scholarly journals Lung lesions caused by COVID-19 in comparison with bacterial pneumonia and influenza pneumonia: pathomorphological features

2021 ◽  
Vol 102 (5) ◽  
pp. 703-715
Author(s):  
R R Gainetdinov ◽  
S V Kurochkin
Keyword(s):  
Bacterial Pneumonia ◽  
Morphological Difference ◽  
Lung Lesions ◽  
Morphological Findings ◽  
Pulmonary Capillary ◽  
Key Factor ◽  
Influenza Pneumonia ◽  
The Difference ◽  
Development Outcomes ◽  
Course Outcomes

This review aimed to summarize the literature data regarding the pathomorphology of lung lesions in COVID-19 and compare it with lung lesions in bacterial pneumonia and pneumonia caused by influenza virus. The analysis of scientific literature containing studies of domestic and foreign authors of different years related to morphology and anatomical pathology of lung injury was carried out. Special attention was paid to the data devoted to COVID-19 obtained between 2019 and 2021. Based on the study, the main aspects of lung lesions were identified and grouped into blocks depending on the etiology of the process. The review collects and summarizes information on etiology, pathogenesis and stages of disease development, outcomes and morphological picture during the autopsy of patients with bacterial pneumonia, influenza pneumonia and COVID-19 pneumonia. The common features and differences in the course, outcomes and typical morphological findings, most characteristics for each of the diseases were presented in the table. There is a great similarity of morphological findings in influenza pneumonia and COVID-19 pneumonia despite the background of the difference in their epidemiology. Most Russian and foreign authors agree that a key factor in the pathogenesis of the development of COVID-19 is the presence of a specific receptor-mediated pathway of penetration into the cells of the respiratory epithelium. According to most authors, the main morphological difference that determines the severity and unfavorable outcome of COVID-19 is angiopathy and microthrombosis of the pulmonary capillary bed, which aggravate the typical picture of viral pneumonia.

scholarly journals Morphological consistency of bilateral hip joints in adults based on the X-ray and CT data

2021 ◽  
Author(s):  
Ran Zhao ◽  
Hong Cai ◽  
Hua Tian ◽  
Ke Zhang
Keyword(s):  
Hip Joint ◽  
Morphological Difference ◽  
Medullary Cavity ◽  
Size Difference ◽  
Single Plane ◽  
X Ray ◽  
Stem Size ◽  
The Difference ◽  
Ct Data ◽  
Anatomical Parameters

Abstract Purpose The application of the anatomical parameters of the contralateral hip joint to guide the preoperative template of the affected side relies on the bilateral hip symmetry. We investigated the bilateral hip symmetry and range of anatomical variations by measurement and comparison of bilateral hip anatomical parameters. Methods This study included 224 patients (448 hips) who were diagnosed with osteoarthritis (OA) and avascular necrosis (AVN) of the femur head, and underwent bilateral primary total hip arthroplasty (THA) in our hospital from January 2012 to August 2020. Imaging data included 224 patients X-ray and 30 CT data at the end of the cohort. Anatomical parameters, including the acetabular abduction angle and trochanteric height, were measured using the Noble method. Postoperative measurements included stem size, difference of leg length and offset. Results Except for the isthmus width, there were no significant differences in the anatomical morphology of the hip joint. Among the demographic factors, there was a correlation between body weight and NSA. Among various anatomical parameters, a correlation was present between medullary cavity widths of T + 20, T, and T − 20. The difference in the use of stem size is not due to the morphological difference of bilateral medullary cavity, but due to the different of 1- or 2-stage surgery. Conclusion Bilateral symmetry was present among the patients with normal morphology of the hip medullary cavity, theoretically confirming the feasibility of structural reconstruction of the hip joint using the hip joint on the uninjured side. Additionally, the difference in the morphology of the hip medullary cavity is not present in a single plane but is synergistically affected by multiple adjacent planes.

scholarly journals A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate and Linezolid for Treatment of Ventilated Gram-Positive Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia

2021 ◽  
Author(s):  
Richard G Wunderink ◽  
Antoine Roquilly ◽  
Martin Croce ◽  
Daniel Rodriguez Gonzalez ◽  
Satoshi Fujimi ◽  
...  
Keyword(s):  
Clinical Response ◽  
Bacterial Pneumonia ◽  
Double Blind Study ◽  
Phase 3 ◽  
Gram Positive ◽  
Double Blind ◽  
Intention To Treat ◽  
The Difference ◽  
Hospital Acquired ◽  
Noninferiority Margin

Abstract Background Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) are associated with high mortality rates. We evaluated the efficacy and safety of tedizolid (administered as tedizolid phosphate) for treatment of gram-positive ventilated HABP/VABP. Methods In this randomized, noninferiority, double-blind, double-dummy, global phase 3 trial, patients were randomized 1:1 to receive intravenous tedizolid phosphate 200 mg once daily for 7 days or intravenous linezolid 600 mg every 12 hours for 10 days. Treatment was 14 days in patients with concurrent gram-positive bacteremia. The primary efficacy end points were day 28 all-cause mortality (ACM; noninferiority margin, 10%) and investigator-assessed clinical response at test of cure (TOC; noninferiority margin, 12.5%) in the intention-to-treat population. Results Overall, 726 patients were randomized (tedizolid, n = 366; linezolid, n = 360). Baseline characteristics, including incidence of methicillin-resistant Staphylococcus aureus (31.3% overall), were well balanced. Tedizolid was noninferior to linezolid for day 28 ACM rate: 28.1% and 26.4%, respectively (difference, –1.8%; 95% confidence interval [CI]: –8.2 to 4.7). Noninferiority of tedizolid was not demonstrated for investigator-assessed clinical cure at TOC (tedizolid, 56.3% vs linezolid, 63.9%; difference, –7.6%; 97.5% CI: –15.7 to 0.5). In post hoc analyses, no single factor accounted for the difference in clinical response between treatment groups. Drug-related adverse events occurred in 8.1% and 11.9% of patients who received tedizolid and linezolid, respectively. Conclusions Tedizolid was noninferior to linezolid for day 28 ACM in the treatment of gram-positive ventilated HABP/VABP. Noninferiority of tedizolid for investigator-assessed clinical response at TOC was not demonstrated. Both drugs were well tolerated. Clinical Trials Registration NCT02019420.

Selective Transport of Water-Soluble Proteins from Aqueous to Ionic Liquid Phase via a Temperature-Sensitive Phase Change of These Mixtures

2012 ◽  
Vol 65 (11) ◽  
pp. 1548 ◽  
Author(s):  
Yuki Kohno ◽  
Nobuhumi Nakamura ◽  
Hiroyuki Ohno
Keyword(s):  
Phase Change ◽  
Aqueous Phase ◽  
Selective Dissolution ◽  
Selective Extraction ◽  
Soluble Proteins ◽  
Water Soluble ◽  
Temperature Sensitive ◽  
Salting Out ◽  
Key Factor ◽  
The Difference

Mixtures of some ionic liquids (ILs) and water show reversible phase change between a homogeneous mixture and phase-separated state by a small change in temperature. Some water-soluble proteins have been migrated from the aqueous to the IL phase. When tetrabutylphosphonium 2,4,6-trimethylbenzenesulfonate was used as an IL, cytochrome c (Cyt.c) was found to be extracted from the water phase to the IL phase. Conversely, both horseradish peroxidase (HRP) and azurin remained in the aqueous phase. This selective extraction was comprehended to be due to the difference in solubility of these proteins in both phases. The separated aqueous phase contained a small amount of IL, which induced the salting-out of Cyt.c. On the other hand, condensed IL phase promoted the salting-in of Cyt.c. As a result, Cyt.c was preferably dissolved in the hydrated IL phase rather than aqueous phase. In the case of HRP, there was only a salting-out profile upon increasing the concentration of IL, which induced selective dissolution of HRP in the aqueous phase. These results clearly suggest that the profile of salting-out and salting-in for proteins is the key factor to facilitate the selective extraction of proteins from aqueous to the IL phase.

Measurement of pulmonary blood flow during exercise using nitrous oxide

1962 ◽  
Vol 17 (4) ◽  
pp. 579-586 ◽  
Author(s):  
Margaret R. Becklake ◽  
C. J. Varvis ◽  
L. D. Pengelly ◽  
S. Kenning ◽  
M. McGregor ◽  
...  
Keyword(s):  
Blood Flow ◽  
Steady State ◽  
Dilution Technique ◽  
Fick Principle ◽  
Pulmonary Capillary Blood Flow ◽  
Time Period ◽  
Pulmonary Capillary ◽  
Wide Range ◽  
Pulmonary Capillary Blood ◽  
The Difference

Pulmonary capillary blood flow (Qc) in the exercising subject was calculated from the rate of disappearance of N2O during steady state breathing of an N2O-He-O2 mixture. Measurements were made after alveolar rinsing (reciprocal of N2 washout) had occurred, and up to 30 sec, a time period accompanied by minimal recirculation, since FaNN2O during this period did not rise significantly. Repeatability of the method, judged as the difference of a second estimate from a first on the same subject, was comparable to that reported for the direct Fick technique in resting subjects (31 of 33 paired observations agreed within 20%). Results over a wide range agreed with almost simultaneous measurements by a dye dilution technique (24 of 26 paired observations agreed within 20%), and when related to pulse rate and to Vo2, were comparable to those of the other workers whose subjects were studied in a similar posture. Indeed, this technique (using the indirect Fick principle under “steady state” conditions) probably attains its greatest accuracy during exercise when other methods become less easily applicable. Submitted on December 18, 1961

Effects of lung inflation and blood flow on capillary transit time in isolated rabbit lungs

1992 ◽  
Vol 72 (6) ◽  
pp. 2420-2427 ◽  
Author(s):  
P. M. Wang ◽  
C. D. Fike ◽  
M. R. Kaplowitz ◽  
L. V. Brown ◽  
I. Ayappa ◽  
...  
Keyword(s):  
Blood Flow ◽  
Transit Time ◽  
Transpulmonary Pressure ◽  
Lung Inflation ◽  
Video Signals ◽  
Pulmonary Capillary ◽  
Direct Measurements ◽  
Video Microscope ◽  
The Difference ◽  
Group 2

In a previous study, direct measurements of pulmonary capillary transit time by fluorescence video microscopy in anesthetized rabbits showed that chest inflation increased capillary transit time and decreased cardiac output. In isolated perfused rabbit lungs we measured the effect of lung volume, left atrial pressure (Pla), and blood flow on capillary transit time. At constant blood flow and constant transpulmonary pressure, a bolus of fluorescent dye was injected into the pulmonary artery and the passage of the dye through the subpleural microcirculation was recorded via the video microscope on videotape. During playback of the video signals, the light emitted from an arteriole and adjacent venule was measured using a video photoanalyzer. Capillary transit time was the difference between the mean time values of the arteriolar and venular dye dilution curves. We measured capillary transit time in three groups of lungs. In group 1, with airway pressure (Paw) at 5 cmH2O, transit time was measured at blood flow of approximately 80, approximately 40, and approximately 20 ml.min-1.kg-1. At each blood flow level, Pla was varied from 0 (Pla less than Paw, zone 2) to 11 cmH2O (Pla greater than Paw, zone 3). In group 2, at constant Paw of 15 cmH2O, Pla was varied from 0 (zone 2) to 22 cmH2O (zone 3) at the same three blood flow levels. In group 3, at each of the three blood flow levels, Paw was varied from 5 to 15 cmH2O while Pla was maintained at 0 cmH2O (zone 2).(ABSTRACT TRUNCATED AT 250 WORDS)

Ontogeny and heterochrony in the ostracode Cavellina Coryell from Lower Permian rocks in Kansas

Paleobiology ◽  
1986 ◽  
Vol 12 (3) ◽  
pp. 290-301 ◽  
Author(s):  
Peter N. Schweitzer ◽  
Roger L. Kaesler ◽  
G. P. Lohmann
Keyword(s):  
Life Histories ◽  
Morphological Difference ◽  
Structural Difference ◽  
Lower Permian ◽  
Closely Related Species ◽  
Know How ◽  
Taxonomic Level ◽  
Yield Information ◽  
Structural Differences ◽  
The Difference

Animals evolve by changing their form and by changing the rate at which they develop. Since evolution of development through time may be directly related to the adaptation of their life histories, study of ontogeny in fossils may yield information about the ecology of extinct animals. We need to know how to measure animals' ontogeny and at what taxonomic level structural differences overshadow differences in development. Two closely related species of the Permian ostracode Cavellina were compared to determine how much of the morphological difference between them is due to differences in their ontogenies. Most of the difference is not related to ontogeny. They also differ in a way that could be explained by heterochrony, although this difference is secondary in importance to the structural difference. These findings suggest that ecological adaptation might best be studied by examining the changes in development that occur within species through time and space.

Transit time dispersion in the pulmonary arterial tree

1998 ◽  
Vol 85 (2) ◽  
pp. 565-574 ◽  
Author(s):  
Anne V. Clough ◽  
Steven T. Haworth ◽  
Christopher C. Hanger ◽  
Jerri Wang ◽  
David L. Roerig ◽  
...  
Keyword(s):  
Transit Time ◽  
Mean Transit Time ◽  
Arterial Tree ◽  
Lung Lobe ◽  
Transit Times ◽  
Pulmonary Capillary ◽  
Time Dispersion ◽  
Pulmonary Arterial ◽  
The Difference ◽  
In Transit

Knowledge of the contributions of arterial and venous transit time dispersion to the pulmonary vascular transit time distribution is important for understanding lung function and for interpreting various kinds of data containing information about pulmonary function. Thus, to determine the dispersion of blood transit times occurring within the pulmonary arterial and venous trees, images of a bolus of contrast medium passing through the vasculature of pump-perfused dog lung lobes were acquired by using an X-ray microfocal angiography system. Time-absorbance curves from the lobar artery and vein and from selected locations within the intrapulmonary arterial tree were measured from the images. Overall dispersion within the lung lobe was determined from the difference in the first and second moments (mean transit time and variance, respectively) of the inlet arterial and outlet venous time-absorbance curves. Moments at selected locations within the arterial tree were also calculated and compared with those of the lobar artery curve. Transit times for the arterial pathways upstream from the smallest measured arteries (200-μm diameter) were less than ∼20% of the total lung lobe mean transit time. Transit time variance among these arterial pathways (interpathway dispersion) was less than ∼5% of the total variance imparted on the bolus as it passed through the lung lobe. On average, the dispersion that occurred along a given pathway (intrapathway dispersion) was negligible. Similar results were obtained for the venous tree. Taken together, the results suggest that most of the variation in transit time in the intrapulmonary vasculature occurs within the pulmonary capillary bed rather than in conducting arteries or veins.

scholarly journals Software-Defined Congestion Control Algorithm for IP Networks

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yao Hu ◽  
Ting Peng ◽  
Lianming Zhang
Keyword(s):  
Congestion Control ◽  
Transmission Control Protocol ◽  
Rapid Evolution ◽  
Centralized Control ◽  
Network Congestion ◽  
Ip Network ◽  
Key Factor ◽  
Flow Information ◽  
Underlying Network ◽  
The Difference

The rapid evolution of computer networks, increase in the number of Internet users, and popularity of multimedia applications have exacerbated the congestion control problem. Congestion control is a key factor in ensuring network stability and robustness. When the underlying network and flow information are unknown, the transmission control protocol (TCP) must increase or reduce the size of the congestion window to adjust to the changes of traffic in the Internet Protocol (IP) network. However, it is possible that a software-defined approach can relieve the network congestion problem more efficiently. This approach has the characteristic of centralized control and can obtain a global topology for unified network management. In this paper, we propose a software-defined congestion control (SDCC) algorithm for an IP network. We consider the difference between TCP and the user datagram protocol (UDP) and propose a new method to judge node congestion. We initially apply the congestion control mechanism in the congested nodes and then optimize the link utilization to control network congestion.

Differences in the level of body equilibrium by sex in early school-age children

2020 ◽  
Author(s):  
Sanja Ljubičić ◽  
Ljubomir Antekolović ◽  
Vedran Dukarić
Keyword(s):  
Statistical Significance ◽  
Parametric Method ◽  
The Body ◽  
School Age Children ◽  
Motor Deficits ◽  
School Age ◽  
Balance Test ◽  
Key Factor ◽  
The Difference ◽  
Female Bodies

Equilibrium represents the motor capability responsible for the performance of virtually all functional movements. Thus, the importance of early diagnosis of equilibrium levels in boys and girls was recognized as the key factor for the prevention of motor deficits and muscles misbalances later in life. Purpose: The purpose of this paper was to show the difference between boys and girls aged 7‒10 years in the level of unilateral static balance of the take-off leg. Methods: Research was conducted at the Kvarner Athletics Club Rijeka, and it involved 80 children aged 7‒10 years (38 boys and 42 girls). Measurement of static unilateral equilibrium was obtained using Gyko Inertial System (Microgate, Bolzano, Italy). Three attempts were made in 20 seconds and two motor variables were observed: medio-lateral and antero-posterior trajectories of the body. For both variables, the arithmetic mean, the minimum and maximum score and standard deviation were calculated. Moreover, a non-parametric method of the Mann-Whitney U test was used to determine statistical significance between boys and girls. Statistical significance was set at p < 0.05. Results: Statistically, girls have significantly better results compared to boys, both in the medio-lateral trajectory variable (M_Sumg = 335.1, M_Sumb = 479.34) and the antero-posterior trajectory variable (M_Sumg = 291.14, M_Sumb = 411.71). Conclusion: The results of this study showed that girls aged 7‒10 years achieved significantly better results compared to boys in observed motor variables (medio-lateral and antero-posterior trajectory of the body), when performing a static unilateral take-off leg balance test. These results are consistent with previous research. Indications for such results stem from different perspectives, among which the most common one refers to the earlier maturation of the systems responsible for postural control in female bodies. Recommendation for further research is to conduct examination on a larger sample of subjects, in younger children (pre-school age) and with both legs.

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