scholarly journals Treatment of Chemotherapy-induced Nausea in Cancer Patients

2010 ◽  
Vol 06 (02) ◽  
pp. 14
Author(s):  
Julie L Ryan ◽  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Metabolic Disorders ◽  
Nausea And Vomiting ◽  
Daily Functioning ◽  
Evidence Based ◽  
Nutritional Depletion

For over 30 years, chemotherapy-induced nausea and vomiting have been the most severe and troublesome symptoms for cancer patients receiving chemotherapy. Unresolved chemotherapy-induced nausea and vomiting can lead to metabolic disorders, dehydration, nutritional depletion and oesophageal tears, and can reduce the daily functioning and quality of life of and interfere with treatment schedules. Despite the widespread use of antiemetics, chemotherapy-induced nausea continues to be problematic. Unlike vomiting, nausea is a subjective and unobservable phenomenon, making it extremely difficult to accurately assess and treat. Current research suggests that management of chemotherapy-induced nausea should focus on treating the symptoms before they occur rather than after they develop. This article highlights evidence-based interventions for the treatment of chemotherapy-related nausea.

Assessing the impact of chemotherapy-induced nausea and vomiting on patients’ quality of life: An Arabic version of the Functional Living Index-Emesis

2021 ◽  
pp. 107815522199844
Author(s):  
Abdullah M Alhammad ◽  
Nora Alkhudair ◽  
Rawan Alzaidi ◽  
Latifa S Almosabhi ◽  
Mohammad H Aljawadi
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Arabic Language ◽  
Nausea And Vomiting ◽  
Cancer Center ◽  
Arabic Version ◽  
Patient Reported ◽  
Arabic Speaking ◽  
The Impact

Introduction Chemotherapy-induced nausea and vomiting is a serious complication of cancer treatment that compromises patients’ quality of life and treatment adherence, which necessitates regular assessment. Therefore, there is a need to assess patient-reported nausea and vomiting using a validated scale among Arabic speaking cancer patient population. The objective of this study was to translate and validate the Functional Living Index-Emesis (FLIE) instrument in Arabic, a patient-reported outcome measure designed to assess the influence of chemotherapy-induced nausea and vomiting on patients’ quality of life. Methods Linguistic validation of an Arabic-language version was performed. The instrument was administered to cancer patients undergoing chemotherapy in a tertiary hospital's cancer center in Saudi Arabia. Results One-hundred cancer patients who received chemotherapy were enrolled. The participants’ mean age was 53.3 ± 14.9 years, and 50% were female. Half of the participants had a history of nausea and vomiting with previous chemotherapy. The Cronbach coefficient alpha for the FLIE was 0.9606 and 0.9736 for nausea and vomiting domains, respectively, which indicated an excellent reliability for the Arabic FLIE. The mean FLIE score was 110.9 ± 23.5, indicating no or minimal impact on daily life (NIDL). Conclusions The Arabic FLIE is a valid and reliable tool among the Arabic-speaking cancer population. Thus, the Arabic version of the FLIE will be a useful tool to assess the quality of life among Arabic speaking patients receiving chemotherapy. Additionally, the translated instrument will be a useful tool for future research studies to explore new antiemetic treatments among cancer patients.

Antiemesis

2007 ◽  
Vol 5 (1) ◽  
pp. 12 ◽  
Author(s):  
_ _
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Nausea And Vomiting ◽  
Poor Adherence ◽  
Chemotherapy Treatment ◽  
Radiation Induced ◽  
Recent Version

Chemotherapy-induced nausea and vomiting (emesis) can significantly affect a patient's quality of life, leading to poor adherence with further chemotherapy treatment. In addition, nausea and vomiting can result in other serious complications and deterioration of the patient's status. These guidelines explore the prevention, treatment, and management of various types of emesis experienced by cancer patients, such as breakthrough, radiation-induced, and anticipatory. For the most recent version of the guidelines, please visit NCCN.org

Development And Validation Of A Voice Script For Telephone Administration Of THE EORTC QLQ-C30

2021 ◽  
Author(s):  
Claire Piccinin ◽  
Madeline Pe ◽  
Dagmara Kuliś ◽  
James W. Shaw ◽  
Sally J. Wheelwright ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Task Force ◽  
Intraclass Correlation ◽  
Nausea And Vomiting ◽  
Self Report ◽  
Equivalence Testing ◽  
The Voice ◽  
Telephone Administration

Abstract Purpose The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life-Core Questionnaire (QLQ-C30) is a widely used generic self-report measure of health-related quality of life (HRQOL) for cancer patients. However, no validated voice script for interviewer-led telephone administration was previously developed that could be used as an alternative to self-completion. The aim of this study was to develop a voice script for interviewer administration via telephone. Methods Following guidelines from the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) PRO Mixed Modes Good Research Practices Task Force, a randomised cross-over equivalence study, including cognitive debriefing, was conducted to assess equivalence between paper and telephone administration modes. Assuming an expected intraclass correlation coefficient (ICC) of 0.70 and a minimally acceptable level of 0.50, a sample size of 63 was required. Results Cognitive interviews with five cancer patients found the voice script to be clear and understandable. Due to a protocol deviation in the first wave of testing, only 26 patients were available for analyses. A second wave of recruitment was conducted, adding 37 patients (n=63; mean age 55.48; 65.1% female). ICCs for mode comparison ranged from 0.72 (nausea and vomiting, 95% CI 0.48-0.86) to 0.90 (global health status/QoL, 95% CI 0.80-0.95; pain, 95% CI 0.79-0.95; constipation, 95% CI 0.80-0.95). For paper versus phone, all ICCs were above 0.70, except nausea and vomiting (95% CI 0.55). For phone versus paper, all ICCs were above 0.70. Conclusions The equivalence testing results support the voice script’s validity for administration of the QLQ-C30 via telephone.

scholarly journals Evaluation of the quality of life of cancer patients undergoing chemotherapy

Rev Rene ◽  
2022 ◽  
Vol 23 ◽  
pp. e71133
Author(s):  
Eliana Aparecida Carlos ◽  
José Adriano Borgato ◽  
Danielle Cristina Garbuio
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Nausea And Vomiting ◽  
Cross Sectional ◽  
Social And Emotional ◽  
Financial Difficulties ◽  
Student’S T

Objective: to assess the quality of life of cancer patients undergoing chemotherapy. Methods: a cross-sectional study carried out in the chemotherapy sector with 51 patients able to answer the data collection instruments. For the analyses, we adopted the variance analysis and Student’s t. Results: the health score indicated moderate quality of life and the symptoms nausea and vomiting, diarrhea, and dyspnea were the most present. The scores of the global health scale showed differences between age groups and presence of metastasis; diarrhea and financial difficulties showed differences with respect to gender; pain was more cited by those who did not undergo surgery; insomnia and nausea and vomiting were related to the time of treatment. Conclusion: participants had moderate overall health scores and the main functional levels affected by the treatment were social and emotional.

scholarly journals Chemotherapy-Induced Nausea and Vomiting

2021 ◽  
Author(s):  
Elisabetta Di Liso
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Common Adverse Effect ◽  
Multiple Organ ◽  
Nausea And Vomiting ◽  
Life Outcomes ◽  
National Guidelines ◽  
Related Factors ◽  
Chemotherapy Agents

Chemotherapy-induced nausea and vomiting is a common adverse effect in cancer patients that not only impacts quality of life, but also treatment outcomes. The prevalence of nausea and vomiting is related to several factors, including the emetogenicity of the chemotherapy regimen, the dose and rate of administration of the chemotherapy agents, various environmental triggers and patient-related factors. The pathogenesis involves multiple organ systems, central nervous system, gastrointestinal tract and neurotransmitters. Clinical management should include a complete assessment of nausea and vomiting to investigate the possible etiology and the pharmacologic approach should involve agents that target each of these pathways and neurotransmitters. Various national guidelines provide recommendations for the prevention and management of CINV and combining these evidence-based strategies into clinical practice is crucial l to improve morbidity and quality-of-life outcomes among cancer patients.

The economic burden of chemotherapy-induced nausea and vomiting and its impact on the quality of life of Italian cancer patients

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 6071-6071
Author(s):  
R. R. Deuson ◽  
E. Ballatori ◽  
B. Ruggeri ◽  
F. Roila ◽  
S. Sarti ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Economic Burden ◽  
Nausea And Vomiting

scholarly journals The Chinese herb Xiaoaiping protects against breast cancer chemotherapy-induced alopecia and other side effects: a randomized controlled trial

2019 ◽  
Vol 47 (6) ◽  
pp. 2607-2614 ◽  
Author(s):  
Fujie Yu ◽  
Yuanmei Li ◽  
Jiaqun Zou ◽  
Lisha Jiang ◽  
Chun Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Side Effects ◽  
Cancer Patients ◽  
Chinese Herb ◽  
Nausea And Vomiting ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Wbc Count

Objective To investigate the effects of the Chinese herbal medicine Xiaoaiping to treat chemotherapy-induced side effects in breast cancer patients. Methods Ninety-three adult patients who attended our hospital and met the entry criteria from January 2016 to December 2017 were included. Patients were randomly divided into the control group (routine chemotherapy only) and the combined group (routine chemotherapy and Xiaoaiping). Demographic data and clinical variables were collected, and side effects including alopecia, nausea and vomiting, diarrhea, white blood cell (WBC) count, aspartate aminotransferase (AST) levels, and the quality of life were evaluated. Results Basic clinical characteristics were not different between the groups. There were significantly fewer patients with alopecia grade 3–4, but significantly more patients with alopecia grade 1–2, in the combined group compared with the control group. Disease-free time for alopecia was longer in the combined compared with the control group. Overall, the side effects were significantly more serious in the control compared with the combined group. Patients in the combined group had better quality of life than the control patients. Conclusion Xiaoaiping can improve alopecia, nausea and vomiting, and diarrhea symptoms, WBC count, AST levels, and the quality of life in breast cancer patients.

scholarly journals Discussing factors associated with quality of life in cancer follow-up appointments: a preliminary test of a pragmatic model for clinical practice

2018 ◽  
Vol 33 (4) ◽  
pp. 762-772 ◽  
Author(s):  
Oana C Lindner ◽  
Martin G McCabe ◽  
Florien Boele ◽  
Andrew Mayes ◽  
Deborah Talmi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Patients ◽  
Illness Perceptions ◽  
Preliminary Test ◽  
Evidence Based ◽  
Cognitive Complaints ◽  
Evidence Based Model ◽  
Subjective Cognitive Complaints

Objective: The aim of this study is to perform a preliminary test of a practical, evidence-based model to enable discussions around quality of life–related concerns during cancer follow-up appointments. Design: Cross-sectional study measuring quality of life, illness perceptions, emotional distress, fatigue, and subjective cognitive complaints. Setting: Cancer outpatient follow-up clinics in four National Health Services in the United Kingdom. Participants: Working-age post-treatment cancer patients, treated with curative intent. Interventions: Not applicable. Main measures: European Organisation for the Research and Treatment of Cancer – Quality of Life Questionnaire – Core 30, Illness Perceptions Questionnaire – Revised, Hospital Anxiety and Depression Scale, Chalder Fatigue Scale, and Cognitive Failures Questionnaire. Results: Fifty-seven cancer patients, with a mean age of 36 years and on average 2.75 years post treatment, returned the completed questionnaires. Anxiety partially mediated the association between subjective cognitive complaints and illness identity (60%) and timeline (25%). Cognitive complaints mediated the relationships between quality of life and anxiety (45%), depression (30%), and fatigue (62%). Depression mediated the relationships between quality of life and illness identity (48%) and timeline (40%). Conclusion: Our study provides a preliminary test of an evidence-based model to help elicit quality of life–related concerns during cancer follow-up appointments. Illness perceptions are associated with quality of life through the mediation of other cancer-relevant factors. Discussing the type, origin, and expected duration of symptoms may elicit other concerns, such as emotional distress, fatigue, or cognitive complaints, which explained a significant amount of the relationship between illness perceptions and quality of life.

scholarly journals A prospective observational analysis: Poor quality of life in cancer patient population of South Indian Territory Hospital, MGM Hospital, Warangal

2016 ◽  
Author(s):  
A. Yedukondala Rao
Keyword(s):  
Quality Of Life ◽  
Head And Neck ◽  
Cancer Patients ◽  
Nausea And Vomiting ◽  
Future Perspective ◽  
Breast Cancer Patients ◽  
Role Function ◽  
Physical Role ◽  
South Indian

Over the ten years, Quality of Life (QOL) investigations of cancer patients have become an important evaluation parameter in the cancer clinical research and treatment evaluation programs. This study was carried out in tertiary hospital located at Warangal, Andhra Pradesh, India. We assessed the overall QOL of patients affected by cervical, breast, head and neck, and stomach cancers by using EORTC QLQ C-30, QLQ-BR23, QLQ-H&N35, QLQ-CX24, and QLQSTO22 on ≤2 cycles as Review-I and ≥5 cycles as Review-II. The data were analyzed for 104 individuals with mean age of 46.1} 11.2 years. In In head and neck cancer patients, physical, role, social function, pain, insomnia, diarrhoea, speech problems, swallowing, dry mouth were significant (P < 0.05). Breast cancer patients, physical, role function, future perspective, fatigue, pain, arm symptoms and upset by hair loss were significant (P < 0.05). In stomach cancer patients, physical, role function, nausea and vomiting, pain, financial problems, Dysphagia, reflux symptoms and eating restrictions were significant (P < 0.05). In cervical cancer patients, physical, emotional function, fatigue, nausea and vomiting, pain, insomnia, symptom experience scale, menopausal symptoms were significant (P < 0.05). Most of the findings are similar to earlier studies, which shows that, QOL was predominantly influenced by the above mentioned factors in this study population and they also have some interesting implications for.

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