scholarly journals Enzymotherapy of toxic anterior segment syndrome after phacoemulsification

2017 ◽  
Vol 10 (2) ◽  
pp. 87-93
Author(s):  
Alexander S Suvorov ◽  
Timur G Sazhin
Keyword(s):  
Visual Acuity ◽  
Anterior Chamber ◽  
Treatment Initiation ◽  
Anterior Segment ◽  
Treatment Result ◽  
Eye Drops ◽  
Group Iii ◽  
Group I ◽  
Toxic Anterior Segment Syndrome ◽  
Observation Period

Purpose. To investigate the efficacy of recombinant prourokinase (RPU) treatment in patients with toxic anterior segment syndrome after phacoemulsification. Material and methods. We observed 123 patients (123 eyes) with toxic anterior segment syndrome after phacoemulsification; patients of the group I (n = 30) received only antiinflammatory treatment; in treatment of patients of the group II (n = 31), instillations of the RPU solution were used, in the group III (n = 31), RPU solution was injected subconjunctivally, in the group IV (n = 31) - RPU solution electrophoresis was used. Treatment result analysis was carried out within 30 days. Results. Initial mean visual acuity in groups was 0.09 ± 0.04; 0.1 ± 0.04; 0.09 ± 0.04; 0.08 ± 0.04, and was virtually the same (p > 0.05). In 24 hours after treatment initiation, mean visual acuity in the group III was higher, than in the others. In three days and up to the end of observation period, the lowest mean visual acuity was noted in the group I (p < 0.05). Anterior chamber assessment showed that beginning from the first 24 hours after treatment initiation, in groups III and IV, fibrin lysis in the anterior chamber was more pronounced, than in groups I and II (p < 0.05); by the end of the observation period, worst indices of anterior chamber state were found in the group I (p < 0.05), in other groups, they were almost identical (p < 0.05). When using RPU, no allergic reaction was noted. Conclusions. RPU use in combined toxic anterior segment syndrome therapy after phacoemulsification allows increasing visual acuity, reducing convalescence time, and reducing the number of laser dissections. It was established that all methods of RPU administration are effective. RPU may be administered as eye drops on an outpatient basis, receiving efficacy similar to other administration methods.

Effect of light backscattering from anterior segment structures on automated flare meter measurements

2021 ◽  
pp. 112067212110393
Author(s):  
Murat Hasanreisoglu ◽  
Cem Kesim ◽  
Duygu Yalinbas ◽  
Mervenur Yilmaz ◽  
Nur Sena Uzunay ◽  
...  
Keyword(s):  
Anterior Chamber ◽  
Scattered Light ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Laser Flare Photometry ◽  
Aqueous Flare ◽  
Group I ◽  
Lens Density ◽  
Laser Flare ◽  
Group Ii

Background: To evaluate effect of maximal anterior cortical lens density, iris scatter and anterior chamber depth on laser flare photometry. Methods: Patients diagnosed with clinical uveitis were enrolled in the study. Clinical flare gradings were recorded upon the Standardization of Uveitis Nomenclature. Aqueous flare was measured with an automated device (Kowa FM-700). Back-scattering from anterior cortical lens and anterior iris surface was calculated from Scheimpflug images. A curvilinear regression model was used to calculate estimated values for each clinical grade. These values were used to split cases in Group I (laser flare photometry lower than estimated) and Group II (laser flare photometry higher than estimated). Mean anterior chamber depth, pupil aperture, maximal anterior cortical lens density and iris scatter values were compared between two groups. A stepwise multiple regression analysis was performed to determine the effect of clinical flare gradings and ocular parameters on aqueous flare measurements. Results: The study included 228 eyes of 114 cases. Scheimpflug images were obtained from 105 eyes. Estimated aqueous flare measurements (in photons/milliseconds) were 4.87, 8.50, 14.81, 25.83, 45.04 and 136.93 for 0, 0.5+, 1+, 1.5+, 2+ and 3+ clinical flare respectively. Group II had higher maximal anterior cortical lens density than Group I (96.6 ± 37.1 vs 77.9 ± 17.1 pixel unit, p = 0.001). The measured aqueous flare was significantly related to clinical flare, maximal anterior cortical lens density and pupil aperture (adjusted R2: 0.480, p < 0.001). Conclusion: The back-scattered light from anterior cortical lens could affect laser flare photometry measurements. This effect might be quantified by Scheimpflug imaging.

scholarly journals Anatomical and Visual Effects of Implantable Phakic Contact Lens on Correction of Myopia

2022 ◽  
Author(s):  
Mahmoud Ekram ◽  
Ahmed Mohamed Kamal Elshafei ◽  
Asmaa Anwar Mohamed ◽  
Mohamed Farouk Sayed Othman Abdelkader
Keyword(s):  
Visual Acuity ◽  
Anterior Chamber ◽  
Contact Lens ◽  
Anterior Segment ◽  
Anterior Chamber Depth ◽  
Case Series ◽  
Care Group ◽  
Case Series Study ◽  
Significant Difference ◽  
The Mean

Abstract Purpose: To evaluate the anatomical effects of implantable phakic contact lens (IPCL) (Care Group, India) on anterior segment and its visual outcomes .Patients and methods: In a prospective interventional case series study, 60 highly myopic eyes of 32 patients were subjected to IPCL implantation in the Ophthalmology Department of Minia University Hospital, Egypt from January 2019 to June 2021. All patients had complete ophthalmic examination and were followed up for 1 year. Pentacam was used for preoperative and postoperative estimation of anterior chamber depth (ACD), anterior chamber angle (ACA), anterior chamber volume (ACV) and IPCL vault in the 1st, 3rd, and 12th months. Assessment of corneal endothelium was done using specular microscope preoperatively and after 12 months. Preoperative and postoperative refraction and visual acuity were measured. Results: There was a statistically significant decrease in ACD, ACA, and ACV. There was no significant difference between preoperative and postoperative mean intraocular pressure (IOP) by the 12th month (P=0.163). The mean preoperative endothelial cell count (ECD) was significantly reduced from 2929.3±248 cells/mm2 to 2737.9±303 cells/mm2 at the 12th month (P<0.001). with a statistically highly significant improvement of mean Log Mar uncorrected visual acuity (UCVA) from 1.48±0.19 preoperatively to 0.46±0.11 by the end of follow up (P<0.001) with insignificant difference between preoperative best corrected visual acuity (BCVA) and postoperative UCVA (P=0.209). In the 12th month, the mean vault was 240±540 μm. No sight threatening complications occurred.Conclusion: Although IPCL induced anatomical changes, it was safe and effective for correction of high myopia.

Prospective Evaluation of Intravitreal Triamcinolone Acetonide Injection in Macular Edema Associated with Retinal Vascular Disorders

2005 ◽  
Vol 15 (5) ◽  
pp. 619-626 ◽  
Author(s):  
H.K. Tewari ◽  
P. Sony ◽  
R. Chawla ◽  
S.P. Garg ◽  
P. Venkatesh
Keyword(s):  
Visual Acuity ◽  
Macular Edema ◽  
Triamcinolone Acetonide ◽  
Macular Thickness ◽  
Intravitreal Triamcinolone ◽  
Group Iii ◽  
Vein Occlusion ◽  
Group I ◽  
Group Ii

Purpose To evaluate the effect of intravitreal triamcinolone acetonide on visual acuity and macular thickness using optical coherence tomography (OCT) in macular edema associated with various retinal vascular disorders. Methods This prospective nonrandomized clinical interventional study included 81 eyes (76 patients) comprised of Group I, 57 eyes (51 patients) with diabetic macular edema; Group II, 10 eyes (10 patients) with branch retinal vein occlusion; and Group III, 13 eyes (13 patients) with central retinal vein occlusion. All eyes received an intravitreal injection of 4 mg triamcinolone acetonide (with the solvent) in the operation theater under sterile conditions. Results Mean preinjection central macular thickness was 531.84±132 μm in Group I, 458.4±149 μm in Group II, and 750.81±148 μm in Group III. All groups showed a statistically significant decrease in mean central macular thickness at 1 month (300.7±119 μM in Group I, 218.2±99 μm in Group II, and 210.5 ±56 μm in Group III) and 3 months (253.19±109 μm in Group I, 187±47 μm in Group II, and 182±50 μm in Group III) after injection (p<0.05). Mean follow-up was 22±2.4 weeks. Mean visual acuity increased in all three groups (preoperative visual acuity in Group I, 1.2±0.4 logMAR units; Group II, 1.24±0.5 logMAR units; Group III, 1.1 ±0.4 logMAR units; 1 month postinjection in Group I, 0.88±0.3 logMAR units; Group II, 0.67±0.3 logMAR units; Group III, 0.86±0.4 logMAR units; 3 months postinjection in Group I, 0.84±0.4 logMAR units; Group II, 0.59±0.3 logMAR units; Group III, 0.82±0.5 logMAR units) (p<0.05). Forty-one eyes completed 6 months and 20 eyes completed 9 months follow-up. Twelve of 20 (41%) eyes in Group I, 2/6 (33%) eyes in Group II, 3/6 (50%) eyes in Group III, and 8/15 (53%) eyes in Group I, 1/3 (33%) eyes in Group II, and 2/2 (100%) eyes in Group III developed recurrence of macular edema with worsening of visual acuity at 6 and 9 months, respectively. Thirty-three (40.7%) eyes developed IOP elevation (at least one reading > 24 mmHg). One eye developed infective endophthalmitis. Conclusions Intravitreal injection of triamcinolone acetonide may be considered as an effective treatment for reducing macular thickening due to diffuse diabetic macular edema, venous occlusion associated macular edema, and may result in increase in visual acuity at least in the short term. Further follow-up and analysis is required to demonstrate its long-term efficacy.

Single-pass four-throw pupilloplasty for secondary angle-closure glaucoma associated with silicon oil tamponade

2018 ◽  
Vol 29 (5) ◽  
pp. 561-565 ◽  
Author(s):  
Priya Narang ◽  
Ashar Agarwal ◽  
Amar Agarwal
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Intraocular Pressure ◽  
Anterior Chamber ◽  
Anterior Segment ◽  
Angle Closure Glaucoma ◽  
Angle Closure ◽  
Single Pass ◽  
Silicon Oil ◽  
The Mean

Purpose: To describe the feasibility and efficacy of performing single-pass four-throw pupilloplasty for secondary angle-closure glaucoma post silicon oil tamponade. Methods: The procedure was performed in five eyes of five patients. All the cases underwent silicon oil removal with single-pass four-throw pupilloplasty. Single-pass four-throw procedure involves a single pass of needle through the iris tissue that is to be apposed followed by taking four throws by passing the suture end through the loop that is withdrawn from the anterior chamber as in a modified Siepser’s slip-knot technique. Both the suture ends are pulled and this leads to sliding of the loop into the anterior chamber. Surgical pupilloplasty stretches the peripheral iris tissue and helps in breaking the peripheral anterior synechia. Intraoperative gonioscopy and anterior segment optical coherence tomography were performed in all the cases. Results: Intraoperative gonioscopy and anterior segment optical coherence tomography demonstrated opening of the anterior chamber angles with breakage of peripheral anterior synechia. The mean preoperative and postoperative best-corrected visual acuity in logarithm of minimum angle of resolution was 1.24 ± 0.23 and 0.56 ± 0.18, respectively (p < 0.001). The mean preoperative and postoperative intraocular pressure was 38.2 ± 4.97 and 13.0 ± 2.35 mm Hg, respectively. There was a significant decrease in intraocular pressure and marked improvement in visual acuity in all the cases. Conclusion: Surgical pupilloplasty helps to relieve the post-silicon oil-induced secondary angle-closure glaucoma by breaking peripheral anterior synechia and significantly opening the anterior chamber angles.

Toxic anterior segment syndrome and possible association with ointment in the anterior chamber following cataract surgery

2006 ◽  
Vol 32 (2) ◽  
pp. 227-235 ◽  
Author(s):  
Liliana Werner ◽  
Jeffrey H. Sher ◽  
Joel R. Taylor ◽  
Nick Mamalis ◽  
Wesley A. Nash ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Anterior Chamber ◽  
Anterior Segment ◽  
Toxic Anterior Segment Syndrome

Assessment of Preoperative and Postoperative Changes in Corneal Astigmatism after Pterygium Excision by Different Techniques

2020 ◽  
Vol 9 (2) ◽  
pp. 1-4
Author(s):  
Madhavi Chevuturu
Keyword(s):  
Visual Acuity ◽  
Amniotic Membrane ◽  
Surgical Techniques ◽  
Corneal Astigmatism ◽  
Group Iii ◽  
Conjunctival Autograft ◽  
Postoperative Changes ◽  
Group I ◽  
Pterygium Excision ◽  
Group Ii

Background: Pterygium causes visual problems due to induced corneal astigmatism or direct encroachment onto the visual axis. The present study was conducted to compare preoperative and postoperative changes in corneal astigmatism after pterygium excision by different techniques. Subjects and Methods: The present study was conducted from May 2018 to August 20018 on 69 patients of age range 20-55 years of primary Pterygium. Patients were divided into three groups of 23 each. Group I was treated with bare sclera (BS) technique, Group II with conjunctival autograft (CAG) technique and Group III with amniotic membrane graft (AMG) technique. All the patients were preoperatively assessed for visual acuity, anterior and posterior segments, autorefraction, and autokeratometry. After surgery, the patients were recalled on day 5, 1 month, and 3 months for the analysis. Results: Uncorrected visual acuity (UCVA) preoperatively was 0.57, on the 5th day was 0.45 after 1 month was and after 3 months was 35. The mean preoperative astigmatism value in group I was 3.45, in group II was 3.52 and in group III was 3.49. Postoperative astigmatism value in group I was 1.60, in group II was 0.92 and in group III was 0.81. The difference was significant (P< 0.05). Conclusion: Authors found that amniotic membrane graft and a conjunctival autograft is better surgical techniques than bare sclera in reducing astigmatism.

The transplantation of normal tissues: with special reference to auto- and homotransplants of thyroid and spleen in the anterior chamber of the eye, and subcutaneously, in guinea-pigs

1950 ◽  
Vol 234 (619) ◽  
pp. 559-582 ◽  
Keyword(s):  
Guinea Pig ◽  
Anterior Chamber ◽  
Clinical Importance ◽  
Group Iv ◽  
Group Iii ◽  
Normal Tissues ◽  
Group I ◽  
Thyrotrophic Hormone ◽  
Long Time ◽  
Immunological Reactions

The transplantation of tissues raises many yet unsolved problems of fundamental interest, and is of potentially great clinical importance, especially in endocrinology. The present investigation is concerned with three main problems: the immunological reactions associated with the growth of homografts in the anterior chamber of the eye and subcutaneously; the role of the reticulo-endothelial system in the resistance to homografts; and the applicability of Halsted’s principle to auto- and homografts of endocrine tissue, and the mechanism involved. Four groups of experiments are described. In group I, a preliminary study of auto- and homografts of thyroid in the guinea-pig, it is shown that, if a total thyroid deficiency is produced in the host, autografts are uniformly successful both in the anterior chamber and subcutaneously, whereas homografts are usually successful in the anterior chamber but rarely so when made subcutaneously. Halsted’s principle holds good for anterior chamber grafts whether auto- or homografts, i.e. the proportion of successful grafts increases pari passu with the degree of thyroid deficiency produced in the host, but appears to be less applicable to subcutaneous autografts. Some light is thrown on the mechanism of Halsted’s principle by the observation that successful anterior chamber grafts can be obtained in non-thyroidectomized hosts if injections of pituitary thyrotrophic hormone are given. The experiments of group II are concerned with the immunological phenomena relating to thyroid homografts. It is shown that a subcutaneous homograft of thyroid in the guinea-pig is demonstrably antigenic and the same is true of a homograft in the anterior chamber provided this is undergoing destruction. The state of immunity induced is general and extends to the anterior chamber. The existence of a state of immunity induced by a homograft is shown by the diminished chance of a subsequent homograft ‘taking’, but ‘immunization’ (by means of a subcutaneous graft) of an animal which already has a homograft established in the anterior chamber does not appear to modify the behaviour of the latter. In group III it is shown that a homograft transferred after some months from the anterior chamber to a subcutaneous site is more likely to survive than a primary subcutaneous homograft. It thus appears that when a homograft is established in the anterior chamber for a sufficiently long time a process of adaptation occurs as between graft and host. The experiments of group IV relate to the behaviour of auto- and homografts of spleen in the anterior chamber, and of simultaneous thyroid and splenic grafts. It is shown that the chances of success of a thyroid homograft in the anterior chamber are greatly reduced if the latter is provided with reticulo-endothelial tissue in the shape of a simultaneous autograft of spleen, but that a simultaneous homograft of spleen from the same donor has little or no deleterious effect. The mechanism of this phenomenon has not been fully elucidated but would appear to be either cellular, humoral or a combination of the two.

scholarly journals The Long-Term Results of ReLEX® SMILE Depending on the Degree of the Corrected Myopia

2020 ◽  
Vol 17 (4) ◽  
pp. 711-718
Author(s):  
O. A. Klokova ◽  
R. O. Damashauskas ◽  
S. V. Kostenev ◽  
E. N. Kalaidin
Keyword(s):  
Visual Acuity ◽  
Laser System ◽  
Study Groups ◽  
Individual Characteristics ◽  
Long Term Results ◽  
Efficiency Coefficient ◽  
Group Iii ◽  
Group I ◽  
Group Ii

The purpose: prospective study of the long-term refractive and visual results of ReLEx® SMILE, depending on the degree of corrected myopia.Material and methods. The three study groups included 71 patients; the mean age was 26.48 ± 5.5 years. Group I consisted of 20 patients (39 eyes) mean SE –2.62 ± 0.87 D, group II — 26 patients (51 eyes), mean SE 4.68 ± 0.74 D, Group III — 25 patients (47 eyes), mean SE 6.88 ± 0.72 D. All patients underwent femtolaser correction of myopia using the ReLEx® SMILE method with the VisuMax™ laser system (Carl Zeiss Meditec AG).Results. Uncorrected visual acuity of 09 — 1.0 was noted in 34 eyes (87.2 %) in group I, in II — in 43 eyes (84.3 %), in 37 eyes (78.7 %) in group III. The efficiency coefficient was 1.0 in groups I — II and 0.89 in group III. There was no decrease in corrected visual acuity (CVA) during the correction of mild and moderate myopia, in group III it was recorded by 0.1 in two cases (4 %), by 0.2 in one case (2 %), the safety factor in I — II groups 1.0, in III 0,89. Two years after ReLEx® SMILE, refraction of ± 0.5 D from planned in the study groups was achieved, respectively, in 94.9, 88.2, 76.6 % of cases, ± 1.0 D in 100 % of cases in I, II groups, in 97 % of cases in III group. The predictability coefficient was 0.95 in group I, 0.88 in group II, and 0.77 in group III. Refractive regression compared with the results 1 month postoperatively was 0.08 D in group I, 0.1 D in group II, and 0.16 D in group III. Analysis of the long-term results of ReLEx® SMILE allows us to conclude: the method is safe and effective, provides high predictability of refractive results in correcting various degrees of myopia. Further study of the long-term results of the operation, the creation and use of nomograms, taking into account the individual characteristics of the cornea, will improve the predictability and stability of refractive results in the correction of high myopia. 

scholarly journals Comparison of safety and number of post-operative visits of patients in convenient day versus conventional first day follow-up after phacoemulsification

2021 ◽  
Vol 37 (5) ◽  
Author(s):  
Zahid Kamal ◽  
Ahmad Zeeshan Jamil ◽  
Hira Shuja Khokhar ◽  
Farah Huma
Keyword(s):  
Visual Acuity ◽  
Intraocular Lens ◽  
Anterior Segment ◽  
Care Facility ◽  
Health Care Facility ◽  
Creative Commons ◽  
Group I ◽  
Department Of Ophthalmology ◽  
Group Ii

Objectives: To compare safety and number of post-operative visits of patients in convenient day versus conventional first day follow-up after phacoemulsification Methods: This observational cohort study was conducted in Department of ophthalmology, Sahiwal Medical College, Sahiwal from November 2019 to August 2020. There were 600 patients who underwent uncomplicated phacoemulsification with intraocular lens implantation. Patients were allocated into two groups. Group-I comprised of patients with convenient day follow-up during the first post-operative week. Group-II comprised of the patients with conventional first day follow-up. Rate of complications, number of visits during the first month and final visual acuity were recorded. Results: In Group-I post-operative complications were noted in 12.67% cases on first follow up visit and in 2.67% cases on first month follow up visit. In Group-II post-operative complication were noted in 22 % cases on first follow up visit and in 4% cases on first month follow up visit. Common postoperative complications were corneal oedema, anterior segment intraocular inflammation, residual lens matter in anterior chamber and intraocular lens subluxation. There was no difference in presenting and postoperative visual acuity between the two groups. Mean follow-up visits were 2.23 ± 0.42 in Group-I and 3.55 ± 0.50 in Group-II. Conclusion: Convenient day follow-up is as safe as conventional first day follow-up. Convenient day follow-up significantly reduces the number of post-operative visits. This would translate into cost reduction both for the patients and the health care facility. doi: https://doi.org/10.12669/pjms.37.5.4121 How to cite this:Kamal Z, Jamil AZ, Khokhar HS, Huma F. Comparison of safety and number of post-operative visits of patients in convenient day versus conventional first day follow-up after phacoemulsification. Pak J Med Sci. 2021;37(5):---------.  doi: https://doi.org/10.12669/pjms.37.5.4121 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals The changes of refractive status and anterior segment parameters after strabismus surgery

2019 ◽  
Author(s):  
Wenke Zhou ◽  
Hanyun Wu ◽  
Yumeng Zheng ◽  
Li Zhang
Keyword(s):  
Anterior Segment ◽  
Strabismus Surgery ◽  
Lateral Rectus ◽  
Medial Rectus ◽  
Group Iii ◽  
Group I ◽  
Surgical Methods ◽  
Refractive Status ◽  
Anterior Segment Parameters ◽  
Operation Results

Abstract Purpose To investigate the effects of strabismus surgery on the refractive status and anterior segment parameters, meanwhile to conduct a research on the causes of these changes. Methods This was a retrospective study about 65 patients (104 eyes) who underwent strabismus surgery by a single surgeon from February 2017 to May 2018. The patients were divided into 4 groups. Group I: unilateral lateral rectus recession (40 eyes), Group II: unilateral medial rectus recession (16 eyes), Group III: monocular lateral rectus recession and medial rectus resection (30 eyes), Group IV: disinsertion of the inferior oblique (18 eyes). Refractive status and anterior segment parameters were measured at 1 day before operation, 1 week, 1 month and at least 3 month after operation. Results Spherical equivalent significantly showed a myopic shift during postoperative 1 week in horizontal rectus surgery, and it still showed a statistical changes during postoperative at least 3 month unilateral medial rectus recession. J0 displayed a shift in the with-the-rule direction in unilateral medial / lateral rectus recession lasted to the at least 3 month after surgery. J45 had no significant change in all groups as time passed by. Patients manifested statistically significant changes in steepest keratometry at 1 week after operation in horizontal rectus surgery.Flattest keratometry changed significantly only in unilateral medial rectus recession lasted to the at least 3 month after surgery .There was no change in disinsertion of the inferior oblique . Conclusions Refractive changes are a significant side effect of strabismus surgery, therefore, patients should be informed about it prior to surgery and the appropriate time for optometry should be chosen according to the different surgical methods after surgery.

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