scholarly journals Results of adding metformin and orlistat to complex treatment of stable angina associated with metabolic syndrome

2013 ◽  
Vol 94 (4) ◽  
pp. 492-496
Author(s):  
R L Dashdamirov
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Body Weight ◽  
Glucose Level ◽  
Stable Angina ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Fasting Serum ◽  
Fasting Serum Glucose Level ◽  
Body Weight Index

Aim. To evaluate the complex therapy with the addition of metformin and orlistat in treatment of II-III functional class stable angina associated with metabolic syndrome. Methods. The study included 143 patients with stable angina at the age of 36 to 70 years (mean age 54.2±3.6). Of these, 59 patients (control group) received standard treatment (isosorbide 5-mononitrate 40 mg/day, amlodipine 5 mg/day, acetylsalicylic acid 100 mg/day, carvedilol 25 mg/day, atorvastatin 20 mg/day, eprosartan 600 mg/day), and 84 patients (study group) were additionally administered metformin 1000 mg/day and orlistat 360 mg/day. Clinical and laboratory examinations (serum glucose and lipid level measurements) as well as instrumental examinations (electrocardiography, Doppler echocardiography, 24-hour electrocardiography and blood pressure monitoring) were performed before the treatment, 3, 6 and 12 months after the treatment start. Results. After 12 months of treatment mean systolic blood pressure in patients of the main group reduced by 24.5%, diastolic - by 18.8%, fasting serum glucose level - by 14.3% compared to the baseline level. Cholesterol level reduced by 13.8%, triglycerides - by 14.7%, low density lipoproteins - by 14.0%, blood level of high density lipoproteins increased by 11.6%. Body weight index reduced by 10.3%. Conclusion. Adding of 1000 mg of metformin and 360 mg of orlistat daily decreased the fasting serum glucose level by 14.3%, body weight index by 10.3%, and reduced the number of angina episodes by 19.6%, of painless myocardial ischemia by 36.3%, as well as increased physical ability tolerance by 26.5%.

scholarly journals Associations between BMI, serum uric acid, serum glucose, and blood pressure with urinary tract stone opacity

2015 ◽  
Vol 24 (2) ◽  
pp. 103-8
Author(s):  
Ikhlas A. Bramono ◽  
Nur Rasyid ◽  
Ponco Birowo
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Uric Acid ◽  
Urinary Tract ◽  
Serum Uric Acid ◽  
Body Mass ◽  
Glucose Level ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Urinary Tract Stone

Background: Urolithiasis refers to formation of stone in the kidney, ureter, or bladder. Several studies showed metabolic abnormalities were common in urolithiasis patients. The aim of this study was to describe the association between body-mass-index (BMI), serum uric acid, serum glucose, and blood pressure toward stone opacity in urinary tract stone patients.Methods: This study was done retrospectively by reviewing registry data of urinary tract stone patients that had undergone ESWL on January 2008 – December 2013 in Department of Urology Cipto Mangunkusumo Hospital. Data concerning body mass index, serum uric acid, serum glucose, blood pressure, and urinary tract stone opacity were recorded. Associations between body mass index, serum uric acid, serum glucose and blood pressure with urinary tract stone opacity were analyzed using chi-square test.Results: There were 2,889 patients who underwent ESWL on January 2008 – December 2013. We analyzed 242 subjects with complete data. Mean age was ± 12.78 (48.02 years). Male-to-female ratio was 2.27:1. Mean BMI was ± 3.78 (29.91 kg/m2). High risk BMIs were found in 161 patients (66.52%). The proportion of radioopaque stone was 77.69% (188 patients). Twenty two patients (9.1%) had normal blood pressure. Patients with high serum uric acid were 34.30% (83 patients). We found a significant association between random serum glucose level and stone opacity (p < 0.05).Conclusion: There is an association between random serum glucose level and stone opacity in urolithiasis patients. Hyperglycemia patients tend to have radiolucent stone, whereas normoglycemia patients tend to have radioopaque stone.

scholarly journals Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

2019 ◽  
Vol 35 (1) ◽  
Author(s):  
Teka Obsa Feyisa ◽  
Daniel Seifu Melka ◽  
Menakath Menon ◽  
Wajana Lako Labisso ◽  
Mezgebu Legesse Habte
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Uric Acid ◽  
Lipid Profile ◽  
Wistar Rats ◽  
Serum Glucose ◽  
Control Group ◽  
Fasting Serum ◽  
High Fructose Diet ◽  
High Fructose

AbstractCoffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high fructose diet. A post-test experimental study was conducted on a total of 30 (9–10 weeks old) male albino Wistar rats. The rats were divided into 6 groups: group I (normal control)-fed on standard chow and plain tap water only; group II (fructose control)-fed on standard chow and 20% of fructose solution; group III–VI (treatment groups)-fed on standard chow, 20% of fructose solution and treated with 71, 142, 213 and 284 mg/kg body weight/day of coffee respectively for six weeks. At the end, body weight, serum glucose, uric acid and lipid profile levels were investigated. Data was entered and cleared by epi-data software version 3.1 and analyzed by one way ANOVA followed by Tukey post hoc multiple comparison tests using SPSS V. 23.00. Statistical significance was considered at p < 0.05. The results showed that body weight, fasting serum glucose and uric acid levels significantly lowered in rats treated with 213 (p = 0.047; 0.049; 0.026) and 284 (p = 0.035; 0.029; 0.010) mg/kg body weight/day of coffee compared to fructose control group. Fasting serum triglycide (TG) and low density lipoprotein (LDL-C) levels showed significant reduction in rats treated with 284 mg/kg body weight/day of coffee as compared to fructose control group (p = 0.031; 0.046) respectively. In conclusion, treating rats with coffee decreased body weight, fasting serum glucose, uric acid, TC, TG and LDL-C, and increased HDL-C in a dose dependent manner in rats feeding on high fructose diet, suggesting that coffee consumption may be helpful in ameliorating metabolic syndrome.

scholarly journals A Cross Sectional Clinical Analysis of Hemiplegia (Pakkavatham) Related to Diabetes Mellitus (Mathumeham) and Hypertension (Erathakothippu)

2019 ◽  
pp. 1-8
Author(s):  
K. Sujeethasai ◽  
A. Manoharan ◽  
A. Rajarajeshwari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Glucose Level ◽  
Serum Glucose ◽  
Serum Glucose Level ◽  
Systemic Hypertension ◽  
Control Blood Pressure ◽  
Cross Sectional ◽  
Male Patients ◽  
Patient Department

Background: Stroke (Pakkavatham) is the second leading mortality cause in global and death occurrence rates, rising in middle to older aged people. This condition is increased due to the dietary pattern and lifestyle modifications. Aim: To determine about the interrelationship of Type II Diabetes Mellitus DM) and Systemic Hypertension (SHT) associated with hemiplegia. Study Design: Cross Sectional Descriptive Observational Study. Place and Duration of Study: This study work was carried out in 50 patients in Government Siddha Medical College and Hospital, Palayamkottai, Tirunelveli, Tamil Nadu from April 2019 to September 2019. Materials and Methods: This study was carried in 50 subjects (30 subjects in Out Patient Department (OPD) and 20 subjects in In Patient Department (IPD) were randomly selected and the data were collected by interviewing with a structured questionnaire. The ethical clearance was attained from the Institutional Ethical Committee. Results: The highest incidence was male patients (38%) than female patients, the affected age group was 51-60 years. The prevalence was seen in male alcoholic consumers (46%), chronic smokers (44%) respectively. The incidence was mostly seen in hypertensive (70%) and non-diabetic (46%) male patients. Among the 50 patients, 14 patients (28%) had both SHT and DM. The most prevalence was seen in hypertensive patients than DM or SHT combined with DM patients. The moderate improvement was seen in the patients (32%) of control blood pressure and serum glucose level. Conclusion: The SHT may influence in the prevalence of Pakkavatham and control blood pressure and serum glucose level may be improved the good prognosis in Pakkavatham patients.

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