The role of trauma in the occurrence of hematogenous osteomyelitis in children

1937 ◽  
Vol 33 (9) ◽  
pp. 1073-1076
Author(s):  
I. S. Vengerovsky
Keyword(s):  
Full Agreement ◽  
Bone Infections ◽  
Hematogenous Osteomyelitis

There is still no full agreement on the question of the role of trauma in the occurrence of endogenous bone infections. While some authors consider trauma to be a significant factor in the onset of osteomyelitis, others do not attach particular importance to it.

scholarly journals Characteristics of Old Georgian Literary Language in Akaki Tsereteli’s Works

2021 ◽  
Author(s):  
Nunu Geldiashvili
Keyword(s):  
Spoken Language ◽  
Literary Language ◽  
Stem Form ◽  
Full Agreement ◽  
Nominative Case ◽  
Public Work ◽  
Proper Name ◽  
Demonstrative Pronouns ◽  
Instrumental Case

Literary Works byAkaki Tsereteli are considered as versatile and diverse. In his works he touches upon almost everything by his poetry, prose, journalism or public work. It is obvious that he established "a type of versatile writer who is equally engaged in prose, poetry, journalism, dramaturgy, translations, children's literature and fables”. He was an extremely optimistic person who deeply believed in the future. The following words from one of his works seem amazingly and expressive: “Even if you kill a swallow, Spring will definitely come”. Connection between the old and the new forms, that is clearly shown within this emotionally colored expression, has become the goal of the research. We tried to find an answer to the question- what is the role of using old Georgian forms in Akaki's work?! Given paper analyses the samples such as: 1. Using proper name by its stem form in nominative case; 2. Ending words by - მან [-man] in the ergative form; 3. Full stems of demonstrative pronouns - ‘ამ’ [am] , ‘ეგ’ [eg] (=this, that); 4. Using postposition – ‘ზე’ [ze] (=on), along with the forms - ზედ [-zed] and -ზედა [-zeda] (=on, over); 5. instrumental case forms formed by a suffix - ით [-it] (=with) (without postpositions); 6. Postposition and full agreement of attribute and antecedent 7. Characteristics of using inflection as a reflection of Old Georgian (გწყალობდესთ [gtskalobdet]...; გამოვჰკითხავ [gamovhkitkhav]...; ჰსვამ [hvsvam]...; ჰნიშნავს [hnishnavs]...; წარმოსთქვა [tsarmostkva]...; გასტეხე [gastekhe]...); 8. Using conjunction - ვით [vit] (=as/like) for comparison and so on. If we ask questions concerning the function of old Georgian forms in Akaki Tsereteli’s works, it becomes clear that they can be used for: 1. rhythm, emotiveness and expressiveness; 2. Preserving traditional forms, to maintain the connection between old and new Georgian. It should be mentioned that similar forms are equally reflected in Akaki’s prose and poetry which further reinforces the idea in favor of showing the connection between the old and the new and the desire to maintain this connection and always remember where we come from and who we are ... .This fact does not completely contradict the idea that Akaki is a representative of the generation that courageously rejected the old linguistic norms and contributed to the democratization (rapprochement process with the spoken language) of the literary language.

scholarly journals Effect of local mechanical stress on piezoelectric pressure sensors for ship automation systems

2021 ◽  
pp. 82-86
Author(s):  
В.В. Бородина
Keyword(s):  
Mechanical Load ◽  
Piezoelectric Materials ◽  
Theoretical Calculations ◽  
Pressure Sensors ◽  
Polarized Light ◽  
Full Agreement ◽  
Automation Systems ◽  
Distribution Of Stress ◽  
Proper Operation

В статье рассматриваются проблемы прочности и надёжности чувствительных элементов пьезоэлектрических датчиков давления, являющихся важной частью систем автоматизации судна. Экспериментально исследуются изменения микроструктуры пьезоэлектрических материалов на примере монокристаллического сегнетоэлектрика BaTiO3 в поле неоднородных механических напряжений. Экспериментальная установка позволила при помощи оптического микроскопа в поляризованном свете «на просвет» производить наблюдения образцов непосредственно под механической нагрузкой. Рассмотрены условия появления пластических деформаций и появления микротрещин, приводящих к разрушению элемента. Определена роль в указанных процессах изменений доменной структуры кристаллов, а именно 90-градусных доменных переориентаций, происходящих в поле локальной механической нагрузки. Экспериментальные результаты полностью согласуются с теоретическими расчётами распределения полей напряжений под локальной механической нагрузкой. Сделан вывод о значении локальных механических воздействий на чувствительный элемент, нарушающих его правильную работу. The article deals with the problems of strength and reliability of the sensitive elements of piezoelectric pressure sensors. They are an important part of ship automation systems. Changes in the microstructure of piezoelectric materials are experimentally investigated using the example of a single-crystal ferroelectric BaTiO3 in the field of non-uniform mechanical stresses. The experimental setup with a polarized light microscope in transmission regime allowed to make observations of samples directly under mechanical load. The conditions for the appearance of plastic deformations and the appearance of microcracks leading to the destruction of the element are considered. The role of changes in the domain structure of crystals in these processes is determined. Specifically, 90-degree domain reorientations that occur in the field of local mechanical load are studied. The experimental results are in full agreement with the theoretical calculations of the distribution of stress fields under local mechanical load. The conclusion is made about the values of local mechanical influences on the sensitive element that violate its proper operation.

The Role of Surgery in the Management of Acute Hematogenous Osteomyelitis

2018 ◽  
Author(s):  
Nicole I. Montgomery ◽  
Erica Gonzalez ◽  
Sheldon Kaplan ◽  
Charles G. Minard ◽  
Danielle Guffey ◽  
...  
Keyword(s):  
Hematogenous Osteomyelitis ◽  
Acute Hematogenous Osteomyelitis

scholarly journals Multitasking by the OC Lineage during Bone Infection: Bone Resorption, Immune Modulation, and Microbial Niche

Cells ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 2157
Author(s):  
Philip M. Roper ◽  
Christine Shao ◽  
Deborah J. Veis
Keyword(s):  
Bone Resorption ◽  
Immune Modulation ◽  
Active Role ◽  
Bone Infection ◽  
Direct Effects ◽  
Skeletal Health ◽  
Growth And Survival ◽  
Bone Infections ◽  
Resorptive Activity

Bone infections, also known as infectious osteomyelitis, are accompanied by significant inflammation, osteolysis, and necrosis. Osteoclasts (OCs) are the bone-resorbing cells that work in concert with osteoblasts and osteocytes to properly maintain skeletal health and are well known to respond to inflammation by increasing their resorptive activity. OCs have typically been viewed merely as effectors of pathologic bone resorption, but recent evidence suggests they may play an active role in the progression of infections through direct effects on pathogens and via the immune system. This review discusses the host- and pathogen-derived factors involved in the in generation of OCs during infection, the crosstalk between OCs and immune cells, and the role of OC lineage cells in the growth and survival of pathogens, and highlights unanswered questions in the field.

scholarly journals A Key Major Guideline for Engineering Bioactive Multicomponent Nanofunctionalization for Biomedicine and Other Applications: Fundamental Models Confirmed by Both Direct and Indirect Evidence

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Roya Dastjerdi ◽  
Andreas Scherrieble ◽  
Shiva Bahrizadeh ◽  
Fatemeh Avareh Sadrabadi ◽  
Laleh Hedayat
Keyword(s):  
Biomedical Applications ◽  
Electrostatic Interactions ◽  
Direct Evidence ◽  
Indirect Evidence ◽  
Surface Modifications ◽  
Surface Interactions ◽  
Full Agreement ◽  
Physicochemical Features ◽  
Complete Series

This paper deals with the engineering multicomponent nanofunctionalization process considering fundamental physicochemical features of nanostructures such as surface energy, chemical bonds, and electrostatic interactions. It is pursued by modeling the surface nanopatterning and evaluating the proposed technique and the models. To this end, the effects of surface modifications of nanoclay on surface interactions, orientations, and final features of TiO2/Mt nanocolloidal textiles functionalization have been investigated. Various properties of cross-linkable polysiloxanes (XPs) treated samples as well as untreated samples with XPs have been compared to one another. The complete series of samples have been examined in terms of bioactivity and some physical properties, given to provide indirect evidence on the surface nanopatterning. The results disclosed a key role of the selected factors on the final features of treated surfaces. The effects have been thoroughly explained and modeled according to the fundamental physicochemical features. The developed models and associated hypotheses interestingly demonstrated a full agreement with all measured properties and were appreciably confirmed by FESEM evidence (direct evidence). Accordingly, a guideline has been developed to facilitate engineering and optimizing the pre-, main, and post-multicomponent nanofunctionalization procedures in terms of fundamental features of nanostructures and substrates for biomedical applications and other approaches.

scholarly journals IgG4-specific responses in patients with Staphylococcus aureus bone infections are not predictive of postoperative complications

2021 ◽  
Vol 42 ◽  
pp. 156-165
Author(s):  
JR Owen ◽  
◽  
MP Campbell ◽  
MD Mott ◽  
CA Beck ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Adverse Outcome ◽  
Host Factors ◽  
Healthy Controls ◽  
Complement Inhibitor ◽  
Inhibitory Protein ◽  
Blood Samples ◽  
Bone Infections ◽  
Prevalent Pathogen

The most prevalent pathogen in bone infections is Staphylococcus aureus; its incidence and severity are partially determined by host factors. Prior studies showed that anti-glucosaminidase (Gmd) antibodies are protective in animals, and 93.3 % of patients with culture-confirmed S. aureus osteomyelitis do not have anti-Gmd levels > 10 ng/mL in serum. Infection in patients with high anti-Gmd remains unexplained. Are anti-Gmd antibodies in osteomyelitis patients of the non-opsonising, non-complement-fixing IgG4 isotype? The relative amounts of IgG4 and total IgG against Gmd and 7 other S. aureus antigens: iron-surface determinants (Isd) IsdA, IsdB, and IsdH, amidase (Amd), α-haemolysin (Hla), chemotaxis inhibitory protein from S. aureus (CHIPS), and staphylococcal-complement inhibitor (SCIN) were determined in sera from healthy controls (Ctrl, n = 92), osteomyelitis patients whose surgical treatment resulted in infection control (IC, n = 95) or an adverse outcome (AD, n = 40), and post-mortem (PM, n = 7) blood samples from S. aureus septic-death patients. Anti-Gmd IgG4 levels were generally lower in infected patients compared to controls; however, levels among the infected were higher in AD than IC patients. Anti-IsdA, IsdB and IsdH IgG4 levels were increased in infected patients versus controls, and Jonckheere-Terpstra tests of levels revealed an increasing order of infection (Ctrl < IC < AD < PM) for anti-Isd IgG4 antibodies and a decreasing order of infection (Ctrl > IC > AD > PM) for anti-autolysin (Atl) IgG4 antibodies. Collectively, this does not support an immunosuppressive role of IgG4 in S. aureus osteomyelitis but is consistent with a paradigm of high anti-Isd and low anti-Atl responses in these patients.

scholarly journals The Effect of Needle Tract Nursing Methods to Reduce Needle Tract Infection in Patients with Indwelling Percutaneous Bone Puncture

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Weichao Li ◽  
Qiongshan Liu
Keyword(s):  
Tract Infection ◽  
Detailed Analysis ◽  
Influencing Factors ◽  
Experimental Studies ◽  
Clinical Work ◽  
Common Complication ◽  
Bone Infections ◽  
Needle Tract ◽  
Tract Infections

Percutaneous bone piercing needles are used in orthopedics, which play the role of needle fixation. Needle tract infection is a common complication during the use of percutaneous bone needles. How to prevent needle tract infection is an important topic, so it is necessary to explore better needle tract care methods during percutaneous bone needle indwelling, to provide a basis for clinical work. Based on this, the purpose of this article is to study the effects of needle tract nursing methods for patients with indwelling percutaneous bone puncture needle infections. In this article, through an overview of percutaneous bone needle tract infection, on this basis, a detailed analysis of its occurrence, causes, and main influencing factors are carried out. Experimental studies have shown that the incidence of needle tract infections is 23.64%, mainly mild needle tract infections. Mild needle tract infections account for 84.62% of all needle tract infections, of which grade 1 needle tract infections account for 50.00 of mild needle tract infections. Severe needle tract infections accounted for 15.38% of all needle tract infections. All severe needle tract infections were grade 4 needle tract infections. No patients had bone infections or osteomyelitis.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor

Role of the allergist in diagnosis and management of patients with uveitis

JAMA ◽  
1966 ◽  
Vol 195 (3) ◽  
pp. 167-172 ◽  
Author(s):  
T. E. Van Metre
Keyword(s):  
Diagnosis And Management

The power of norms to sway fused group members

2018 ◽  
Vol 41 ◽  
Author(s):  
Winnifred R. Louis ◽  
Craig McGarty ◽  
Emma F. Thomas ◽  
Catherine E. Amiot ◽  
Fathali M. Moghaddam
Keyword(s):  
Evolutionary Anthropology ◽  
Normative Systems ◽  
Violent Extremism ◽  
Identity Fusion ◽  
Group Members

AbstractWhitehouse adapts insights from evolutionary anthropology to interpret extreme self-sacrifice through the concept of identity fusion. The model neglects the role of normative systems in shaping behaviors, especially in relation to violent extremism. In peaceful groups, increasing fusion will actually decrease extremism. Groups collectively appraise threats and opportunities, actively debate action options, and rarely choose violence toward self or others.

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