИИ И ИХ ПРОГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ У ДЕТЙ С ОТРОЙ ЛИМФОБЛАСТНОЙ ЛЕЙКЕМИЕЙ Ю.В. Одинец, Т.А. Кондратюк, М.Л. Койда. Острая лимфобластная лейкемия (ОЛЛ) у детей ассоциируется с возникновением значительного количества тяжелых осложнений. Провоспалительная и проагрегационная активация эндотелиальных клеток сопровождает течение лейкемии. При этом эндотелиальная дисфункция (ЭД) является неотъемлемой частью патогенеза ОЛЛ и ее осложнений. Материалы и методы. Исследовано содержание оксида азота в сыроватке крови по концентрации его стабильных метаболитов – NO₂, NO₃ у 73 детей с ОЛЛ и 19 здоровых детей. Определение оксида азота проводили на разных этапах протекания ОЛЛ: 49 детей иссследовано во время манифестации лейкемии (группа 1А), из них 36 детей (группа 1Б) повторно обследованы в течение первого курса терапии – индукции ремиссии. Также 8 детей (группа 2) были обследованы во время проведения поддерживающей терапии и 16 детей (группа 3), которые завершили химиотерапевтическое лечение. Результаты. Ми наблюдали увеличение нитритов и уменьшение нитратов на фоне сниженного общего содержания оксида азота в течение всех периодов лечения и ремиссии ОЛЛ у детей. Кроме того, признаки эндотелиальной дисфункции фиксировались у больных после окончания лечения. ROC-анализ проказал, что снижение содержание NO₂ ниже, чем 12.31 мкмоль/л и суммы NO₂+ NO₃ ниже 32.99 мкмоль/л  - достоверно влияет на неблагоприятный результат выживания детей с ОЛЛ. Выводы. ЭД сопровождает течение детской ОЛЛ. Определение оксида азота имеет диагностическое и прогностическое значение у пациентов с лейкемией. Критическое падение концентрации NO и NO₂ сопровождает возникновение полиорганной недостаточности с летальным результатом у детей, страдающих ОЛЛ. Сохранение признаков ЭД после завершения лечения у детей, перенесших ОЛЛ указывают на необходимость кардиологического наблюдения за данными пациентами в катамнезе. Ключевые слова: дети, эндотелиальная дисфунцкия, острая лейкемия, оксид азота

The Prognostic Value of Renal Function in Acute Pulmonary Embolism—A Multi-Centre Cohort Study

2018 ◽  
Vol 119 (01) ◽  
pp. 140-148 ◽  
Author(s):  
Maciej Kostrubiec ◽  
Magdalena Pływaczewska ◽  
David Jiménez ◽  
Mareike Lankeit ◽  
Michał Ciurzynski ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Pulmonary Embolism ◽  
Cohort Study ◽  
Prognostic Value ◽  
Acute Pulmonary Embolism ◽  
Fatal Outcome ◽  
Prognostic Significance ◽  
Prognostic Models ◽  
All Cause Mortality ◽  
Acute Pe

Background Haemodynamic alterations caused by acute pulmonary embolism (PE) may affect multi-organ function including kidneys. This multi-centre, multinational cohort study aimed to validate the prognostic significance of estimated glomerular filtration rate (eGFR) and its potential additive value to the current PE risk assessment algorithms. Methods The post hoc analysis of pooled prospective cohort studies: 2,845 consecutive patients (1,424 M/1,421 F, 66 ± 17 years) with confirmed acute PE and followed up for 180 days. We tested prognostic value of pre-specified eGFR level ≤60 mL/min/1.73 m2 calculated on admission according to the Modification of Diet in Renal Disease study equation. The primary outcome was all-cause 30-day mortality; the secondary outcomes were PE-related mortality, 180-day all-cause mortality, bleeding and composite outcome (PE-related death, thrombolysis or embolectomy). Results Two hundred and twenty-three patients (8%; 95% confidence interval [CI]: 7–9%) died within the first 30 days after the diagnosis. The eGFR on admission was significantly lower in non-survivors than in survivors (64 ± 34 vs. 75 ± 3 mL/min/1.73 m2, p < 0.0001). Independent predictors for a fatal outcome included: cancer, systolic blood pressure, older age, hypoxia, eGFR, heart rate and coronary artery disease. The eGFR of ≤60 mL/min/1.73 m2 independently predicted all-cause mortality (hazard ratio: 2.3; 95% CI: 1.7–3.0, p < 0.0001), PE-related outcome and clinically relevant bleedings (odds ratio: 0.90 per 10 mL/min/1.73 m2, 95% CI: 0.85–0.95, p = 0.0002). The eGFR assessment significantly improved prognostic models proposed by European guidelines with net re-classification improvement of 0.42 (p < 0.0001). Conclusion The eGFR of ≤60 mL/min/1.73 m2 not only independently predicted higher 30- and 180-day all-cause mortality and bleeding events, but when added to the current European Society of Cardiology risk stratification algorithm improved identification of both low- and high-risk patients. Therefore, eGFR calculation should be implemented in the risk assessment of acute PE.

Prognostic value of p53 and Ki67 expression in gastric carcinoid tumors

2001 ◽  
Vol 120 (5) ◽  
pp. A298-A299
Author(s):  
A SAFATLERIBEIRO ◽  
U RIBEIRO ◽  
C KOBATA ◽  
C CORBETT ◽  
K IRIYA ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Carcinoid Tumors ◽  
Gastric Carcinoid ◽  
Ki67 Expression
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