scholarly journals FAS-receptor expression in peripheral blood lymphocytes and monocytes in pregnant women with fetal growth restriction

2014 ◽  
Vol 95 (4) ◽  
pp. 511-515 ◽  
Author(s):  
E V Kazantseva ◽  
N V Dolgushina ◽  
P P Tereshkov
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Receptor Expression ◽  
Fas Receptor ◽  
Normal Birth ◽  
T Lymphocyte Subpopulations ◽  
Low Birth Weight Children ◽  
Group 1

Aim. To study the expression of Fas-receptor on peripheral blood monocytes and lymphocytes in women who have given birth to children with low birth weight. Methods. Population-based study recruited 242 women who have given birth at the gestation term of more than 35 weeks. Group 1 (n=108) included mother-newborn pairs with low birth weight of newborns, group 2 (n=134) - mother-newborn pairs with normal birth weight for the gestational age. Peripheral blood lymphocytes and monocytes total count and subpopulations, CD95 (Fas-receptor) apoptosis receptor expression level (using four- and five-parametric phenotypic test) were determined, using a combination of monoclonal antibodies to differentiation and activation markers. Results. CD3+CD95+ cells levels were significantly higher in women who delivered of low birth weight children. In T-cell subpopulation of group 1 women, there was a statistically significant increase in relative values of Fas-receptor expression on T-helpers and T-cytotoxic lymphocytes - by 1.6 (p 0.001) and 6.3 (p 0.001) times, respectively, and by 2.9 (p 0.001) and 2.6 (p 0.001) times, respectively, in absolute values. There was a reduction in absolute counts of CD3+CD4+ and CD3+CD8+ T-lymphocyte subpopulations in women who delivered of low birth weight children compared to controls. The ratio of CD95+-expressing T-lymphocyte subpopulations in group 1 women was the following: CD4+CD95+/CD8+CD95+ ratio was 4.9 times higher compared to the second group (p 0.001). Increased absolute and relative Fas-receptor expression on B-lymphocytes [by 63.9% (p 0.001) and 33.3% (p=0.002), respectively] was found in women who delivered of low birth weight children compared to women who delivered of children with normal birth weight. CD14+CD95+ expression analysis revealed increased absolute and relative counts of Fas-receptor expressing monocytes. Conclusion. Marked expression of CD95+ in circulating monocytes and raised CD4+CD95+/CD8+CD95+ ratio in women who delivered of low birth weight children may be a laboratory test for detecting higher chance for fetal growth restriction.

scholarly journals Comparing Growth and Development of Low and Normal Birth Weight Children at Age of 60 Months

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Najmeh Maharlouei ◽  
Sogand Farhangian ◽  
Hadi Raeisi Shahraki ◽  
Abbas Rezaianzadeh ◽  
Kamran Bagheri Lankarani
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Growth And Development ◽  
Normal Birth Weight ◽  
Growth Indices ◽  
Normal Birth ◽  
Significant Difference ◽  
Low Birth Weight Children ◽  
Children's Development ◽  
Children’S Development

Background: Low birth weight (LBW < 2500 g) is one of the most serious problems in today’s world. It is also a predictor for mortality and stunting. Objectives: This study aimed to compare the growth and development at the age of 60 months between children born with low and normal birth weight in Shiraz, Iran. Methods: This study is part of the Fars birth cohort (FBC) study with the data of children who were born in 2011. We called mothers and asked them to bring their children to the FBC clinic for further evaluation. We also determined the level of development at the age of 60 months for each child by using the Ages and Stages questionnaire (ASQ) for the children. Results: Of the children, 304 (51.4%) were girls. Most of them had normal birth weight (93.2%), had exclusive breastfeeding for five to six months (79.9%), and did not have any chronic diseases (77.8%). Growth indices at the age of 60 months were significantly higher in children with normal birth weight than in their LBW peers (P < 0.001). However, we found no significant difference in children’s development at the age of 60 months between normal and low birth weight children. Conclusions: Although growth indices of children at the age of 60 months were higher in children with normal birth weight, we found no significant difference in children’s development at the age of 60 months between normal and low birth weight children.

Social Environment and Vulnerability of Low Birth Weight Children: A Social-Epidemiological Perspective

PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 943-953
Author(s):  
Peggy J. MCGauhey ◽  
Barbara Starfield ◽  
Cheryl Alexander ◽  
Margaret E. Ensminger
Keyword(s):  
Birth Weight ◽  
High Risk ◽  
Child Health ◽  
Low Birth Weight ◽  
Health Outcomes ◽  
Social Environment ◽  
Normal Birth Weight ◽  
Social Environments ◽  
Normal Birth ◽  
Low Birth Weight Children

This study examined the impact of low birth weight on children's health and assessed the influence of the social environment on various aspects of health in low birth weight and normal birth weight children. Data on 8661 children aged 2 through 11 from the 1981 Child Health Supplement of the National Health Interview Survey provided strong evidence for two major conclusions: (1) Low birth weight children in high-risk social environments are at increased for poor health outcomes compared with comparable normal birth weight children. This vulnerability was found across all age groups, suggesting that the effects of low birth weight are long-lasting. The poor health outcomes for low birth weight children in high-risk social environments were found for all seven aspects of child health status studied: excessive bed days, restricted-activity days, and school-loss days; school failure, low school-ranking, behavior problems, and maternal perception of child health status as fair/ poor. (2) The mechanism of risk was complex and differed by birth weight group. Whereas certain combinations of individual risk factors protected normal birth weight children from several adverse outcomes, none for low birth weight children were identified. However, low birth weight children in low-or moderate-risk social environments were not at greater risk for poor outcomes compared with comparable normal birth weight children. This study underscores the importance of a healthy social environment for children who are already at high risk for poor health outcomes by virtue of being low birth weight.

Dental Caries in Pre-term and Low Birth-weight Children and Related Factors

2009 ◽  
Vol 10 (4) ◽  
pp. 51-58 ◽  
Author(s):  
M. Ghasempour ◽  
M. Ahmadpour-Kacho ◽  
S. Sheikhi
Keyword(s):  
Birth Weight ◽  
Dental Caries ◽  
Low Birth Weight ◽  
Demographic Data ◽  
Related Factors ◽  
Cross Sectional ◽  
Normal Birth ◽  
Low Birth Weight Children ◽  
The Impact ◽  
Control Study

Abstract Aim The aims of this study were to determine the prevalence of dental caries in three to four-year-old children born pre-term and with a low birth weight (PLBW) to be compared with normal birth-weight children (NBW) and further to investigate the impact of relative risk factors on the development of dental caries in primary teeth. Methods and Materials This cross-sectional case-control study was conducted on 90 children (45 PLBW and 45 NBW). The demographic data and information about feeding practices was ascertained using a structured questionnaire. Dental caries status (dmft) was determined, and the differences between the two groups were tested using the Fisher's exact and the Mann-Whitney U tests at a confidence level of 5%. Results Twenty-five children (eight PLBW and 17 NBW) were caries free, and the mean±SD dmft was 2.5±0.3 in PLBW and 2.2±0.4 in NBW children (p>0.05). The length of feeding in PLBW children was lower than the NBW group (p>0.05). Conclusion The prevalence of dental caries did not differ between the PLBW and NBW children. Clinical Significance Enamel hypoplasia and snacking were not common in PLBW children which may account for the lack of difference in dental caries between the two groups. Citation Ghasempour M, Ahmadpour-Kacho M, Sheikhi S. Dental Caries in Pre-term and Low Birth-weight Children and Related Factors. J Contemp Dent Pract 2009 July; (10)4:051-058.

Antioxidant Levels in Cord Blood of Term Low Birth Weight Neonates Requiring Delivery Room Resuscitation

2021 ◽  
pp. 097321792199140
Author(s):  
Rimjhim Sonowal ◽  
Anamika Jain ◽  
V. Bhargava ◽  
H.D. Khanna ◽  
Ashok Kumar
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Vitamin A ◽  
Cord Blood ◽  
Serum Levels ◽  
Study Groups ◽  
Delivery Room ◽  
Normal Birth Weight ◽  
Normal Birth ◽  
Major Congenital Malformations

Objective: The objective of this study was to evaluate the serum levels of various antioxidants, namely, vitamin A and E, superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) in the cord blood of term low birth weight (LBW) neonates who required delivery room resuscitation (DRR). Materials and Methods: This case control study included 37 term LBW neonates who needed DRR as cases and 44 term neonates as controls (15 term LBW and 29 term normal birth weight) who did not require resuscitation at birth. Neonates suffering from major congenital malformations, infection, or hemolytic disease were excluded. Standard methods were used to measure the levels of vitamin A, vitamin E, SOD, catalase, and GPx levels in the cord blood. Results: Vitamin A and E levels were significantly low in cases compared to term LBW controls as well as term normal birth weight controls. Levels of SOD, GPx, and catalase were comparable in different study groups. Conclusion: Our study shows that term LBW neonates requiring DRR had significantly low levels of vitamin A and E in their cord blood. This might compromise their ability to tolerate oxidative stress during DRR.

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