scholarly journals The search for genetic factors of predisposition to the development of liver cirrhosis in the course of viral hepatitis B in patients from the Republic of Bashkortostan

2012 ◽  
Vol 93 (2) ◽  
pp. 197-203 ◽  
Author(s):  
G T Gusmanova ◽  
D Kh Kalimullina ◽  
A B Bakirov ◽  
R I Khusainova
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Control Group ◽  
Genetic Associations ◽  
Glutathione S Transferase ◽  
Increased Risk ◽  
Viral Hepatitis B ◽  
The Republic ◽  
Severity Of The Disease

Aim. To identify the clinical and genetic associations of polymorphisms of the detoxification of xenobiotics genes during liver cirrhosis that developed as a result of viral hepatitis B. Methods. The study randomly included 38 patients with liver cirrhosis at the age of 25 to 54 years. The control group consisted of 147 healthy individuals. Conducted was an analysis of mutations in the deletion polymorphism of gene CYP1A1, leading to the replacement of the amino acid isoleucine with valine (Ile462Val) in position 462 of the cytochrome P-450 CYP1A1 and polymorphism of the gene GSTM1, which codes an enzyme antioxidant enzyme from the family of glutathione-S-transferase in patients with liver cirrhosis, which developed as a result of hepatitis B with the aim to identify possible associations with an increased risk and severity of the disease. Results. Revealed was a statistically significant increase in the proportion of patients with genotype Ile-Val/(+) compared to genotype Ile-Ile/(+), established was an association between the genotype S65C/N with polymorphism S65C of the gene HFE and liver cirrhosis of combined genesis (viral B + toxic). Conclusion. Ile462Val genotype of the CYP1A1 gene of the cytochrome P450, as well as the presence of a deletion of the glutathione-S-transferase M1 gene are risk factors for the development of liver cirrhosis secondary to hepatitis B.

scholarly journals The main aspects of the immunoprophylaxis of infectious diseases in the Republic of Dagestan

2019 ◽  
Vol 18 (3) ◽  
pp. 42-45
Author(s):  
N. S. Karnayeva ◽  
L. U. Ulukhanova ◽  
A. G. Gadzhimirzaevа ◽  
S. G. Agaevа
Keyword(s):  
Hepatitis B ◽  
Infectious Diseases ◽  
Viral Hepatitis ◽  
Viral Hepatitis B ◽  
The Republic ◽  
Vaccine Prophylaxis ◽  
Religious Reasons ◽  
To Receive ◽  
Positive Effect ◽  
Epidemiological Situation

The analysis of the epidemiological situation of vaccine-preventable infections in the Republic of Dagestan. The introduction of mass vaccine prophylaxis had a positive effect on reducing the incidence of infections such as poliomyelitis, diphtheria, tetanus, rubella, and viral hepatitis B in the Republic of Dagestan. However, despite the ongoing routine immunization of the population for “controlled” infections, the incidence of measles and parotitis infection remains high in 2018, this is due to an increase in the number of people who refuse to receive preventive vaccinations, in most cases, for religious reasons.

Costs of viral hepatitis B in the Republic of Korea, 2002‐2015

2019 ◽  
Vol 27 (2) ◽  
pp. 156-167
Author(s):  
Dahye Baik ◽  
Byung‐Woo Kim ◽  
Jin‐Kyoung Oh ◽  
Kyung‐Ah Kim ◽  
Moran Ki
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Republic Of Korea ◽  
Viral Hepatitis B ◽  
The Republic

scholarly journals PROSPECTS OF THE USE "STIMFORTE" IN CHRONIC HEPATITIS B

2013 ◽  
Vol 18 (5) ◽  
pp. 15-20
Author(s):  
L. V Pogorelskaya ◽  
I. N Khlopova ◽  
S. S Grigoryan ◽  
I. P Tryakina ◽  
N. A Rick ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Viral Load ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Chronic Hepatitis B ◽  
Well Being ◽  
Chronic Viral Hepatitis ◽  
Control Group ◽  
Positive Hbsag ◽  
Viral Hepatitis B

Despite the fact that over the last few years downward trend in the incidence of acute forms of viral hepatitis B continues, the incidence of chronic hepatitis B (CHV) has increased by 2.5 times since 1998. To date, there are a sufficient number of antiviral drugs, but their use is associated with a set of contraindications, as well as the development of resistance. In this study there was performed an evaluation of a new national drug " Stimforte " in patients with chronic viral hepatitis B (CVHB - DNA positive, HBsAg - positive) at the stage of exacerbation. In the study there were included 28 patients with chronic hepatitis B (HBsAg positive), at different grades of activity, at a stage of viral replication. The diagnosis of chronic hepatitis B was made on the presence in a history acute viral hepatitis for more than 1 year, complaints, hepatolienal, astenovegetative, cytolytic syndromes, the presence of DNA-HBV, anti-HBcore IgM, HBsAg. After 1 course of treatment with " Stimforte " the well-being of patients has improved: in 30% of patients asthenic- vegetative syndrome had disappeared, weakness, fatigue and dyspeptic symptoms were decreased. The use of "Stimforte" in chronic hepatitis B with positive HBsAg at the stage of exacerbation contributed to a more rapid normalization of such indices as ALT, AST, compared with those in the control group. Long-term biochemical and virological remission was achieved in 40 %. It is established that during the treatment the viral load was reduced progressively until the undetectable or low level of HBV DNA and anti-HBc IgM disappeared. In only one case an allergic reaction was observed, which has not hindered to perform a complete course of treatment. No other side effects were detected. The inclusion of the drug "Stimforte" in the complex therapy of patients with exacerbation of chronic hepatitis B reduces the time of recovery of immune status and functional activity of IFN system and contributes to reduction of the viral load or elimination of the virus.

scholarly journals Chronic viral hepatitis B and D in pregnant women: course and outcomes (review)

2021 ◽  
Vol 13 (2) ◽  
pp. 29-37
Author(s):  
M. D. Akhmedova ◽  
Sh. A. Tashpulatova ◽  
G. A. Ikhtiyarova ◽  
M. T. Karimova
Keyword(s):  
Hepatitis B ◽  
Pregnant Women ◽  
Viral Hepatitis ◽  
Vascular Wall ◽  
High Viral Load ◽  
Chronic Viral Hepatitis ◽  
Current Data ◽  
Hepatitis D ◽  
Increased Risk ◽  
Viral Hepatitis B

Hepatitis B is most common among young people, which is explained by the ways of infection – parenteral, sexual and vertical. Mother-to-child transmission is the main route of infection for children in areas where the hepatitis B virus (HBV) is endemic.The available current data on the course and outcomes of chronic viral hepatitis B are contradictory in pregnant women. Some authors argue that the exacerbation of chronic hepatitis B is more common in the first and third trimesters in pregnant women, and with an increase in gestation, there is a deterioration in liver function and an increased risk of fulminant liver failure. Other researchers note a more severe course in the second half of pregnancy or in the first months after delivery.High replication of the virus increases the frequency of gestational diabetes mellitus, hemostatic disorders, the threat of termination of pregnancy, gestosis, fetoplacental insufficiency, risk of bleeding in childbirth, premature birth, untimely discharge of amniotic fluid, and the birth of premature babies.Children become chronic carriers of HBsAd in neonatal hepatitis. These findings suggest that transplacental infection before birth may be a mechanism contributing to higher rates of failed prevention in newborns born to women with a high viral load.We could not find data on the features of the course and outcomes of viral hepatitis D in pregnant women in the available sources,. At the same time, it is known that mixed infection is more severe.Polymorphisms of genes associated with the regulation of the state of the vascular wall can have a significant impact on the course of infection.The high prevalence of hepatitis D infection in different parts of the world indicates the need for a comprehensive study of this disease, followed by the development of special programs for the prevention, early diagnosis and treatment of hepatitis B and D in pregnant women. 

scholarly journals THE INVESTIGATION OF DNA DAMAGE IN LYMPHOCYTES BY COMET ASSAY IN CHRONIC VIRAL HEPATITIS B PATIENTS

2017 ◽  
Vol 22 (2) ◽  
pp. 64-68
Author(s):  
A. O Mikhailov ◽  
A. F Popov ◽  
N. S Ivanova ◽  
A. I Simakova
Keyword(s):  
Dna Damage ◽  
Liver Fibrosis ◽  
Hepatitis B ◽  
Comet Assay ◽  
Viral Hepatitis ◽  
Chronic Viral Hepatitis ◽  
The Body ◽  
Control Group ◽  
Blood Samples ◽  
Viral Hepatitis B

The investigation of the degree of the lymphocyte DNA damage in chronic viral hepatitis B (HBV) patients is of interest for several reasons. Firstly, it is possible to judge indirectly about the depth of the pathological process at the level of the whole organism, with bearing in mind features of the pathogenic replication of hepatitis B virus. Secondly, it is possible to give an estimation of the degree of genotoxic impact of the virus on blood cells that plays an essential role in the shaping of the immune response of the body. The study was executed on 50 blood samples from HBV patients, divided in 5 groups on the fibrosis grade according to METAVIR score: F0 (n = 10), F1 (N = 10), F2 (N = 10), F3 (n = 10), F4 (n = 10). The control group was consisted of 43 volunteers matched by the age and gender without concomitant diseases. From blood samples taken at the time of the admission to the hospital lymphocytes were isolated by density gradient on Ficoll-urografin. The degree of DNA damage in lymphocytes was determined by virtue of alkaline version of the DNA comet assay. There was noted the direct relationship between an increase in % DNA in the tail of comets and the grade of liver fibrosis. So in the control group, % DNA in the tail accounted for 3.75 ± 1.44. In the F0 group % of DNA in the tail was 5.07 ± 1.25, F1 - 6.79 ± 1.79, F2 - 7.65 ± 1.62, F3 - 8.05 ± 1.18, F4 - 9.84 ± 3.09. It is noteworthy that in groups F2, F3, F4 differences were statistically significant in comparison with the control group. Also there was noted the presence of apoptotic cells in F3, F4 groups: 1 and 0.88%, respectively. Identified changes are both important in the description of to molecular patterns of the pathogenesis of chronic hepatitis B associated with damage, and also can serve as an indirect indication of the stage of liver fibrosis.

scholarly journals Features during labor in women with chronic hepatitis B

2015 ◽  
Vol 96 (1) ◽  
pp. 10-12
Author(s):  
N D Shoonaeva
Keyword(s):  
Hepatitis B ◽  
Cesarean Section ◽  
Viral Hepatitis ◽  
Chronic Viral Hepatitis ◽  
Control Group ◽  
Study Group ◽  
Fetal Hypoxia ◽  
Premature Rupture Of Membranes ◽  
Early Postpartum ◽  
Viral Hepatitis B

Aim. To examine the course of labor in women with chronic hepatitis B.Methods. The course of labor was studied in 391 female patients with chronic viral hepatitis B, included in the study group (mean age 22.7±2.5 years), who delivered off in the National Maternity Hospital (Bishkek). The control group included 59 healthy women in labor (mean age 22.5±1.3 years).Results. The vast majority of patients - 53 (89.8%) of the control group and 328 (83.9%) of the study group - had delivered off at term. Post-term births were registered in both groups. Operative delivery by cesarean section was performed in 13.0% of chronic viral hepatitis B cases - by 4.5% higher compared to control group. In the study group, planned cesarean section was performed in 21 (5.4%) patients, the main indication was burdened obstetric history - in 8 (2.0%) patients; 5 (1.3%) patients had multiple indications. Emergency operations were conducted in 30 (7.7%) patients. Indications were premature rupture of membranes - 15 (3.8%) of cases, fetal hypoxia during labor and multiple indications - 10 (2.6%) cases each. The average blood loss at cesarean section in the group of patients with chronic viral hepatitis B was 870±15.2 ml, compared to 700±10.2 ml in the control group, which can be associated with low coagulation seen in hepatitis. Comparative analysis of the complications rate in the control group revealed that delayed rupture of membranes was the most frequent - 11 (18.6%) cases, followed by intrauterine fetal hypoxia - 5 (8.5%) cases, early postpartum bleeding - 4 (6.8%) cases, hypertensive disorders at labor and retained placenta - 3 (5.1%) cases each. In the group with chronic viral hepatitis B, premature rupture of membranes occurred in 51.5% of cases, (relative risk 2.8). Early postpartum bleedings were seen in 38.9% of the cases at the main group (relative risk 5.7).Conclusion. The above data gives us every reason to include women with chronic viral hepatitis B at high-risk group for possible bad pregnancy and childbirth outcomes both for the mother and the fetus.

scholarly journals IMMUNOPROPHYLAXIS OFVIRAL HEPATITIS "B"IN THE REPUBLIC OF KAZAKHSTAN

2020 ◽  
Vol 3 (4(73)) ◽  
pp. 17-19
Author(s):  
G. K. Kazbekova ◽  
D.S. Tupenova ◽  
B. S. Malgazhdarova
Keyword(s):  
Public Health ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Health Problem ◽  
Public Health Problem ◽  
Preventive Measure ◽  
Viral Hepatitis B ◽  
Preventive Vaccination ◽  
The Republic ◽  
Effective Preventive Measure

In article presented effectiveness of conducted vaccine prevention of viral hepatitis “B” in Republic of Kazakhstan, decreasing of level of morbidity by viral hepatitis, disability because of viral hepatitis against the background of vaccination. Vaccination against hepatitis “B” is known to be an effective preventive measure. According to the program of preventive vaccination in our republic the practical use of hepatitis “B” vaccine allowed us to achieve significant in the fight against this infection.Hepatitis “B” is a priority public health problem worldwide, which is associated with a highinfection of the population with the virus, leading to dire consequencesю.

Treatment of decompensated viral hepatitis B induced liver cirrhosis with low dose interferon alpha (IFN)

1991 ◽  
Vol 13 ◽  
pp. S151
Author(s):  
F. Nevens ◽  
P. Goubau ◽  
P. Van Eyken ◽  
J. Desmyter ◽  
V. Desmet ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis B ◽  
Viral Hepatitis ◽  
Interferon Alpha ◽  
Low Dose ◽  
Viral Hepatitis B

Serological and molecular-biological verification of viral hepatitis B, C, D and E in various populations of the Republic Sakha (Yakutia)

2018 ◽  
pp. 55-60
Author(s):  
S.I. Semenov ◽  
K.M. Stepanov ◽  
F.A. Platonov ◽  
S.S. Shadrina ◽  
M.M. Pisareva ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Viral Hepatitis B ◽  
The Republic
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