Complex pharmacotherapy of peptic ulcer disease taking into account its complications from other parts of the digestive system

The progressive view of domestic clinicians on peptic ulcer disease is well known not as a local process in the stomach or in the duodenum, but as a general disease of the body (M. M. Gubergrits, M. P. Konchalovsky, R. A. Luria, N. D. Strazhesko , M.V. Chernorutsky, etc.). However, despite the great work invested in the study of peptic ulcer disease, much in this problem remains unclear and not specified. In particular, the demands of healthcare practice and the results of existing methods of treating peptic ulcer disease do not meet.

The influence of vaginal ovules on vaginal microbiome and vulvovaginitis

Vaginal microbiome is submitted to permanent changes accordingly to age, menopausal status or association of different pathological conditions such as inflammation or mucosal atrophy. The presence of these modifications is usually associated with local development of infectious, inflammatory or atrophic vulvovaginitis. These represent the most commonly complaints which affect women at all ages. Therefore, attention was focused on creating a topic product which is able to control the local process and to alleviate the symptoms. The aim of the current paper is to analyze the physiology, physiopathology and therapeutic strategies in such cases with special focus on Cerviron, a product which seems to provide multiple therapeutic benefits in such cases.

Blood for major diseases. Brückner (I Vers. d. Opht. Gesel., Heidelberg, 1918)

Having studied the composition of blood in 90 patients with eye diseases. - blenorrhoid conjunctivitis, serpiginous ulcer, perforating lesions, sympathetic inflammation and trachoma, Brckner (I Vers. D. Opht. Gesel., Heidelberg, 1918) found that an acute local process in the eye can affect the composition of the blood, and the latter changes depending on the improvement or deterioration of the process.

Forced settlement of Vlach Roma in Žatec and Louny in the late 1950s

The author of the study presents a micro-historical study of a family of Vlach Roma (Lovára) of western Slovakian origin, who were one of the few Romani groups still on the move in the mid-1950s and who in the late 1950s were forced to settle in the towns of Louny and Žatec in north-western Bohemia. Against this background the author focuses on some aspects of the Czechoslovak assimilation policy of the 1950s regarding ‘itinerant Gypsies’, designed to limit their mobility, which is represented mainly by the implementation of the Law on the Permanent Settlement of Itinerant Persons (No. 74/1958 Coll.). Using a combination of oral history methods involving Vlach Romani narrators and of archival research, the author clarifies some aspects of the local process of the implementation of the above-mentioned law and of selected impacts of the registration of travelling and semi-travelling people in February 1959. The forced sedentarization which occurred in the two localities under study is presented in the context of the regime of state socialism and the policies of central as well as local authorities towards so-called ‘travelling Gypsies’ in the late 1950s.

An Integrated Three-Level Synergetic and Reliable Optimization Method Considering Heat Transfer Process, Component, and System

Optimization of heat transfer systems (HTSs) benefits energy efficiency. However, current optimization studies mainly focus on the improvement of system design, component design, and local process intensification separately, which may miss the optimal results and lack reliability. This work proposes a synergetic optimization method integrating levels of the local process, component to system, which could guarantee the reliability of results. The system-level optimization employs the heat current method and hydraulic analysis, the component level optimization adopts heuristic optimization algorithm, and the process level optimization applies the field synergy principle. The introduction of numerical simulation and iteration provides the self-consistency and credibility of results. Optimization results of a multi-loop heat transfer system present that the proposed method can save 16.3% pumping power consumption comparing to results only considering system and process level optimization. Moreover, the optimal parameters of component originate from the trade-off relation between two competing mechanisms of performance enhancement, i.e., the mass flow rate increase and shape variation. Finally, the proposed method is not limited to heat transfer systems but also applicable to other thermal systems.

Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity

Sleep homeostasis manifests as a relative constancy of its daily amount and intensity. Theoretical descriptions define ‘Process S’, a variable with dynamics dependent on global sleep-wake history, and reflected in electroencephalogram (EEG) slow wave activity (SWA, 0.5–4 Hz) during sleep. The notion of sleep as a local, activity-dependent process suggests that activity history must be integrated to determine the dynamics of global Process S. Here, we developed novel mathematical models of Process S based on cortical activity recorded in freely behaving mice, describing local Process S as a function of the deviation of neuronal firing rates from a locally defined set-point, independent of global sleep-wake state. Averaging locally derived Processes S and their rate parameters yielded values resembling those obtained from EEG SWA and global vigilance states. We conclude that local Process S dynamics reflects neuronal activity integrated over time, and global Process S reflects local processes integrated over space.