Complex pharmacotherapy of peptic ulcer disease taking into account its complications from other parts of the digestive system

The progressive view of domestic clinicians on peptic ulcer disease is well known not as a local process in the stomach or in the duodenum, but as a general disease of the body (M. M. Gubergrits, M. P. Konchalovsky, R. A. Luria, N. D. Strazhesko , M.V. Chernorutsky, etc.). However, despite the great work invested in the study of peptic ulcer disease, much in this problem remains unclear and not specified. In particular, the demands of healthcare practice and the results of existing methods of treating peptic ulcer disease do not meet.

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The Role of Gastric Acid in Preventing Foodborne Disease and How Bacteria Overcome Acid Conditions†

Journal of Food Protection ◽

10.4315/0362-028x-66.7.1292 ◽

2003 ◽

Vol 66 (7) ◽

pp. 1292-1303 ◽

Cited By ~ 126

Author(s):

JAMES L. SMITH

Keyword(s):

Peptic Ulcer ◽

Acid Secretion ◽

Peptic Ulcer Disease ◽

Gastric Acid Secretion ◽

Gastric Acid ◽

Gastric Fluid ◽

The Body ◽

Peptic Ulcers ◽

Ulcer Disease ◽

H Pylori

The secretion of hydrochloric acid by the stomach plays an important role in protecting the body against pathogens ingested with food or water. A gastric fluid pH of 1 to 2 is deleterious to many microbial pathogens; however, the neutralization of gastric acid by antacids or the inhibition of acid secretion by various drugs may increase the risk of food- or waterborne illnesses. Peptic ulcer disease is often treated by decreasing or eliminating gastric acid secretion, and such treatment blocks the protective antibacterial action of gastric fluid. The majority of peptic ulcer disease cases originate from Helicobacter pylori infections. Treatment of H. pylori–induced peptic ulcers with antibiotics reduces the need for drugs that inhibit gastric acid secretion and thereby diminishes the risk of food- and waterborne illness for peptic ulcer disease patients. Many bacterial pathogens, such as Escherichia coli, Salmonella Typhimurium, and H. pylori, can circumvent the acid conditions of the stomach by developing adaptive mechanisms that allow these bacteria to survive in acid environments. As a consequence, these bacteria can survive acidic stomach conditions and pass into the intestinal tract, where they can induce gastroenteritis.

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Autonomic dystonia syndrome in conditions of failure of the Bauhinia valve and after its surgical correction as a possible link in the etiopathogenesis of peptic ulcer disease

Journal of Surgical Case Reports and Images ◽

10.31579/2690-1897/067 ◽

2021 ◽

Vol 4 (5) ◽

pp. 01-05

Author(s):

Martynov Vladimir Leonidovich

Keyword(s):

Nervous System ◽

Peptic Ulcer ◽

Autonomic Nervous System ◽

Peptic Ulcer Disease ◽

Parasympathetic Nervous System ◽

The Body ◽

Surgical Correction ◽

Ulcer Disease ◽

Autonomic Nervous

The classic works of I.P. Pavlov shows strong communication mechanisms between the two most important life-supporting systems of the body - the nervous and the digestive. The role of the autonomic nervous system (ANS) in the occurrence of acute gastroduodenal erosions and ulcers has been proven [1]. The flow of sympathetic impulses causes an excessive release of mediators (catecholamines), which leads to disruption of tissue trophism. An important role in ulceration belongs to the parasympathetic nervous system.

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Multi- Factor etiopathogenesis of gastric and duodenal peptic ulcer disease

Experimental and Clinical Gastroenterology ◽

10.31146/1682-8658-ecg-192-8-154-159 ◽

2021 ◽

pp. 154-159

Author(s):

O. V. Rashina ◽

M. I. Churnosov

Keyword(s):

Risk Factors ◽

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Local Reaction ◽

The Body ◽

General Reaction ◽

Ulcer Disease ◽

Combined Action ◽

Local Reactions ◽

Humoral Regulation

Gastric and duodenal peptic ulcer disease is a multifactorial pathology, in the etiopathogenesis of which the general and local reactions of the body to external and internal risk factors play a role. Psychoemotional stress is the main cause of the pathology of nervous and humoral regulation (general reaction), and the local reaction is expressed in a violation of the ratio between the factors of aggression and protection factors in the mucous membrane of the stomach and / or duodenum. The combined action of these components leads to the formation of an ulcerative defect.

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A PROSPECTIVE, OBSERVATIONAL STUDY ON THE EFFICACY OF DRUG REGIMEN USED FOR HELICOBACTER PYLORI ERADICATION IN PEPTIC ULCER DISEASE

International Research Journal of Pharmacy ◽

10.7897/2230-8407.1206142 ◽

2021 ◽

Vol 12 (6) ◽

pp. 40-47

Author(s):

Abdullah . ◽

Mounika Pamukuntla

Keyword(s):

Peptic Ulcer ◽

Peptic Ulcer Disease ◽

Drug Regimen ◽

The Body ◽

Rapid Urease Test ◽

Medication History ◽

Patient Counselling ◽

Ulcer Disease ◽

Urease Test ◽

H Pylori

Aim of the study: We aimed to study the efficacy of triple drug therapy which is considered as a standard regimen. Objective of the study: To observe the role of pharmacist in preventing the recurrence of H. pylori infection. To assess whether the drug regimen prescribed eradicates the H. pylori infection. Results: In a period of 6 months a total of 358 cases were observed. Among them 142 cases are rapid urease test +ve and 216 are rapid urease test – ve cases. Of 142 patients included in the analysis, Peptic ulcer disease was more common in men when compared to women and prevalent in age group of 51-60 years. The body mass index analysis showed that 35.2% of patients were obese. From the personal history of the patients, it was concluded that 32.3% were smokers whereas 31.6% were alcoholic. The medication history analysis showed non-steroidal anti-inflammatory drugs were commonly used by the patients. The diagnostic endoscopic reports show that patients suffer from erosive pan gastritis followed by erosive gastritis. Conclusion: A 14-day triple therapy was found to be completely eradicate H. pylori infection. Out of the various demographic details that were taken into consideration age, gender, BMI, smokers, alcoholics, spicy food intake and drug abuse increased symptoms whereas co-morbid illness, sleeping pattern and food interval didn’t affect much. Structured patient counselling and follow up had a significant effect which was seen in the form of zero recurrence, 100% medication adherence and improved quality of life.

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Methodology for determining the anthrofundal border of the stomach in the surgical treatment of peptic ulcer disease

Kazan medical journal ◽

10.17816/kazmj70744 ◽

1986 ◽

Vol 67 (6) ◽

pp. 405-407

Author(s):

V. F. Naumov ◽

V. Ya. Popov

Keyword(s):

Peptic Ulcer ◽

Surgical Treatment ◽

Peptic Ulcer Disease ◽

Mucous Membrane ◽

Distal Part ◽

The Body ◽

Selective Proximal Vagotomy ◽

Gastric Stump ◽

Ulcer Disease ◽

The Right

Special methods allowing during the operation to establish the boundary between the mucous membrane of the body and the antral part of the stomach have an important practical value. Knowledge of gastric secretory topography provides clear performance of organ-saving operations (antrumectomy and selective proximal vagotomy). We propose to "cut out" the gastric stump so that it retains a part of the vagal nerve branches (in the area of cardia, esophagus, along the right gastroesophageal artery) and in its distal part it is represented by the antral part of the stomach.

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