scholarly journals Pathophysiologic aspects of the development of cognitive disorders in chronic heart failure in elderly patients

2018 ◽  
Vol 99 (2) ◽  
pp. 260-264 ◽  
Author(s):  
M A Pokachalova ◽  
M V Silyutina
Keyword(s):  
Heart Failure ◽  
Cerebral Ischemia ◽  
Chronic Heart Failure ◽  
Elderly Patients ◽  
Cognitive Dysfunction ◽  
Age Groups ◽  
Cognitive Disorders ◽  
Chronic Cerebral Ischemia ◽  
Course Of Disease

The present literature review presents current views on pathophysiologic aspects of the formation and progression of cognitive disorders in chronic heart failure in elderly patients. Advanced age itself is an important predictor of the development of cardiovascular, neurodegenerative and other diseases. Involutive changes of cardiovascular system are known to potentiate the development of chronic heart failure. Heart failure in older people usually develops gradually. Formation of the cognitive deficit in heart disease is associated with chronic cerebral ischemia as well as a cascade of neurochemical processes occurring in the brain, eventually forming a vicious circle. Often the symptoms of cerebral ischemia due to reduced stroke volume occur much earlier than congestion signs in other organs and systems. Chronic cerebral ischemia that occurs due to violation of cerebral hemodynamics, is associated with both extracerebral and intracerebral causes, which in turn contributes to the development of chronic brain hypoxia and aggravation of cognitive dysfunction. Thus, the features of the development and course of disease in people of older age groups indicate that in geriatric practice existing diagnostic schemes are not always applicable. When observing patients of elderly and senile age with chronic heart failure, during the assessment of their condition and running diagnostic tests, special attention should be payed to the earliest detection of cognitive dysfunction signs in order to correct the patient's treatment and improve quality of life.

scholarly journals Comparative analysis of clinical and neurological manifestations in patients with chronic cerebral ischemia and chronic heart failure with stored and reduced release fraction

2017 ◽  
pp. 42-48
Author(s):  
N. Zhhilova
Keyword(s):  
Heart Failure ◽  
Comparative Analysis ◽  
Cerebral Ischemia ◽  
Chronic Heart Failure ◽  
The State ◽  
Chronic Cerebral Ischemia ◽  
Significant Difference ◽  
Group 2 ◽  
Group 1

Chronic heart failure relates to the priorities of national health systems in most countries due to the high prevalence, steady increase in the number of new cases in all countries, frequent repeated hospitalizations, poor quality of treatment, high levels of disability and mortality, and increased treatment costs. An important multidisciplinary task is to study the state of the brain in the background of chronic cardiac pathology, which is associated with a violation of the pumping function of the heart and central hemodynamics. The purpose of the study was to investigate the state of the cognitive and psychoemotional sphere in patients with chronic cerebral ischemia and chronic heart failure with a preserved and reduced release fraction. In a comparative analysis in patients with chronic cerebral ischemia and chronic heart failure with a preserved and reduced emission fraction, a statistically significant difference was not found. Direct correlation dependence with complaints of memory impairment (r = 0.34), anxiety manifestations (r = 0.44), depression (r = 0.42). According to the study, cognitive impairment was observed in 95.3% of patients in group 1 and in 71.1% of patients in group 2. Dementia of light severity was found in patients with 1 group in 18.6% and in patients with 2 groups in 11.1%. Data from a neuropsychological study showed cognitive safety in 4.6% of patients in group I and 28.8% in group 2, which were characterized by mild modal-nonspecific mantle disorders. Premedicinal cognitive disorders were observed in group 1 in 33 (76.7%) patients and in 27 (60%) patients in group 2 (Table 1). There was a statistically significant difference between the groups p = 0.009 (p <0.05) and the direct correlation between MMSE and age (r = 0.63), quality of life (r = 0.31), complaints when considering deterioration of memory (r = 0.39).

Clinical and neuroimaging features of chronic cerebral ischemia in polycythemia vera

2021 ◽  
pp. 58-62
Author(s):  
G. V. Zyrina ◽  
T. A. Slyusa
Keyword(s):  
Cerebral Ischemia ◽  
Polycythemia Vera ◽  
Mini Mental State Examination ◽  
Comparison Group ◽  
Cognitive Disorders ◽  
Chronic Cerebral Ischemia ◽  
State Examination ◽  
The Brain

The purpose of the study. To study clinical and neuroimaging features of chronic cerebral ischemia (CCI) in polycythemia vera (PV).Materials and methods. 66 patients with PV were examined – the main group (43 men, 23 women; mean age 62.0 ± 3.4 years), of which 64 (97.0%) patients were diagnosed with CCI. The comparison group consisted of 85 patients with CCI (34 men, 51 women; mean age 67.7 ± 4.6 years), who developed against the background of cerebral vascular atherosclerosis and arterial hypertension. To identify cognitive disorders, we used Mini Mental State Examination (MMSE). Insomnia was studied in accordance with the criteria of the International Classification of Sleep ICDS‑22005. The quality of sleep was determined using a questionnaire from the Federal Somnological Center. Neuroimaging (MRI of the brain) was performed on Siemens Symphony 1.5 T and GE Signa 1.5 T tomographs.Results. Subjective symptoms CCI are characterized by a greater representation of asthenic and insomniac disorders. Transient ischemic attacks in patients with PV are significantly more common than in the comparison group, their frequency depends on the duration of PV. The revealed changes in MRI of the brain in the majority of PV patients with CCI are characteristic of multiinfarction vascular encephalopathy; in the comparison group, changes that characteristic for subcortical arteriosclerotic encephalopathy were more often recorded.

scholarly journals Comparative analysis of clinical and neurological manifestations in patients with chronic cerebral ischemia and chronic heart failure with stored and reduced release fraction

2017 ◽  
pp. 43-52
Author(s):  
N. Zhhilova
Keyword(s):  
Heart Failure ◽  
Nervous System ◽  
Comparative Analysis ◽  
Cerebral Ischemia ◽  
Chronic Heart Failure ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Neurological Manifestations ◽  
Chronic Cerebral Ischemia ◽  
Ventricular Ejection Fraction

The activation of the sympathetic nervous system plays an important pathophysiological role in the development of heart failure, in particular, in the development of left ventricular insufficiency. Although high blood pressure is considered as the main determinant of structural changes in the left ventricle, sex, salt intake, obesity, diabetes, as well as neurohumoral and genetic factors can affect the mass and left ventricular geometry. The usual concept of hypertonic re-modeling. In the comparative analysis of clinical and neurological manifestations in patients with chronic cerebral ischemia and chronic heart failure with a preserved and reduced release fraction, changes in the nervous system that showed a tendency to increase the disturbances and deviations from the norm with increasing heart failure, the fraction of release and the presence of hypertensive encephalopathy In the correlation analysis, a direct correlation between the quality of life indicator and the degree of heart failure (r = 0.56), the presence of myocardial infarction in the history (r = 0.42), arterial hypertension (r = 0.33) and the presence of valvular pathology the heart (r = 0.31) and the inverse correlation dependence on the indicator of the left ventricular ejection fraction (r = -0.69). A comparative analysis of correlation relationships indicates a reliable clinical and social significance of the left ventricular ejection fraction in patients with chronic cerebral ischemia and chronic heart failure.

scholarly journals Health-related quality of life in elderly patients hospitalized with chronic heart failure

2013 ◽  
pp. 1539 ◽  
Author(s):  
Predrag Erceg ◽  
Nebojsa Despotovic ◽  
Dragoslav Milosevic ◽  
Ivan Soldatovic ◽  
Sanja Zdravkovic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Elderly Patients ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals The influence of the autonomic nervous system in the development of chronic heart failure in patients with chronic brain ischemia combined with myocardial infarction

2018 ◽  
pp. 37-40
Author(s):  
N. O. Kravchuk
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Acute Myocardial Infarction ◽  
Chronic Heart Failure ◽  
Heart Diseases ◽  
Clinical Syndrome ◽  
Chronic Cerebral Ischemia ◽  
Course Of Disease ◽  
Number Of Patients ◽  
Chronic Brain Ischemia

Heart failure - severe, common clinical syndrome that is the result of many heart diseases is progressive, significantly reduces the life expectancy of patients and impairs its quality. Leading nosological forms the structure of coronary heart disease for many years, is a myocardial infarction. Growing proportion of elderly in most populations, increased survival after acute myocardial infarction (AMI) resulted in a significant increase in the number of patients with chronic heart failure (CHF). Increased tone of the sympathetic division precedes the development of chronic cerebral ischemia and, therefore, may complicate the course of disease in the presence of chronic heart failure.

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