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2021 ◽  
Vol 22 ◽  
Author(s):  
Suman Kumar Ray ◽  
Sukhes Mukherjee

: Precision medicine represents the most modern contemporary medicine trend, based on enormous amounts of data relating to people's health, individual characteristics, and life context using the most appropriate strategies to prevent and cure them. Precision medicine in cancer coordinates most precisely and viable treatment to every individual cancer patient based on the disease's genetic profile. Precision medicine changes the standard one size fits all medication model, which has focused on average responses to care. Significantly, consolidating different modern methodologies for streamlining and checking anticancer drugs can have continuous effects on understanding results. Precision medicine can help explicit anticancer treatments using various drugs and even in discovery, thus becoming the paradigm of future cancer medicine. Cancer biomarkers are a significant focus point in precision medicine, and findings of different biomarkers make this field more promising and challenging. Naturally, genetic instability and the collection of extra changes in malignant growth cells are ways that cancer cells use to adapt and survive in a hostile environment, for example, one made by these treatment modalities. Precision medicine is centered around recognizing which treatments are best for individual patients, dependent on their malignant growth and genetic characterization. This new era of genomics, which is progressively referred to as precision medicine, has ignited a new episode in the relationship between genomics and anticancer drug development.


2021 ◽  
Vol 10 (4) ◽  
pp. 76-84
Author(s):  
V. I. Chernyavskii ◽  
V. P. Truten ◽  
Kh. A. Abduvosidov ◽  
M. P. Tolstykh

One of the up-to-date issues of contemporary medicine is the study of the features of individual anatomical structure variability of various organs. In recent years, the incidence of parotid gland diseases has been rising. This phenomenon can be associated with an absolute increase in this organ pathologies incidence as well as with the development of additional methods of examination and visualization of the gland. Most pathologies of major salivary glands, in particular the parotid gland, require surgical treatment. Knowledge of topographical relationship of the parotid gland with the adjacent vessels and nerve trunks is utterly necessary for planning and performing surgical interventions and reconstructive operations in the parotid region. According to the statistics, surgical interventions on the parotid gland take the leading place among the causes of damage to the facial nerve branches. This fact may also prove a large variation in the syntopy of the facial nerve and the parotid gland. The paper reviews the data of native and foreign literature on the anatomy of parotid gland and the place of radiation research methods in the study of its topographical and anatomical features. The analysis revealed a wide range of anatomical norm of parotid gland in many parameters, including shape, linear size, blood supply, and topographical features. The practice of using anthropometric studies aimed at structuring the existing knowledge and narrowing the borders of anatomical norm for various organs proved to be successful. However, in the pool of scientific papers, we have not found similar studies concerning parotid gland. The facts mentioned above make the background and justify further studies of parotid gland in the context of normal individual variability.


AYUSHDHARA ◽  
2021 ◽  
pp. 3535-3541
Author(s):  
Kusum Mahajan ◽  
Yasmeen A. Phaniband

In recent years; there has been a considerable increase in the incidence of skin problems in the developing countries like India and tropical countries due to less immunity, unhygienic, living conditions, and nutrition. The most exposed part of the body is skin. In cosmetic point of view patient who suffers with any skin diseases leads to experience physical, emotional and socio-economic embarrassment in his/her society because mirror that reflects internal & external pathology in such diseases is skin which helps in diagnosis. In among the various skin infections tinea/ringworm is one which is spreading rapidly and affecting all the age group of population. Skin infection is termed as Twak Vikara or Kushta roga in Ayurveda. In among the Kushta Roga, Dadru termed as a Dadru Kushta. In contemporary medicine, tinea/ringworm which is skin fungal infection is correlated to Dadru Kushta due to similarities in their signs and symptoms. Large community prevalence studies have demonstrated that between 20-30% of the population have various skin problems requiring attention. Present study was conducted on diagnosed patients of Dadru Kushta in patients Moolakabeejadi Lepa was applied. The drugs used in the formulations having Kandughana, Kushtahara, Krimighna, Shodhana and Tridoshahara in their properties. The results revealed highly significant effect of Moolakabeejadi Lepa in various subjective and objective parameters like Raga, Kandu and number of Pidika, number of Mandala after treatment. During follow up period of 15 days the drug effect suggested the sustained effect on the disease.


2021 ◽  
Author(s):  
Indumathi J ◽  
Sendhilkumar A

The contemporary pandemic scenario of COVID-19 has brought to surface the efficacy of old health care wisdom in inhibition and care of diseases where contemporary medicine deceptively wants a real cure. Undeniably, viral diseases for the fascinating vitality of their causal organisms, top this wish list. Ultimately the world seems to be enthusiastic to pay attention about old health care approaches to control viral pandemics if these are found well-intentioned in handling such situations. One such demand is to energetically or intelligently use the therapeutic devices especially the Shirodhara device, at the convenience, anytime, anywhere in a teleconsultation mode. The Shirodhara device design is to be in a manageable form without trailing the legitimacy and principals of Ayurveda. The main elements used in the device comprises of a sensor for perceiving the temperature, a pump for salvaging the medicine, programming device to control the temperature, and regulate the heater and a wavering pipe for free flow of the medicine. The device is premeditated in such a way to evade the faults and snags produced while doing the procedure Shirodhara. Hence, this device is built which is portable, cost effective; it provides a technologically enhanced Shirodhara instrument curtailing the practice of medicine and man power for the procedure.


2021 ◽  
Vol 48 (4) ◽  
pp. 62-68
Author(s):  
V. Mihaylova ◽  
I. Ivanova ◽  
A. Alakidi ◽  
K. Kilova ◽  
M. Liochkova

Abstract A doctrine was established regarding the so called “new beginning” – the transition to the post-retirement period for a full-value experience of the available compensatory reserves and creation of overcoming strategies for opposing and coping with the obstacles in the still uncommon lifestyle of the senior citizen. By outlining the role of physical activity in a synthesized format, a successful attempt for data classification worldwide was made; in one fourth of the elderly people there is insufficient physical activity, more evident in the women and for Bulgaria this percent is higher (95%). The role and effect of categorized physical exercises for mobility, flexibility, and stretching, aerobic and anaerobic movements have been pointed out. Moreover, the review discusses the preventive effects of rehabilitation, including psychological ones and the role of it in helping patients live with socially significant diseases, coping with disability. The contribution of physical activity and rehabilitation as protective factors of non-infectious diseases is associated with good mental health, improved quality of life and well-being. Within this meaning, while contemporary medicine adds years to life, physical activity and mostly rehabilitation is a significant reason for adding a meaningful life in the course of aging and old age.


Botany ◽  
2021 ◽  
Author(s):  
John Thomas Weber

There are many different types of berry plants that grow throughout North America. These various species of plants produce berries known by their common names such as blueberry, lingonberry, cranberry, crowberry, blackberry, bunchberry, bearberry and strawberry. The berry fruits are important food sources and can be eaten fresh or preserved. The leaves of several species can also be enjoyed in teas. Contemporary medicine has demonstrated many potential health benefits of berries, due to their antioxidant and anti-inflammatory activity. Indigenous Peoples have not only utilized berries as food, likely over many centuries, but have also passed down knowledge on the medicinal uses of various parts of these plants, including the fruits, leaves and roots. This short review provides a synopsis of some of the major species of berry-producing plants that are prevalent in Canada, particularly eastern Canada. Current knowledge and traditional uses of important species of berry-producing plants are discussed.


2021 ◽  
Vol 70 (3) ◽  
pp. 143-150
Author(s):  
Vitaly F. Bezhenar ◽  
Lidia A. Ivanova ◽  
Dmitry O. Ivanov

BACKGROUND: Perinatal death is the death of the fetus, starting from 22 weeks of pregnancy and in childbirth, as well as the death of a newborn in the first seven days of life. Despite the fact that reducing perinatal losses is one of the most important tasks of contemporary medicine, the level of perinatal mortality in Russia in recent years has been about 7.5 . AIM: The aim of this study was to analyze documentation related to the legal aspects of perinatal loss. MATERIALS AND METHODS: The article analyzes the main federal laws, agency regulations, orders, methodological letters, recommendations, and materials on the Internet concerning the main aspects and questions that most often arise among doctors, as well as postpartum women who have undergone perinatal loss and their family members. RESULTS: The article provides data on: the medical criteria for birth, basic documentation issued in case of stillbirth, the birth of a live child who died in the perinatal period, and the rules for their issuance; the rules and procedure for notifying state bodies in case of perinatal death, the rules for registering a stillborn and a child who died in the first 168 hours of extrauterine life; the types of perinatal death certificate; the rules for conducting a pathological autopsy and the possibility of refusing it; the issues of burial of children who died perinatally; the rules for handling material obtained during termination of pregnancy up to 22 weeks. CONCLUSIONS: The legislative framework was analyzed and answers were given to the most frequently asked questions regarding the legal aspects of perinatal loss.


2021 ◽  
Vol 22 (15) ◽  
pp. 8214
Author(s):  
Luca Ambrosio ◽  
Maria Grazia Raucci ◽  
Gianluca Vadalà ◽  
Luigi Ambrosio ◽  
Rocco Papalia ◽  
...  

Bone cancer is a demanding challenge for contemporary medicine due to its high frequency of presentation and significant heterogeneity of malignant lesions developing within the bone. To date, available treatments are rarely curative and are primarily aimed at prolonging patients’ survival and ameliorating their quality of life. Furthermore, both pharmacological and surgical therapies are aggravated by a consistent burden of adverse events and subsequent disability due to the loss of healthy bone structural and functional properties. Therefore, great research efforts are being made to develop innovative biomaterials able to selectively inhibit bone cancer progression while reducing the loss of bone structural properties secondary to local tissue invasion. In this review, we describe the state of the art of innovative biomaterials for the treatment of bone cancer. Along with physiological bone remodeling, the development of bone metastasis and osteosarcoma will be depicted. Subsequently, recent advances on nanocarrier-based drug delivery systems, as well as the application of novel, multifunctional biomaterials for the treatment of bone cancer will be discussed. Eventually, actual limitations and promising future perspectives regarding the employment of such approaches in the clinical scenario will be debated.


AYUSHDHARA ◽  
2021 ◽  
pp. 3334-3338
Author(s):  
Jayashree Gunjigonvi ◽  
Venkatesh Polampalli

Low back pain is one of the most common diseases affecting 70% to 80% of population. Low back pain affects the people of all ages from children to elder one. Among various causes of low back pain Sciatica is most appearing one. Sciatica is a condition in which pain radiating along the sciatica nerve, which runs down one or both legs from the lower back. Sciatica pain sometimes hampers the person daily activities because of its intensity. As per Ayurvedic classics its features closely resembles the Gridhrasi. In Gridhrasi pain starts from Sphik (hip) and runs down to Kati Prusta (back), Uru (thigh), Jaanu (knee), Jangha (calf), and Pada (foot) along with pain it may be associated with stiffness, heaviness based on Dosha involvement. Contemporary medicine has limitation with short term pain relief or surgical interventions which are sometime more costly to afford and also long term pain medication will have side effects. Ayurvedic treatment has good scope in managing Gridhrasi with Panchakarma procedures with oral medication. Here in this case study Patient was suffering from low back pain radiating to right lower limb she was treated with one course of Katibasti followed by Sarvanga basphasweda with one course of Yogabasti with oral medication. After treatment patient showed remarkable improvement in symptoms, shows improvement of Oswestry Disability score from 68.88% to 22.22% that is moderate disability and would do all routine daily activities properly.


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