scholarly journals Our Experience Olopatadine Treatment of Allergic Conjunctivitis in Children

2021 ◽  
Vol 18 (2) ◽  
pp. 361-367
Author(s):  
T. N. Vorontsova ◽  
M. V. Zaitseva ◽  
M. A. Chramtsova
Keyword(s):  
Dry Eye ◽  
Allergic Conjunctivitis ◽  
Tear Film ◽  
Term Treatment ◽  
Dry Eye Syndrome ◽  
Chronic Type ◽  
Film Stability ◽  
Lissamine Green ◽  
Long Term Treatment

The authors analyzed the treatment results of 53 patients (106 eyes) with allergic conjunctivitis. All patients received Olopatadine 0.2 % (Visallergol) in drops once a day during 1 month. All patients underwent the same tests: scraping from the conjunctiva for the presence of eosinophils, evaluation of the inflammation symptoms using 4-ball scale, biomicroscopy of cornea and conjunctiva with staining by lissamine green and tear film stability (Norn’s method). All of the above-mentioned tests were performed before the treatment, on 14-th day and after the course of therapy. The inflammatory reaction of conjunctiva, the amount of discharge in the conjunctival cavity and the staining of the conjunctiva with lissamine green decreased in all patients starting from the 14-th day of treatment. The maximal effectiveness of the drop was registered in patients with the chronic type of allergic conjunctivitis. The manifestation of the disease reduced significantly after 1 month of treatment, but it does not disappear completely. So it is necessary to continue therapy after 1 month. The laboratory methods of diagnosis confirm the effectiveness of Visallergol by disappearance of eosinophils in the conjunctiva scrapings. The secondary dry eye syndrome developed in all types of the allergic conjunctivitis and needs a long-term treatment. The maximal intensity of dry eye syndrome was registered in patients with chronic type of the allergic conjunctivitis. The drop can be used starting from 2 years old. 

scholarly journals Diquafosol zur Behandlung der Keratokonjunktivitis sicca: 12-Monats-Ergebnisse einer prospektiven Studie

2021 ◽  
pp. 1-2
Author(s):  
Björn Bachmann
Keyword(s):  
Dry Eye ◽  
Real World ◽  
Tear Film ◽  
Ophthalmic Solution ◽  
Term Treatment ◽  
Summary Score ◽  
Open Label ◽  
Staining Score ◽  
Long Term Treatment

<b>Introduction:</b> Diquafosol is a P2Y<sub>2</sub> receptor agonist that has been shown to be effective in the treatment of dry eye disease (DED) in short-term studies; however, its long-term safety and effectiveness have not been evaluated in a real-world setting. <b>Methods:</b> This prospective, multicentre, open-label observational study was conducted in patients with DED over 12 months. Safety endpoints included the incidence of adverse drug reactions (ADRs) and serious ADRs. Effectiveness endpoints included change from baseline in keratoconjunctival staining score, tear film break-up time (BUT) and Dry Eye-related Quality of Life Score (DEQS). <b>Results:</b> A total of 580 patients were included, most of whom were female (82.9%). The proportion of patients who completed 12 months of observation was 55.0%, the most common reason for discontinuation was patient decision (54.6%). The incidence of ADRs was 10.7% and was highest during the first month of treatment (5.5%); no serious ADRs were reported. Compared with baseline, significant improvements in all effectiveness outcomes, including keratoconjunctival fluorescein staining score, BUT and DEQS summary score, were observed at each evaluation during the treatment period (p &#x3c; 0.001). <b>Conclusion:</b> The present, real-world study showed that diquafosol 3.0% ophthalmic solution was well tolerated and effective in the long-term treatment of DED.

scholarly journals Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome

2016 ◽  
Vol 95 (3) ◽  
pp. e230-e235 ◽  
Author(s):  
Ki Won Jin ◽  
Jin Woo Ro ◽  
Young Joo Shin ◽  
Joon Young Hyon ◽  
Won Ryang Wee ◽  
...  
Keyword(s):  
Vitamin D ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Film Stability ◽  
Vitamin D Levels ◽  
Tear Film Stability

Choosing the optimal method for preoperative risk assessment of dry eye syndrome development in patients with myopia

Reflection ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 30-36
Author(s):  
O.V. Kolenko ◽  
◽  
Y.V. Kutuzova ◽  
I.V. Dutchin ◽  
E.L. Sorokin ◽  
...  
Keyword(s):  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Rupture Time ◽  
Film Rupture ◽  
Optimal Method ◽  
Film Stability ◽  
Tear Film Stability ◽  
Keratorefractive Surgery ◽  
The Stability

Aim. Comparative analysis of the effectiveness of keratotopography methods and classical Norn’s test in assessing the stability of the tear film (TF) in patients with myopia before photorefractive surgery. Methods. The study involved 26 patients. All of them were planned for keratorefractive surgery to correct myopic refraction and astigmatism. Their age averaged 32.5±14.5 years (18-47 years). The stability of pre-corneal tear film was assessed using computed keratotopography and Norn’s test - the tear film rupture time (TFRT) was determined. A standard questionnaire was also used to assess the severity of symptoms of dry eye syndrome (DES). A comparison was made of the indicators of tear film, stability obtained by the methods of keratotopography and Norn’s test, with their subsequent comparison with the data of the questionnaire. Results. In 17 patients (65.4 %), TFRT index corresponded to the age norm. In the remaining 9 people (34.6 %), indicators of tear film stability were reduced both by keratotopography (12±4 sec) and by Norn’s test (13.5± 4.5 sec), and there were also subjective signs of dry eye syndrome according to questionnaire data. The data turned out to be comparable. Conclusion. The incidence of impaired stability of the TF and subjective manifestations of DES among patients planned for keratorefractive surgery for myopia and myopic astigmatism was significant and, according to our data, made 34.6 %. To prevent complicated postoperative course of photorefractive surgery, it is necessary to assess the condition of the ocular surface immediately before refractive surgery, to identify the risk group for DES development. Key words: dry eye syndrome; tear film; keratotopography; Norn’s test; tear film rupture time.

Clinical manifestations of the dry eye syndrome for women in menopause

2014 ◽  
Vol 5 (2) ◽  
pp. 25-29
Author(s):  
Nataliya Nikolayevna Sadovnikova ◽  
Galiya Fettyakhovna Kutusheva
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Clinical Manifestations ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Menopausal Syndrome ◽  
Film Stability ◽  
Tear Film Stability ◽  
Functional Features ◽  
Subjective Discomfort

To assess the effect of menopausal syndrome manifestations in the manifestation of «dry eye» examined 63 women . All examined the condition of the ocular surface, tear film stability, severity of subjective discomfort . Revealed that the dry eye syndrome in postmenopausal women occurs predominantly in the mild and moderate forms, with the severity of clinical and functional features of dry eye syndrome significantly correlated with severity of menopausal symptoms .

scholarly journals Dry Eye Syndrome in Glaucomatous Patients using Topical Anti-Glaucoma Therapy

2020 ◽  
Vol 36 (1) ◽  
Author(s):  
Nabila Zulfiqar ◽  
Muhammad Sufyan Aneeq Ansari ◽  
Khurram Nafees ◽  
Rabia Nawaz ◽  
Manzra Shaheen
Keyword(s):  
Observational Study ◽  
Study Design ◽  
Dry Eye ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Film Stability ◽  
Glaucoma Therapy ◽  
Tear Film Stability ◽  
Time Test ◽  
Break Up

Purpose:  To determine the frequency of Dry eye in Glaucoma patients using topical anti-glaucoma therapy. Study Design:  Descriptive Observational study. Place and Duration of Study:  Study was conducted in outpatient department of Fatima Memorial Hospital Shadman, Lahore, from October 2016 to February 2017. Material & Methods:  In this study, 61 diagnosed cases of glaucoma were included. Patients with significant dermatological problems that may be associated with dry eye such as rosacea and blepharitis were excluded from the study. The individuals were assessed by consultant Ophthalmologist for Dry eye syndrome having symptoms of stinging and burning sensations itching, watering, irritation, due to regular use of topical anti-glaucoma drugs. A written consent was taken from every patient before the test. The ocular surfaces of the patients were evaluated using Tear film break-up time test and Basal Schrimer’s test. Patients having TBUT less than 11 seconds were categorized as having dry eye. The degree of dryness was categorized as mild, moderate and sever Dry eye. Results:  Among 61 patients of glaucoma using topical anti-glaucoma therapy, 22 (36.1%) were male and 39 (63.9%) were female. Mean age of the patients was 50.76 ± 15.67 years. On the basis of Tear film Break-up time test, 49 (81%) patients had Tear Break-up time less than 10 seconds and 12 (19%) patients were normal. On the basis of Schrimer`s test 51 (83.66%) patients had Dry eye. Conclusion:  Topical use of anti-glaucoma therapy affects tear film stability and its functions leading to Dry eye syndrome.

scholarly journals Compliance as an Integral Part of the Dry Eye Syndrome Prevention Using Silicone Hydrogel Contact Lenses

2016 ◽  
Vol 23 (4) ◽  
pp. 201647
Author(s):  
Rimma Skrypnyk ◽  
Olga Selezneva
Keyword(s):  
Dry Eye ◽  
Contact Lenses ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Film Stability ◽  
Silicone Hydrogel ◽  
Clinical Guidance ◽  
Schirmer’S Test ◽  
Group I ◽  
Tear Film Stability

The probability of dry eye syndrome (DES) in the patients using the Silicone-Hydrogel Contact Lenses is examined in many researches. Therefore, adhering to clinical recommendations is an important factor for DES prevention. The urgent issue is also a comprehensive assessment of functional parameters as pathogenetic base of DES.The objective of the research was tostudy DES development depending on compliance of silicone hydrogel contact lenses users.Matherials and methods. 97 patients (194 eyes) were included into the research. They formed 2 groups: group I with incomplete compliance (36 persons) and group II with complete compliance (61 persons). All the patients underwent the Norn’s test, Schirmer’s test, Jones test, tear film stability was defined. The probability of the dry eye syndrome development due to the subjective signs was also analysed.Results. The reliable decrease in the total (р<0.05) and basale lacrimation (р<0.05) indexes, the increase in osmolarity (р<0.05) and decrease in tear film stability (р<0.05) were detected in the patients who did not follow the clinical guidance during the Silicone-Hydrogel Contact Lenses wearing. In the same group the higher risk of dry eye syndrome development was verified (р<0.05).Conclusion. Compliance disorder in the patients using Silicone-Hydrogel Contact Lenses was found to induce the reliable decrease in total and basale lacrimation, increase in osmolarity and tear stability disorder. All of this factors increase the risk of dry eye syndrome.

scholarly journals New Possibilities of Tear Replacement Therapy in Patients with Dry Eye Syndrome of Various Origins

2019 ◽  
Vol 16 (2) ◽  
pp. 244-251
Author(s):  
V. V. Brzheskiy ◽  
S. Yu. Golubev ◽  
I. V. Brzheskaya ◽  
V. Yu. Popov
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Severe Form ◽  
Dry Eye Syndrome ◽  
Degenerative Changes ◽  
Ocular Surface Disease Index ◽  
Film Stability ◽  
Days Of Therapy

The artificial tears on the basis hyaluronic acid is primary importance today in dry eye syndrome (DES) treatment. In recent years, they have been supplemented Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) differing concentrations of sodium hyaluronate and viscosity. The study is devoted to assessing the effectiveness of these drugs in the treatment of patients with dry eye syndrome (DES) of various etiology and severities.There were 73 volunteers with DES of various etiology: 21 — Sjogren’s syndrome, 24 — meibomian blepharitis, and 28 — perimenopause in the study. All patients were divided into 2 groups: 36 patients of the first group received instillations into conjunctival cavity of the Optinol® Express Moisture (0.21 %) and 37 patients of the second group — Optinol® Deep moistening (0.4 %).Starting from the first days of therapy, all patients had a decrease in the severity of subjective signs of DES, estimated by the value of the ocular surface disease index (OSDI). At the same time, tendency to stop of the degenerative changes in the epithelium of the ocular surface was established. It is characterized by a decrease in the degree of staining. The increasement of the tear film stability and an index of the tear meniscus was found in all patients. The dynamics of the controlled parameters increased, as the instillation of the drugs took place and by the 30th day of therapy. There were significant differences from the baseline values. At the same time, the Optinol® Express Moisture (0.21 %) was more effective (mainly in terms of subjective discomfort and the severity of degenerative changes in the epithelium of the ocular surface) in patients with mild and extremely severe form of the xerosis process.The drug Optinol® Deep Moisture (0.4 %) was more effective in patients with xerosis of moderate severity and severe by the same parameters. In the course of research, we have not observed any side effects of both drugs. It allows us to recommend the drugs Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) to widespread clinical use in treating patients with DES of various etiology. 

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