scholarly journals The future of mRNA vaccines for autoimmune diseases

2021 ◽  
Vol 7 (2) ◽  
pp. 32-33
Author(s):  
Patricia Langjahr
Keyword(s):  
Autoimmune Diseases ◽  
The Future

scholarly journals Back to the future: oral targeted therapy for RA and other autoimmune diseases

2013 ◽  
Vol 9 (3) ◽  
pp. 173-182 ◽  
Author(s):  
John J. O'Shea ◽  
Arian Laurence ◽  
Iain B. McInnes
Keyword(s):  
Targeted Therapy ◽  
Autoimmune Diseases ◽  
The Future ◽  
Oral Targeted Therapy

scholarly journals Immunoproteasome-selective inhibitors: the future of autoimmune diseases?

2020 ◽  
Vol 12 (4) ◽  
pp. 269-272 ◽  
Author(s):  
Chong Zhang ◽  
Huajian Zhu ◽  
Jiaan Shao ◽  
Ruoyu He ◽  
Jianjun Xi ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Selective Inhibitors ◽  
The Future

scholarly journals Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel

2014 ◽  
Vol 8 ◽  
pp. BBI.S13403 ◽  
Author(s):  
Angélica Sabogal-Arango ◽  
George E. Barreto ◽  
David Ramírez-Sánchez ◽  
Juan González-Mendoza ◽  
Viviana Barreto ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Computational Methods ◽  
Future Generation ◽  
Autoimmune Disorders ◽  
Sea Anemone ◽  
Selectivity Filter ◽  
Sea Anemones ◽  
Kv1.3 Channel ◽  
The Future ◽  
The Common

Sea anemone neurotoxins are peptides that interact with Na+ and K+ channels, resulting in specific alterations on their functions. Some of these neurotoxins (1ROO, 1BGK, 2K9E, 1BEI) are important for the treatment of about 80 autoimmune disorders because of their specificity for Kv1.3 channel. The aim of this study was to identify the common residues among these neurotoxins by computational methods, and establish whether there is a pattern useful for the future generation of a treatment for autoimmune diseases. Our results showed eight new key common residues between the studied neurotoxins interacting with a histidine ring and the selectivity filter of the receptor, thus showing a possible pattern of interaction. This knowledge may serve as an input for the design of more promising drugs for autoimmune treatments.

scholarly journals Glycosylation of immune system proteins and its role in autoimmune diseases and cancer

2020 ◽  
Vol 18 (1) ◽  
pp. 32-37
Author(s):  
Anna Trzyna ◽  
◽  
Jacek Tabarkiewicz ◽  
Artur Mazur ◽  
◽  
...  
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Literature Search ◽  
Biological Significance ◽  
Cell Communication ◽  
Bibliographic Databases ◽  
Systematic Literature Search ◽  
Enzymatic Process ◽  
The Future ◽  
New Treatments

Introduction. Structural glycans have great biological significance and are involved in signaling and cell communication of the immune system. They are attached to proteins and lipids in an enzymatic process called glycosylation where glycosyltransferase and glycosidases bind sugar residues and lead to the formation of bioconjugates. Aim. In this paper we describe the importance of glycosylation in the immune system and its changes in diseases. Material and methods. This review was performed according to systematic literature search of major bibliographic databases. Results. Proper glycosylation ensures the functioning of the organism, however, defects in structural glycans of immune system changes their properties and can lead to disorders and further to autoimmune diseases. It has been also proven that glycosylation of autoimmune system is changed during cancer. In this paper we described types of structural glycans, significance of glycosylation of selected components of the immune system and its modifications in disorders. Conclusions. Knowledge about changes in the glycosylation in diseases is the key to understanding the processes of autoimmune diseases and may allow the development of new treatments in the future.

AB0155 A biorepository and a clinical-laboratorial database of juvenile autoimmune diseases: a resource for the future

2013 ◽  
Vol 72 (Suppl 3) ◽  
pp. A833.1-A833
Author(s):  
B. L. Liphaus ◽  
D. F. C. Patrão ◽  
J. M. A. Reis ◽  
F. A. M. Fonseca ◽  
F. C. Neto ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
The Future

The Future of Medicine

2019 ◽  
pp. 812-829
Author(s):  
Martin Brüne ◽  
Wulf Schiefenhövel
Keyword(s):  
Mental Health ◽  
Autoimmune Diseases ◽  
Medical Treatment ◽  
Preventive Measures ◽  
Evolutionary Medicine ◽  
Physical And Mental Health ◽  
The Future ◽  
Causes Of Disease ◽  
Contemporary Medicine ◽  
Pathogenic Agents

Ever since the dawn of humankind, people have been preoccupied with their physical and mental health. Even though many causes of disease remained obscure for millennia, humans have been quite inventive to find remedies for many ailments. Only quite recently, discoveries of pathogenic agents such as bacteria and viruses have paved the way for the development of modern antimicrobial therapies and preventive measures including hygiene. We now know, however, that the indiscriminate use of antibiotics has produced new problems, and excessive hygiene may be causally involved in the emergence of autoimmune diseases. Chapter 18 proposes that evolutionary medicine may be informative in understanding seemingly unpredictable consequences of advances in some areas of medical treatment. Moreover, the authors believe that evolutionary medicine could help avoid many of the pitfalls associated with the negligence of important evolutionary concepts by contemporary medicine.

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